Article
Health Care Sciences & Services
Dayang Nooreffazleen Yahya, Rhanye Mac Guad, Yuan-Seng Wu, Siew Hua Gan, Subash C. B. Gopinath, Hasif Adli Zakariah, Rusdi Abdul Rashid, Maw Shin Sim
Summary: The rs4755404 gene polymorphism of SLC1A2 is significantly associated with METH-induced psychosis, especially for individuals with the GG homozygous genotype.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Article
Genetics & Heredity
Huan Liu, Wei Zhang, Xiao-Dong Deng, Ying Ma, Yun Liu
Summary: The study showed that the NQO1 gene may play a significant role in the pathophysiological process of METH dependence, and the 609C/T polymorphism may contribute to the susceptibility to METH dependence in the Chinese Han population.
MOLECULAR GENETICS & GENOMIC MEDICINE
(2021)
Review
Behavioral Sciences
Alexandre A. Guerin, Eric J. Nestler, Michael Berk, Andrew J. Lawrence, Susan L. Rossell, Jee Hyun Kim
Summary: This review systematically reviewed hypothesis-driven candidate gene association studies related to methamphetamine use disorder. Eleven gene markers were significantly associated with the disorder from adequately powered studies, but limitations include unclear rationale for candidate gene selection, low power and high risk of bias in some studies.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Psychiatry
Yuxuan Wu, Xiangdong Du, Ruchang Yang, Yan Yue, Ruijie Peng, Siqi Wu, Haitao Wang, Yue Zhou, Xiaojia Fang, Nian Yuan, Ronghua Li, Jun Zhang, Siyun Zou, Xueli Zhao, Xiaoli Lyu, Zhe Li, Xiaobin Zhang, Xiangyang Zhang
Summary: This study found that serum BDNF levels were lower in patients with first-episode and drug-naive schizophrenia compared with healthy controls. However, patients with depressive symptoms exhibited higher serum BDNF levels. Additionally, there was an association between BDNF levels and the positive symptoms of schizophrenia, but no significant association with depressive symptoms.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Medicine, Research & Experimental
Min Mo, Xi-yue Fu, Xu-lan Zhang, Shao-chuan Zhang, Hai-qing Zhang, Li Wu, Jia-lei Li, Li Zhou
Summary: The study aimed to investigate the relationships between the BDNF gene Val66Met polymorphism and the plasma levels of proBDNF and mBDNF in patients with alcohol dependence. The results showed no association between the Val66Met polymorphism and alcohol dependence, but the levels of proBDNF were increased and mBDNF were decreased in the alcohol dependence group, correlating with alcohol consumption and drinking history.
MEDICAL SCIENCE MONITOR
(2021)
Article
Neurosciences
Anahita Moaveni, Yasha Fayaz Feyzi, Seyedeh Tayebeh Rahideh, Reza Arezoomandan
Summary: This study investigated the serum level of brain-derived neurotrophic factor (BDNF) and cognitive functions in chronic methamphetamine (METH) users. The results showed impaired executive function and working memory in METH users, as well as significantly higher serum BDNF concentrations. However, the increased BDNF level was not associated with cognitive impairments.
NEUROSCIENCE LETTERS
(2022)
Review
Behavioral Sciences
Xi-Yi Hu, Yu-Long Wu, Chao-Hui Cheng, Xiao-Xi Liu, Lan Zhou
Summary: The meta-analysis suggests that the BDNF rs6265 G > A polymorphism is associated with PTSD susceptibility, with an increased risk of A allele mutations. Subgroup analysis showed similar situations in Asian populations and other groups.
BRAIN AND BEHAVIOR
(2021)
Article
Immunology
Yan Li, Wei Li, Li Huang, Huijia Li, Peipeng He, Chao Xue
Summary: This study investigated the association between microscopic polyangiitis and the single nucleotide polymorphism rs807185 in autophagy-associated gene 4A (ATG4A) in the Chinese population. Using multiplex polymerase chain reaction and high-throughput sequencing, it was found that the control group had a higher frequency of the A allele of rs807185 compared to the microscopic polyangiitis group, suggesting that the A allele of rs807185 may have a protective effect against microscopic polyangiitis in the Chinese population. However, the molecular mechanisms remain unclear.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Behavioral Sciences
Sagun Tiwari, Lili Qi, John Wong, Zhenxiang Han
Summary: According to a meta-analysis, peripheral levels of brain-derived neurotrophic factor (BDNF) significantly decrease in depression compared to nondepressed healthy controls. However, the study reveals significant heterogeneity among the included studies. Factors such as history of depression and alcohol consumption affect the level of BDNF, while age and gender do not impact the heterogeneity. Although decreased BDNF expression is a risk factor for depression, it cannot be used as a reliable biomarker to assess depression in clinical practice.
BRAIN AND BEHAVIOR
(2022)
Article
Genetics & Heredity
Juncheng Guo, Yijun Yang, Xiangling Jiang, Min Guo, Xiang Li, Ping Huang, Zhuo Liu
Summary: The study explored the correlations of BDNF promoter methylation and SNP with PTSD in Li and Han nationalities in Hainan province. The study found differences in PTSD incidence between the two nationalities, with lower BDNF levels in Li nationality PTSD patients and higher BDNF promoter methylation. The G-712A genotype and BDNF promoter methylation were identified as independent risk factors for PTSD.
Article
Psychiatry
Ting Fang, Meng-Nan Liu, Xiao-Yu Tian, Guan-Yi Lu, Fei Li, Xiaojie Zhang, Feng Liu, Wei Hao, Ning Wu, Hong Li, Jin Li
Summary: This study found that two variants of the FKBP5 gene (rs4713916A and rs6926133A) were associated with an increased risk of severe DD in patients with MAUD. These findings would help with the development of biological early warning markers and the creation of personalized treatment strategies for MAUD.
FRONTIERS IN PSYCHIATRY
(2023)
Article
Neurosciences
Mauricio Sepulveda, Elizabeth E. Manning, Andrea Gogos, Matthew Hale, Maarten van den Buuse
Summary: This study evaluated the long-term effects of chronic METH treatment on the serotonin system in the brain using various techniques. The results indicated that METH treatment can lead to long-term or selective effects on brain serotonin systems. METH pretreatment may affect 5-HT1A receptor binding and reduce DRN cell counts selectively in BDNF HET mice.
Article
Clinical Neurology
Emilio Portaccio, Angelo Bellinvia, Elio Prestipino, Benedetta Nacmias, Silvia Bagnoli, Lorenzo Razzolini, Luisa Pasto, Claudia Niccolai, Benedetta Goretti, Mattia Fonderico, Giovanni Bosco Zimatore, Nunzia Alessandra Losignore, Sandro Sorbi, Maria Pia Amato
Summary: The study suggests a potential protective effect of BDNF Val66Met polymorphism against cognitive impairment in MS patients, possibly due to the detrimental effect of increased BDNF concentration in a neuroinflammatory environment. Higher EDSS score is associated with a progressive disease course, with a marginal association with the presence of the BDNF Val66Met polymorphism.
FRONTIERS IN NEUROLOGY
(2021)
Article
Genetics & Heredity
Jinzhong Xu, Fenzan Wu, Fan Wang, Fan Yang, Meng Liu, Mengbei Lou, Linman Wu, Hui Li, Wenhui Lin, Yunchao Fan, Li Chen, Yanlong Liu, Haiyun Xu, Jue He
Summary: The study revealed a significant association among the interaction of single nucleotide polymorphisms of the FGF 19 superfamily, AD severity, and aggressive behavior in patients with AD.
FRONTIERS IN GENETICS
(2021)
Review
Cell Biology
Van Thuan Nguyen, Braxton Hill, Naiya Sims, Aaron Heck, Marcus Negron, Claire Lusk, Cristi L. Galindo
Summary: This article introduces the significance of brain-derived neurotrophic factor, which plays a crucial role in neurological disorders and various other biological functions.
NEURAL REGENERATION RESEARCH
(2023)
Review
Medicine, Research & Experimental
Ummi Zulaiqha Hamid, Maw Shin Sim, Rhanye Mac Guad, Vetriselvan Subramaniyan, Mahendran Sekar, Neeraj Kumar Fuloria, Shivkanya Fuloria, Ker Woon Choy, Ismail Muhamad Fareez, Srinivasa Reddy Bonam, Yuan Seng Wu
Summary: HOTTIP, a long non-coding RNA (lncRNA), plays a crucial regulatory role in GI cancer, affecting multiple aspects of cancer progression and chemoresistance, including cellular functions and molecular mechanisms. It also exhibits a higher diagnostic value compared to existing biomarkers, making it a potential novel therapeutic target and diagnostic biomarker in GI cancer treatment.
CURRENT MOLECULAR MEDICINE
(2022)
Article
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
Summary: This study developed and evaluated a decision aid tool for Malaysian patients with MDD to support treatment decision-making during consultation. The tool increased patients' involvement in shared decision making and enhanced their preparedness for decision making without extending the consultation time.
PATIENT EDUCATION AND COUNSELING
(2022)
Article
Neurosciences
Hong Jin Jeon, Po-Chung Ju, Ahmad Hatim Sulaiman, Salina Abdul Aziz, Jong-Woo Paik, Wilson Tan, Daisy Bai, Cheng-Ta Li
Summary: This study evaluated the long-term safety and efficacy of intranasal esketamine in Asian patients with treatment-resistant depression. The results showed that esketamine was generally safe and effective in the Asian subgroup, with no new safety signals or indications of abuse. Most patients experienced improvement during the early stages of treatment.
CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE
(2022)
Review
Oncology
Bernadette Xin Jie Tune, Maw Shin Sim, Chit Laa Poh, Rhanye Mac Guad, Choy Ker Woon, Iswar Hazarika, Anju Das, Subash C. B. Gopinath, Mariappan Rajan, Mahendran Sekar, Vetriselvan Subramaniyan, Neeraj Kumar Fuloria, Shivkanya Fuloria, Kalaivani Batumalaie, Yuan Seng Wu
Summary: Cancer, a major cause of death worldwide, often becomes resistant to treatment and metastasizes. This review focuses on the role of matrix metalloproteinases (MMPs) in promoting chemoresistance and metastasis through the epithelial-to-mesenchymal transition (EMT) pathway. The review also explores the potential diagnostic and prognostic value of specific MMPs and discusses strategies to inhibit MMPs and reduce chemoresistance.
JOURNAL OF ONCOLOGY
(2022)
Article
Health Care Sciences & Services
Dayang Nooreffazleen Yahya, Rhanye Mac Guad, Yuan-Seng Wu, Siew Hua Gan, Subash C. B. Gopinath, Hasif Adli Zakariah, Rusdi Abdul Rashid, Maw Shin Sim
Summary: The rs4755404 gene polymorphism of SLC1A2 is significantly associated with METH-induced psychosis, especially for individuals with the GG homozygous genotype.
JOURNAL OF PERSONALIZED MEDICINE
(2023)
Review
Chemistry, Medicinal
Nur Syafiqah Rahim, Yuan Seng Wu, Maw Shin Sim, Appalaraju Velaga, Srinivasa Reddy Bonam, Subash C. B. Gopinath, Vetriselvan Subramaniyan, Ker Woon Choy, Sin-Yeang Teow, Ismail M. M. Fareez, Chandramathi Samudi, Shamala Devi Sekaran, Mahendran Sekar, Rhanye Mac Guad
Summary: There are six members of the transmembrane 4 superfamily (TM4SF) that have similar topology and sequence homology. Among these members, TM4SF1, TM4SF4, and TM4SF5 play crucial roles in cancer angiogenesis, progression, and chemoresistance. Targeting these TM4SF members has emerged as a promising strategy for cancer therapy.
Article
Psychiatry
Michael Bauer, Tasha Glenn, Eric D. Achtyes, Martin Alda, Esen Agaoglu, Kuersat Altinbas, Ole A. Andreassen, Elias Angelopoulos, Raffaella Ardau, Memduha Aydin, Yavuz Ayhan, Christopher Baethge, Rita Bauer, Bernhard T. Baune, Ceylan Balaban, Claudia Becerra-Palars, Aniruddh P. Behere, Prakash B. Behere, Habte Belete, Tilahun Belete, Gabriel Okawa Belizario, Frank Bellivier, Robert H. Belmaker, Francesco Benedetti, Michael Berk, Yuly Bersudsky, Sule Bicakci, Harriet Birabwa-Oketcho, Thomas D. Bjella, Conan Brady, Jorge Cabrera, Marco Cappucciati, Angela Marianne Paredes Castro, Wei-Ling Chen, Eric Y. W. Cheung, Silvia Chiesa, Marie Crowe, Alessandro Cuomo, Sara Dallaspezia, Maria Del Zompo, Pratikkumar Desai, Seetal Dodd, Bruno Etain, Andrea Fagiolini, Frederike T. Fellendorf, Ewa Ferensztajn-Rochowiak, Jess G. Fiedorowicz, Kostas N. Fountoulakis, Mark A. Frye, Pierre A. Geoffroy, Michael J. Gitlin, Ana. Gonzalez-Pinto, John F. Gottlieb, Paul Grof, Bartholomeus C. M. Haarman, Hirohiko Harima, Mathias Hasse-Sousa, Chantal Henry, Lone Hoffding, Josselin Houenou, Massimiliano Imbesi, Erkki T. Isometsa, Maja Ivkovic, Sven Janno, Simon Johnsen, Flavio Kapczinski, Gregory N. Karakatsoulis, Mathias Kardell, Lars Vedel Kessing, Seong Jae Kim, Barbara Koenig, Timur L. Kot, Michael Koval, Mauricio Kunz, Beny Lafer, Mikael Landen, Erik R. Larsen, Melanie Lenger, Rasmus W. Licht, Carlos Lopez-Jaramillo, Alan MacKenzie, Helle Ostergaard Madsen, Simone Alberte Kongstad A. Madsen, Jayant Mahadevan, Agustine Mahardika, Mirko Manchia, Wendy Marsh, Monica Martinez-Cengotitabengoa, Julia Martini, Klaus Martiny, Yuki Mashima, Declan M. McLoughlin, Ybe Meesters, Ingrid Melle, Fatima Meza-Urzua, Pavol Mikolas, Yee Ming Mok, Scott Monteith, Muthukumaran Moorthy, Gunnar Morken, Enrica Mosca, Anton A. Mozzhegorov, Rodrigo Munoz, Starlin V. Mythri, Fethi Nacef, Ravi K. Nadella, Takako Nakanotani, Rene Ernst Nielsen, Claire O'Donovan, Adel Omrani, Yamima Osher, Uta Ouali, Maja Pantovic-Stefanovic, Pornjira Pariwatcharakul, Joanne Petite, Johannes Petzold, Andrea Pfennig, Yolanda Pica Ruiz, Marco Pinna, Maurizio Pompili, Richard J. Porter, Danilo Quiroz, Francisco Diego Rabelo-da-Ponte, Raj Ramesar, Natalie Rasgon, Woraphat Ratta-apha, Michaela Ratzenhofer, Maria Redahan, M. S. Reddy, Andreas Reif, Eva Z. Reininghaus, Jenny Gringer Richards, Philipp Ritter, Janusz K. Rybakowski, Leela Sathyaputri, Angela M. Scippa, Christian Simhandl, Daniel Smith, Jose Smith, Jr Paul W. Stackhouse, Dan J. Stein, Kellen Stilwell, Sergio Strejilevich, Kuan-Pin Su, Mythily Subramaniam, Ahmad Hatim Sulaiman, Kirsi Suominen, Andi J. Tanra, Yoshitaka Tatebayashi, Wen Lin Teh, Leonardo Tondo, Carla Torrent, Daniel Tuinstra, Takahito Uchida, Arne E. Vaaler, Eduard Vieta, Biju Viswanath, Maria Yoldi-Negrete, Oguz Kaan Yalcinkaya, Allan H. Young, Yosra Zgueb, Peter C. Whybrow
Summary: This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production. The results showed that the age of onset at locations with UVB threshold below the threshold was 1.66 years younger than those with UVB threshold equal to or above the threshold. The conclusion suggests that UVB and vitamin D may play an important role in the development of bipolar disorder.
INTERNATIONAL JOURNAL OF BIPOLAR DISORDERS
(2023)
Article
Health Care Sciences & Services
Zuraida Ahmad Sabki, Lee Hui Kim, Mahmoud Danaee, Ahmad Hatim Sulaiman, Khairul Arif Razali, Ong Hui Koh, Sharmilla Kanagasundram, Manveen Kaur, Fatin Liyana Azhar, Benedict Francis
Summary: This study aimed to validate the Malay version of the Brief Resilience Scale (BRS-M) and found it to have favorable psychometric properties in terms of reliability and validity. Exploratory and confirmatory factor analyses were conducted, revealing a two-factor model of resilience and succumbing. The BRS-M showed satisfactory concurrent validity, and household income and marital status were found to be associated with resilience levels.
Article
Psychology, Clinical
Ruzmayuddin Mamat, Rusdi Abd Rashid, Maw Shin Sim, Baharuddin Ibrahim, Suzaily Wahab, Azmir Ahmad
Summary: ATS dependence in Malaysia is a growing concern among multiracial Malaysian groups. A study with 327 participants found that 58.1% were ATS dependent, with Malays reporting the highest number of ATS dependence. Factors such as a history of needle sharing, heroin use, and being unmarried were associated with a higher likelihood of ATS dependence. Comprehensive harm reduction strategies are urgently needed to address the alarming rates of ATS use in Malaysia.
JOURNAL OF PSYCHOACTIVE DRUGS
(2023)
Article
Psychiatry
Jin Pyo Hong, Akramul Zikri Abd Malek, Cheng-Ta Li, Jong-Woo Paik, Ahmad Hatim Sulaiman, Gilbert Madriaga, Jianmin Zhuo, Sarah Siggins, Dong-Jing Fu, Po-Chung Ju
Summary: This post-hoc analysis evaluated the efficacy and safety of intranasal esketamine in the Asian subgroup from ASPIRE I. The results showed that intranasal esketamine significantly improved depressive symptoms and had a good safety profile compared to placebo. The findings in the Asian subgroup were consistent with the overall results of the study.
ASIA-PACIFIC PSYCHIATRY
(2023)
Correction
Public, Environmental & Occupational Health
Aya Ahmed Abousheishaa, Nor Hazila Mat Lazim, Song Ling Tang, Ahmad Hatim Sulaiman, Hasniza Zaman Huri, Ng Chong Guan
PATIENT EDUCATION AND COUNSELING
(2023)
Review
Psychiatry
Mrugesh Vaishnav, Afzal Javed, Snehil Gupta, Vinay Kumar, Parth Vaishnav, Akash Kumar, Hakimullah Salih, Petros Levounis, Bernardo Ng, Samia Alkhoori, Cora Luguercho, Armen Soghoyan, Elizabeth Moore, Vinay Lakra, Martin Aigner, Johannes Wancata, Jamila Ismayilova, Md. Azizul Islam, Antonio Geraldo Da Silva, Gary Chaimowitz, Wang Xiaoping, Tarek Okasha, Andreas Meyer-Lindenberg, Thomas Schulze, Roger Ng, Sn Chiu, Chan Kit Wa (Sherry), Andi J. Tanra, Yong Chon Park, Liliya Panteleeva, Marisol Taveras, Ramune Mazaliauskiene, Ahmad Hatim Bin Sulaiman, Thelma Sanchez, Chandra Prasad Sedain, Taiwo Lateef Sheikh, Lars Lien, Ghulam Rasool, Robert Buenaventura, Harish Chandra Gambheera, Kapila Ranasinghe, Norman Sartorius, Chawanun Charnsil, Amine Larnaout, Juliet Nakku, Zarif Ashurov
Summary: Mental health stigma is prevalent in Asia and low- and middle-income countries, but there is a lack of research and anti-stigma interventions. Although there are some educational interventions, long-term effectiveness data is lacking. Government, international organizations, and other stakeholders can play a crucial role in addressing mental health stigma.
INDIAN JOURNAL OF PSYCHIATRY
(2023)
Article
Clinical Neurology
Phern Chern Tor, Nurmiati Amir, Johnson Fam, Roger Ho, Pichai Ittasakul, Margarita Maramis, Benita Ponio, Dharmawan Ardi Purnama, Wanida Rattanasumawong, Elizabeth Rondain, Ahmad Hatim Bin Sulaiman, Kannokarn Wiroteurairuang, Kok Yoon Chee
Summary: Despite the lack of uniform definition and treatment pathways for treatment-resistant depression (TRD) in Southeast Asia, this study developed consensus-based recommendations for a more appropriate term, pharmacotherapy-resistant depression (PRD), and outlined a stepwise treatment approach. Non-pharmacological treatments were also deemed suitable options for PRD patients.
NEUROPSYCHIATRIC DISEASE AND TREATMENT
(2022)
Article
Health Care Sciences & Services
Amir Zulhilmi Bin Yahaya, Anne Yee, Ahmad Hatim Sulaiman
Summary: This study investigates the changes in the pattern of substance usage among drug users during the COVID-19 pandemic, as well as the effects of anxiety and depression, coping mechanisms, and factors affecting substance use patterns. The findings suggest that depression, isolation status, dysfunctional coping, and intention to seek professional support play a role in influencing substance use patterns.
Article
Health Care Sciences & Services
Mehul Kumar Narendra Kumar, Benedict Francis, Aili Hanim Hashim, Nor Zuraida Zainal, Rusdi Abdul Rashid, Chong Guan Ng, Mahmoud Danaee, Nurulwafa Hussain, Ahmad Hatim Sulaiman
Summary: The prevalence of anxiety and depression is high among psychiatric healthcare workers. Marital status, financial hardship, vaccination status, and duration of service in the psychiatric department are associated with the level of depression symptoms. Avoidant coping increases the odds of anxiety and depression, while religious coping reduces the odds of anxiety. Psychosocial measures should be a priority to address the high levels of anxiety and depression among psychiatric healthcare workers.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.