Article
Clinical Neurology
Helena Hybbinette, Ellika Schalling, Jeanette Plantin, Catharina Nygren-Deboussard, Marika Schutz, Per Ostberg, Pavel G. Lindberg
Summary: This study found that AOS and aphasia are common in left hemisphere stroke patients with hand motor impairment, and recovery shows similar trends across speech-language and motor domains, supporting the shared recovery hypothesis. Initial aphasia score was the strongest predictor of AOS recovery, while lesion volume did not correlate with recovery.
FRONTIERS IN NEUROLOGY
(2021)
Article
Clinical Neurology
Nigul Ilves, Silva Loo, Norman Ilves, Rael Laugesaar, Dagmar Loorits, Pille Kool, Tiina Talvik, Pilvi Ilves
Summary: The aim of this study was to evaluate the relationship between subcortical structure volumes and hand motor function in children with perinatal stroke (PS), as well as to compare the volumes of subcortical structures between PS children and healthy controls. The results showed that PS children had smaller volumes of certain subcortical structures, which were correlated with hand motor function. This study highlights the importance of evaluating subcortical structures in predicting motor outcome following perinatal stroke.
Article
Engineering, Biomedical
Donovan B. Smith, Stephen H. Scott, Jennifer A. Semrau, Sean P. Dukelow
Summary: This study assessed ipsilesional arm motor impairments using a robot-based assessment over the first 6 months post-stroke. The robot-based assessment revealed a higher incidence of ipsilesional arm impairments than clinical measures. The severity of ipsilesional arm impairments was moderately correlated with contralesional arm impairment severity, but not with the hemisphere of lesion.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2023)
Article
Behavioral Sciences
Mitchell W. Isaacs, Laurel J. Buxbaum, Aaron L. Wong
Summary: Imitating observed actions is an efficient method for learning novel movements. This study investigated the role of proprioception in imitation and found that representing movement goals proprioceptively is crucial for successful imitation. Patients with apraxia, a neurological disorder commonly seen after left hemisphere stroke, showed deficits in representing and accessing proprioceptive goals, which contributed to their imitation impairments.
Article
Engineering, Biomedical
Jianghong Fu, ZeWu Jiang, Xiaokang Shu, Shugeng Chen, Jie Jia
Summary: This study compares the brain activation of stroke patients with different levels of motor impairment during hand grasping and opening tasks. The results show that patients in different groups have similar brain responses during the grasping task, but mildly injured patients have more brain activation in opening the hand compared to patients with poor hand function.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Rehabilitation
Brian P. Johnson, Kelly P. Westlake
Summary: Individuals with chronic stroke showed poorer fine and gross motor hand dexterity in their ipsilesional hand compared to controls and normative values, but performed significantly better than their contralesional hand. These findings suggest residual deficits in hand manipulation abilities post-stroke.
AMERICAN JOURNAL OF PHYSICAL MEDICINE & REHABILITATION
(2021)
Article
Engineering, Mechanical
Guotao Li, Peng Xu, Shangling Qiao, Bing Li
Summary: This paper investigates grasp stability analysis and optimal enveloping grasp planning of a deployable robotic hand, proposes a method for computing the grasp stability evaluation index, analyzes the effects of friction coefficients and deployment length on grasp stability, and finally presents an optimal enveloping grasp planning method.
MECHANISM AND MACHINE THEORY
(2021)
Article
Automation & Control Systems
Shuwei Qiu, Mehrdad R. Kermani
Summary: In this paper, a human-inspired approach to simultaneously solve grasp planning and inverse kinematics problems for integrated arm-hand systems is proposed. This approach treats the arm and hand as a kinematically integrated system and utilizes a coarse-to-fine strategy. By integrating grasp planning and inverse kinematics, the proposed method achieves force-closure fingertip grasping and reduces computational power.
ROBOTICS AND AUTONOMOUS SYSTEMS
(2023)
Article
Neurosciences
Rafaela Barroso de Souza Costa Garbus, Alethea Gomes Nardini, Sandra Regina Alouche, Sandra Maria Sbeghen Ferreira de Freitas
Summary: Individuals with stroke present impairments in ipsilesional arm reaching movements that are influenced by the side of the brain lesion. This study compared reaching movements in sitting and standing positions and found that stroke survivors were slower and less accurate, especially when reaching the upper target under uncertainty. The central nervous system modulates reaching movements based on target position, posture, and uncertainty.
HUMAN MOVEMENT SCIENCE
(2021)
Article
Computer Science, Artificial Intelligence
Tianqiang Zhu, Rina Wu, Jinglue Hang, Xiangbo Lin, Yi Sun
Summary: Intelligent robotic manipulation is a challenging field of machine intelligence, and teaching robotic hands to perform dexterous operations like human hands remains a challenge. To address this, we conducted an in-depth analysis of human behavior in manipulating objects and proposed an object-hand manipulation representation. Additionally, we proposed a functional grasp synthesis framework and a network pre-training method to improve grasp synthesis results.
IEEE TRANSACTIONS ON PATTERN ANALYSIS AND MACHINE INTELLIGENCE
(2023)
Article
Neurosciences
Alexander B. Remsik, Klevest Gjini, Leroy Williams, Peter L. E. van Kan, Shawna Gloe, Erik Bjorklund, Cameron A. Rivera, Sophia Romero, Brittany M. Young, Veena A. Nair, Kristin E. Caldera, Justin C. Williams, Vivek Prabhakaran
Summary: Stroke survivors may benefit from brain-computer interface (BCI) devices in improving motor function and inducing neuroplastic changes associated with motor rehabilitation. Research on 16 stroke survivors shows that BCI intervention can enhance motor capacity and behavior by altering information transmission pathways in cerebral cortical sensorimotor areas.
FRONTIERS IN HUMAN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Sandeep Bodda, Shyam Diwakar
Summary: This study investigates the underlying neural activity and mechanisms of grasped motor tasks by recording EEG signals, and identifies potential biomarkers for distinguishing movement initiation and grasped movement. Additionally, machine learning classifiers are explored for categorizing movement conditions.
Article
Behavioral Sciences
Alice Rossi Sebastiano, Karol Poles, Luke E. Miller, Carlotta Fossataro, Edoardo Milano, Patrizia Gindri, Francesca Garbarini
Summary: This study investigates the relationship between body ownership and motor control by examining patients with a rare pathological embodiment disorder. The findings demonstrate that individuals with pathological embodiment plan reaching movements based on the position of the embodied hand, providing clear evidence for the role of body ownership in reach planning.
Article
Computer Science, Information Systems
Yihe Wu, Zhenning Zhang, Dong Qiu, Weiqing Li, Zhiyong Su
Summary: This paper proposes a fast and easy framework for the design of grasping controllers using abundant and flexible videos of desired grasps and kinematic algorithms based on monocular 3D hand pose estimation and deep reinforcement learning. With this framework, natural and stable grasps can be easily generated from monocular video demonstrations, and adaptive abilities can be added to objects of different shapes and sizes in the target object library.
MULTIMEDIA TOOLS AND APPLICATIONS
(2023)
Review
Engineering, Biomedical
Jitka Veldema, Dennis Alexander Nowak, Alireza Gharabaghi
Summary: Resting motor threshold is closely related to hand motor recovery in stroke patients. Severe hand impairment is associated with suppressed cortical excitability within both hemispheres and with great between-hemispheric imbalance; favorable motor recovery is associated with an increase of ipsilesional motor cortex excitability and reduction of between-hemispheric imbalance; the direction of change depends on the amount of hand motor impairment.
JOURNAL OF NEUROENGINEERING AND REHABILITATION
(2021)
Article
Neuroimaging
Christine E. Watson, Stephen J. Gotts, Alex Martin, Laurel J. Buxbaum
NEUROIMAGE-CLINICAL
(2019)
Article
Neurosciences
Frank E. Garcea, Laurel J. Buxbaum
HUMAN BRAIN MAPPING
(2019)
Article
Neurosciences
Aaron L. Wong, Steven A. Jax, Louisa L. Smith, Laurel J. Buxbaum, John W. Krakauer
JOURNAL OF NEUROSCIENCE
(2019)
Article
Behavioral Sciences
Cortney M. Howard, Louisa L. Smith, H. Branch Coslett, Laurel J. Buxbaum
Article
Behavioral Sciences
Frank E. Garcea, Harrison Stoll, Laurel J. Buxbaum
Article
Neurosciences
Harrison Stoll, Matthieu M. de Wit, Erica L. Middleton, Laurel J. Buxbaum
Summary: This preliminary study explored a novel treatment approach for apraxia patients and found that a semantic network strengthening method may be effective in at least some individuals with apraxia. It also laid the foundation for future research on the characteristics of apraxia patients who benefit from different treatment approaches.
NEUROPSYCHOLOGICAL REHABILITATION
(2021)
Article
Behavioral Sciences
Gabriella Vigliocco, Anna Krason, Harrison Stoll, Alessandro Monti, Laurel J. Buxbaum
Article
Neurosciences
Amanda S. Therrien, Cortney Howard, Laurel J. Buxbaum
Summary: This study is the first to assess residual muscle activity during movement of a phantom limb in individuals with lower limb amputations. The findings suggest that phantom foot movement is associated with aberrant recruitment of a residual thigh muscle and that this aberrant activity is related to phantom limb pain.
JOURNAL OF NEUROPHYSIOLOGY
(2021)
Article
Behavioral Sciences
Heath E. Matheson, Frank E. Garcea, Laurel J. Buxbaum
Summary: The study suggests that certain regions in the tool network reflect category information about tools, and this category information has a stronger impact on the representational geometry in use contexts. Furthermore, scene context helps shape the representational geometry of the tool network.
Article
Behavioral Sciences
Mitchell W. Isaacs, Laurel J. Buxbaum, Aaron L. Wong
Summary: Imitating observed actions is an efficient method for learning novel movements. This study investigated the role of proprioception in imitation and found that representing movement goals proprioceptively is crucial for successful imitation. Patients with apraxia, a neurological disorder commonly seen after left hemisphere stroke, showed deficits in representing and accessing proprioceptive goals, which contributed to their imitation impairments.
Article
Neurosciences
Erica M. Barhorst-Cates, Mitchell W. Isaacs, Laurel J. Buxbaum, Aaron L. Wong
Summary: This study investigates the difference between posture matching and trajectory imitation and examines whether they can be interchangeably used in imitation tasks. The results show that when imitating trajectories, there is a processing cost when performing posture-matching tasks, leading to less consistency in movement. However, this effect is not observed when imitating limb postures. These findings suggest the existence of two computationally distinct imitation mechanisms.
HUMAN MOVEMENT SCIENCE
(2022)
Article
Behavioral Sciences
Rachel Metzgar, Harrison Stoll, Scott T. Grafton, Laurel J. Buxbaum, Frank E. Garcea
Summary: This study investigates the relationship between meaningless gesture imitation and tool use pantomiming and their corresponding brain lesions. The results suggest that specific brain regions are associated with different subtypes of limb apraxia, providing important insights into the understanding of this condition.
Article
Computer Science, Software Engineering
Erica M. Barhorst-Cates, Mitchell W. Isaacs, Laurel J. Buxbaum, Aaron L. Wong
Summary: This study used virtual reality technology to investigate two factors in the imitation of novel movements: the imitation of complex movements and the effect of spatial perspective. The results showed that imitation accuracy was highest in the first-person perspective, and patients and controls performed similarly in the imitation task for all spatial perspectives.
FRONTIERS IN VIRTUAL REALITY
(2022)
Article
Clinical Neurology
Elisabetta Ambron, Laurel J. Buxbaum, Alexander Miller, Harrison Stoll, Katherine J. Kuchenbecker, H. Branch Coslett
Summary: Immersive VR activities can reduce phantom limb pain in subjects with lower-limb amputation. Both treatments, one without leg movements and one with leg motions, were successful in reducing PLP by 28% and 39.6% respectively.
NEUROREHABILITATION AND NEURAL REPAIR
(2021)
Article
Clinical Neurology
Laurel J. Buxbaum, Rini Varghese, Harrison Stoll, Carolee J. Winstein
NEUROREHABILITATION AND NEURAL REPAIR
(2020)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.