Article
Psychology, Biological
Anika Guha, Cindy M. Yee, Wendy Heller, Gregory A. Miller
Summary: Individuals with a history of depression exhibited greater overall network activation, stronger directed connectivity from DMN to SAL, and worse task performance during positive-word trials. This pattern was not observed among healthy comparison participants.
Article
Neurosciences
Zachary H. Pugh, Sanghyun Choo, Joseph C. Leshin, Kristen A. Lindquist, Chang S. Nam
Summary: This study used Granger causality analysis to examine the influence of cultural background and situation on emotions. The results showed that mainland Chinese participants have a different neural representation of fear compared to US participants, with a greater emphasis on the social aspects of scenes.
SOCIAL COGNITIVE AND AFFECTIVE NEUROSCIENCE
(2022)
Article
Environmental Sciences
Maryam Zavareh, Viviana Maggioni, Vadim Sokolov
Summary: This study investigates the inter-relationships among stream water quality indicators, hydroclimatic variables, and land characteristics using statistical tools. Results show that watershed size, land use, and hydrometeorological variables have complex impacts on water quality.
Article
Neurosciences
Peishan Dai, Xiaoyan Zhou, Yilin Ou, Tong Xiong, Jinlong Zhang, Zailiang Chen, Beiji Zou, Xin Wei, Ying Wu, Manyi Xiao
Summary: The study investigated the altered effective connectivity (EC) in children and young adults with amblyopia, showing significant impairments in the EC network of amblyopia patients, which may have a stronger correlation with feedback pathways.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Saurabh Sonkusare, Ding Qiong, Yijie Zhao, Wei Liu, Ruoqi Yang, Alekhya Mandali, Luis Manssuer, Chencheng Zhang, Chunyan Cao, Bomin Sun, Shikun Zhan, Valerie Voon
Summary: Using intracranial electroencephalography, this study investigated the amygdala, orbitofrontal cortex (OFC), and medial prefrontal cortex (mPFC) and found that they play important roles in the emotion circuit. The three regions showed different emotion-induced responses and interactions. The results demonstrated greater broadband gamma activity in the negative condition, increased beta activity in the amygdala and OFC, and decreased beta activity in mPFC during the emotional picture viewing task. Furthermore, model-based computational analyses revealed unidirectional connectivity from mPFC to the amygdala and bidirectional communication between OFC-amygdala and OFC-mPFC.
MOLECULAR PSYCHIATRY
(2023)
Article
Clinical Neurology
Lei Li, Changchun He, Taorong Jian, Xiaonan Guo, Jinming Xiao, Ya Li, Heng Chen, Xiaodong Kang, Huafu Chen, Xujun Duan
Summary: The study found impaired mPFC-amygdala pathway in the social brain network of children with autism spectrum disorders (ASD), which is associated with social deficits, providing a new perspective into the neuropathology of the developing autistic brain.
PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY
(2021)
Article
Multidisciplinary Sciences
M. Zulkifli Salim, Dadang Ramdhan, Kevin Daly
Summary: This paper examines the use of asset returns as a proxy for detecting interlinkages in the financial system. The study utilizes a US dataset covering the period from 2002 to 2021, and finds that pairwise returns correlation can indicate interconnectedness in the preliminary stage. The Principal Component Analysis identifies a significant portion of variance and detects the co-movement and highly connected state of the financial market during crises. Granger centrality, tested with pairwise directional variance decomposition, highlights the importance of banks and insurance companies in the US financial system. The paper suggests that policymakers should employ multiple network models to validate and calibrate the list of Systemically Important Financial Institutions (SIFIs).
Article
Radiology, Nuclear Medicine & Medical Imaging
Zhiyong Zhao, Huaying Cai, Manli Huang, Weihao Zheng, Tingting Liu, Di Sun, Guocan Han, Linhui Ni, Yi Zhang, Dan Wu
Summary: The study found that patients with PSD showed specific alterations in the transmission and reception of information in the hippocampal subfields, leading to decreases in inward information flow and increases in outward information flow. Additionally, there were significant correlations between cognitive scores and dFCs in the PSD group related to the hippocampal subfields. Furthermore, dFCs of the hippocampus and its subfields improved the classification between PSD and PSND patients compared to clinical and demographic parameters alone, with high accuracy, sensitivity, and specificity.
JOURNAL OF MAGNETIC RESONANCE IMAGING
(2021)
Article
Engineering, Mechanical
Unai Ugalde, Javier Anduaga, Oscar Salgado, Aitzol Iturrospe
Summary: In this study, a structural health monitoring method is proposed for damage localization. It combines a substructuring approach and connectivity analysis of a substructure, aiming to isolate and monitor multiple substructures individually. The health of the substructure is determined by analyzing connectivity variations using multivariate and conditional Granger causality analysis. The proposed method can determine whether the substructure is damaged and locate the damage within the substructure, without the need for a dynamic model of the structure.
MECHANICAL SYSTEMS AND SIGNAL PROCESSING
(2023)
Article
Neuroimaging
Gang-Ping Zhou, Yu-Chen Chen, Wang-Wei Li, Heng-Le Wei, Yu-Sheng Yu, Qing-Qing Zhou, Xindao Yin, Yue-Jin Tao, Hong Zhang
Summary: This study combined resting-state functional connectivity and Granger causality analysis to investigate frontostriatal network dysfunction in unilateral acute tinnitus patients with hearing loss. The results showed a general reduction in FC between seed regions in the frontostriatal network and nonauditory areas in AT patients, as well as abnormal effective connectivity in several nonauditory regions. Correlations between disrupted FC/EC and clinical characteristics, especially tinnitus distress-related characteristics, were found in AT patients.
BRAIN IMAGING AND BEHAVIOR
(2022)
Article
Neuroimaging
Michele Allegra, Chiara Favaretto, Nicholas Metcalf, Maurizio Corbetta, Andrea Brovelli
Summary: Stroke disrupts long-range anatomical connections and functional organization of brain networks, leading to abnormalities in functional connectivity. Interhemispheric information transfer is significantly decreased, and stroke induces inter-hemispheric asymmetries, particularly in networks related to attention and language, correlating with impaired performance in multiple behavioral domains.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Hsi T. Wei, Alex Francois-Nienaber, Tiffany Deschamps, Buddhika Bellana, Melissa Hebscher, Gayatri Sivaratnam, Maryam Zadeh, Jed A. Meltzer
Summary: Our study compared different oscillatory connectivity measures in revealing interhemispheric interactions between primary motor cortices during unilateral finger movements. While phase-based metrics were effective during the beta rebound period, amplitude correlation metrics showed robust connectivity during both periods. Techniques for estimating the direction of connectivity had limited success, with Granger causality being confounded by differences in signal-to-noise ratio.
Review
Mathematics, Applied
Tom Edinburgh, Stephen J. Eglen, Ari Ercole
Summary: Inferring nonlinear and asymmetric causal relationships between multivariate longitudinal data is crucial in various fields such as clinical medicine, mathematical biology, economics, and environmental research. Evaluation of ten prominent causality indices showed strong agreement between methods in general, but they may not always be robust to real-world relevant transformations.
Article
Biology
Victor J. Lopez-Madrona, Santiago Canals
Summary: The study analyzed the functional connectivity between theta generators from different sources in the hippocampus during exploration, showing that novelty stimulus increased connectivity from entorhinal cortex layer II while decreasing influence from CA3. This suggests a driving role of entorhinal cortex layer II in theta interactions and synchronization during novelty exploration in the hippocampus.
Article
Multidisciplinary Sciences
Antoine Bernas, Lisanne E. M. Breuer, Albert P. Aldenkamp, Svitlana Zinger
Summary: Accelerated cognitive ageing (ACA) in epilepsy is diagnosed by a significant IQ decline around age 50, and this study used resting-state fMRI data to assess brain dynamics. Novel methods such as emulative power were found to be effective descriptors of ACA, with SVM achieving a peak accuracy of 95.8% when combining different features for classification.
Article
Environmental Sciences
Na Li, Honglin Zhang, Zhimao Bai, Haitao Jiang, Fan Yang, Xiao Sun, Zuhong Lu, Dongrui Zhou
Summary: This study found that exposure to low cleanliness helps prevent allergic diseases and increase the diversity of intestinal microbiota. Dust exposure after antibiotic treatment can prevent reduction in gut microbiota diversity and accelerate its recovery.
ENVIRONMENTAL MICROBIOLOGY REPORTS
(2021)
Correction
Developmental Biology
Chunpeng He, Tingyu Han, Xin Liao, Rui Guan, J. -Y. Chen, Kimberly D. Tremblay, Zuhong Lu
GENE EXPRESSION PATTERNS
(2021)
Article
Chemistry, Multidisciplinary
Jing Tu, Hao Meng, Linlin Wu, Guohao Xi, Jiye Fu, Zuhong Lu
Summary: EasyNanopore is a user-friendly software designed for selecting events in nanopore molecular translocation experiments. It utilizes an adaptive threshold and multiprocess method to quickly extract data from large-scale experiments and generate result txt files for further analysis.
Article
Biochemistry & Molecular Biology
Mengting Huang, Yixuan Yang, Xingzhao Wen, Weiqiang Xu, Na Lu, Xiao Sun, Jing Tu, Zuhong Lu
Summary: Although single cell RNA sequencing technologies are well developed, acquiring large-scale single cell expression data can still be costly. The study proposes a method of compressing expression profiles from the sample dimension by assigning each cell into multiple pools and demonstrates that expression profiles can be inferred from pool expression data with a overlapping pooling design and compressed sensing strategy. This approach, when combined with plate-based scRNA-seq measurement, maintains superior gene detection sensitivity and individual identity while reducing library costs by half.
NUCLEIC ACIDS RESEARCH
(2021)
Article
Biodiversity Conservation
Yixin Li, Xin Liao, Chunpeng He, Zuhong Lu
Summary: This study used high resolution micro-computed tomography to investigate morphological changes in Acropora corallites, revealing patterns of calcium carbonate deposition during new branch formation and truncated tip repair. The results showed that the volume ratio of calcareous deposits in the axial canal of truncated branches significantly increased within the first three weeks, then returned to initial levels in the following week. These findings demonstrate the temporary storage and remobilization of calcium carbonate for rapid growth in Acropora.
Article
Clinical Neurology
Michael J. O'Sullivan, Lena K. L. Oestreich, Paul Wright, Andrew N. Clarkson
Summary: A study has found that the recovery of cognitive function after stroke is related to neurotransmitter systems, learning-related networks, and brain regions that can adapt to demand. The status of the cholinergic basal forebrain, fornix, and hippocampal subfields predicted improvement in long-term memory performance. These findings provide important information for personalized therapeutic strategies after stroke.
Article
Chemistry, Physical
Liqin Ge, Chenxi Luo, Dan You, Ning Yang, Qianli Zhang, Renqiang Yuan, Jieran Wang, Zuhong Lu
Summary: A new strategy for preparing stable coatings on alloy substrates using layer-by-layer self-assembly technique with hydrogen peroxide, chitosan, and dialdehyde starch was reported. The resulting coating showed good cellular compatibility and promoted cell adhesion, demonstrating promising application for high adhesive properties on iron-contained alloy substrates.
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
(2021)
Article
Mathematical & Computational Biology
Eilidh MacNicol, Paul Wright, Eugene Kim, Irene Brusini, Oscar Esteban, Camilla Simmons, Federico E. Turkheimer, Diana Cash
Summary: Age-specific resources in human and rat MRI are important for mitigating processing biases and accurately estimating tissue volumes. This study found that by using age-specific rat brain templates and tissue probability maps, better estimations of gray matter volumes could be achieved. Furthermore, it was discovered that tissue volumes and proportions relative to total brain volume vary across adulthood in rats.
FRONTIERS IN NEUROINFORMATICS
(2022)
Article
Multidisciplinary Sciences
Jing Tu, Zengyan Yang, Na Lu, Zuhong Lu
Summary: This study presents an efficient method for analyzing copy number variation (CNV) in single cells using overlapping pooling and branch and bound algorithm. By overlapping pooling, the number of required libraries is reduced, resulting in lower costs. Computer simulations showed high accuracy in classifying cells based on CNV pattern, with significantly fewer sequencing libraries required. This method is expected to improve the efficiency of single-cell genome sequencing.
ROYAL SOCIETY OPEN SCIENCE
(2022)
Article
Multidisciplinary Sciences
Cheng Zhang, Xueying Ma, Xuedong Zheng, Yonggang Ke, Kuiting Chen, Dongsheng Liu, Zuhong Lu, Jing Yang, Hao Yan
Summary: A general and programmable strategy for allosteric DNA regulations was developed, allowing precise control through varying the dimensions, positions, and number of conformational signals. This strategy enables the creation of fan-out/fan-in DNA gates, multiple-layer DNA cascading networks, and long-range allosteric signal transmission. It has significant implications for nano-engineering, chemical, and biomedical applications.
Article
Clinical Neurology
Nacim Betrouni, Jiyang Jiang, Marco Duering, Marios K. Georgakis, Lena Oestreich, Perminder S. Sachdev, Michael O'Sullivan, Paul Wright, Jessica W. Lo, Regis Bordet
Summary: This study examined the reliability of texture features against imaging settings using data from different centers and found that texture features obtained from routine clinical MR images are robust early predictors of poststroke cognitive impairment and can be combined with other demographic and clinical predictors to build an accurate prediction model.
Review
Biochemistry & Molecular Biology
Na Lu, Yi Qiao, Zuhong Lu, Jing Tu
Summary: Multiple displacement amplification (MDA) using isothermal random priming and high fidelity phi29 DNA polymerase has revolutionized whole genome amplification by enabling amplification of DNA from single cells. However, MDA faces challenges, such as the formation of chimeric sequences, which disrupt downstream analysis. This review provides a comprehensive overview of current research on MDA chimeras, including the mechanisms of formation, detection methods, characteristics, and methods for processing chimeric sequences.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2023)
Article
Geriatrics & Gerontology
Chiara de Lucia, Tytus Murphy, Aleksandra Maruszak, Paul Wright, Timothy R. Powell, Naomi Hartopp, Simone de Jong, Michael J. O'Sullivan, Gerome Breen, Jack Price, Simon Lovestone, Sandrine Thuret
Summary: The study found that exposure to older human serum can increase apoptotic cell death of hippocampal progenitor cells, leading to changes in hippocampal morphology. Additionally, the use of antihypertensive medication and mild cognitive decline in elderly subjects were shown to impact the variability in cell proliferation and differentiation markers. The findings suggest a role for the systemic environment in neural stem cell maintenance, with implications for understanding the effects of environmental exposures and age-related changes on health and disease.
Article
Nanoscience & Nanotechnology
Han Yan, Ting Weng, Libo Zhu, Peng Tang, Zhen Zhang, Pang Zhang, Deqiang Wang, Zuhong Lu
Summary: In this study, a method for improving the accuracy of nanopore analysis using the central limit theorem is proposed, resulting in more concentrated distributions of blockage signals and avoiding common issues in data analysis. The effectiveness of this method is validated by detecting microRNAs in solid-state nanopores.
ACS APPLIED BIO MATERIALS
(2021)
Article
Chemistry, Multidisciplinary
Jing Tu, Yi Qiao, Yuhan Luo, Naiyun Long, Zuhong Lu
Summary: DNA quantification is crucial in life sciences research, and real-time MDA technology can provide template amount information during whole-genome amplification with a very low detection limit, offering a promising tool to quantify entire DNA without sacrificing sample completeness or introducing redundant steps.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
