Article
Neurosciences
Yunyun Zhang, Huiming Li, Xinxin Zhang, Sa Wang, Dan Wang, Jiajia Wang, Tingting Tong, Zhen Zhang, Qianzi Yang, Hailong Dong
Summary: A recent study has found that there are sex differences in response to general anesthesia, but the neural mechanisms behind this are unclear. This study showed that male mice were more sensitive to sevoflurane anesthesia and that estrogen receptor alpha in the medial preoptic area played a critical role in regulating sleep in males. Furthermore, pharmacological inhibition of estrogen receptor alpha eliminated sex differences in sevoflurane anesthesia.
NEUROSCIENCE BULLETIN
(2022)
Article
Endocrinology & Metabolism
Coltan G. Parker, Sarah E. Craig, Abigail R. Histed, Joanne S. Lee, Emma Ibanez, Veronica Pronitcheva, Justin S. Rhodes
Summary: Sex differences in cell number in the preoptic area of the hypothalamus (POA) contribute to differential regulation of reproductive behavior between sexes. Anemonefish provide a unique opportunity to study sexual differentiation mechanisms. This study shows that sex-changing fish add more new cells to the POA, revealing insights into the unique characteristics of protandrous sex change and the potential for future research in sex-changing fishes.
GENERAL AND COMPARATIVE ENDOCRINOLOGY
(2023)
Article
Neurosciences
Jia Ryoo, Seahyung Park, Daesoo Kim
Summary: Animals have an innate motivation to explore unknown objects and environments. Photostimulation of a subset of medial preoptic area (MPA) neurons can increase exploration without causing place preference. Photoinhibition of these neurons does not lead to emotional changes, suggesting they can enhance innate exploration behavior.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Physiology
Sergio A. Daiuto, Rodrigo P. de Carvalho, Barbara do Vale, Nuha A. Dsouki, Gisele Giannocco, Eduardo M. Cafarchio, Patrik Aronsson, Monica A. Sato
Summary: This study found that Ang II in the mPOA is involved in the regulation of cardiovascular and central micturition pathways, while GABA is involved in cardiovascular control but not micturition control.
FRONTIERS IN PHYSIOLOGY
(2023)
Article
Behavioral Sciences
Julia R. Martz, Adriana Vasquez, Ross Gillette, Andrea C. Gore, Juan M. Dominguez
Summary: The medial preoptic area (mPOA) in the hypothalamus plays a crucial role in integrating neuroendocrine signaling and regulating reward responses. This study aimed to investigate the mPOA's involvement in sex differences related to cocaine response. Results showed that high-estradiol females exhibited increased cocaine-induced neural activity and locomotion, while high-estradiol males showed decreased cocaine-induced neural activity and locomotion. These findings highlight the mPOA's role in endocrine-mediated cocaine response and suggest its contribution to sex differences and vulnerability to cocaine use disorders.
HORMONES AND BEHAVIOR
(2023)
Review
Neurosciences
Alessandro Carollo, Jan Paolo Macapinlac Balagtas, Michelle Jin-Yee Neoh, Gianluca Esposito
Summary: Research on the neural substrates of parental behavior, particularly focusing on the hypothalamic medial preoptic area (MPOA), has gained momentum. A scientometric analysis of publications from 1972 to 2021 revealed a trend of initially studying MPOA's response to parental behavior and later exploring the brain network regulating such behavior, including reward circuits. The focus has expanded from maternal behavior to understanding paternal behaviors as well.
Article
Neurosciences
Kseniia Prokofeva, Yuki C. Saito, Yasutaka Niwa, Seiya Mizuno, Satoru Takahashi, Arisa Hirano, Takeshi Sakurai
Summary: To understand the regulation of sleep-wakefulness cycles, it is important to study the relationship between the preoptic area (POA) and lateral hypothalamic area (LHA), which have opposing roles in sleep-wakefulness regulation. This study revealed the direct connection between GABA- and galanin-producing neurons in the ventrolateral preoptic nucleus (VLPO) and orexin-producing neurons in the LHA. It also discovered that the VLPOGABA-LHA pathway plays a previously unknown role in the regulation of sleep and wakefulness.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Elli P. Sellinger, Victoria R. Riesgo, Amara S. Brinks, Jari Willing, Janice M. Juraska
Summary: The study revealed that exposure to phthalates led to a decrease in cellular proliferation and an increase in apoptosis in the rat medial prefrontal cortex. Both prenatal and perinatal exposure to phthalates resulted in these effects, indicating potential harmful impacts on brain development.
Article
Endocrinology & Metabolism
Satoshi Ogawa, Priveena Nair Ramadasan, Rachel Anthonysamy, Ishwar S. Parhar
Summary: Substance P (SP) and neurokinin A (NKA) regulate reproductive hormone secretion in mammals via kisspeptin neurons, but their roles in non-mammalian vertebrates are not well understood. This study in zebrafish found male-dominant expression of Tac1 in specific brain regions, with associations between Tac1 and GnRH3 neurons but not with kiss2 neurons. Expression of the SP/NKA receptor tacr1a mRNA in brain regions containing GnRH3 or Kiss2 neurons suggests a potential direct action on male reproductive functions in zebrafish.
FRONTIERS IN ENDOCRINOLOGY
(2021)
Article
Neurosciences
Kevin R. Coffey, Vaishnavi Venkat, Mark O. West, David J. Barker
Summary: Neurons in the lateral preoptic area show varied responses to different components of drug self-administration. The majority of these neurons signal the operant response with increases in spiking activity.
EUROPEAN JOURNAL OF NEUROSCIENCE
(2021)
Article
Psychology, Biological
Joseph S. Lonstein, Thierry D. Charlier, Jodi L. Pawluski, Nadege Aigueperse, Maryse Meurisse, Frederic Levy, Sophie Lumineau
Summary: The study investigates the neural mechanisms underlying maternal caregiving behavior in laboratory rodents and Japanese quail. The medial preoptic area (mPOA) plays a crucial role in maternal acceptance and motivation, while the nucleus accumbens (NAC) shows longer-term changes in response to maternal experience. The findings suggest a conserved role for mPOA and NAC in maternal caregiving across vertebrates.
PHYSIOLOGY & BEHAVIOR
(2021)
Article
Ecology
Guozhen Shang, Shouyang Du, Yanbin Yang, Yan Wu, Yifan Cao, Jianghui Bian
Summary: Density dependence in reproduction stabilizes population dynamics via negative feedback from population density to reproductive output. This study investigates the effects of density-induced stress on reproduction in root voles and reveals that density-induced stress negatively affects reproductive traits, contributing to negative density-dependent reproduction.
ECOLOGY AND EVOLUTION
(2022)
Review
Neurosciences
Sarah L. Reitz, Max B. Kelz
Summary: The hypothalamic preoptic area (POA) plays a crucial role in regulating arousal states in both natural and drug-induced forms of unconsciousness. While known for promoting sleep and wake, the complexity and molecular heterogeneity of the POA make it challenging to distinguish between different populations of neurons involved in these processes.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Lindsay A. Pickett, Jonathan W. VanRyzin, Ashley E. Marquardt, Margaret M. McCarthy
Summary: The SDN-POA is a sexually dimorphic brain structure that is larger in males and is associated with mating preference. Microglia play a crucial role in reducing the size of the SDN in females by engulfing more neurons. Inhibiting microglia phagocytosis increases the SDN volume in females and affects their preference for male odors in adulthood.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2023)
Article
Multidisciplinary Sciences
Kansai Fukumitsu, Misato Kaneko, Teppo Maruyama, Chihiro Yoshihara, Arthur J. Huang, Thomas J. McHugh, Shigeyoshi Itohara, Minoru Tanaka, Kumi O. Kuroda
Summary: Social animals experience stress upon isolation and actively engage in contact with conspecifics. This study demonstrates that amylin-calcitonin receptor signaling in the medial preoptic area mediates affiliative social contacts among adult female mice. Isolation leads to active contact-seeking behavior and depressive-like behavior, along with a decrease in Amylin mRNA expression. Reuniting with peers induces physical contacts and a recovery of Amylin mRNA expression.
NATURE COMMUNICATIONS
(2022)
Article
Biochemistry & Molecular Biology
Marilda da Cruz Fernandes, Antonio Generoso Severino, Adriana Maria Zago, Lucas Tortorelli, Fabiano B. Carvalho, Felipe Luis Schneider
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2018)
Article
Chemistry, Applied
Adriana M. Zago, Fabiano B. Carvalho, Jessie Martins Gutierres, Crystiani Bohnert, Marilda da Cruz Fernandes, Liziane M. Morandini, Helena S. Coelho, Aline O. Fogaca, Cinthia M. Andrade, Marco A. Mostardeiro, Ionara I. Dalcol, Ademir F. Morel
NATURAL PRODUCT RESEARCH
(2019)
Article
Neurosciences
Cristine de Paula Nascimento-Castro, Ana Claudia Wink, Victor Silva da Fonseca, Claudia Daniele Bianco, Elisa C. Winkelmann-Duarte, Marcelo Farina, Ana Lucia S. Rodrigues, Joana Gil-Mohapel, Andreza Fabro de Bem, Patricia S. Brocardo
Article
Food Science & Technology
Alexandre Jose Cichoski, Diego Rafael Martins Flores, Cristiano Ragagnin De Menezes, Eduardo Jacob-Lopes, Leila Queiroz Zepka, Roger Wagner, Juliano Smanioto Barin, Erico Marlon de Moraes Flores, Marilda da Cruz Fernandes, Paulo Cezar Bastianello Campagnol
INTERNATIONAL JOURNAL OF FOOD MICROBIOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Luana Mota Ferreira, Juliana Hofstatter Azambuja, Elita Ferreira da Silveira, Marcel Henrique Marcondes Sari, Bruna da Cruz Weber Fulco, Vinicius Costa Prado, Nicolly Espindola Gelsleichter, Liziane Raquel Beckenkamp, Marilda da Cruz Fernandes, Roselia Maria Spanevello, Marcia Rosangela Wink, Rita de Cassia Sant Anna Alves, Cristina Wayne Nogueira, Elizandra Braganhol, Leticia Cruz
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2019)
Article
Materials Science, Biomaterials
Cristiano Rodrigues, Liliana Ivet Sous Naasani, Carla Zanatelli, Thais Casagrande Paim, Jessica Goncalves Azevedo, Joao Cardoso de Lima, Marilda da Cruz Fernandes, Silvio Buchner, Marcia Rosangela Wink
MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS
(2019)
Article
Clinical Neurology
Jayme Augusto Bertelli, Sushil Nehete, Elisa Cristiana Winkelmann Duarte, Neehar Patel, Marcos Flavio Ghizoni
Summary: The distal motor branch of the pronator teres can be used for reinnervation of the extensor carpi radialis brevis in patients with radial nerve paralysis, with successful outcomes observed in patients followed for at least 24 months postoperatively.
JOURNAL OF NEUROSURGERY
(2021)
Article
Neurosciences
Jucara Loli de Oliveira, Marina Avila, Thiago Cesar Martins, Marcio Alvarez-Silva, Elisa Cristiana Winkelmann-Duarte, Afonso Shiguemi Inoue Salgado, Francisco Jose Cidral-Filho, William R. Reed, Daniel F. Martins
COGNITIVE NEURODYNAMICS
(2020)
Article
Orthopedics
Jayme Augustoonil Bertelli, Sushil Nehete, Elisa Cristiana Winkelmann Duarte, Marcos Flavio Ghizoni
JOURNAL OF HAND SURGERY-AMERICAN VOLUME
(2020)
Article
Behavioral Sciences
Julia M. Rosa, Francis L. Pazini, Anderson Camargo, Ingrid A. Wolin, Gislaine Olescowicz, Livia B. Eslabao, Oscar Bruna Romero, Elisa C. Winkelmann-Duarte, Ana Lucia S. Rodrigues
BEHAVIOURAL BRAIN RESEARCH
(2020)
Review
Physiology
Maisa Maria Spagnol Trento, Ari Ojeda Ocampo More, Elisa Cristiana Winkelmann Duarte, Daniel Fernandes Martins
Summary: This study aims to describe the state-of-the-art preclinical studies on peripheral receptors and neuromediators involved in the antihyperalgesic effects of acupuncture. Findings revealed correlations between various families of receptors and neuromediators with the pain control effects of acupuncture, emphasizing the importance of further exploring the peripheral mechanisms of acupuncture.
PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY
(2021)
Article
Clinical Neurology
Jayme A. Bertelli, Neehar Patel, Francisco Soldado, Elisa Cristiana Winkelmann Duarte
Summary: This study aimed to describe the anatomy of donor and recipient median nerve motor branches for nerve transfer surgery within the cubital fossa. The branching pattern of the median nerve in the cubital fossa is predictable, with the most important variation being the FCR motor branch. These anatomical findings are helpful for nerve transfer surgery to restore function in cases of paralysis caused by radial or median nerve, brachial plexus, or spinal cord injury.
JOURNAL OF NEUROSURGERY
(2021)
Article
Surgery
Eitan Melamed, Neehar Patel, Elisa Cristiana Winkelmann Duarte, Alexandra S. C. Q. Nascimento, Jayme Augusto Bertelli
Summary: This study investigates the feasibility of nerve transfer to restore finger extension in patients with central cord syndrome. The results showed that it is anatomically possible to perform nerve transfer of supinator motor branches to achieve this restoration. The study also found favorable results in terms of regeneration distance and axonal count ratio.
Article
Biochemistry & Molecular Biology
Cristine De Paula Nascimento-Castro, Elisa C. Winkelmann-Duarte, Gianni Mancini, Priscilla Gomes Welter, Evelini Placido, Marcelo Farina, Joana Gil-Mohapel, Ana Lucia S. Rodrigues, Andreza Fabro de Bem, Patricia S. Brocardo
Summary: Huntington's disease is a genetic neurodegenerative disease that affects motor, psychiatric, and cognitive functions. Recent evidence suggests that the emotional and cognitive deficits observed in patients with HD might be associated with hippocampal dysfunction. In this study using a HD mouse model, researchers found that mice in the late symptomatic stage exhibited depressive-like behavior and cognitive deficits. Additionally, they observed degenerative changes in the hippocampal dentate gyrus, including the presence of dark neurons and structural alterations in the rough endoplasmic reticulum and Golgi apparatus.
Article
Clinical Neurology
Jayme A. Bertelli, Mayur Sureshlal Goklani, Neehar Patel, Elisa Cristiana Winkelmann Duarte
Summary: Through the axillary anterior arm approach, the anatomy of the radial nerve and its branches can be clearly dissected and individualized, as well as all heads of the triceps muscle. In most dissections, a single branch to the long head and dual innervations for the lateral and medial heads were observed.
JOURNAL OF NEUROSURGERY
(2022)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.