Article
Engineering, Biomedical
Jinbiao Liu, Gansheng Tan, Yixuan Sheng, Yina Wei, Honghai Liu
Summary: This study developed a novel delay estimation method, RVC, to detect time delay between coupled neurophysiological signals. The results showed that RVC method was superior in estimating different time delays and had better optimization effect on MSC image compared to the CMCTL method. The RVC-based delay compensation also significantly optimized the MSC of specific regions.
IEEE TRANSACTIONS ON BIOMEDICAL ENGINEERING
(2022)
Article
Clinical Neurology
Amina Coffey, Saroj Bista, Antonio Fasano, Teresa Buxo, Matthew Mitchell, Eileen Rose Giglia, Stefan Dukic, Matthew Fenech, Megan Barry, Andrew Wade, Mark Heverin, Muthuraman Muthuraman, Richard G. Carson, Madeleine Lowery, Orla Hardiman, Bahman Nasseroleslami
Summary: The study investigated the motor network connectivity in adult survivors of polio by analyzing the corticomuscular coherence during a pincer grip task. The results showed significant coherence in low gamma frequency bands in the frontal and parietal regions of polio survivors, suggesting a disease-related functional reorganisation of the cortical motor network, which has implications for other LMN conditions like SMA.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Clinical Neurology
Sang Wook Lee, Hyun Joo Cho, Hae-Won Shin, Mark Hallett
Summary: The study revealed that sensory tricks can improve cortical function and reduce corticomuscular connectivity in cervical dystonia patients, ultimately alleviating the dystonic symptoms. Differences in corticocortical and corticomuscular coherence were observed between healthy subjects and different patient subgroups during the execution of sensory tricks.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
J. Ibanez, A. Del Vecchio, J. C. Rothwell, S. N. Baker, D. Farina
Summary: This study investigates the transmission speeds of cortical beta rhythms to arm and leg muscles during mild contractions in humans. Two improvements for estimating corticomuscular beta transmission delays are proposed, leading to the discovery that descending corticomuscular beta transmission is only slightly slower than expected from the fastest corticospinal pathways. Simulation results suggest two possible scenarios to explain fast corticomuscular transmission, with implications for our understanding of corticomuscular interactions.
JOURNAL OF NEUROSCIENCE
(2021)
Article
Engineering, Biomedical
Li-Wei Chou, Shiang-Lin Hou, Hui-Min Lee, Felipe Fregni, Alice Yen, Vincent Chen, Shun-Hwa Wei, Chung-Lan Kao
Summary: This study investigated the immediate effects of noise electrical stimulation on proprioceptive senses and grip force control, as well as the associated neural activities in the central nervous system. The results showed that optimal intensity noise stimulation could improve both force and joint proprioceptive senses, and individuals with higher gamma coherence demonstrated better force proprioceptive sense improvement with 30-min noise electrical stimulation. These findings suggest the potential clinical benefits of noise stimulation for individuals with impaired proprioceptive senses and indicate the characteristics of individuals who might benefit from noise stimulation.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Chemistry, Analytical
Vania Guimaraes, Ines Sousa, Miguel Velhote Correia
Summary: Inertial sensors have the potential to aid clinical decision making in gait-related disorders, but the robustness of gait analysis with respect to differences in sensor orientation has not been thoroughly investigated. The authors introduce an orientation-invariant gait analysis approach and validate it through a study on young adults. The results show good agreement between systems in analyzing an extensive set of gait metrics, demonstrating the stability of the proposed approach.
Article
Computer Science, Artificial Intelligence
Emma Colamarino, Valeria de Seta, Marcella Masciullo, Febo Cincotti, Donatella Mattia, Floriana Pichiorri, Jlenia Toppi
Summary: This study proposes a novel hybrid BCI for post-stroke rehabilitation by combining corticomuscular coherence (CMC) and intermuscular coherence (IMC) as control features, which showed potential advantages in classifying hand movements and rehabilitation outcomes.
INTERNATIONAL JOURNAL OF NEURAL SYSTEMS
(2021)
Review
Engineering, Biomedical
Hua Ling, Hui Guo, Hao Zhou, Xiao-Qian Chang, Zi-Yang Guo, Sumiko Yamamoto, Li-Fei Cai, Jun Zhao
Summary: This study investigated the effects of different types of ankle foot orthosis (AFO) on pelvic and thoracic movements in stroke patients during gait. The results showed that the use of AFO-OD improved pelvic and lower limb movements and had better gait performance compared to RAFO. However, the use of AFO resulted in in-phase rotation of the thoracic, indicating insufficient trunk control and dissociation movement. These findings have important implications for gait rehabilitation in stroke patients.
BIOMEDICAL ENGINEERING ONLINE
(2023)
Article
Engineering, Biomedical
Rui Xu, Haichao Zhang, Xianle Shi, Jun Liang, Chunxiao Wan, Dong Ming
Summary: Motor impairment after stroke is caused by damage to the neural networks controlling movement. Corticomuscular coherence (CMC) is useful for analyzing the connectivity between the cerebral cortex and muscles. However, previous studies have only focused on the upper limbs, neglecting the functional connectivity between the brain and lower limbs. In this study, CMC values were found to be significantly lower in stroke patients compared to healthy controls. CMC may serve as a new rehabilitation assessment biomarker for stroke patients.
IEEE TRANSACTIONS ON NEURAL SYSTEMS AND REHABILITATION ENGINEERING
(2023)
Article
Neurosciences
Meaghan E. Spedden, Mikkel M. Beck, Timothy O. West, Simon F. Farmer, Jens B. Nielsen, Jesper Lundbye-Jensen
Summary: This study investigates the cortical mechanisms underlying visually guided steps and highlights the role of oscillatory communication in the parieto-frontal and corticomuscular network. The findings suggest that the brain utilizes coherence to flexibly fine-tune inter-regional communication during human stepping, contributing to the precision control of large-scale movements.
Article
Neurosciences
Scott J. Mongold, Harri Piitulainen, Thomas Legrand, Marc Vander Ghinst, Gilles Naeije, Veikko Jousmaki, Mathieu Bourguignon
Summary: This study reveals fine-grained temporal modulations in the beta sensorimotor brain rhythm and its coupling with muscle activity, which precede changes in muscle force and predict the stability of force output.
Article
Physics, Fluids & Plasmas
Daniel Renjewski, Susanne Lipfert, Michael Guenther
Summary: This article proposes a mathematical model that captures the dynamics of human foot during walking and analyzes the functional interplay of biomechanical contributors. It identifies the foot as the key functional element in walking and provides insights for gait therapy, assistive device development, and humanoid robot design and control.
Review
Clinical Neurology
Mark Hallett, Lourdes M. DelRosso, Rodger Elble, Raffaele Ferri, Fay B. Horak, Stephan Lehericy, Martina Mancini, Masao Matsuhashi, Riki Matsumoto, Muthuraman Muthuraman, Jan Raethjen, Hiroshi Shibasaki
Summary: Clinical neurophysiology studies play a crucial role in understanding the physiology of human movement and the pathophysiology and diagnosis of various movement disorders, utilizing a range of methods and techniques such as EMG, EEG, MEG, etc.
CLINICAL NEUROPHYSIOLOGY
(2021)
Article
Neurosciences
Teresa L'Abbate, Karolina Armonaite, Eugenia Gianni, Massimo Bertoli, Livio Conti, Joy Grifoni, Andrea Cancelli, Carlo Cottone, Elisabetta Trombetta, Matteo Padalino, Camillo Porcaro, Franca Tecchio
Summary: This study aimed to investigate the influence of visual feedback and executing body side on corticomuscular coherence (CMC). The results showed that the absence of visual feedback decreased CMC peak frequency and amplitude, as well as decreased beta band power in the electroencephalogram. Additionally, CMC was not dependent on the executing hand. Modulation of visual information changed corticomuscular synchronizations and cortical involvement.
Review
Clinical Neurology
Emma Elkjaer, Mai B. Mikkelsen, Johannes Michalak, Douglas S. Mennin, Mia S. O'Toole
Summary: This systematic review and meta-analysis examined motor alterations in individuals with depression and anxiety disorders compared to healthy individuals, as well as the effects of experimental manipulations of the motor system within these clinical groups. The findings indicate that there are significant motor differences between clinical and healthy groups, and manipulating the motor system can have effects on affective outcomes.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Clinical Neurology
Katina Aleksovska, Teia Kobulashvili, Joao Costa, Georg Zimmermann, Karen Ritchie, Carola Reinhard, Luca Vignatelli, Alessandra Fanciulli, Maxwel Damian, Lucia Pavlakova, Jean-Marc Burgunder, Svetlana Kopishinskaya, Martin Rakusa, Norbert Kovacs, Fusun Ferda Erdogan, Lori Renna Linton, Massimiliano Copetti, Costanza Lamperti, Serenella Servidei, Theresina Evangelista, Segolene Ayme, Davide Pareyson, Johann Sellner, Christian Krarup, Marianne de Visser, Peter van den Bergh, Antonio Toscano, Holm Graessner, Thomas Berger, Claudio Bassetti, Marie Vidailhet, Eugene Trinka, Guenther Deuschl, Antonio Federico, Maurizio A. Leone
Summary: This article introduces the impact of rare diseases on patients and the existing problems within the European Union. It also provides recommendations and methods for developing and reporting high-quality clinical practice guidelines (CPGs) for rare neurological diseases (RNDs). Through a consensus procedure, 63 final items were identified. These recommendations provide solutions to the specific issues of RNDs and are considered as a starting point for further harmonization and improving the quality of CPGs.
EUROPEAN JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Joshua K. Wong, Guenther Deuschl, Robin Wolke, Hagai Bergman, Muthuraman Muthuraman, Sergiu Groppa, Sameer A. Sheth, Helen M. Bronte-Stewart, Kevin B. Wilkins, Matthew N. Petrucci, Emilia Lambert, Yasmine Kehnemouyi, Philip A. Starr, Simon Little, Juan Anso, Ro'ee Gilron, Lawrence Poree, Giridhar P. Kalamangalam, Gregory A. Worrell, Kai J. Miller, Nicholas D. Schiff, Christopher R. Butson, Jaimie M. Henderson, Jack W. Judy, Adolfo Ramirez-Zamora, Kelly D. Foote, Peter A. Silburn, Luming Li, Genko Oyama, Hikaru Kamo, Satoko Sekimoto, Nobutaka Hattori, James J. Giordano, Diane DiEuliis, John R. Shook, Darin D. Doughtery, Alik S. Widge, Helen S. Mayberg, Jungho Cha, Kisueng Choi, Stephen Heisig, Mosadolu Obatusin, Enrico Opri, Scott B. Kaufman, Prasad Shirvalkar, Christopher J. Rozell, Sankaraleengam Alagapan, Robert S. Raike, Hemant Bokil, David Green, Michael S. Okun
Summary: The DBS Think Tank IX conference provided an open platform for clinicians, engineers, and researchers to discuss DBS technologies and related issues. The consensus among the speakers was that DBS is expanding its scope and being applied to various brain disorders. Over 230,000 DBS devices have been implanted globally.
FRONTIERS IN HUMAN NEUROSCIENCE
(2022)
Article
Clinical Neurology
Lena Haarmann, Elke Kalbe, Catharine J. Lewis, Carsten Eggers, Andrea A. Kuehn, Henriette Krug, Jens Volkmann, Anna D. Kirsch, Lars Wojtecki, Alfons Schnitzler, Guenther Deuschl, Joachim K. Krauss, Christiane Woopen, Lars Timmermann, Franziska Maier
Summary: By comparing DBS and non-DBS patients, this study found that DBS patients had higher impairment in postural instability, gait difficulties, and speaking difficulties. Age and disease duration were found to affect the level of impairment, with greater differences observed with increasing age. Overall quality of life was lower but not significantly different in DBS patients. Therefore, it is recommended to use the DBS-IS in addition to the PDQ-39 when evaluating DBS patients.
PARKINSONISM & RELATED DISORDERS
(2022)
Article
Clinical Neurology
Katina Aleksovska, Claudio L. A. Bassetti, Thomas Berger, Vanessa Carvalho, Joao Costa, Guenther Deuschl, Kristian S. Frederiksen, Joke Jaarsma, Teia Kobulashvili, Maurizio Leone, Lucia Pavlakova, Michele Romoli, Luca Vignatelli
Summary: This paper aims to establish a set of criteria for prioritizing topics for future European Academy of Neurology (EAN) guidelines. Through literature review, a Delphi consensus procedure, and voting, a set of approved criteria were determined, and the first 30 topics were selected. The process involved both a bottom-up approach with community involvement and a top-down approach with board member selection.
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Henrieke L. Frequin, Jason Schouten, Constant V. M. Verschuur, Sven R. Suwijn, Judith A. Boel, Bart Post, Bastiaan R. Bloem, Johannes J. van Hilten, Teus van Laar, Gerrit Tissingh, Alexander G. Munts, Joke M. Dijk, Gunther Deuschl, Anthony Lang, Marcel G. W. Dijkgraaf, Rob J. de Haan, Rob M. A. de Bie
Summary: The study found that levodopa had similar effects on bradykinesia, rigidity, and tremor in patients with early Parkinson's disease. The improvements in symptoms were larger at 22 weeks compared to 4 weeks. At 80 weeks, fewer patients in the early-start group experienced motor response fluctuations.
Article
Clinical Neurology
Robin Wolke, Olga Gavriliuc, Oliver Granert, Guenther Deuschl, Nils G. Margraf
Summary: Using computer vision technology, 3D human body models are generated from regular photographs to evaluate postural disorders. The accuracy and applicability of this method are validated by comparing with the gold standard. The generated 3D models are not affected by the camera angle and provide a comprehensive analysis.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Letter
Clinical Neurology
Gunther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
EUROPEAN JOURNAL OF NEUROLOGY
(2023)
Article
Clinical Neurology
Johannes Meyne, Mirjam Domschikowski, Johannes Hensler, Ann-Kristin Helmers, Daniela Berg, Guenther Deuschl, Steffen Paschen
Summary: The study found that patients with previous deep brain stimulation (DBS) surgery can undergo intravenous thrombolysis (IVT) and endovascular mechanical thrombectomy therapy (MT) for acute ischemic stroke, without bleeding complications, at least 6 months after the surgery.
JOURNAL OF NEUROLOGY
(2023)
Letter
Clinical Neurology
Guenther Deuschl, Angelo Antonini, Joao Costa, Katarzyna Smilowska, Daniela Berg, Jean-Christophe Corvol, Giovanni Fabbrini, Joaquim Ferreira, Tom Foltynie, Pablo Mir, Anette Schrag, Klaus Seppi, Pille Taba, Evzen Ruzicka, Marianna Selikhova, Nicholas Henschke, Gemma Villanueva, Elena Moro
MOVEMENT DISORDERS
(2023)
Editorial Material
Clinical Neurology
Guenther Deuschl
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Dana Brinker, Oliver Granert, Felix Goevert, Inken Toedt, Alexander Baumann, Kirsten E. Zeuner, Robin Wolke, Guenther Deuschl, Jos S. Becktepe
Summary: This study aims to explore alterations of brain grey matter in patients with essential tremor (ET) combined with dystonic soft signs (ET + ds). The results showed a significant increase of grey matter in the right lentiform nucleus in ET + ds and tremor associated with manifest dystonia (TAWD) compared to healthy controls and ET patients without dystonic soft signs (ET-ds). Additionally, an increase of cortical grey matter in the middle frontal gyrus was observed in ET + ds. The hypertrophy of the lentiform nucleus in ET + ds was correlated with disease severity and duration.
PARKINSONISM & RELATED DISORDERS
(2023)
Article
Clinical Neurology
Steffen Paschen, Jos S. Becktepe, Markus A. Hobert, Kirsten E. Zeuner, Ann-Kristin Helmers, Daniela Berg, Gunther Deuschl
Summary: The current analysis of clinical symptomatology is not sufficient to predict surgical success for patients with combined tremor and dystonia syndromes. Other criteria are needed to determine the best target for deep brain stimulation, and rescue surgery may be considered for severely disabled patients if the initial target fails.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Jacopo Pasquini, Gunther Deuschl, Alessandro Pecori, Stefano Salvadori, Roberto Ceravolo, Nicola Pavese
Summary: This study conducted a comprehensive longitudinal analysis on tremor in de-novo PD patients, revealing that tremor severity increases over time and the response to medication varies. The findings provide an evidence-based framework for future pathophysiological and interventional studies on PD tremor.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Article
Clinical Neurology
Robin Wolke, Jos Steffen Becktepe, Steffen Paschen, Ann-Kristin Helmers, Dorothee Kuebler-Weller, Jinyoung Youn, Dana Brinker, Hagai Bergman, Andrea A. Kuehn, Alfonso Fasano, Guenther Deuschl
Summary: The efficacy of deep brain stimulation of the subthalamic nucleus (STN-DBS) for Parkinson's disease varies among patients. The levodopa challenge can be used to predict individual responses, but its accuracy is limited.
MOVEMENT DISORDERS CLINICAL PRACTICE
(2023)
Meeting Abstract
Clinical Neurology
P. R. Schuurman, Guenther Deuschl, Lilly Chen, Roshini Jain
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
