Article
Clinical Neurology
Ghufran Alhassani, Matthew B. Liston, Peter J. Clothier, Siobhan M. Schabrun
Summary: This study found that acute muscle pain does not affect interhemispheric inhibition between primary sensory cortices, but it does increase sensitivity to pressure pain in the unaffected limb.
Article
Biology
Masaaki Hayashi, Kohei Okuyama, Nobuaki Mizuguchi, Ryotaro Hirose, Taisuke Okamoto, Michiyuki Kawakami, Junichi Ushiba
Summary: This study used EEG neurofeedback technique to enable participants to modulate their bilateral sensorimotor activities. The results showed that participants learned to regulate the excitability of the ipsilateral hand, thereby modulating the inhibition between the two brain hemispheres. Further analysis revealed that the modulation capability of inhibition magnitude was related to interhemispheric connectivity in EEG and TMS, as well as bilateral cortical oscillatory activities.
Article
Psychology, Biological
Nicola Loi, Francesca Ginatempo, Miriam Carta, Francesco Melis, Andrea Manca, Franca Deriu
Summary: The processing of face expressions is crucial for social interactions. This study investigated the influence of face emotional expressions on the excitability of the hand primary motor cortex (M1) and found that passive viewing of negative face expressions can reduce interhemispheric inhibition.
Article
Neurosciences
Monica Christova, Victoria Sylwester, Eugen Gallasch, Shane Fresnoza
Summary: This study explored the effects of peripherally applied vibrotactile stimuli on cerebello-cortical functional connections. The results showed that hand stimulation led to a reduction in cerebellar brain inhibition and increased vibration perception threshold, indicating functional connections between the cerebellum and primary motor cortex, and suggesting that the cerebellum influences the processing of vibrotactile stimulus through motor-sensory interactions.
Article
Neurosciences
Marta Fernandez, Carlos A. Sanchez-Leon, Javier Llorente, Teresa Sierra-Arregui, Shira Knafo, Javier Marquez-Ruiz, Olga Penagarikano
Summary: Research on a mouse model of autism with Cntnap2 gene knockout showed alterations in cerebellar sensory processing, including changes in firing patterns of Purkinje cells and intrinsic properties, providing insight into the pathophysiological mechanisms of core sensory deficits in autism.
Article
Multidisciplinary Sciences
Yanjie Wang, Zhaonan Chen, Guofen Ma, Lizhao Wang, Yanmei Liu, Meiling Qin, Xiang Fei, Yifan Wu, Min Xu, Siyu Zhang
Summary: Lesions in the ACA cause visuospatial bias, which is mediated by a transcallosal inhibition loop. Activation of contralesional PV+ neurons improves contralesional detection and restores interhemispheric balance. Rating: 9/10.
NATURE COMMUNICATIONS
(2023)
Article
Neuroimaging
Joana R. A. Loureiro, Ashish K. Sahib, Megha Vasavada, Amber Leaver, Antoni Kubicki, Benjamin Wade, Shantanu Joshi, Gerhard Hellemann, Eliza Congdon, Roger P. Woods, Randall Espinoza, Katherine L. Narr
Summary: Patients with major depressive disorder (MDD) show impaired cognitive and emotional control, attributed to abnormal communication between cortical networks and altered communication with the cerebellum. This study found significant changes in cerebro-cerebellar circuitry during response-inhibition with ketamine treatment, highlighting potential biomarkers for fast-acting antidepressant therapies.
NEUROIMAGE-CLINICAL
(2021)
Article
Neurosciences
Corey G. Wadsley, John Cirillo, Arne Nieuwenhuys, Winston D. Byblow
Summary: This study aimed to investigate the role of interhemispheric primary motor cortex (M1-M1) influences during selective stopping with proactive cueing. The results showed that increased stopping uncertainty led to slower response times and reduced stopping interference. Proactive response inhibition was characterized by a slower rate of rise and faster cancel time in electromyographical bursts during stopping. There was a reduction in muscle excitability when the left hand was cued to stop, but there was no reinstatement of interhemispheric inhibition between the motor cortices.
JOURNAL OF NEUROSCIENCE
(2023)
Article
Neurosciences
Francesco Palazzo, Niloofar Lamouchideli, Alfio Caronti, Fabrizio Tufi, Elvira Padua, Giuseppe Annino
Summary: This study investigated the effects of textured insoles on walking at different speeds. The results showed that textured insoles improved walking parameters and had a more significant impact at higher speeds. This suggests that sensory interventions through appropriate insoles can adjust walking strategy and improve walking efficiency.
Article
Neurosciences
Michel Belyk, Russell Banks, Anna Tendera, Robert Chen, Deryk S. Beal
Summary: Neurophysiological experiments using transcranial magnetic stimulation have revealed a surprising effect where larger CS MEPs are associated with reduced interhemispheric inhibition, potentially leading to a net effect of facilitation in nearly all participants. Further research is needed to explore the underlying mechanisms of this phenomenon.
EXPERIMENTAL BRAIN RESEARCH
(2021)
Article
Psychology, Multidisciplinary
Sangyub Kim, Kichun Nam
Summary: Existing research favors the Split Fovea Theory (SFT) and suggests that the division of labor in foveal word recognition serves as a regulatory mechanism to reduce redundant processing in both hemispheres.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Nutrition & Dietetics
Ryan J. Benson, Evan J. Lockyer, Chris T. Compton, Kevin E. Power
Summary: This study demonstrates the activation of interhemispheric inhibition during arm cycling for the first time, quantifying it through assessing the depth of the ipsilateral silent period. Significant reduction in electromyography amplitude of the iSP during cycling was observed.
APPLIED PHYSIOLOGY NUTRITION AND METABOLISM
(2021)
Article
Multidisciplinary Sciences
Lorenz A. Fenk, Juan Luis Riquelme, Gilles Laurent
Summary: A study found that the coordination between the two sides of the claustrum in bearded dragons differ during slow-wave sleep and REMP sleep. During slow-wave sleep, the claustra activity is independent, while during REMP sleep, they are precisely coordinated but not synchronous, with one side leading the other by about 20 ms.
Article
Clinical Neurology
Jasmine L. Mirdamadi, Jing Xu, Karla M. Arevalo-Alas, Liana K. Kam, Michael R. Borich
Summary: This study aimed to investigate state-dependent interhemispheric inhibition (IHI) in chronic stroke survivors compared to neurotypical older adult controls and examined its association with upper extremity motor behavior. The results showed that stroke survivors had reduced IHI at rest and less modulation of IHI during activity compared to controls. Individual differences in IHI modulation were related to motor behavior differences, where greater modulation was associated with greater motor impairment and more mirroring. The findings suggest that abnormal state-dependent interhemispheric circuit activity may be more sensitive to post-stroke motor deficits. Characterizing state-dependent changes in neural circuitry could enhance stroke recovery models and inform rehabilitation interventions.
CLINICAL NEUROPHYSIOLOGY
(2023)
Article
Neurosciences
R. Sasaki, B. J. Hand, W. Y. Liao, N. C. Rogasch, L. Fernandez, J. G. Semmler, G. M. Opie
Summary: This study investigated the utility of combining electroencephalography (EEG) with transcranial magnetic stimulation (TMS) to measure the response to cerebellar-brain inhibition (CBI). The results showed that both F8 and DC coils suppressed TMS-evoked EEG potentials (TEPs) in the motor cortex, and the TEP produced by CBI stimulation was related to the motor inhibitory response to CBI. These findings suggest that TMS-EEG can be used to measure the response to CBI.
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.