Article
Biochemistry & Molecular Biology
Aishika Datta, Pramod Suthar, Deepaneeta Sarmah, Poonam Jadhav, Jinagna Shah, Mounika Katamneni, Nikhil Bhosale, Vishal Gupta, Mariya Bohra, Falguni Baidya, Nikita Rana, Bijoyani Ghosh, Harpreet Kaur, Anupom Borah, Rajeshwari Rathod, Pinaki Sengupta, Pallab Bhattacharya
Summary: Various agents have been developed to treat post-stroke neuroinflammation, but none of them has been successful in clinical settings yet. Inosine, an adenosine derivative, has been reported to maintain cellular energy homeostasis and stimulate axonal sprouting in neurodegenerative diseases. This study aimed to investigate the molecular mechanism of inosine-mediated neuroprotection by modulating inflammasome signaling and microglial polarization in ischemic stroke. The results showed that inosine administration at 1 h post-ischemic stroke reduced infarct size, improved motor coordination, and promoted the anti-inflammatory polarization of microglia through regulating inflammasome activation.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2023)
Review
Medicine, General & Internal
Lilian M. Mennink, Marlien W. Aalbers, Pim van Dijk, J. Marc C. van Dijk
Summary: This systematic review examines the role of inflammation in subjective tinnitus, finding that increased levels of TNF-alpha and IL-1 beta, as well as activation of microglia and astrocytes, may be associated with tinnitus.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Plant Sciences
Yuanyuan Li, Chao Tian, Yufei Wei, Haoqi Liu, Na An, Ke Song, Yikun Sun, Yonghong Gao, Ying Gao
Summary: This study explored the pharmacological mechanism of Naoxueshu oral liquid in the treatment of intracerebral hemorrhage (ICH). It was found that Naoxueshu oral liquid suppressed the inflammatory response and accelerated hematoma absorption, possibly through the regulation of Nrf2/CD163/HO-1 pathway. The study suggests that Naoxueshu oral liquid could be a potential drug for ICH treatment.
Article
Pharmacology & Pharmacy
Sara Sattar, Arham Shabbir, Muhammad Shahzad, Tasleem Akhtar, Syed Muneeb Anjum, Mohammed Bourhia, Hiba-Allah Nafidi, Yousef A. Bin Jardan, Musaab Dauelbait, Aisha Mobashar
Summary: The study found that Lawsone possesses anti-arthritic properties and can ameliorate arthritis symptoms through immunomodulatory and anti-inflammatory effects. The results demonstrate that Lawsone inhibits the progression of arthritis and reduces paw edema.
FRONTIERS IN PHARMACOLOGY
(2023)
Review
Biochemistry & Molecular Biology
Kaitryn E. Ronning, Paul-Alexandre Dechelle-Marquet, Yueshen Che, Xavier Guillonneau, Florian Sennlaub, Cecile Delarasse
Summary: Alzheimer's disease (AD) is characterized by impaired memory, amyloid plaques, and neurofibrillary tangles. The release of ATP and the upregulation of P2X7 receptor in AD patients contribute to the disease's pathological processes. Various pathways involving P2X7 have been identified to influence the development of AD, including modulation of Aβ plaques, Tau protein lesions, and inflammatory response.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Abdur Rauf, Himani Badoni, Tareq Abu-Izneid, Ahmed Olatunde, Md Mominur Rahman, Sakshi Painuli, Prabhakar Semwal, Polrat Wilairatana, Mohammad S. Mubarak
Summary: Neuroinflammation plays a crucial role in the pathogenesis of neurodegenerative diseases, and the release of neuroinflammatory markers can lead to the development of various neuronal disorders. Identifying these markers can assist in early diagnosis and treatment of these diseases.
Review
Neurosciences
Jay Amin, Daniel Erskine, Paul C. Donaghy, Ajenthan Surendranathan, Peter Swann, Amy P. Kunicki, Delphine Boche, Clive Holmes, Ian G. McKeith, John T. O'Brien, Jessica L. Teeling, Alan J. Thomas
Summary: This article provides a review of the role of inflammation in Dementia with Lewy bodies (DLB). The research suggests an increase in cerebral and peripheral inflammation in the early stages of DLB, which decreases as the disease progresses. Alpha-synuclein is found to directly promote inflammation, and the presence of Alzheimer's disease (AD) co-pathology contributes to the profile of neuroinflammation in DLB. Further longitudinal studies are recommended to enhance our understanding of the disease's pathogenesis and develop a composite biomarker for DLB diagnosis and identification of new therapeutic targets.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Biochemistry & Molecular Biology
Julie Somkhit, Constantin Yanicostas, Nadia Soussi-Yanicostas
Summary: Organophosphate compounds cause toxic poisoning and neuroinflammation, and microglia play a crucial role in the pathophysiology of OP intoxication. A study using zebrafish larvae as a model revealed that acute exposure to diisopropylfluorophosphate (DFP) induced microglial phenotypic remodelling and massive neuroinflammation. Depletion of microglia reduced OP-induced neuronal hyperactivation, suggesting that microglia could be a therapeutic target for OP poisoning.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Jinming Han, Yueshan Fan, Kai Zhou, Klas Blomgren, Robert A. Harris
Summary: There are inherent structural and functional differences in the central nervous systems of females and males, including sex-specific differences in genetic, epigenetic, and hormonal factors. Microglia, as principal resident macrophages in the CNS, have recently been found to exhibit sex-dependent structural and functional differences, which has implications for the design of sex- and microglia-specific therapeutic approaches for CNS diseases.
JOURNAL OF NEUROINFLAMMATION
(2021)
Article
Immunology
Vijayasree V. Giridharan, Jaqueline S. Generoso, Leonardo Lence, Gabriela Candiotto, Emilio Streck, Fabricia Petronilho, Anilkumar Pillai, Tarek Sharshar, Felipe Dal-Pizzol, Tatiana Barichello
Summary: Sepsis disrupts the microbiota-gut-brain axis homeostasis and leads to cognitive impairment. Survivors of sepsis show significant decline in memory and learning. Understanding the function of glial cells and gut microbiota can provide new approaches for treating sepsis patients.
JOURNAL OF NEUROINFLAMMATION
(2022)
Article
Neurosciences
Jaqueline S. Generoso, Cristiano Julio Faller, Allan Collodel, Carlos Henrique Rocha Catalao, Diogo Dominguini, Fabricia Petronilho, Tatiana Barichello, Vijayasree V. Giridharan
Summary: This study aimed to investigate the role of NLRP3 and its inhibitor MCC950 in neurochemical, immunological, and behavioral parameters in the early and late stages of experimental pneumococcal meningitis. The results showed that the rats in the meningitis group had increased levels of cytokines, NLRP3, and microglial activation markers at 24 hours, and the use of MCC950 significantly reduced those levels. Although free from infection, the animals in the meningitis group at ten days demonstrated elevated cytokine levels and behavioral deficits, which were rescued by a single dose of NLRP3 inhibitor.
MOLECULAR NEUROBIOLOGY
(2023)
Article
Neurosciences
Arielle J. D. Hay, Amanda S. S. Latham, Genova Mumford, Amelia D. D. Hines, Sydney Risen, Elizabeth Gordon, Connor Siebenaler, Vincenzo S. S. Gilberto, Mark D. D. Zabel, Julie A. A. Moreno
Summary: Mesenchymal stromal cells (MSCs) have the ability to migrate to sites of neuroinflammation and respond to paracrine signaling by secreting cytokines, growth factors, and other neuromodulators, making them a potential treatment option for neurological disorders. In this study, adipose-derived MSCs (AdMSCs) were stimulated with inflammatory molecules to enhance their migratory and secretory properties, and were delivered intranasally in a mouse model of prion disease. Treatment with AdMSCs reduced vacuolization in the brain, decreased expression of genes associated with inflammatory signaling, and induced changes in microglia and astrocytes indicative of a quiescent state. While this treatment did not prolong survival or rescue neurons, it demonstrated the benefits of MSCs in combating neuroinflammation and astrogliosis.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Cell Biology
Maria Iribarne, David R. Hyde
Summary: This study investigated the role of microglia in zebrafish retinal regeneration after damage. The researchers found that acute and chronic damage led to different inflammation profiles and regeneration outcomes. Understanding the differences could provide valuable insights for improving therapeutic strategies for repairing injured mammalian tissues.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2022)
Article
Pharmacology & Pharmacy
Ashley Wagner, Marcus Pehar, Zhimin Yan, Marianna Kulka
Summary: Recent interest in mushrooms and their components as potential therapies for mental health has led to the need for a better understanding of their effects on the brain's cellular microenvironment. This study investigated the effects of Amanita muscaria extract on human microglial cell line expression and inflammatory responses. The extract was found to upregulate the expression of certain surface receptors and alter the production of inflammatory cytokines.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Cell Biology
Allison Costello, Katrina Linning-Duffy, Carleigh Vandenbrook, Joseph S. Lonstein, Lily Yan
Summary: This study reveals the impact of environmental lighting conditions on neuroinflammation in a diurnal rodent model. Winter-like dim light during the day leads to increased neuroinflammation indicators in a brain site- and sex-specific manner.
CELLULAR AND MOLECULAR NEUROBIOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Joy Armistead, Nehal Patel, Xiaoli Wu, Richard Hemming, Biswajit Chowdhury, Gagandeep Singh Basra, Marc R. Del Bigio, Hao Ding, Barbara Triggs-Raine
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2015)
Review
Neurosciences
Hassan Marzban, Marc R. Del Bigio, Jayed Alizadeh, Seek Ghayami, Robby M. Zechariah, Mojgan Rastegar
FRONTIERS IN CELLULAR NEUROSCIENCE
(2015)
Letter
Clinical Neurology
Carly Scramstad, Michael J. Ellis, Marc R. Del Bigio
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2017)
Article
Clinical Neurology
Marc R. Del Bigio, Johannes A. Hainfellner, Catriona A. McLean, Suzanne Z. Powell, Beata Sikorska, Hitoshi Takahashi, Joachim Weis, John H. Xuereb
Article
Clinical Neurology
P. Frosk, S. M. Phillips, M. R. Del Bigio, B. N. Chodirker
NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY
(2014)
Article
Neurosciences
Marc A. Ranson, Marc R. Del Bigio
Article
Multidisciplinary Sciences
Karen Bailey, Maryam Rahimi Balaei, Ashraf Mannan, Marc R. Del Bigio, Hassan Marzban
Article
Genetics & Heredity
Jessica N. Hartley, Louise R. Simard, Valentina Ly, Marc R. Del Bigio, Patrick Frosk
AMERICAN JOURNAL OF MEDICAL GENETICS PART A
(2019)
Article
Oncology
Jessica S. Jarmasz, Hannah Stirton, James R. Davie, Marc R. Del Bigio
CLINICAL EPIGENETICS
(2019)
Article
Substance Abuse
Jessica S. Jarmasz, Hannah Stirton, Duaa Basalah, James R. Davie, Sterling K. Clarren, Susan J. Astley, Marc R. Del Bigio
ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH
(2019)
Article
Clinical Neurology
Robert Hammond, Chris Dunham, Deborah McFadden, Marc Del Bigio, Mari Perez-Rosendahl, Harry V. Vinters
Summary: Post-mortem examination of the nervous system culminates in brain cutting, which relies on expertise to recognize subtle abnormalities. Some Canadian jurisdictions have imposed restrictions on tissue retention due to aberrant practices. Surveying Canadian neuropathologists, most believe that cutting and sampling a brain before full fixation leads to a loss of diagnostic accuracy and academic deliverables.
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Thatchawan Thanasupawat, Aleksandra Glogowska, Christopher Pascoe, Sai Nivedita Krishnan, Maliha Munir, Farhana Begum, Jason Beiko, Jerry Krcek, Marc R. Del Bigio, Marshall Pitz, Yaoqing Shen, Victor Spicer, Kevin M. Coombs, John Wilkins, Sabine Hombach-Klonisch, Thomas Klonisch
Summary: Researchers used patient-derived cell models and high-throughput analysis to characterize the proteomic profiles of malignant gliomas, identifying specific protein markers for different types of gliomas and validating their presence in disease cells.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Neurosciences
Domenico L. Di Curzio, Xiaoyan Mao, Aidan Baker, Marc R. Del Bigio
FLUIDS AND BARRIERS OF THE CNS
(2018)
Article
Public, Environmental & Occupational Health
Jayantha C. Herath, Saman Kalikias, Susan M. Phillips, Marc R. Del Bigio
CANADIAN JOURNAL OF PUBLIC HEALTH-REVUE CANADIENNE DE SANTE PUBLIQUE
(2014)
Article
Medicine, Research & Experimental
Xiaoyan Mao, Marc R. Del Bigio
JOURNAL OF NEGATIVE RESULTS IN BIOMEDICINE
(2015)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.
