Article
Nutrition & Dietetics
Shirelle X. Liu, Tenille K. Fredrickson, Natalia Calixto Mancipe, Michael K. Georgieff, Phu V. Tran
Summary: Fetal-neonatal iron deficiency (ID) causes long-term neurocognitive and affective dysfunctions, with sex-specific effects that are poorly understood at the molecular level. In this study using a rat model, both ID and prenatal choline treatment induced sex-specific transcriptome alterations in the adult rat hippocampus. ID induced changes in gene networks related to enhanced neuroinflammation, while choline supplementation partially rescued ID-induced dysregulation and had both beneficial and adverse effects on hippocampal gene expression.
Article
Multidisciplinary Sciences
Laura Green, David Tingley, John Rinzel, Gyorgy Buzsaki
Summary: This study investigates the role of action in the neuronal organization of the hippocampus through a behavioral experiment of training rats to jump a gap. The results indicate that jumping induces consistent electrophysiological patterns in the hippocampus, while the theta spike phase versus animal position relationship remains unchanged.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Timothy Tadros, Giri P. Krishnan, Ramyaa Ramyaa, Maxim Bazhenov
Summary: By implementing a sleep-like phase, artificial neural networks can protect old memories during new training and alleviate catastrophic forgetting.
NATURE COMMUNICATIONS
(2022)
Article
Multidisciplinary Sciences
Rafael Pedrosa, Mojtaba Nazari, Majid H. Mohajerani, Thomas Knopfel, Federico Stella, Francesco P. Battaglia
Summary: Hippocampus-neocortex interactions play a critical role in memory processes during sleep. Activation transients in the neocortex are associated with communication across remote brain areas and consolidation processes rely on bidirectional signaling between hippocampus and neocortex, with slow gamma rhythms being particularly important.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Mathematical & Computational Biology
Umesh Kumar Verma, G. Ambika
Summary: The study demonstrates the emergence of various spatio temporal patterns among neurons connected in a multiplex framework, with different functional couplings on two layers. Patterns such as in-phase synchronized oscillations, amplitude death, and anti-phase mixed-mode oscillations are observed.
FRONTIERS IN COMPUTATIONAL NEUROSCIENCE
(2021)
Article
Multidisciplinary Sciences
Leila Reddy, Matthew W. Self, Benedikt Zoefel, Marlene Poncet, Jessy K. Possel, Judith C. Peters, Johannes C. Baayen, Sander Idema, Rufin VanRullen, Pieter R. Roelfsema
Summary: Research in the human temporal lobe shows that the timing of neuronal activity relative to theta brain oscillation reflects sequence order. The study found that spikes in three consecutive items in a sequence were phase-locked at distinct phases of the theta oscillation, with spikes being fired at progressively earlier phases as the sequence advanced.
NATURE COMMUNICATIONS
(2021)
Article
Nutrition & Dietetics
Erin L. Grafe, Mira M. M. Wade, Claire E. Hodson, Jennifer D. Thomas, Brian R. Christie
Summary: This study found that choline supplementation can restore hippocampal synaptic plasticity impaired by prenatal alcohol exposure. The results showed that choline supplementation improves excitability in female offspring affected by PNEE, and rescues decreased long-term potentiation in male offspring with PNEE.
Article
Neurosciences
Jehoon Lee, Vishal Naik, Marcus Orzabal, Raine Lunde-Young, Jayanth Ramadoss
Summary: Prenatal alcohol exposure can lead to increased dendritic arborization in the developing rat hippocampus, potentially playing a critical role in FASD neurobiological phenotypes.
Article
Physics, Multidisciplinary
Yuzhen Qin, Tommaso Menara, Danielle S. Bassett, Fabio Pasqualetti
Summary: This study investigates the mechanism of cross-frequency phase-amplitude coupling (PAC) in neuronal networks, demonstrating the phenomenon of PAC in different structures using the Stuart-Landau oscillators model and analyzing the parameters that affect PAC behavior. Experimental results show that low-frequency phase synchrony can integrate high-frequency activities and control the direction of information flow.
PHYSICAL REVIEW RESEARCH
(2021)
Article
Multidisciplinary Sciences
Antonio Fernandez-Ruiz, Azahara Oliva, Marisol Soula, Florbela Rocha-Almeida, Gergo A. Nagy, Gonzalo Martin-Vazquez, Gyorgy Buzsaki
Summary: Gamma oscillations coordinate spike timing of functionally specialized neuronal ensembles across different brain regions, impacting learning tasks and transmitting task-relevant information in the entorhinal-hippocampal circuit, serving as a mechanism of neuronal communication.
Article
Cell Biology
Colin G. McNamara, Max Rothwell, Andrew Sharott
Summary: Closed-loop interaction regulates ongoing brain activity by binding external stimulation to specific neural circuit dynamics. By delivering stimulation aligned with each cycle, oscillatory brain activity can be maintained in a desired state, allowing for modulation of behavior.
Article
Physics, Fluids & Plasmas
Katiele V. P. Brito, Fernanda S. Matias
Summary: Several experiments and models have shown the importance of neuronal heterogeneity in brain dynamics and function. The effect of neuronal variability on phase relations between two populations is studied, with the potential to influence cortical communication hypotheses. The proposed model demonstrates that neuronal heterogeneity can determine phase relations and reproduce experimental results, showing both anticipated synchronization and delayed synchronization regimes.
Article
Multidisciplinary Sciences
Gabriel Moreno Cunha, Gilberto Corso, Marcelo M. S. Lima, Gustavo Zampier dos Santos Lima
Summary: The brain is a complex network system with specific organization and topology, and it exhibits specific electrophysiological patterns. However, the cellular communication mechanism known as ephapticity has been understudied. In this study, we used numerical simulations to examine the relationship between ephaptic neuronal entrainment and impaired electrophysiological properties, which can be observed in neurodegenerative diseases. Our results indicate that damage to ion channels can affect ephaptic entrainment, suggesting a potential link between ephapticity and aging-related neurodegenerative diseases.
SCIENTIFIC REPORTS
(2023)
Article
Biochemistry & Molecular Biology
Danying Wang, Kimron L. Shapiro, Simon Hanslmayr
Summary: This study provides evidence for the role of spike-timing-dependent plasticity (STDP) in human episodic memory, bridging the gap between animal in vitro studies and human memory behavior.
Review
Neurosciences
Antonio Fernandez-Ruiz, Anton Sirota, Vitor Lopes-dos-Santos, David Dupret
Summary: Gamma oscillations (-30-150 Hz) are widespread correlates of neural circuit functions. These network activity patterns have been described across multiple animal species, brain structures, and behaviors, and are usually identified based on their spectral peak frequency. However, whether gamma oscillations implement specific brain functions or represent a general dynamic mode of neural circuit operation remains unclear. This perspective reviews recent advances in the study of gamma oscillations and proposes shifting the attention from a frequency-based to a circuit-level definition.
Review
Behavioral Sciences
Bon-Mi Gu, Hedderik van Rijn, Warren H. Meck
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2015)
Review
Neurosciences
Hugo Merchant, Deborah L. Harrington, Warren H. Meck
ANNUAL REVIEW OF NEUROSCIENCE, VOL 36
(2013)
Review
Psychology
Melissa J. Allman, Sundeep Teki, Timothy D. Griffiths, Warren H. Meck
ANNUAL REVIEW OF PSYCHOLOGY, VOL 65
(2014)
Article
Behavioral Sciences
Warren H. Meck, Russell M. Church, David S. Olton
BEHAVIORAL NEUROSCIENCE
(2013)
Article
Behavioral Sciences
Warren H. Meck, Russell M. Church, Matthew S. Matell
BEHAVIORAL NEUROSCIENCE
(2013)
Article
Psychology, Biological
Sarah R. Heilbronner, Warren H. Meck
BEHAVIOURAL PROCESSES
(2014)
Article
Behavioral Sciences
P. V. Agostino, R. -K. Cheng, C. L. Williams, A. E. West, W. H. Meck
GENES BRAIN AND BEHAVIOR
(2013)
Article
Behavioral Sciences
Jessica I. Lake, Warren H. Meck
Article
Biology
Bin Yin, Warren H. Meck
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2014)
Editorial Material
Biology
Valter Tucci, Catalin V. Buhusi, Randy Gallistel, Warren H. Meck
PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
(2014)
Article
Multidisciplinary Sciences
Alex J. Bartholomew, Warren H. Meck, Elizabeth T. Cirulli
Review
Behavioral Sciences
Zhuanghua Shi, Russell M. Church, Warren H. Meck
TRENDS IN COGNITIVE SCIENCES
(2013)
Article
Psychology, Experimental
Sara Cordes, Warren H. Meck
JOURNAL OF EXPERIMENTAL PSYCHOLOGY-GENERAL
(2014)
Article
Psychology, Experimental
Jessica I. Lake, Kevin S. LaBar, Warren H. Meck
Review
Psychology, Experimental
William J. Matthews, Warren H. Meck
WILEY INTERDISCIPLINARY REVIEWS-COGNITIVE SCIENCE
(2014)
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.