Article
Neurosciences
Tjerk T. Dercksen, Andreas Widmann, Toemme Noesselt, Nicole Wetzel
Summary: This study recorded action-induced somatosensory omission responses using EEG in humans and found that these responses may reflect prediction errors at multiple levels in the brain.
HUMAN BRAIN MAPPING
(2023)
Article
Clinical Neurology
Haike Dietrich, Cauchy Pradhan, Felix Heidger, Roman Schniepp, Max Wuehr
Summary: This study found that ocular-motor deficits in patients with downbeat nystagmus (DBN) were attenuated and nystagmus frequency was reduced during walking. This suggests that ocular-motor control disturbances are selectively suppressed during locomotion in DBN.
JOURNAL OF NEUROLOGY
(2022)
Article
Neurosciences
Roozbeh Behroozmand, Leonardo Bonilha, Chris Rorden, Gregory Hickok, Julius Fridriksson
Summary: We used left-hemisphere stroke as a model to examine the impairment of vocal auditory feedback processing and control in sensorimotor brain networks. The findings showed that individuals with aphasia exhibited aberrant modulation of ERP activity during vocalization, accompanied by reduced compensatory vocal responses to pitch-shift alterations in the auditory feedback. Lesion-mapping revealed that the abnormal pattern of ERP modulation was accounted for by damage to sensorimotor networks within specific areas of the left-hemisphere cortex. These results provide translational synergy for theoretical models of sensorimotor integration and have clinical applications for communication disabilities in stroke and other neurological conditions.
Article
Behavioral Sciences
Mikaela Bubna, Melanie Y. Lam, Erin K. Cressman
Summary: This study aimed to determine whether awareness of the temporal lag between motor response and sensory event is necessary for Temporal recalibration (TR) and whether manipulating motor and perceptual judgment tasks would modify the influence of awareness on TR. The results suggest that awareness of the temporal lag does not influence the magnitude of TR achieved and that motor and perceptual judgment task demands do not modulate the influence of awareness on TR.
FRONTIERS IN INTEGRATIVE NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Giorgio Vallortigara
Summary: The distinction between sensation and perception lies in their association with consciousness, with the former being connected to bodily actions. The evolutionary reason for this distinction can be traced back to organisms' movement and their understanding of external stimuli. The Erich von Hoist Reafferenzprinzip effectively models this distinction by generating efference copies associated with motor commands.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2021)
Article
Neurosciences
Eleftherios Kavroulakis, Bianca M. van Kemenade, Belkis Ezgi Arikan, Tilo Kircher, Benjamin Straube
Summary: The study found that predictive mechanisms enable earlier processing and shorter duration of action feedback for self-generated movements, potentially reducing the ability to detect short delays between action and feedback.
HUMAN BRAIN MAPPING
(2022)
Article
Neurosciences
Jin Hyung Chung, Sarah W. Bottjer
Summary: The study reveals developmental changes in axonal projections in songbirds during vocal learning, providing pathways for the reintegration of vocal motor output information and aiding in the refinement of juvenile vocalizations. The decline in LMAN-core -> AId projection suggests a loss of efference copy during early sensorimotor learning, while the persistence of the RA -> DLM projection facilitates song production during learning and maintenance stages.
JOURNAL OF COMPARATIVE NEUROLOGY
(2022)
Article
Neurosciences
Francois M. Lambert, Mathieu Beraneck, Hans Straka, John Simmers
Summary: Neural replicas of the spinal motor commands play an important role in producing gaze-stabilizing eye movements and have been conserved during vertebrate evolution. They provide estimates of the sensory consequences of behavioral action and can counteract the perturbing effects of self-generated head/body motion.
CURRENT OPINION IN NEUROBIOLOGY
(2023)
Article
Multidisciplinary Sciences
Elena Fuehrer, Dimitris Voudouris, Alexandra Lezkan, Knut Drewing, Katja Fiehler
Summary: The article discusses the phenomenon of tactile suppression, where tactile sensations on a moving hand are perceived weaker compared to a stationary hand. It presents evidence that tactile suppression is specifically tuned to predicted sensory states of a movement, supporting the role of precise sensorimotor predictions in this phenomenon.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Neurosciences
Alessandro Benedetto, Hao Tam Ho, Maria Concetta Morrone
Summary: The modulation of visual perception during action execution is related to the readiness potential, an event-related potential linked to motor preparation. The magnitude of visual modulation following a voluntary button press was found to correlate with the amplitude of the readiness potential measured during visual discrimination. Moreover, the amplitude of the readiness potential in a purely motor task was also found to correlate with the extent of the motor-induced modulation of visual perception. These findings suggest that perceptual changes close to action execution are associated with motor preparation processes and that the readiness potential can serve as a fingerprint of individual visuomotor interaction.
Article
Neurosciences
Raul Luna, Ignacio Serrano-Pedraza, Karl R. Gegenfurtner, Alexander C. Schuetz, David Souto
Summary: During smooth pursuit eye movements, repeatedly exposing observers to background motion with a fixed direction relative to the pursued target can lead to a shift in their point of subjective stationarity (PSS), reflecting a recalibration of the reference signal in response to prevailing retinal motion during pursuit. This recalibration effect is specific to the exposed visual hemifield.
Article
Psychology, Biological
Edward Ody, Benjamin Straube, Yifei He, Tilo Kircher
Summary: Efference copy-based forward model mechanisms help distinguish between self-generated and externally-generated sensory consequences. This study examined visual stimuli following active and passive button presses and found that there was suppression of early visual responses in the active condition, and this suppression was correlated with the suppression of the visual P2 component. These findings support the idea of efference copy-based forward model predictions in the visual sensory modality.
Article
Biology
Min-Hee Ahn, Nour Alsabbagh, Hyo-Jeong Lee, Hyung-Jong Kim, Myung-Hun Jung, Sung-Kwang Hong
Summary: The principle of Bayesian inference provides a theoretical framework for stable perception; efference copy signals reduce cognitive loading by decreasing sensory processing of one's own actions. Sensory prediction errors lead to false perceptions, such as auditory hallucinations in schizophrenia and phantom perceptions like tinnitus. Failures in N1 attenuation suggest impairment in the efference copy mechanism for auditory phantom perception, with differences in neural representation between schizophrenia and tinnitus patients present.
Review
Neurosciences
Kathleen E. Cullen, Rui-Han Wei
Summary: The mammalian vestibular efferent system remains a mystery, as it does not relay inputs from other sensory modalities or motor-related signals to the vestibular periphery, but likely plays a key role in calibrating and protecting vestibular circuits during development and aging.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Psychiatry
Lukas Uhlmann, Mareike Pazen, Bianca M. van Kemenade, Tilo Kircher, Benjamin Straube
Summary: The study found that disturbances in self-other distinction in schizophrenia spectrum disorders are particularly driven by agency, while self-other distinction based on hand identity might be spared.
SCHIZOPHRENIA BULLETIN
(2021)
Article
Clinical Neurology
Lindsey E. Fraser, Avril Mansfield, Laurence R. Harris, Daniel M. Merino, Svetlana Knorr, Jennifer L. Campos
CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES
(2018)
Article
Neurosciences
Stefania S. Moro, Laurence R. Harris
EXPERIMENTAL BRAIN RESEARCH
(2018)
Article
Ophthalmology
Jing Chen, Meaghan McManus, Matteo Valsecchi, Laurence R. Harris, Karl R. Gegenfurtner
Article
Neurosciences
Adam J. Toth, Laurence R. Harris, Leah R. Bent
EXPERIMENTAL BRAIN RESEARCH
(2019)
Article
Neurosciences
Lukas Uhlmann, Mareike Pazen, Bianca M. van Kemenade, Olaf Steinstraeter, Laurence R. Harris, Tilo Kircher, Benjamin Straube
HUMAN BRAIN MAPPING
(2020)
Article
Neurosciences
Andrew P. Lauzon, Frank A. Russo, Laurence R. Harris
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Multidisciplinary Sciences
Sarah D'Amour, Laurence R. Harris
Editorial Material
Psychology
Laurence R. Harris
COGNITIVE NEUROPSYCHOLOGY
(2020)
Article
Neurosciences
Molly E. Gibson, John J. -J. Kim, Meaghan McManus, Laurence R. Harris
EXPERIMENTAL BRAIN RESEARCH
(2020)
Article
Multidisciplinary Sciences
Nils-Alexander Bury, Michael R. Jenkin, Robert S. Allison, Laurence R. Harris
Article
Psychology
Sarah D'Amour, Laurence R. Harris, Stefan Berti, Behrang Keshavarz
Summary: The study found that cognitive manipulations such as expectation and plausibility can alter the intensity of vection, while individual traits such as field dependence and depersonalization are also related to vection. Additionally, the configuration of the chair can affect the perception of vection.
ATTENTION PERCEPTION & PSYCHOPHYSICS
(2021)
Article
Multidisciplinary Sciences
Meaghan McManus, Laurence R. Harris
Summary: Human perception is based on expectations and the agreement between visual and vestibular information. When these assumptions are violated, it can affect the perception of self-motion. Research has shown that experiencing visual reorientation illusion can impact the effectiveness of simulating self-motion through optic flow.
Article
Psychology, Multidisciplinary
Sarah D'Amour, Laurence R. Harris
FRONTIERS IN PSYCHOLOGY
(2019)
Meeting Abstract
Ophthalmology
Simon Rushton, Laurence Harris, Geoffrey Megardon, Phoebe Asquith
Article
Psychology, Experimental
B. Ezgi Arikan, Bianca M. van Kemenade, Benjamin Straube, Laurence R. Harris, Tilo Kircher
Article
Neurosciences
Xiaomei Lin, Tianyuyi Feng, Erheng Cui, Yunfei Li, Zhang Qin, Xiaohu Zhao
Summary: This study successfully established a rat model based on the genetic-environmental interaction, which exhibited phenotype characteristics similar to human AD in terms of cognitive function, brain microstructure, and immunohistochemistry. The genetic factor (APP mutation) and the environmental factor (acrolein exposure) accounted for 39.74% and 33.3% of the AD-like phenotypes in the model, respectively.
Article
Neurosciences
Gustavo Guimara Guerrero, Giovanna Bignoto Minhoto, Camilla dos Santos Tiburcio-Machado, Itza Amarisis Ribeiro Pinto, Claudio Antonio Federico, Marcia Carneiro Valera
Summary: The present study evaluated the influence of head and neck radiotherapy on the behavior and body weight gain in Wistar rats. The results demonstrated that different doses of radiation induced depressive behavior in the animals, and that the weight gain tended to be lower in the irradiated groups.
Article
Neurosciences
Ziwei Gao, Chao Lu, Yaping Zhu, Yuxin Liu, Yuesong Lin, Wenming Gao, Liyuan Tian, Lei Wu
Summary: This study reveals the underlying mechanisms of the rapid antidepressant effects of merazin hydrate (MH), which activates CaMKII to promote neuronal activities and proliferation in the hippocampus.
Article
Neurosciences
Kathleen E. Murray, Whitney A. Ratliff, Vedad Delic, Bruce A. Citron
Summary: Gulf War Illness (GWI) is a chronic disorder that affects approximately 30% of Veterans deployed to the Persian Gulf. This study found that exposure to toxicants during the Gulf War resulted in long-term changes in the morphology of dentate granule cells and that treatment with Nrf2 activator could improve neuronal health in the hippocampus.
Article
Neurosciences
Jing Li, Yan Zou, Xiangchuang Kong, Yangming Leng, Fan Yang, Guofeng Zhou, Bo Liu, Wenliang Fan
Summary: This study examines the functional connectivity changes in individuals with sudden sensorineural hearing loss (SSNHL) at the integrity, network, and edge levels. The findings reveal reduced intranetwork connectivity strength and increased internetwork connectivity in SSNHL patients. These alterations are associated with the duration of SSNHL and Tinnitus Handicap Inventory scores. The study provides crucial insights into the neural mechanisms of SSNHL and the brain's network-level responses to sensory loss.
Review
Neurosciences
Didier Majou, Anne-Lise Dermenghem
Summary: In the early stages of SAD, memory impairment is strongly correlated with cortical levels of soluble amyloid-beta peptide oligomers. A beta disrupts glutamatergic synaptic function and leads to cognitive deficits. This article describes the pathogenic mechanisms underlying cerebral amyloidosis, involving amyloid precursor protein synthesis, A beta residue clearance processes, and the role of specific molecules.
Article
Neurosciences
Jing Li, Yi Shan, Xiaojing Zhao, Guixiang Shan, Peng-Hu Wei, Lin Liu, Changming Wang, Hang Wu, Weiqun Song, Yi Tang, Guo-Guang Zhao, Jie Lu
Summary: This study investigates changes in brain anatomical structures and functional network connectivity after chronic complete thoracic spinal cord injury (cctSCI) and their impact on clinical outcomes. The findings reveal alterations in gray matter volume and functional connectivity in specific brain regions, indicating potential therapeutic targets and methods for tracking treatment outcomes.
Article
Neurosciences
Anllely Fernandez, Katherine Corvalan, Octavia Santis, Maxs Mendez-Ruette, Ariel Caviedes, Matias Pizarro, Maria -Teresa Gomez, Luis Federico Batiz, Peter Landgraf, Thilo Kahne, Alejandro Rojas-Fernandez, Ursula Wyneken
Summary: This study reveals the importance of SUMOylation in modulating the protein cargo of astrocyte-derived small extracellular vesicles (sEVs) and its potential impact on neurons.
Article
Neurosciences
Anika Luettig, Stefanie Perl, Maria Zetsche, Franziska Richter, Denise Franz, Marco Heerdegen, Ruediger Koehling, Angelika Richter
Summary: This study found that changes in c-Fos activity during short-term stimulation of the entopeduncular nucleus (EPN) are associated with improvement in dystonia, and also discovered that the cerebellum may be involved in the antidystonic effects.
Article
Neurosciences
Yanlin Tao, Wei Shen, Houyuan Zhou, Zikang Li, Ting Pi, Hui Wu, Hailian Shi, Fei Huang, Xiaojun Wu
Summary: Depression has a higher incidence in women compared to men, and this study investigated the impact of sex on depressive behaviors and underlying mechanisms using a corticosterone-induced depression model in mice. The results showed sex-specific anxiety and depression behaviors in the model group, as well as differences in protein expression and neurotransmitter levels between male and female mice. These findings enhance our understanding of sex-specific differences in depression and support tailored interventions.
Review
Neurosciences
Dnyandev G. Gadhave, Vrashabh V. Sugandhi, Chandrakant R. Kokare
Summary: This article discusses the characteristics and importance of the tight junctions of endothelial cells in the CNS, which act as a biological barrier known as the blood-brain barrier (BBB). It focuses on overcoming the challenges of delivering therapeutic agents to the brain in neurodegenerative disorders, particularly multiple sclerosis, through the use of biomaterials. The article also highlights the current limitations of animal models for studying multiple sclerosis and suggests a potential future research direction.
Article
Neurosciences
Li-Min Mao, Khyathi Thallapureddy, John Q. Wang
Summary: Propofol can enhance synapsin phosphorylation and modulate synaptic transmission in the mouse brain. The study reveals the potential role of synapsin as a substrate of propofol and its effects on neurotransmitter release machinery.
Article
Neurosciences
Syed Maaz Ahmed Rizvi, Abdul Baseer Buriro, Irfan Ahmed, Abdul Aziz Memon
Summary: This study explores the effects of prolonged mask usage on the human brain by analyzing EEG and physiological parameters. The results show that the mean EEG spectral power in alpha, beta, and gamma sub-bands of individuals wearing masks is smaller than those without masks. The performances on cognitive tasks and oxygen saturation level differ between the two groups, while blood pressure, body temperature, and heart rate are similar. The analysis also reveals that the occipital and frontal lobes exhibit the greatest variability in channel measurements.
Article
Neurosciences
Rui-Fang Ma, Lu-Lu Xue, Jin-Xiang Liu, Li Chen, Liu-Lin Xiong, Ting-Hua Wang, Fei Liu
Summary: This study observed changes in brain infarction and blood vessels in rats during neonatal hypoxic ischemic encephalopathy (NHIE) modeling using Transcranial Doppler Ultrasonography (TCD). Longer duration of hypoxia was associated with more severe nerve damage. TCD can dynamically monitor cerebral infarction after NHIE modeling, which may serve as a useful auxiliary method for evaluating animal experimental models.
Article
Neurosciences
Yuxiang Dai, Chen Yu, Lu Zhou, Longyang Cheng, Hongbin Ni, Weibang Liang
Summary: Overexpression of CXCR4 in glioma is correlated with patient survival, and its inhibition can reduce invasion and migration of glioma cells. Inhibiting Nur77 also decreases cancer progression associated with CXCR4.