Review
Cell Biology
Maria Isabel Cuartero, Alicia Garcia-Culebras, Cristina Torres-Lopez, Violeta Medina, Enrique Fraga, Sandra Vazquez-Reyes, Tania Jareno-Flores, Juan M. Garcia-Segura, Ignacio Lizasoain, Maria angeles Moro
Summary: After stroke injury, there is ongoing neurogenesis in the adult mammalian brain which can contribute to recovery. However, the neurogenic response may lead to different functional consequences, suggesting a complex interplay between physiological and pathological regulation. More in-depth understanding is needed on the key cell types, cell-cell interactions, and molecular pathways involved in neurogenic response after brain damage.
FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY
(2021)
Article
Neurosciences
Oladiran I. Olateju, Lorenzo More, J. Simon C. Arthur, Bruno G. Frenguelli
Summary: Neurogenesis in the adult hippocampus can be stimulated by exposure to an enriched environment, leading to increased production of neurons and benefits for health and cognition. MSK1 plays a negative regulatory role post-enrichment by influencing the number of cells destined to become neurons, thereby potentially serving as a homeostatic control on the integration of new neurons into the dentate gyrus.
Article
Oncology
Zoe Schmal, Claudia E. Ruebe
Summary: Radiation-induced brain injury significantly affects the neurocognitive functions of brain cancer survivors, especially in pediatric patients. This study investigated the underlying mechanisms of radiation-induced brain injury by analyzing different hippocampal subregions in a mouse model. The findings suggest that region-specific differences in radiosensitivity are primarily determined by the presence of proliferating neuroprogenitors.
Article
Biochemistry & Molecular Biology
Jia-He Zhang, Takashi Tasaki, Manabu Tsukamoto, Ke-Yong Wang, Kin-ya Kubo, Kagaku Azuma
Summary: The deletion of Wnt10a leads to decreased neurogenesis, impaired synaptic function, and neuroinflammation in the hippocampus, ultimately resulting in hippocampal neurodegeneration and memory deficits.
Article
Biochemistry & Molecular Biology
Xiaohan Luan, Wenxian Yang, Xiaoyuan Bai, Heqiao Li, Huizi Li, Wenhui Fan, He Zhang, Wenjun Liu, Lei Sun
Summary: CypA positively regulates the IL-6 trans-signaling pathway by inhibiting degradation of IL-6 membrane receptor gp130 and enhancing its dimerization, while its expression is negatively regulated by SOCS1. SOCS1 interacts with CypA and promotes its degradation through ubiquitination, thus inhibiting the IL-6 trans-signaling pathway.
Article
Biochemistry & Molecular Biology
Ekaterina Kurilova, Maria Sidorova, Oksana Tuchina
Summary: We used a single prolonged stress protocol to study the susceptibility and neuroinflammatory response of C57BL/6 and wild-derived (house) mice to psychological trauma. The results showed that long-inbred C57BL/6 mice are more susceptible to prolonged stress and demonstrated elevated expression levels of proinflammatory cytokines in the hippocampus compared to house mice. The study also suggested that decreased microglia levels in the hippocampus of C57BL/6 mice might contribute to their sensitivity to prolonged stress.
CURRENT ISSUES IN MOLECULAR BIOLOGY
(2023)
Article
Pharmacology & Pharmacy
Luwen Zhang, Wenjuan Tang, Yinan Ouyang, Miao Zhang, Ruirui Li, Lianping Sun, Chao Liu, Hailing Yu
Summary: This study investigates the antidepressant property of PEA and its potential therapeutic effects on depressive mood disorders. The results suggest that PEA can target hippocampal neuroplasticity, including increasing adult neurogenesis and synaptic plasticity, as well as reducing neuronal apoptosis, to remodel hippocampal circuitries. The PPAR & alpha; pathway may be involved in this process.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Amarjot Kaur Grewal, Thakur Gurjeet Singh, Deepak Sharma, Veerta Sharma, Manjinder Singh, Md. Habibur Rahman, Agnieszka Najda, Magdalena Walasek-Janusz, Mohamed Kamel, Ghadeer M. Albadrani, Muhammad Furqan Akhtar, Ammara Saleem, Mohamed M. Abdel-Daim
Summary: Quercetin, a flavonoid widely distributed among plants, has significant pharmacological effects and therapeutic potential, showing neuroprotection by modulating and inhibiting a wide range of pathways. Its exact mechanisms of action remain a mystery, but studies have explored its role in enhancing neuronal longevity and neurogenesis in the context of neurodegenerative diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Biochemistry & Molecular Biology
Juliane Lokau, Christoph Garbers
Summary: IL-6 and IL-11 are important pleiotropic cytokines that signal through specific receptors, with unique structures. Research has shown that chimeric receptors containing the stalk region of IL-11R can be blocked by a protease inhibitor other than ADAM10 during cleavage.
Article
Multidisciplinary Sciences
Zhao Zhang, Yuze Yang, Lijiao Yan, Xuerui Wan, Kangyongjie Sun, Huitian Gou, Jucai Ding, Jie Peng, Guo Liu, Chuan Wang
Summary: In this study, the toxicity and apoptosis-inducing effects of matrine on bovine mammary epithelial cells were investigated. It was found that matrine exhibited cytotoxicity and induced apoptosis in these cells. Furthermore, transcriptome analysis revealed the signaling pathways associated with matrine-induced toxicity and apoptosis. These findings provide a basis for the safe use of matrine in the prevention and treatment of mastitis.
Article
Neurosciences
Ane Rodriguez-Bodero, Juan Manuel Encinas-Perez
Summary: Postnatal and adult neurogenesis occur in the dentate gyrus of the hippocampus in most mammals. Neural stem cells and newborn neurons serve as biosensors of hippocampal health, providing valuable information about neuronal activity and disease injuries.
FRONTIERS IN NEUROSCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Tim Schumertl, Juliane Lokau, Stefan Rose-John, Christoph Garbers
Summary: Interleukin-6 (IL-6) is a pleiotropic cytokine involved in various physiological and pathophysiological functions. It can signal through different pathways, with trans-signaling playing a crucial role in its pro-inflammatory properties. The soluble form of the IL-6 receptor (sIL-6R) is generated by different mechanisms, including proteolysis. Attempts to selectively block IL-6 trans-signaling are being made in pre-clinical animal models and clinical studies for inflammatory bowel disease.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2022)
Article
Neurosciences
Ye Li, Cuiqin Fan, Rui Gao, Tian Lan, Wenjing Wang, Shu Yan Yu
Summary: The study reveals that altered levels of miR-211-5p in the hippocampal DG area have a significant impact on neurogenesis, apoptosis, and depression-like behaviors in rats. Specifically, up-regulation of miR-211-5p can alleviate depression-like behaviors, reduce neuronal apoptosis, and promote neuronal regeneration; while down-regulation of miR-211-5p can induce depression-like behaviors, increase neuronal apoptosis, and decrease neuronal regeneration.
Review
Biochemistry & Molecular Biology
Jurgen Scheller, Julia Ettich, Christoph Wittich, Silke Pudewell, Doreen M. M. Floss, Puyan Rafii
Summary: IL-6-type cytokines play important roles in immunomodulation and homeostasis. Synthetic biology approaches including mutations, fusion proteins, and inter-cytokine swapping have resulted in IL-6-type cytokines with altered properties. These synthetic cytokines show potential for clinical applications such as aiding type 2 diabetes and brain injuries.
Article
Biochemistry & Molecular Biology
Muriel D. Mardones, Kunal Gupta
Summary: Mesial temporal lobe epilepsy (mTLE) is a life-threatening condition characterized by recurrent hippocampal seizures. This study used a mouse model to investigate the transcriptional dysregulation in different zones of the hippocampus during the epileptogenic period. The findings suggest that early gene expression changes related to cell signaling, migration, and proliferation may play a role in the development of mTLE.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Pharmacology & Pharmacy
Ruben Orihuela, Christopher A. McPherson, Gaylia Jean Harry
BRITISH JOURNAL OF PHARMACOLOGY
(2016)
Article
Toxicology
Steven T. Szabo, G. Jean Harry, Kathleen M. Hayden, David T. Szabo, Linda Birnbaum
TOXICOLOGICAL SCIENCES
(2016)
Article
Neurosciences
Andrew D. Kraft, Christopher A. McPherson, G. Jean Harry
NEUROTOXICITY RESEARCH
(2016)
Article
Biochemistry & Molecular Biology
Valeria Avdoshina, Seamus P. Caragher, Erin D. Wenzel, Francesca Taraballi, Italo Mocchetti, Gaylia Jean Harry
JOURNAL OF NEUROCHEMISTRY
(2017)
Retraction
Immunology
Jagadeesh Sridhara Rao, Hyung-Wook Kim, Matthew Kellom, Dede Greenstein, Mei Chen, Andrew David Kraft, Gaylia Jean Harry, Stanley Isaac Rapoport, Mireille Basselin
JOURNAL OF NEUROINFLAMMATION
(2017)
Article
Neurosciences
David R. Goulding, Sally S. White, Sandra J. McBride, Suzanne E. Fenton, G. Jean Harry
Article
Behavioral Sciences
David R. Goulding, Viktoriya D. Nikolova, Lopa Mishra, Lisheng Zhuo, Koji Kimata, Sandra J. McBride, Sheryl S. Moy, G. J. Harry, Stavros Garantziotis
GENES BRAIN AND BEHAVIOR
(2019)
Article
Neurosciences
Christopher A. McPherson, Guozhu Zhang, Richard Gilliam, Sukhdev S. Brar, Ralph Wilson, Amy Brix, Catherine Picut, G. Jean Harry
NEUROTOXICITY RESEARCH
(2018)
Article
Multidisciplinary Sciences
Kelvin Yen, Junxiang Wan, Hemal H. Mehta, Brendan Miller, Amy Christensen, Morgan E. Levine, Matthew P. Salomon, Sebastian Brandhorst, Jialin Xiao, Su-Jeong Kim, Gerardo Navarrete, Daniel Campo, G. Jean Harry, Valter Longo, Christian J. Pike, Wendy J. Mack, Howard N. Hodis, Eileen M. Crimmins, Pinches Cohen
SCIENTIFIC REPORTS
(2018)
Article
Neurosciences
David R. Goulding, Andrew Kraft, Peter R. Mouton, Christopher A. McPherson, Valeria Avdoshina, Italo Mocchetti, G. Jean Harry
NEUROTOXICITY RESEARCH
(2019)
Article
Environmental Sciences
Christine Bowen, Gabrielle Childers, Caroline Perry, Negin Martin, Christopher A. McPherson, Tatlock Lauten, Janine Santos, G. Jean Harry
Review
Biochemistry & Molecular Biology
Gaylia Jean Harry
Summary: Changes in microglia are commonly associated with neurodegeneration, but it is not clear if they initiate the process. Communication between microglia and neurons helps maintain the cells in a surveillance state, suggesting a partnership role rather than an initiating one in neurodegeneration.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Environmental Sciences
Gabrielle M. Childers, Caroline A. Perry, Barbara Blachut, Negin Martin, Carl D. Bortner, Stella Sieber, Jian-Liang Li, Michael B. Fessler, G. Jean Harry
Summary: The study investigated the role of mitochondrial toxicants in inflammasome activation and IL-1β processing in murine macrophages. Results showed that mitochondrial toxicants induced inflammasome activation, suppressed mitochondrial bioenergetics and ROS production, and impacted the transcriptional response of macrophages, potentially leading to suppressed host defense.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2021)
Meeting Abstract
Neurosciences
G. J. Harry
JOURNAL OF NEUROIMMUNE PHARMACOLOGY
(2019)
Meeting Abstract
Biochemistry & Molecular Biology
G. J. Harry, C. Perry, C. McPherson
JOURNAL OF NEUROCHEMISTRY
(2017)
Letter
Immunology
Wan-Ju Cheng, Hong-Mo Shih, Kuan-Pin Su, Po-Ren Hsueh
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Felipe Kenji Sudo, Talita P. Pinto, Fernanda G. Q. Barros-Aragao, Ivanei Bramati, Theo F. Marins, Marina Monteiro, Fernanda Meireles, Rejane Soares, Pilar Erthal, Victor Calil, Naima Assuncao, Natalia Oliveira, Joana Bondarovsky, Camila Lima, Beatriz Chagas, Alana Batista, Julia Lins, Thais L. Pinheiro, Felippe Mendonca, Andrea Silveira de Souza, Fernanda C. Rodrigues, Gabriel R. de Freitas, Pedro Kurtz, Paulo Mattos, Erika C. Rodrigues, Fernanda G. De Felice, Fernanda Tovar-Moll
Summary: Post-COVID-19 Condition (PCC) is a multisystemic syndrome that persists for months after SARS-CoV-2 infection, affecting cognitive function and neuropsychiatric features. A study on COVID-19 survivors in Brazil found that these patients experienced significant difficulties in overall cognition, memory, working memory, and inhibitory control, as well as fatigue, anxiety, and depressive symptoms. In addition, elevated levels of inflammatory markers in the blood were associated with brain microstructural damage and cognitive impairments.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Letter
Immunology
Tieh-Cheng Fu, Juei-Chao Chen, Ching-Mao Chang
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Aastha Dheer, Dale B. Bosco, Jiaying Zheng, Lingxiao Wang, Shunyi Zhao, Koichiro Haruwaka, Min-Hee Yi, Abhijeet Barath, Dai-Shi Tian, Long-Jun Wu
Summary: Microglial activation plays a crucial role in the pathology of epilepsy, with both acute and prolonged activation affecting seizure severity and neuronal loss.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Julie B. Rosenberg, Jens Richardt Mollegaard Jepsen, Parisa Mohammadzadeh, Astrid Sevelsted, Rebecca Vinding, Mikkel E. Sorensen, David Horner, Kristina Aagaard, Birgitte Fagerlund, Susanne Brix, Nilofar Folsgaard, Ann -Marie M. Schoos, Jakob Stokholm, Bo Chawes, Christos Pantelis, Soren Dalsgaard, Birte Y. Glenthoj, Niels Bilenberg, Klaus Bonnelykke, Bjorn H. Ebdrup
Summary: Clinical data demonstrates a strong association between prenatal maternal inflammation assessed by hs-CRP and a diagnosis of ADHD by age 10. Maternal inflammation is also associated with ADHD symptom load in the entire cohort.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
India Boyton, Stella M. Valenzuela, Lyndsey E. Collins-Praino, Andrew Care
Summary: Neuronanomedicine is a multidisciplinary field that aims to develop innovative nanotechnologies for the treatment of neurodegenerative disorders. Nanoparticles are an important component of neuronanomedicine, as they can improve drug properties and enhance safety and delivery across the blood-brain barrier. However, a major challenge for neuronanomedicine translation is the poor understanding of bio-nano interactions, partly due to inconsistent reporting in published works. This review provides specific recommendations to guide researchers in harnessing the unique properties of nanoparticles for breakthrough treatments of Alzheimer's and Parkinson's disease.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Celine De Looze, Cathal McCrory, Aisling O'Halloran, Silvia Polidoro, Rose Anne Kenny, Joanne Feeney
Summary: Our study found that subjective measures of stress and biological metrics may be independently associated with cognitive function over time in older adults, hinting at potential different underlying mechanisms.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Beatrice Bravi, Elisa Maria Teresa Melloni, Marco Paolini, Mariagrazia Palladini, Federico Calesella, Laura Servidio, Elena Agnoletto, Sara Poletti, Cristina Lorenzi, Cristina Colombo, Francesco Benedetti
Summary: Depressed patients show changes in immune-inflammatory markers in their blood and cerebrospinal fluid. The Choroid Plexus, located at the base of the brain ventricles, plays a key role in regulating the exchange of substances between the brain and immune cells. Patients with bipolar disorder or major depressive disorder have larger Choroid Plexus volumes compared to healthy controls. Age and levels of circulating cytokines are associated with Choroid Plexus volumes in the clinical groups.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Mingxuan Zheng, Huaiyu Ye, Xiaoying Yang, Lijun Shen, Xuemei Dang, Xiaoli Liu, Yuying Gong, Qingyuan Wu, Li Wang, Xing Ge, Xiaoli Fang, Benchi Hou, Peng Zhang, Renxian Tang, Kuiyang Zheng, Xu-Feng Huang, Yinghua Yu
Summary: Obesity is linked to cognitive dysfunction and neurodegenerative disease. The connection between the gut microbiota and the brain is altered in obesity. The probiotic Clostridium butyricum can improve cognitive impairment caused by obesity and prevent gut microbiota dysbiosis and inflammation.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Edward Drydale, Phalguni Rath, Katie Holden, Gregory Holt, Laurissa Havins, Thomas Johnson, James Bancroft, Lahiru Handunnetthi
Summary: This study created a novel three-dimensional neurosphere assay using induced pluripotent stem cell differentiation and live cell imaging techniques to investigate the effect of a simulated viral infection on cortical development. The findings demonstrated that the infection led to reduced radial glial growth and neural migration.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Yuancheng Weng, Ningting Chen, Rui Zhang, Jian He, Xukai Ding, Guo Cheng, Qianqian Bi, Ying-mei Lu, Xiao Z. Shen, Shu Wan, Peng Shi
Summary: This study reveals that microglia is the primary cellular source of PDGFB in adults, and microglial PDGFB is crucial for maintaining BBB integrity in adult mice.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Evan A. Bordt, Haley A. Moya, Young Chan Jo, Caitlin T. Ravichandran, Izabella M. Bankowski, Alexis M. Ceasrine, Christopher J. Mcdougle, William A. Carlezon Jr, Staci D. Bilbo
Summary: There is a strong male bias in many neurodevelopmental disorders such as autism spectrum disorder, but the mechanisms behind this bias are unknown. Infection during the perinatal period increases the risk of neurodevelopmental disorders. Using a mouse model, researchers found that early-life immune activation only induced deficits in social behaviors in male mice. These behavioral changes were associated with alterations in microglial immune signaling, mitochondrial morphology, gene expression, and function specifically in microglia, the brain's innate immune cells. Furthermore, the vulnerability to early-life immune activation and its effects on behavior and microglial mitochondria were programmed by the male-typical perinatal gonadal hormone surge. These findings highlight the role of microglia-specific mechanisms shaped by early developmental events in regulating male social behavior throughout lifespan.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Maria Amalia Di Castro, Stefano Garofalo, Alessandro Mormino, Laura Carbonari, Erika Di Pietro, Eleonora De Felice, Myriam Catalano, Laura Maggi, Cristina Limatola
Summary: Cytokines, such as interleukin-15 (IL-15), play important roles in modulating the central nervous system (CNS). In this study, the authors found that exposure to IL-15 enhances GABA release and reduces glutamatergic currents in hippocampal slices. Chronic treatment with IL-15 has negative effects on memory formation. Serotonin is involved in mediating these effects, as a selective 5-HT3A receptor antagonist prevents the effects on inhibitory neurotransmission and improves performance in a memory test.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Immunology
Nikhitha Sreenivas, Michael Maes, Hansashree Padmanabha, Apoorva Dharmendra, Priyanka Chakkera, Saptamita Paul Choudhury, Fazal Abdul, Thrinath Mullapudi, Vykuntaraju K. Gowda, Michael Berk, John Vijay Sagar Kommu, Monojit Debnath
Summary: Neurodevelopmental disorders (NDDs) are a spectrum of conditions with both common and differing characteristics in terms of phenome, symptomatome, neuropathology, risk factors and underlying mechanisms. This study investigates the possibility of a shared immune etiology among three early-onset NDDs, namely Autism Spectrum Disorder (ASD), Attention Deficit Hyperactivity Disorder (ADHD) and Intellectual Disability Disorder (IDD).
BRAIN BEHAVIOR AND IMMUNITY
(2024)