Article
Endocrinology & Metabolism
Xiaoqin Lu, Jiapei Wei, Yupeng Liu, Yangzhen Lu
Summary: This meta-analysis of 10 randomised controlled trials suggests that exercise has a statistically significant, but relatively mild, improvement effect on bone mineral density in middle-aged and older men, indicating that exercise has the potential to be a safe and effective way to prevent bone loss in men.
ARCHIVES OF OSTEOPOROSIS
(2023)
Review
Geriatrics & Gerontology
Charlotte Beaudart, Celine Demonceau, Shaun Sabico, Nicola Veronese, Cyrus Cooper, Nicholas Harvey, Nicholas Fuggle, Olivier Bruyere, Rene Rizzoli, Jean-Yves Reginster
Summary: This systematic review and meta-analysis aimed to evaluate the efficacy of pharmacological treatments in men with osteoporosis. The analysis showed that treatment improved bone mineral density and reduced the incidence of fractures in men with osteoporosis.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Review
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Benjamin K. Weeks, Belinda R. Beck
Summary: Meta-analysis based on exercise intensity revealed that high intensity exercise has a stronger positive effect on lumbar spine BMD in postmenopausal women compared to low or moderate intensity exercise. Resistance training, potentially combined with impact training, appears to be the most effective osteogenic stimulus for the spine and hip.
Review
Endocrinology & Metabolism
H. Sanchez-Trigo, J. Rittweger, B. Sanudo
Summary: This study examines the effects of non-supervised osteoporosis prevention programs on bone mineral density, and finds that non-supervised exercise can increase femoral neck and lumbar spine bone mineral density in adult women, which may be effective for preventing or treating osteoporosis or osteopenia in this population.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Nursing
Shifang Zhang, Xiuxiu Huang, Xiaoyan Zhao, Bei Li, Ying Cai, Xiaoqin Liang, Qiaoqin Wan
Summary: The study systematically reviewed and compared different exercise interventions on bone mineral density in patients with osteoporosis and osteopenia. The findings indicated that mind-body exercise was most effective in increasing BMD in the lumbar spine and femoral neck, while resistance exercise showed promising results for total hip BMD.
JOURNAL OF CLINICAL NURSING
(2022)
Review
Physiology
Wenlai Cui, Dong Li, Yueshuai Jiang, Yang Gao
Summary: This study aims to analyze the effects of different exercise doses on lumbar spine and femoral neck bone mineral density (BMD) in individuals with osteoporosis. A systematic review was conducted, and 32 studies involving 2005 participants were included in the analysis. The results suggest that exercise interventions with high adherence to ACSM recommendations are more effective in improving BMD compared to interventions with low or uncertain adherence.
FRONTIERS IN PHYSIOLOGY
(2023)
Review
Endocrinology & Metabolism
Ramin Mohebbi, Mahdieh Shojaa, Matthias Kohl, Simon von Stengel, Franz Jakob, Katharina Kerschan-Schindl, Uwe Lange, Stefan Peters, Friederike Thomasius, Michael Uder, Wolfgang Kemmler
Summary: This systematic review and meta-analysis aimed to determine the effects of exercise on bone mineral density in postmenopausal women and investigate the relationship between bone density and menopausal status or supervision. The results of 80 studies involving 5581 participants showed that exercise has a positive effect on bone density at the lumbar spine, femoral neck, and total hip. Furthermore, the study found that differences in bone status, menopausal status, and supervision did not significantly affect the exercise effects on bone mineral density.
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Sport Sciences
Horacio Sanchez-Trigo, Carol Maher, Job G. Godino, Borja Sanudo
Summary: This study evaluated the effects of a non-supervised exercise program delivered and monitored through wearable technology and an mHealth app on bone mineral density (BMD). The intervention group showed significant improvements in BMD and physical fitness measures compared to the control group, suggesting the potential of this intervention for osteoporosis prevention.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Review
Biochemistry & Molecular Biology
Aleksandra Ryl, Aleksandra Szylinska, Karolina Skonieczna-Zydecka, Tomasz Miazgowski, Iwona Rotter
Summary: The relationship between components of metabolic syndrome (MetS) and bone mineral density (BMD), particularly in men, remains unclear. This systematic review and meta-analysis found that adult males with MetS have normal bone mass at the femoral neck (FN) and lumbar spine (LS). However, due to heterogeneity in the analyzed studies and the absence of control groups, further research is needed to fully understand the associations between MetS and BMD in men.
Article
Endocrinology & Metabolism
Alexander N. Comninos, Morten S. Hansen, Alan Courtney, Sirazum Choudhury, Lisa Yang, Edouard G. Mills, Maria Phylactou, Mark Busbridge, Muaza Khir, Thilipan Thaventhiran, Paul Bech, Tricia Tan, Ali Abbara, Morten Frost, Waljit S. Dhillo
Summary: This study aims to assess the effects of kisspeptin on human bone metabolism. In vitro experiments showed that kisspeptin promoted osteoblast differentiation and inhibited osteoclastic resorptive activity. Clinical experiments showed that kisspeptin increased bone formation markers without affecting bone resorption markers.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2022)
Review
Nutrition & Dietetics
Elham Kazemian, Ali Pourali, Fatemeh Sedaghat, Mehrdad Karimi, Vahid Basirat, Zohreh Sajadi Hezaveh, Sayed Hossein Davoodi, Michael F. Holick
Summary: A systematic review and meta-analysis evaluated the effects of vitamin D-3 supplementation on bone health in adults. The results showed a protective effect of vitamin D-3 supplementation on bone mineral density (BMD) at the lumbar spine, femoral neck, and total hip. Dose-response analysis revealed a linear relationship between vitamin D-3 supplementation doses and BMD. However, no significant effect of vitamin D-3 supplementation on whole-body or total hip BMD was found. The relationship between vitamin D-3 supplement doses and markers of bone turnover was nonlinear.
Review
Endocrinology & Metabolism
Mingwei Hu, Yifan Zhang, Jianjun Guo, Cuicui Guo, Xue Yang, Xue Ma, Hao Xu, Shuai Xiang
Summary: This study evaluated the changes in bone mineral density and bone turnover markers after denosumab and romosozumab therapies in patients with osteoporosis. The results showed that the romosozumab group exhibited greater changes in lumbar BMD and bone turnover markers at 3 months of treatment, while changes in BMD of total hip and femoral neck were relatively delayed. From 6 to 12 months of treatment, romosozumab showed greater changes in bone mineral density and markers of bone turnover.
FRONTIERS IN ENDOCRINOLOGY
(2023)
Review
Physiology
Hassane Zouhal, Abdel Jalil Berro, Sarah Kazwini, Ayoub Saeidi, Ayyappan Jayavel, Cain C. T. Clark, Anthony C. Hackney, Trisha A. VanDusseldorp, Abderraouf Ben Abderrahman, Rawad El Hage
Summary: Physical training has little to no effect on whole body bone mineral density (WB BMD) in individuals with overweight/obesity. Currently, there is insufficient evidence to recommend any specific type of exercise for enhancing bone health in overweight/obese individuals.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Sport Sciences
Benjamin Singh, Kellie Toohey
Summary: This study evaluated the effectiveness of exercise in improving bone-related outcomes among cancer survivors through a systematic review and meta-analysis. The results showed that various modes of supervised and unsupervised exercise were associated with improvements in bone density, providing evidence for clinicians and other healthcare professionals to recommend exercise for preventing bone loss in cancer survivors.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2022)
Article
Endocrinology & Metabolism
L. E. Flores, S. Nelson, N. Waltman, K. Kupzyk, J. Lappe, L. Mack, L. D. Bilek
Summary: This study found that bone structure in post-menopausal women is closely related to levels of physical activity. Increasing physical activity can improve bone structure, particularly in the lower leg.
OSTEOPOROSIS INTERNATIONAL
(2022)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.