Article
Nutrition & Dietetics
Patricia Paula da Fonseca Grili, Camila Vilarinho Vidigal, Geise Ferreira da Cruz, Ben-Hur Albergaria, Jose Luiz Marques-Rocha, Taisa Sabrina Silva Pereira, Valdete Regina Guandalini
Summary: This study aimed to identify nutrient patterns (NPs) and their association with bone mineral density (BMD) categories in postmenopausal women. The results showed that lower consumption of NP1 and NP2 was associated with an increased risk of osteopenia, but not osteoporosis.
Review
Orthopedics
Filippo Migliorini, Nicola Maffulli, Giorgia Colarossi, Joerg Eschweiler, Markus Tingart, Marcel Betsch
Summary: This study found that Denosumab has a higher impact on spine bone mineral density in selected postmenopausal women, and has the highest influence on hip and femur bone mineral density.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2021)
Review
Endocrinology & Metabolism
Keyvan Hejazi, Roya Askari, Martin Hofmeister
Summary: This study aimed to evaluate the effects of physical exercise on bone mineral density in postmenopausal women. The meta-analysis found that exercise training significantly increased bone mineral density in the femoral neck, lumbar spine, and trochanter, but not in total body and total hip. These findings suggest that exercise training may improve bone mineral density in older postmenopausal women, specifically in specific areas of the skeleton.
ARCHIVES OF OSTEOPOROSIS
(2022)
Article
Endocrinology & Metabolism
Julien Paccou, Sammy Badr, Daniela Lombardo, Huda Khizindar, Valerie Deken, Stefan Ruschke, Dimitrios C. Karampinos, Anne Cotten, Bernard Cortet
Summary: This study aimed to determine the association between proton density fat fraction (PDFF) and fractures. A case-control study was conducted on postmenopausal women, and it was found that MRI-based measurement of proximal femur PDFF can discriminate between postmenopausal women with and without clinical vertebral fractures, independent of age, CCI, and BMD.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
(2023)
Review
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Benjamin K. Weeks, Belinda R. Beck
Summary: This systematic review evaluates the effects of exercise on bone health in postmenopausal women, suggesting that moderate to high intensity interventions, especially those combining resistance and impact training, are most beneficial for bone mass. Only high intensity exercise appears to improve structural parameters of bone strength, while low and moderate intensity interventions do not show notable benefits. The heterogeneity in study quality and outcomes limits the ability to draw strong conclusions.
Article
Orthopedics
Jiemei Gu, Hao Zhang, Qingyun Xue, Li Wang, Zhifeng Cheng, Yawei Zhang, Qifu Li, Lingqing Yuan, Yukun Li, Jin Dong, Yanan Huo, Xin Tang, Ling Hu, Xinjia Wang, Fei Hua, Lin Shen, Jinluo Cheng, Huimin Zhou, Youjia Xu, Tao Yang, Chuansuo Wang, Jin Xu, Jie Shen, Ying Zhang, Xiaomei Zhang, Dun Hong, Xiaoling Guan, Xinhua Xiao, Guang Wang, Yonghua Liu, Liujun Fu, Jianting Chen, Xigao Cheng, Yue Ding, Lijun Liu, Qi Yao, Xinchao Zhang, Lixin Li, Panjun Zhang, Chunying Deng, Chengyan Jiang, Li You, Kai Wang, Shimin Zhang, Jianzhong Xiao, Wei Liu, Xiaohong Du, Xianwen Shang, Tianrong Pan, Chen Lei, Shuren Guo, Zhenlin Zhang
Summary: This study assessed the efficacy, safety, pharmacokinetics, and immunogenicity of a denosumab biosimilar (LY06006) in Chinese postmenopausal women with osteoporosis. The results showed that LY06006 significantly increased bone mineral density and reduced bone resorption. The safety and tolerability of LY06006 were comparable to the reference drug Prolia(R).
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Orthopedics
Weibin Du, Zhenwei Wang, Yi Dong, Jintao Hu, Xiaoping Chen
Summary: This study aimed to examine the relationship between fibrinogen and bone mineral density (BMD) in postmenopausal women. The findings of this cross-sectional analysis showed a negative association between fibrinogen levels and total BMD in most postmenopausal women, with a lack of significant correlation in Non-Hispanic Blacks.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Orthopedics
Yimei Yang, Shanshan Wang, Hui Cong
Summary: The study aimed to determine the association between age at menarche and lumbar spine bone mineral density (BMD) in postmenopausal women. The results showed that postmenopausal women with a menarche age ≥ 16 years had significantly lower lumbar spine BMD compared to those with a menarche age ≤ 12 years.
JOURNAL OF ORTHOPAEDIC SURGERY AND RESEARCH
(2023)
Article
Endocrinology & Metabolism
Xiaoqin Lu, Jiapei Wei, Yupeng Liu, Yangzhen Lu
Summary: This meta-analysis of 10 randomised controlled trials suggests that exercise has a statistically significant, but relatively mild, improvement effect on bone mineral density in middle-aged and older men, indicating that exercise has the potential to be a safe and effective way to prevent bone loss in men.
ARCHIVES OF OSTEOPOROSIS
(2023)
Article
Nutrition & Dietetics
Raul Roncero-Martin, Ignacio Aliaga, Jose M. Moran, Luis M. Puerto-Parejo, Purificacion Rey-Sanchez, Maria de la Luz Canal-Macias, Antonio Sanchez-Fernandez, Juan D. Pedrera-Zamorano, Fidel Lopez-Espuela, Vicente Vera, Purificacion Cerrato-Carretero, Jesus M. Lavado-Garcia
Summary: The study found a significant positive association between plasma n-3 polyunsaturated fatty acid levels and bone density in Spanish postmenopausal women, independent of BMI and total plasma n-3 PUFAs.
Article
Endocrinology & Metabolism
E. Michael Lewiecki, Edward Czerwinski, Chris Recknor, Anna Strzelecka, Guillermo Valenzuela, Mary Lawrence, Stuart Silverman, Jose Cardona, Susan M. Nattrass, Neil Binkley, Miriam Annett, Leny Pearman, Bruce Mitlak
Summary: This study evaluated the safety and efficacy of the abaloparatide microstructured transdermal system (abaloparatide-sMTS) as an alternative to subcutaneous injection. The results showed that the abaloparatide-sMTS was not noninferior to the subcutaneous injection in terms of lumbar spine bone density at 12 months, but both treatments significantly increased lumbar spine and total hip bone density.
JOURNAL OF BONE AND MINERAL RESEARCH
(2023)
Review
Nursing
Shifang Zhang, Xiuxiu Huang, Xiaoyan Zhao, Bei Li, Ying Cai, Xiaoqin Liang, Qiaoqin Wan
Summary: The study systematically reviewed and compared different exercise interventions on bone mineral density in patients with osteoporosis and osteopenia. The findings indicated that mind-body exercise was most effective in increasing BMD in the lumbar spine and femoral neck, while resistance exercise showed promising results for total hip BMD.
JOURNAL OF CLINICAL NURSING
(2022)
Article
Clinical Neurology
Kye-Yeung Park, Jin-Hyung Jung, Hwan-Sik Hwang, Hoon-Ki Park, Kyungdo Han, Ga Eun Nam
Summary: This study examined the association between bone mineral density (BMD) and Parkinson's disease (PD) in postmenopausal women. It found that lower BMD and osteoporosis were associated with an increased risk of PD, and this association could be mitigated using antiosteoporosis medications. Proper management of BMD in postmenopausal women may help prevent PD.
MOVEMENT DISORDERS
(2023)
Review
Pharmacology & Pharmacy
Yi Chen, Jun Zhu, Yiqin Zhou, Jinhui Peng, Bo Wang
Summary: Denosumab is a promising antiresorptive agent in postmenopausal women with osteoporosis or low bone mineral density, showing greater increase in bone mineral density and reduced fracture risk compared to placebo, without excess risks of adverse events.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Orthopedics
Hao Chai, Jirong Ge, Li Li, Jianyang Li, Yunjin Ye
Summary: This study revealed that Chinese postmenopausal women with osteoporosis had a higher prevalence of hypertension, indicating a significant association between hypertension and osteoporosis.
BMC MUSCULOSKELETAL DISORDERS
(2021)
Article
Medicine, General & Internal
Narelle Hall, Maria Constantinou, Mark Brown, Belinda Beck, Suzanne Kuys
Summary: This retrospective observational study aimed to identify the incidence and patterns of injuries reported from physical therapy presentations for New Zealand Army recruits undertaking basic training over a 4-year period. The results showed that lower limb injuries, especially those sustained at the knee and below, were the most commonly injured regions, suggesting a need for injury prevention interventions to focus on reducing lower limb injuries. Future research on injury surveillance should incorporate clear injury and severity definitions, established injury classification systems, and standardized incidence calculations.
Review
Physiology
Belinda R. Beck
Summary: This article revisits the fundamental principles of mechanical loading and bone adaptation for the ideal exercise prescription for osteoporosis, presenting their relevance to human trials and recent advances. It also describes a model for broadscale implementation and identifies areas for further investigation.
EXERCISE AND SPORT SCIENCES REVIEWS
(2022)
Article
Medicine, Research & Experimental
Belinda Beck, Clinton Rubin, Amy Harding, Sanjoy Paul, Mark Forwood
Summary: The VIBMOR trial aims to determine the efficacy of low-intensity whole-body vibration (LIV), bone-targeted high-intensity resistance and impact training (HiRIT), or the combination of LIV and HiRIT on risk factors for hip fracture in postmenopausal women with osteopenia and osteoporosis. The study may provide alternative therapeutic options for individuals who are unresponsive to or unwilling or unable to take osteoporosis medications.
Review
Gerontology
Cindy Jones, Meiling Qi, Zihui Xie, Wendy Moyle, Benjamin Weeks, Ping Li
Summary: This study conducted a systematic review and meta-analysis to evaluate the health effects of Baduanjin exercise on adults aged 65 years and older. The findings indicated significant benefits on physical function, balance, anxiety, and improvements in quality of life, reducing falls and pain. However, the conclusions are limited by the lack of rigorous studies both within and outside mainland China, calling for larger, well-designed RCTs to confirm these findings.
JOURNAL OF APPLIED GERONTOLOGY
(2022)
Article
Medicine, General & Internal
Narelle Hall, Maria Constantinou, Mark Brown, Belinda Beck, Michael Steele, Jacques Rousseau, Suzanne Kuys
Summary: This study aimed to describe the personal, lifestyle, and physical performance characteristics of New Zealand Army recruits upon entry to basic training. The findings showed that a significant proportion of recruits had reported injuries in the previous year, with the majority of injuries occurring in the lower limbs. Pre-entry alcohol consumption was higher than recommended, and a minority of recruits were smokers. Most recruits had low aerobic fitness, average ankle dorsiflexion range, and low dynamic lower limb stability.
Letter
Endocrinology & Metabolism
Robin M. Daly, David Scott, Jakub Mesinovic, Belinda R. Beck
OSTEOPOROSIS INTERNATIONAL
(2023)
Article
Endocrinology & Metabolism
Benjamin K. Weeks, Amy T. Harding, Steven L. Watson, Conor Lambert, Rossana C. Nogueira, Rebecca Hirsch, Timo Rantalainen, Jayde Collier, Belinda R. Beck
Summary: The bone-specific physical activity questionnaire (BPAQ) provides an index of bone-relevant physical activity participation. This study aimed to examine the relationship between historical bone-relevant physical activity and pQCT-derived parameters of bone strength.
JOURNAL OF BONE AND MINERAL METABOLISM
(2023)
Review
Orthopedics
Christian A. Than, Maamoun Adra, Tom J. Curtis, Ao Shi, Grace E. Kim, Hayato Nakanishi, Reem H. Matar, J. Mark M. Brown, Zaher Dannawi, Belinda R. Beck
Summary: This meta-analysis examines the effects of exercise on Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) scores in osteoporotic fractures. The study finds that exercise leads to significant reductions in VAS and ODI scores, particularly after 6 months.
JOURNAL OF ORTHOPAEDIC RESEARCH
(2023)
Article
Sport Sciences
Julie P. Greeves, Belinda Beck, Bradley C. Nindl, Thomas J. O'Leary
Summary: Bone stress injuries (BSIs) are a significant burden on the military, affecting a considerable percentage of recruits. The mechanisms for bone maladaptation are not yet fully understood, but excessive and early training is a primary risk factor for BSIs. Proper physical preparation and nutritional interventions can help reduce the risk, and monitoring physiological conditions such as ovulation, sleep, and stress can provide valuable information for prevention strategies.
JOURNAL OF SCIENCE AND MEDICINE IN SPORT
(2023)
Letter
Geriatrics & Gerontology
Belinda R. Beck, David Scott, Robin M. Daly, Jakub Mesinovic
ANNALS OF GERIATRIC MEDICINE AND RESEARCH
(2023)
Article
Geriatrics & Gerontology
Eva Kettig, Melanie Kistler-Fischbacher, Caroline de Godoi Rezende Costa Molino, Heike A. Bischoff-Ferrari, Devine Shimbagha Frundi
Summary: This study examined the association between magnesium status and grip strength and fatigue scores, and assessed whether this association differs by vitamin D status among older participants undergoing geriatric rehabilitation. The results showed that magnesium status was associated with grip strength among older participants, especially among those with sufficient vitamin D levels, but not with fatigue.
AGING CLINICAL AND EXPERIMENTAL RESEARCH
(2023)
Article
Geriatrics & Gerontology
Joseph C. H. Wong, Sheila O'Neill, Belinda R. Beck, Mark R. Forwood, Soo Keat Khoo
Summary: Reducing fat mass may decrease the risk of cardiovascular events in middle-aged and older women; an increase in fat mass may not contribute to additional cardiovascular events; a reduction in limb muscle mass may serve as an independent marker for cardiometabolic risk and peripheral artery disease; no independent association was found between anthropometric measurements and incident cardiovascular events.
Article
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Jedidah S. Yong, Benjamin K. Weeks, Belinda R. Beck
Summary: This study compares the effects of high-intensity resistance and impact training (HiRIT) with low-intensity, Pilates-based exercise (LiPBE) on proximal femur geometry. The results show that HiRIT improves geometric parameters of proximal femur strength, while LiPBE exercise is largely ineffective. The combination of HiRIT and medication achieves greater improvements in bone mineral density and strength.
CALCIFIED TISSUE INTERNATIONAL
(2022)
Meeting Abstract
Endocrinology & Metabolism
Melanie Kistler-Fischbacher, Jedidah S. Yong, Benjamin K. Weeks, Belinda R. Beck
JOURNAL OF BONE AND MINERAL RESEARCH
(2022)
Review
Endocrinology & Metabolism
Jemima E. Schadow, David Maxey, Toby O. Smith, Mikko A. J. Finnila, Sarah L. Manske, Neil A. Segal, Andy Kin On Wong, Rachel A. Davey, Tom Turmezei, Kathryn S. Stok
Summary: This study systematically reviewed the published parameters for assessing subchondral bone in human osteoarthritis using computed tomography. The study identified clinically meaningful parameter categories and emphasized the importance of quantification and standardized measurement methods for improving the evaluation of disease progression.
Article
Endocrinology & Metabolism
Lindsay L. Loundagin, Kim D. Harrison, Xuan Wei, David M. L. Cooper
Summary: This study developed new techniques to define zones of BMU activity based on the 3D morphology of remodeling spaces in rabbit cortical bone and integrated morphological data with the BMU longitudinal erosion rate (LER) to elucidate the spatial-temporal coordination of BMUs and estimate mineral apposition rate (MAR). The results showed that the manual and semi-automated methods accurately defined the zones of remodeling spaces, and these techniques have the potential to assess dynamic parameters of bone resorption and formation.
Article
Endocrinology & Metabolism
Soroush Masrouri, Farzad Esmaeili, Maryam Tohidi, Fereidoun Azizi, Farzad Hadaegh
Summary: This study examined the association between estimated glomerular filtration rate (eGFR) decline and fracture incidence. The results showed that rapid kidney function decline (RKFD) can increase the incidence of fractures among the general population.
Article
Endocrinology & Metabolism
Steven J. Meas, Gabriella M. Daire, Michael A. Friedman, Rachel Denapoli, Preetam Ghosh, Joshua N. Farr, Henry J. Donahue
Summary: Age- and disuse-related bone loss both lead to decreases in bone mineral density, cortical thickness, and trabecular thickness and connectivity. It is important to experimentally compare these two mechanisms at a structural and transcriptomic level to better understand their similarities and differences. This study compares the effects of hindlimb unloading and aging on bone microarchitecture and gene expression in mice, finding that while both induce similar changes, aging has a greater impact on the transcriptome and tissue level.
Correction
Endocrinology & Metabolism
Masaru Matsuoka, Sho Tsukamoto, Yuta Orihara, Rieko Kawamura, Mai Kuratani, Nobuhiko Haga, Kenji Ikebuchi, Takenobu Katagiri
Article
Endocrinology & Metabolism
Rachel Kohler, Amy Creecy, David R. Williams, Matthew R. Allen, Joseph M. Wallace
Summary: Osteogenesis imperfecta is a hereditary bone disease that weakens bones and increase fracture risk. Current interventions mainly focus on increasing bone mass, but the compromised tissue-level material properties are not addressed. A study found that a RAL analog could reduce fracture risk, but further development is needed for optimal results in patients with osteogenesis imperfecta.
Article
Endocrinology & Metabolism
So Jeong Park, Eunhye Ji, Hyun Ju Yoo, Kyunggon Kim, Sunghwan Ji, Ji Yeon Baek, Jin Young Lee, Hee-Won Jung, Il-Young Jang, Eunju Lee, Namki Hong, Beom-Jun Kim
Summary: The study analyzed the relationship between serum lumican levels and osteosarcopenia in older adults, showing that older adults with osteosarcopenia had lower serum lumican levels. Lower serum lumican levels were associated with reduced bone mass and grip strength, indicating that lumican levels could be used as a biomarker for assessing the risk of osteosarcopenia, osteoporosis, or sarcopenia in older adults.
Article
Endocrinology & Metabolism
Michael B. Chavez, Michelle H. Tan, Tamara N. Kolli, Natalie L. Andras, Brian L. Foster
Summary: This study revealed the complex mechanisms by which disabling BSP functional domains led to profound and distinct changes in cementoblast cell functions, including dysregulated gene expression and reduced mineralization.
Article
Endocrinology & Metabolism
Julien Seiller, Blandine Merle, Romain Fort, Emilie Virot, Solene Poutrel, Giovanna Cannas, Arnaud Hot, Roland Chapurlat
Summary: The purpose of this study was to assess the prevalence of bone fragility in sickle cell patients and to evaluate the potential risk factors and associated complications.
Article
Endocrinology & Metabolism
Chirantap Oza, Anuradha Khadilkar, Pranay Goel, Madhura Karguppikar, Nikhil Shah, Nikhil Lohiya, Shruti Mondkar, Prashant Patil, Hemchand Prasad, Ankita Maheshwari, Dipali Ladkat, Neha Kajale, Chidvilas More, Devarati Khurjekar, Vaman Khadilkar
Summary: This study revealed that BoneXpert (BX) can be used for accurate assessment of bone age and screening of bone health in Indian children and youth with type-1 diabetes (T1D). 51.5% of T1D subjects showed significantly decreased metacarpal index (MCI). Height, Tanner stage, and vitamin D concentrations were positively correlated with MCI, while HbA1c and disease duration were negatively correlated with MCI.
Article
Endocrinology & Metabolism
Mariam R. Farman, Catherine Rehder, Theodora Malli, Cheryl Rockman-Greenberg, Kathryn Dahir, Gabriel Angel Martos-Moreno, Agnes Linglart, Keiichi Ozono, Lothar Seefried, Guillermo del Angel, Gerald Webersinke, Francesca Barbazza, Lisa K. John, Sewmi M. A. Delana Mudiyanselage, Florian Hoegler, Erica Burner Nading, Erin Huggins, Eric T. Rush, Ahmed El-Gazzar, Priya S. Kishnani, Wolfgang Hoegler
Summary: The ALPL gene variant database serves as an archive for interpreting the clinical significance of ALPL gene variants, facilitating the reclassification of VUS and continuous updates. The project establishes an international expert consortium, providing a multidisciplinary collaboration framework to improve genetic counseling and medical decision-making for HPP patients.
Article
Endocrinology & Metabolism
Giovanni Adami, Davide Gatti, Maurizio Rossini, Alessandro Giollo, Matteo Gatti, Francesco Bertoldo, Eugenia Bertoldo, Amy S. Mudano, Kenneth G. Saag, Ombretta Viapiana, Angelo Fassio
Summary: Certain diseases requiring glucocorticoids are independently associated with an increased risk of fractures. Chronic obstructive pulmonary disease (COPD) and neurological diseases are associated with both vertebral and non-vertebral fracture risk, while rheumatoid arthritis (RA) and inflammatory bowel disease (IBD) are only associated with non-vertebral fractures.
Article
Endocrinology & Metabolism
Frank C. Ko, Rong Xie, Brandon Willis, Zoe G. Herdman, Bryan A. Dulion, Hoomin Lee, Chun-do Oh, Di Chen, D. Rick Sumner
Summary: Intramembranous bone regeneration is important in joint and tooth replacement, but its underlying mechanisms are not well understood. This study found that increased periostin gene expression preceded increases in osteogenic genes during bone regeneration. Using a genetic mouse model, the researchers discovered that cells transiently expressing periostin played a critical role in intramedullary intramembranous bone regeneration.
Article
Endocrinology & Metabolism
T. Savikangas, T. H. Suominen, M. Alen, T. Rantalainen, S. Sipila
Summary: Regular exercise, especially high-intensity physical activity, can help slow down age-related bone loss and prevent a decline in femoral neck bone mineral density.
Article
Endocrinology & Metabolism
Mishaela R. Rubin, Ruban Dhaliwal
Summary: The increased risk of fractures observed in adults with type 1 diabetes (T1D) cannot be solely explained by modest decreases in areal bone mineral density (BMD). Accumulation of advanced glycation endproducts (AGEs) in bone has been suggested as a possible cause for the increased bone fragility in diabetes. Although the evidence linking AGEs and fractures in individuals with T1D is limited, recent data show that AGEs, as measured by skin intrinsic fluorescence, are a risk factor for lower BMD in T1D. Further research is needed to determine if there is a causal relationship between fractures and AGEs in T1D. If confirmed, this could lead to interventions that can reduce AGE accumulation and ultimately reduce fractures in T1D patients.