Article
Chemistry, Applied
Valeria Vanoli, Sara Delleani, Mose Casalegno, Fabio Pizzetti, Pooyan Makvandi, Havard Haugen, Andrea Mele, Filippo Rossi, Franca Castiglione
Summary: Hydrogels based on hyaluronic acid and agarose-carbomer have attracted attention as drug delivery systems. The structure of the polymer network greatly affects the release capability of these materials. Using HR-MAS NMR spectroscopy, this study investigated the motion of drugs within the hydrogels and found evidence of superdiffusive motion, which may be responsible for the faster release of sodium salicylate.
CARBOHYDRATE POLYMERS
(2023)
Review
Biochemistry & Molecular Biology
Dieuwertje Augustijn, Huub J. M. de Groot, A. Alia
Summary: Metabolomics is a method used to simplify the complexity of plants and understand the pathways of plant phenotypes. HR-MAS NMR can eliminate the extraction step of metabolites from samples, saving time and costs. HR-MAS NMR has important applications in plant metabolomics.
Article
Biochemistry & Molecular Biology
Karolina Krajewska, Anna M. Golkowska, Maciej Nowak, Marta Kozakiewicz-Latala, Wojciech Pudlo, Andrzej Zak, Bozena Karolewicz, Yaroslav Z. Khimyak, Karol P. Nartowski
Summary: This study proposes the use of HR-MAS NMR spectroscopy for a molecular level characterisation of the external surface of carbohydrate-functionalised nanoparticles. The results demonstrate that HR-MAS NMR can provide detailed structural information on the organic functionalities attached at the external surface of MSN within short experimental times.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Chemistry, Multidisciplinary
Chang Lu, Linbo Han, Joanna Wang, Jiacheng Wan, Guosheng Song, Jianghong Rao
Summary: Magnetic particle imaging (MPI) is a promising non-invasive imaging technique with advantages such as signal linearly proportional to tracer mass, positive contrast, and unlimited tissue penetration. The properties of magnetic nanoparticles (MNPs) play a crucial role in determining the sensitivity and resolution of MPI. Challenges lie in translating MPI imaging into clinical applications and overcoming existing obstacles.
CHEMICAL SOCIETY REVIEWS
(2021)
Article
Chemistry, Applied
Elisa S. Ferreira, James Drummond, Anderson T. V. Veiga, Aurelien Sibellas, Samuel Brown, Emily D. Cranston, Mark Martinez
Summary: Understanding water absorbency in paper is challenging due to the simultaneous occurrence of fibre swelling and out-of-plane deformation during liquid imbibition. In this study, we developed iron tracers to map liquid imbibition in paper by precipitating iron oxide nanoparticles during wetting. The iron tracers were found to be firmly attached to the cellulose fibers. Through X-ray micro-computed tomography (μCT) and energy-dispersive X-ray spectroscopy, we demonstrated the distribution of iron in 3D and 2D, and also showed that these iron tracers enhance image contrast and allow for new imaging modalities in μCT for fiber networks.
CARBOHYDRATE POLYMERS
(2023)
Article
Chemistry, Applied
Maria de Fatima C. Santos, Katlin S. Rech, Livia M. Dutra, Leociley R. A. Menezes, Alan D. da C. Santos, Noemi Nagata, Maria Elida A. Stefanello, Andersson Barison
Summary: This study evaluated the impact of climatic parameters on the chemical composition of green tea. It was found that the concentrations of theanine and caffeine were influenced by climate, while epicatechin concentrations were affected by solar radiation. Monitoring the fluctuations of compounds in green tea and correlating them with climatic parameters can help establish quality standards for green tea.
Article
Biotechnology & Applied Microbiology
Danijela Stanisic, Guilherme C. F. Cruz, Leonardo Abdala Elias, Junko Tsukamoto, Clarice W. Arns, Douglas Soares da Silva, Stanislav Mochkalev, Raluca Savu, Ljubica Tasic
Summary: This study evaluated the antiviral and non-toxic effects of silver nanoparticles on in vitro cells infected with coronavirus using High-Resolution Magic-Angle Spinning Nuclear Magnetic Resonance (HR-MAS NMR) spectroscopy. The bio-inspired synthesis of silver nanoparticles using an orange flavonoid-hesperetin (HST) was successful, and the nanoparticles showed great colloidal stability and antiviral activity. The fabricated nanomaterials inhibited viral activity and showed no toxicity towards the cells. The findings suggest potential antiviral applications for the 3D flexible nanostructured composite and colloidal spray.
FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY
(2022)
Article
Multidisciplinary Sciences
Chunmei Huang, Miriding Mutailipu, Fangfang Zhang, Kent J. Griffith, Cong Hu, Zhihua Yang, John M. Griffin, Kenneth R. Poeppelmeier, Shilie Pan
Summary: Borates exhibit extended structural diversity and potential in various applications, with one borate containing linear BO2 structural units. The study provides a quantitative basis for identifying BO2 units in borates through NMR spectroscopy characterization.
NATURE COMMUNICATIONS
(2021)
Review
Chemistry, Multidisciplinary
H. T. Kim Duong, Ashkan Abdibastami, Lucy Gloag, Liam Barrera, J. Justin Gooding, Richard D. Tilley
Summary: Magnetic Particle Imaging (MPI) is a non-invasive technique that offers high quality images with no radiation, high depth penetration and minimal tissue background. The selection of suitable nanoparticles as tracers is crucial for optimal results, and the synthetic pathways as well as surface modifications play important roles in their biomedical applications.
Article
Biochemistry & Molecular Biology
Carolina da Silva Canielles Caprara, Tatiane Ksyvickas Mathias, Maria de Fatima C. Santos, Marcelo G. M. D'Oca, Caroline Da R. M. D'Oca, Fabio Roselet, Paulo Cesar Abreu, Daniela Fernandes Ramos
Summary: This study aimed to characterize the main metabolites of three species of microalgae using H-1 HR-MAS NMR. Although the three species were found in the same ecosystem and had a high production of lipid compounds, significant differences were identified in the production of specialized metabolites. These unique properties make these compounds potential leaders in the development of new bioactive compounds for One Health and alternatives for aquaculture.
Article
Biochemistry & Molecular Biology
Valtteri Virtanen, Susanna Raikkonen, Elina Puljula, Maarit Karonen
Summary: The study revealed that ellagitannins interacting with lipids share clear structural similarities, with all interacting ellagitannins possessing glucopyranose cores. The most important structural feature affecting the interaction appeared to be the structural flexibility of the ellagitannin, as even dimeric and trimeric ellagitannins could penetrate lipid bilayers if their structures were flexible.
Article
Medicine, General & Internal
Paolo Izzo, Claudia De Intinis, Simone Sibio, Luigi Basso, Andrea Polistena, Raimondo Gabriele, Massimo Codacci-Pisanelli, Luciano Izzo, Sara Izzo
Summary: This study proposed new techniques to prevent complications of sentinel lymph node biopsy and presented initial data from our experience. The identification rates of sentinel lymph node detection using radioactive tracers and the magnetic tracer technology (Sentimag) were 88.9% and 89.5% respectively.
Article
Electrochemistry
Abraham Sainz-Rosales, Leonardo D. Pedraza-Herrera, M. E. Cano, N. Casillas, Maximiliano Barcena-Soto, Erika Roxana Larios-Duran
Summary: This study presents a simple and innovative method to efficiently produce magnetite nanoparticles and selectively generate side products by controlling the dissolved oxygen in the reaction media.
JOURNAL OF THE ELECTROCHEMICAL SOCIETY
(2022)
Article
Chemistry, Multidisciplinary
Kyle M. Kirkpatrick, Benjamin H. Zhou, Philip C. Bunting, Jeffrey D. Rinehart
Summary: Magnetization is a measurable property of materials that provides information about their electronic structure, phase purity, and impurities. Superparamagnetism, a size-dependent property of magnetic materials, has been underexplored in the field of quantum materials. In this study, a statistical model is used to analyze a dataset of variable-size superparamagnetic Fe3O4 particles. The results show that parameters of the intrinsic probability distribution, such as the maximum susceptibility, are more suitable for describing the superparamagnetic behavior compared to standard measures like saturation magnetization. This analysis has potential applications in synthesis diagnostics and prediction of new properties and functionality.
Article
Physics, Condensed Matter
Ahmad Telfah, Qais M. Al Bataineh, Marwan S. Mousa, Anas Ababneh, Diyar Sadiq, Carlos J. Tavares, Roland Hergenroeder
Summary: The amorphous/crystalline phase transition behavior of PEO films prepared by spin casting method was studied. The PEO film shows semicrystalline nature at room temperature and becomes amorphous at 333 K. 1H NMR spectra analysis reveals two main peaks corresponding to mobile polymer chains in the amorphous phase and more rigid molecules in the crystalline phase. The calculated activation energies for crystalline and amorphous phases are comparable.
PHYSICA B-CONDENSED MATTER
(2022)
Article
Biochemical Research Methods
Glenn Carroy, Vincent Lemaur, Celine Henoumont, Sophie Laurent, Julien De Winter, Edwin De Pauw, Jerome Cornil, Pascal Gerbaux
JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY
(2018)
Article
Public, Environmental & Occupational Health
Jean Noel Nyemb, Roland Ndoubalem, Emmanuel Talla, Alembert Tiabou Tchinda, Dieudonne Ndjonka, Celine Henoumont, Sophie Laurent, Joseph Tanyi Mbafor
ASIAN PACIFIC JOURNAL OF TROPICAL MEDICINE
(2018)
Article
Chemistry, Multidisciplinary
Jean Noel Nyemb, Larissa Mekontso Magnibou, Emmanuel Talla, Alembert Tiabou Tchinda, Roland Tchuente Tchuenguem, Celine Henoumont, Sophie Laurent, Joseph Tanyi Mbafor
Article
Chemistry, Inorganic & Nuclear
Marie Devreux, Celine Henoumont, Fabienne Dioury, Dimitri Stanicki, Sebastien Boutry, Lionel Larbanoix, Clotilde Ferroud, Robert N. Muller, Sophie Laurent
EUROPEAN JOURNAL OF INORGANIC CHEMISTRY
(2019)
Article
Chemistry, Applied
Achi Mahamat, Abel Joel Yaya Gbaweng, Maurice Tagatsing Fotsing, Emmanuel Talla, Fabrice Boyom Fekam, Celine Henoumont, Laurent Sophie, Joseph Tanyi Mbafor
Summary: Clerodendrum formicarum Gurke is a Cameroonian medicinal plant from the Lamiaceae family. Phytochemical studies of its leaf extracts revealed the isolation of four compounds, with clerodendronone 1b showing good antibacterial activity against Shigella flexineri and Staphylococcus aureus. Ethyl acetate extract also exhibited good antibacterial activity against Staphylococcus aureus.
NATURAL PRODUCT RESEARCH
(2021)
Article
Chemistry, Applied
Isaac Silvere Gade, Jean Noel Nyemb, Achi Mahamat, Alex De Theodore Atchade, Emmanuel Talla, Sophie Laurent, Celine Henoumont, Alessandro Venditti
Summary: A phytochemical study was conducted on the stem bark of Combretum fragrans F. Hoffm., a medicinal plant traditionally used for treating various ailments. The study isolated a new pentacyclic triterpene acid, fragransinic acid (1), along with four known compounds. The structures were elucidated through extensive spectroscopic analyses and comparisons with literature data. Implications for chemosystematics and traditional medicine were briefly discussed.
NATURAL PRODUCT RESEARCH
(2022)
Article
Biochemistry & Molecular Biology
Nathalie Tanko Metiefeng, Alfred Ngenge Tamfu, Maurice Fotsing Tagatsing, Turibio Kuiate Tabopda, Selcuk Kucukaydin, Martin Noah Mbane, Alex de Theodore Atchade, Emmanuel Talla, Celine Henoumont, Sophie Laurent, El Hassane Anouar, Rodica Mihaela Dinica
Summary: In this study, seven compounds were isolated from Graptophyllum pictum and evaluated for their anticholinesterase activities and antidiabetic potential. The results showed that G. pictum and its compounds could be used in the development of therapies for Alzheimer's disease and diabetes.
Article
Chemistry, Multidisciplinary
Samila Leon-Chaviano, Mariia Kiseleva, Philippe Legros, Simon Collin, Theophraste Lescot, Celine Henoumont, Yves Gossuin, Sophie Laurent, Dominique Mayrand, Julie Fradette, Andre Begin-Drolet, Jean Ruel, Marc-Andre Fortin
Summary: In this study, a magnetic ink based on ultra-small iron oxide nanoparticles is developed and integrated into biocompatible alginate hydrogel used in cell scaffolding applications. It is found that this magnetic hydrogel can produce positive contrast in magnetic resonance imaging to clearly visualize the contours of tissue grafts.
Article
Pharmacology & Pharmacy
Barbara Freis, Maria De Los Angeles Ramirez, Celine Kiefer, Sebastien Harlepp, Cristian Iacovita, Celine Henoumont, Christine Affolter-Zbaraszczuk, Florent Meyer, Damien Mertz, Anne Boos, Mariana Tasso, Sonia Furgiuele, Fabrice Journe, Sven Saussez, Sylvie Begin-Colin, Sophie Laurent
Summary: Functionalized iron oxide nanoparticles (IONPs) with different shapes and sizes are synthesized and coated with dendron molecules to ensure biocompatibility and colloidal stability. These IONPs show promise in combining magnetic hyperthermia (MH) and photothermia (PTT) for cancer therapy. The 22 nm nanospheres and the 19 nm nanocubes exhibit the most promising theranostic properties, including efficient MRI contrast and hyperthermia abilities.
Review
Biochemistry & Molecular Biology
Celine Henoumont, Marie Devreux, Sophie Laurent
Summary: MRI contrast agents are crucial for clinical diagnosis, but non-specific gadolinium complexes currently used may pose safety concerns. Manganese-based agents could serve as alternatives, and research in this area is growing.
Article
Chemistry, Applied
Matthieu Matcheme, Bernard Dabole, Djaouda Moussa, Jean Noel Nyemb, Talla Emmanuel, Sophie Laurent, Celine Henoumont, Alessandro Venditti
Summary: Chemical investigation on Cordia myxa L. resulted in the isolation of ten known compounds. Compounds 1, 3, 4, 8, and 10 were isolated for the first time from the Cordia genus. Some of these compounds exhibited antibacterial activities.
NATURAL PRODUCT RESEARCH
(2023)
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge of imaging is to combine resolution and sensitivity in order to gain accuracy in diagnosis. No single modality can provide comprehensive information. Then, the solution is to design probes that are able to gather on a single platform the best features of the different imaging modalities. To achieve this objective, we have combined two types of probes, one associated with photoacoustic imaging (PAI) and the other with magnetic resonance imaging (MRI), within polysaccharide-based nanohydrogels.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Inorganic & Nuclear
Camille Gosee, Juliette Moreau, Cyril Cadiou, Maite Callewaert, Celine Henoumont, Lionel Larbanoix, Michael Molinari, Sorina N. Voicu, Christophe Portefaix, Sophie Laurent, Francoise Chuburu
Summary: The challenge in imaging is to achieve accurate diagnosis by combining resolution and sensitivity. To overcome the limitations of single modality imaging, a solution is to design probes that combine the best features of different imaging modalities. In this study, we successfully combined photoacoustic imaging and magnetic resonance imaging within polysaccharide-based nanohydrogels to create an 'all in one' bimodal imaging system. The nanohydrogels showed significant signals in both MSOT and MRI experiments, demonstrating their potential for accurate imaging.
INORGANIC CHEMISTRY FRONTIERS
(2023)
Article
Chemistry, Multidisciplinary
Thibaut Blondy, Julien Poly, Camille Linot, Joanna Boucard, Emilie Allard-Vannier, Steven Nedellec, Phillipe Hulin, Celine Henoumont, Lionel Larbanoix, Robert N. Muller, Sophie Laurent, Elena Ishow, Christophe Blanquart
Summary: The surface chemistry of nanoparticles has a significant impact on their cellular uptake, and the residual groups of chain transfer agents (CTAs) introduced in the main chain can modulate the cell uptake of nanoparticles. This study demonstrates that the cellular internalization of functionalized nanoparticles can be controlled by the compaction of the PEG comb-like shell incorporating CTAs with a long alkyl chain, without changing the overall surface potential.
Article
Polymer Science
Volodymyr Malytskyi, Juliette Moreau, Maite Callewaert, Celine Henoumont, Cyril Cadiou, Cecile Feuillie, Sophie Laurent, Michael Molinari, Francoise Chuburu
Summary: Hyaluronic acid was functionalized with different amino synthons, and nanohydrogels were prepared via ionic gelation. The stability of these nano-assemblies was evaluated using FRET experiments.
