Article
Biochemistry & Molecular Biology
Zengxin Jiang, Hao Wang, Guobin Qi, Chang Jiang, Kangning Chen, Zuoqin Yan
Summary: Growing evidence suggests that iron overload is an independent risk factor for osteoporosis. This study demonstrates that iron overload can lead to ferroptosis in osteoblasts, and the ferroptosis of osteoblasts plays a crucial role in iron overload-induced osteoporosis. Targeting ferroptosis of osteoblasts and maintaining iron homeostasis may be potential strategies for treating or preventing iron overload-induced osteoporosis.
Article
Biochemistry & Molecular Biology
Francois Robin, Daniel Chappard, Patricia Leroyer, Chloe Latour, Guillaume Mabilleau, Valerie Monbet, Thibault Cavey, Mathieu Horeau, Frederic Derbre, Marie-Paule Roth, Martine Ropert, Pascal Guggenbuhl, Olivier Loreal
Summary: This study investigates the respective roles of iron excess and hepcidin in the development of iron-related osteoporosis. The findings suggest that iron overload alone is not sufficient to induce osteoporosis, and low levels of hepcidin also contribute to its development.
Article
Hematology
Maria G. Ledesma-Colunga, Heike Weidner, Maja Vujic Spasic, Lorenz C. Hofbauer, Ulrike Baschant, Martina Rauner
Summary: Well-controlled iron levels are essential for health and bone health. Iron deficiency and overload both impact bone density and fragility. Understanding mechanisms like iron-regulatory proteins can provide new opportunities for treating disorders related to iron and bone health.
SEMINARS IN HEMATOLOGY
(2021)
Article
Pharmacology & Pharmacy
Archita Venugopal Menon, Jonghan Kim
Summary: This study investigates the impact of iron on doxorubicin-induced cardiotoxicity and finds that ABCB8 mediates the efflux of doxorubicin. High iron increases the retention and toxicity of doxorubicin, while iron deficiency improves this effect. The results are further validated in a mouse model of hereditary hemochromatosis.
FRONTIERS IN PHARMACOLOGY
(2022)
Review
Biochemistry & Molecular Biology
Elizabeta Nemeth, Tomas Ganz
Summary: Iron regulation in organisms is primarily controlled by the interaction of the iron-regulatory peptide hormone hepcidin and its receptor ferroportin, which plays a crucial role in maintaining iron homeostasis. Dysregulation of hepcidin can lead to iron overload disorders or iron deficiency, affecting iron delivery and compensatory erythropoiesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Ali Shahandeh, Bang V. Bui, David I. Finkelstein, Christine T. O. Nguyen
Summary: Iron plays a crucial role in neuronal health, but excessive levels can be toxic and lead to cell death. Hemochromatosis is a genetic disorder that causes iron overload and injury in multiple organs. Recent findings have shown that genes associated with hemochromatosis can disrupt retinal iron metabolism. Therefore, studying the effects of iron overload on the retina is important for understanding its implications in various retinal disorders.
FRONTIERS IN NEUROSCIENCE
(2022)
Article
Agriculture, Dairy & Animal Science
Kathleen E. Sullivan, Shana R. Lavin, Shannon Livingston, Mitchell Knutson, Eduardo V. Valdes, Lori K. Warren
Summary: Iron overload disorder is prevalent in black rhinoceroses, and the use of an oral iron chelator showed potential for treatment in horses. The study found that the chelator increased urinary iron output in horses without any adverse effects.
JOURNAL OF ANIMAL PHYSIOLOGY AND ANIMAL NUTRITION
(2022)
Article
Urology & Nephrology
Goran Mohammad, Athena Matakidou, Peter A. Robbins, Samira Lakhal-Littleton
Summary: This study using a mouse model demonstrates that endogenous hepcidin regulates ferroportin-mediated tubular iron reabsorption under physiological conditions, playing a crucial role in maintaining kidney and systemic iron homeostasis.
KIDNEY INTERNATIONAL
(2021)
Article
Biology
Abdolamir Allameh, Nico Huettmann, Edouard Charlebois, Angeliki Katsarou, Wen Gu, Konstantinos Gkouvatsos, Elisa Pasini, Mamatha Bhat, Zoran Minic, Maxim Berezovski, Maria Guido, Carine Fillebeen, Kostas Pantopoulos
Summary: HJV has a hepatoprotective function and its deficiency in mice leads to mitochondrial dysfunction and hepatocarcinogenesis.
COMMUNICATIONS BIOLOGY
(2022)
Article
Multidisciplinary Sciences
Klaus Rieneck, Karen Koefoed Rasmussen, Erwin M. Schoof, Frederik Banch Clausen, Henrietta Holze, Thomas Bergholt, Marianne Horby Jorgensen, Vibeke Brix Christensen, Runar Almaas, Peter Luttge Jordal, Marie Locard-Paulet, Kasper Runager, Leif Kofoed Nielsen, Balthasar Clemens Schlotmann, Joachim Lutken Weischenfeldt, Lars Juhl Jensen, Morten Hanefeld Dziegiel
Summary: The prevailing concept suggests that gestational alloimmune liver disease (GALD) is caused by maternal antibodies targeting an unknown antigen on the fetal liver. This study used three different experimental approaches to identify the liver target antigen of maternal antibodies from women with GALD-diagnosed babies, but did not find the GALD target antigen. The results also did not support the hypothesis that the GALD antigen is an alloantigen.
Article
Biochemistry & Molecular Biology
Claudia Abadia Molina, Nuria Goni Ros, Ricardo Gonzalez Tarancon, Luis Rello Varas, Valle Recasens Flores, Silvia Izquierdo Alvarez
Summary: Haemochromatosis (HC) is an inherited disorder of iron metabolism, mainly caused by mutations in the HFE gene (HC type 1). Genetic studies and analysis of biochemical parameters are important in the diagnosis of HC. Other non-HFE genes can also cause HC. The genotype may not always determine the phenotype expression in this disease.
JOURNAL OF TRACE ELEMENTS IN MEDICINE AND BIOLOGY
(2023)
Article
Gastroenterology & Hepatology
Edouard Bardou-Jacquet, Houda Hamdi-Roze, Anita Paisant, Marie Decraecker, Marc Bourliere, Nathalie Ganne-Carrie, Victor de Ledinghen, Christophe Bureau
Summary: Increased serum ferritin is a common reason for referral, requiring thorough evaluation to avoid unnecessary exploration and inaccurate diagnosis. Factors and tools relevant to this situation must be known by clinicians. Magnetic resonance imaging is a reference method for accurately determining liver iron content.
CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY
(2022)
Article
Biochemistry & Molecular Biology
Darrell H. G. Crawford, Diana G. F. Ross, Lesley-Anne Jaskowski, Leslie J. Burke, Laurence J. Britton, Nick Musgrave, David Briskey, Gautam Rishi, Kim R. Bridle, Nathan Subramaniam
Summary: Results from experiments on Hfe(-/-) mice indicate that reducing iron intake can alleviate the development of steatosis caused by a high-calorie diet, suggesting that modulation of iron balance could be a potential approach for treating NAFLD.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Biochemistry & Molecular Biology
Hui Zhang, Aifei Wang, Guangfei Li, Qiaocheng Zhai, Zhengyun Huang, Xiao Wang, Zihou Cao, Lulin Liu, Gongwen Liu, Bin Chen, Keyu Zhu, Ying Xu, Youjia Xu
Summary: Excessive iron accumulation is a risk factor for osteopenia and osteoporosis, and ferroptosis, a form of cell death, is related to iron-dependent lipid peroxide accumulation. This study reveals that ferroptosis is involved in excess-iron-induced bone loss and demonstrates elevated presence of the NOX4 enzyme in osteoporotic mice and humans. Mechanistically, iron induces dissociation of the iron regulatory protein 1 (IRP1) from the iron-response element-like (IRE-like) sequences in the NOX4 locus, leading to increased NOX4 transcription and lipid peroxide accumulation. Treatment with a ferroptosis inhibitor and an iron chelator shows potential for preventing osteoporotic bone loss.
FREE RADICAL BIOLOGY AND MEDICINE
(2023)
Review
Nutrition & Dietetics
Wanhui Kang, Alexa Barad, Andrew G. Clark, Yiqin Wang, Xu Lin, Zhenglong Gu, Kimberly O. O'Brien
Summary: Iron is unique among minerals because humans lack a regulatable pathway to eliminate excess iron after absorption. Iron deficiency leads to anemia, while iron overload can result in deposition in key organs. Accumulation of iron in the body increases the risk of chronic diseases. Only about 30% of variability in iron absorption can be captured by biomarkers or hormones.
ADVANCES IN NUTRITION
(2021)
Article
Physiology
Kevin Nay, David Martin, Luz Orfila, Dany Saligaut, Brice Martin, Mathieu Horeau, Thibaut Cavey, Moussa Kenawi, Marie-Laure Island, Martine Ropert, Olivier Loreal, Christelle Koechlin Ramonatxo, Frederic Derbre
Summary: This study investigated the effects of simulated microgravity on iron metabolism in rats, finding that exposure to microgravity leads to iron misdistribution and durable reduction in iron availability. The upregulation of hepcidin in response to microgravity is not a transient adaptation, and skeletal muscle may not play a key role in the iron misdistribution that occurs in this environment.
EXPERIMENTAL PHYSIOLOGY
(2021)
Article
Nutrition & Dietetics
Noemie Le Tallec-Esteve, Chloe Rousseau, Benoit Desrues, Olivier Loreal, Ronan Thibault
Summary: The study found that serum iron parameters were positively associated with the severity of OSAS and time spent under hypoxia, indicating a potential impact of OSAS-induced hypoxia on iron metabolism in obese patients.
CLINICAL NUTRITION
(2021)
Article
Rheumatology
Jean-David Albert, Maena Le Corvec, Olivia Berthoud, Claire David, Xavier Guennoc, Emmanuel Hoppe, Sandrine Jousse-Joulin, Benoit Le Goff, Hugues Tariel, Olivier Sire, Anne Jolivet-Gougeon, Guillaume Coiffier, Olivier Loreal
Summary: The study demonstrates that mid-infrared fibre evanescent wave spectroscopy can effectively differentiate septic from non-septic synovial fluids in a multicentre cohort, and is particularly useful in ruling out septic arthritis.
Review
Hematology
Eolia Brissot, Marie-Berengere Troadec, Olivier Loreal, Pierre Brissot
Summary: Iron plays a crucial role in hematopoiesis, including thrombopoiesis, directing the lineage commitment of progenitor cells. While iron deficiency can lead to thrombocytosis and potentially favor vascular thrombosis, severe iron deficiency anemia can also cause thrombocytopenia. The relationship between iron and platelet function remains debated, with different conditions like iron overload or sequestration leading to diverse effects on platelet counts and functioning.
AMERICAN JOURNAL OF HEMATOLOGY
(2021)
Review
Microbiology
Thomas Gautier, Sandrine David-Le Gall, Alaa Sweidan, Zohreh Tamanai-Shacoori, Anne Jolivet-Gougeon, Olivier Loreal, Latifa Bousarghin
Summary: The global pandemic caused by the emergence of SARS CoV-2 has led to significant health impacts, with no specific treatment available yet. Alterations in gut microbiota in COVID-19 patients have drawn attention to the potential use of probiotics as alternative therapies.
Article
Multidisciplinary Sciences
Luis Cano, Stephane Bertani, Marie-Laure Island, Juan Pablo Cerapio, Eloy Ruiz, Pascal Pineau, Valerie Monbet, Karim Boudjema, Luis Taxa, Sandro Casavilca-Zambrano, Martine Ropert, Bruno Turlin, Olivier Loreal
Summary: The study analyzed the metallomic profiles of HCC-NC patients from Peru and France, revealing significant differences between the two cohorts, with higher metal concentrations observed in Peruvian patients. The concentrations of metals such as Cu and Se in HCC areas were found to be associated with survival time, indicating similarities in the metallomic profile during hepatic tumorigenesis in these specific patient groups.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Laura E. Diepeveen, Gaby Stegemann, Erwin T. Wiegerinck, Rian Roelofs, Myrthe Naber, Olivier Loreal, Bart Smeets, Frank Thevenod, Dorine W. Swinkels, Rachel P. L. van Swelm
Summary: Hemolysis can cause acute kidney injury, and the iron regulatory hormone hepcidin plays a protective role during this process. The synthesis of renal hepcidin is induced by iron and hemin through the Nrf2 pathway. Kidney-specific mechanisms of hepcidin regulation exist, highlighting the complexity of iron regulatory mechanisms during AKI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Geriatrics & Gerontology
David Martin, Kevin Nay, Francois Robin, Amelie Rebillard, Luz Orfila, Brice Martin, Patricia Leroyer, Pascal Guggenbuhl, Suzanne Dufresne, Philippe Noirez, Martine Ropert, Olivier Loreal, Frederic Derbre
Summary: This study investigates the impact of iron excess on skeletal muscle structure and metabolic adaptations. The results suggest that skeletal muscle can protect itself from the deleterious effects of iron overload under pathophysiological conditions.
JOURNAL OF CACHEXIA SARCOPENIA AND MUSCLE
(2022)
Article
Medicine, General & Internal
Emmanuelle Albalat, Thibault Cavey, Patricia Leroyer, Martine Ropert, Vincent Balter, Olivier Loreal
Summary: Hereditary hemochromatosis is a genetic iron overload disease caused by a mutation in the HFE gene. Using Hfe(-/-) mice, this study found that the concentration of iron and stable isotope composition increased in the liver and red blood cells, but not in the spleen. The results suggest that the increase in whole blood isotope composition in hemochromatosis patients is mainly due to the release of heavy isotope-enriched iron from the liver, rather than increased dietary iron absorption.
FRONTIERS IN MEDICINE
(2021)
Article
Gastroenterology & Hepatology
Amandine Landemaine, Houda Hamdi-Roze, Severine Cunat, Veronique Loustaud-Ratti, Xavier Causse, Si Nafa Si Ahmed, Bernard Drenou, Christophe Bureau, Gilles Pelletier, Caroline De Kerguenec, Nathalie Ganne-Carrie, Stephane Durupt, Fabrice Laine, Olivier Loreal, Martine Ropert, Lenaick Detivaud, Jeff Morcet, Patricia Aguilar-Martinez, Yves M. Deugnier, Edouard Bardou-Jacquet
Summary: Based on the derivation cohort study of ferroportin disease, we have developed a simple and readily available scoring system that can be used for screening in routine clinical practice. The scoring system has good diagnostic performance for identifying patients with ferroportin disease.
JOURNAL OF HEPATOLOGY
(2022)
Article
Immunology
Guillaume Coiffier, Emmanuelle Ducasse, Arthur Keraudren, Emilie Prat, Hortense Modeste, Jean-David Albert, Olivier Loreal, Pascal Guggenbuhl, Anne Jolivet-Gougeon
Summary: The performance of different types of blood culture vials was compared in osteoarticular specimens. The use of these vials shortened the positive detection time, and there was no significant difference in the positivity rate between different vials. It is crucial to use both aerobic and anaerobic vials simultaneously to maximize the positive detection time during diagnostic procedures.
MICROBIAL PATHOGENESIS
(2022)
Review
Medicine, General & Internal
Pierre Allaume, Noemie Rabilloud, Bruno Turlin, Edouard Bardou-Jacquet, Olivier Loreal, Julien Calderaro, Zine-Eddine Khene, Oscar Acosta, Renaud De Crevoisier, Nathalie Rioux-Leclercq, Thierry Pecot, Solene-Florence Kammerer-Jacquet
Summary: This study provides a systematic review of applications and performances of deep neural network algorithms in liver pathology. The results show that DNN models have diverse applications in this field, but most studies have a high risk of bias. Therefore, DNN models in liver pathology present both opportunities and limitations.
Article
Nutrition & Dietetics
Kevin Nay, Mathieu Horeau, Olivier Loreal, Frederic Derbre
Summary: This study discusses the regulation of iron metabolism and the potential harm of iron misdistribution on health under microgravity or bedrest, proposing new ways to improve nutritional care for astronauts and bedridden patients.
CAHIERS DE NUTRITION ET DE DIETETIQUE
(2021)
Article
Rheumatology
F. Robin, O. Berthoud, J. D. Albert, S. Cadiou, A. Gougeon-Jolivet, C. Bendavid, P. Guggenbuhl, Guillaume Coiffier
Summary: The study evaluated the performance of the Gout-calculator in patients with consecutive acute arthritis affecting large and intermediate joints, finding that while the calculator showed relatively good diagnostic performance for gout, it was not sufficient to rule out the differential diagnosis of septic arthritis in the SYNOLACTATE cohort.
CLINICAL RHEUMATOLOGY
(2021)
Review
Endocrinology & Metabolism
F. Robin, S. Cadiou, J-D Albert, G. Bart, G. Coiffier, P. Guggenbuhl
Summary: Methotrexate (MTX)-related osteopathy, characterized by pain, osteoporosis, and atypical fractures, is a rare condition that has been reported in patients treated with low doses of MTX for inflammatory diseases. Pathophysiological studies suggest a possible dose-dependent residual effect of MTX on osteo-forming bone cells.
OSTEOPOROSIS INTERNATIONAL
(2021)
