Article
Clinical Neurology
Elisa Dal Bo, Ludovica Natali, Claudio Gentili, Cinzia Cecchetto
Summary: This study found that odor awareness may be a key factor in the relationship between emotional symptoms and olfactory abilities. The association between depressive symptoms and olfactory abilities was moderated by odor awareness, while the relationship between anxiety symptoms and olfactory abilities was not affected by odor awareness. Therefore, odor awareness may be a useful target for treating olfactory dysfunction in clinical settings.
JOURNAL OF AFFECTIVE DISORDERS
(2023)
Article
Biology
Sudeshna Das Chakraborty, Hetan Chang, Bill S. Hansson, Silke Sachse, Sonia Sen
Summary: This study investigated the transformation and representation of odor information in higher-order neurons of the lateral horn in Drosophila melanogaster. The researchers found that these neurons exhibited reproducible, stereotypic, and odor-specific response patterns. Importantly, the response amplitude of these neurons was positively correlated with innate odor preferences, suggesting that their activity is valence-specific. The study also revealed that the excitatory input to glutamatergic lateral horn neurons primarily came from uniglomerular projection neurons, while odor-specific inhibition was mediated by inhibitory multiglomerular neurons.
Article
Multidisciplinary Sciences
Devasena Thiagarajan, Franziska Eberl, Daniel Veit, Bill S. Hansson, Markus Knaden, Silke Sachse
Summary: Animals form sensory associations and store them as memories to guide behavioral decisions. In our study using Drosophila melanogaster, we found that bimodal training improved long-lasting olfactory memory but did not enhance short-term olfactory memory.
Article
Multidisciplinary Sciences
Agnieszka Sabiniewicz, Leonie Hoffmann, Antje Haehner, Thomas Hummel
Summary: Improvement in olfactory performance corresponds with a decrease in depression severity, particularly in dysosmic patients.
SCIENTIFIC REPORTS
(2022)
Article
Biology
Amit Kumar, Edi Barkai, Jackie Schiller
Summary: Contrary to previous beliefs, this study found that synaptic plasticity in LOT synapses is stronger and more robust than in IC synapses when receiving specific stimulation, suggesting a self-potentiating mechanism for odor information via NMDA-spikes. Additionally, association between olfactory and contextual information through STDP mechanisms provides cognitive and emotional value to odors.
Article
Clinical Neurology
Elisa Dal Bo, Claudio Gentili, Andrea Castellani, Carmen Tripodi, Florian Ph S. Fischmeister, Cinzia Cecchetto
Summary: This study found that symptoms of anxiety were associated with higher levels of awareness of common odors, while symptoms of depression and social anxiety were associated with increased awareness of social odors. Assessing meta-cognitive abilities may be a useful tool in preventing and evaluating symptoms of depression, anxiety, and social anxiety.
JOURNAL OF AFFECTIVE DISORDERS
(2022)
Article
Psychology, Multidisciplinary
Mira Schwarz, Kai Hamburger
Summary: Despite the focus on visual perception, recent research has shown that humans can use their sense of smell for orientation, especially when processed implicitly.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Multidisciplinary Sciences
Marcela Martoncikova, Pavel Dolezal, Kamila Fabianova, Miloslav Karhanek, Jan Galik, Adam Racek, Alexandra Popovicova, Eniko Racekova
Summary: From March to June 2021, a total of 1025 patients requested smell testing and 824 met the study inclusion criteria. Impaired smell ability was confirmed in 82.6% of participants, while 17.4% showed normal smell ability but complained of parosmia and/or phantosmia. This study demonstrates the relevance of remote psychophysical smell testing during the pandemic and reveals correlations between prolonged olfactory dysfunction and monitored parameters.
SCIENTIFIC REPORTS
(2023)
Article
Multidisciplinary Sciences
Carl E. Schoonover, Sarah N. Ohashi, Richard Axel, Andrew J. P. Fink
Summary: The study found that although activity in the primary olfactory cortex could discriminate between odorants at any time, the odor-evoked responses drifted over days to weeks. Daily exposure to the same odorant slowed the rate of drift, but when exposure was halted the rate increased again. This instability may be related to the unstructured connectivity of the piriform cortex.
Editorial Material
Biochemistry & Molecular Biology
Carolyn Diaz, Kevin M. Franks, Robin M. Blazing
Summary: Many cortical brain regions are organized to optimize sensory representation in a spatially organized manner. A high-throughput tracing study shows that the neural circuits connecting olfactory regions are indeed topographically organized.
Article
Psychology, Multidisciplinary
Hao Zhang, Mingyao Wang, Meiyu Qian, Hongquan Wei
Summary: This study aims to design the Chinese Modified Olfactory Identification (CMOI) test by changing unfamiliar distractors and odors for more familiar ones, improving the test scores.
FRONTIERS IN PSYCHOLOGY
(2023)
Article
Biology
Kevin S. Chen, Rui Wu, Marc H. Gershow, Andrew M. Leifer
Summary: Olfactory navigation plays a crucial role in the survival of animals and is observed across species. This study presents a method to control and measure airborne odor concentration in an arena compatible with an agar substrate, allowing continuous monitoring of odor profile while imaging animal behavior. The researchers successfully measured the odor concentration experienced by C. elegans and D. melanogaster larvae populations as they navigate spatial odor landscapes.
Article
Chemistry, Applied
Yue Ma, Anais Guilbert, Noelle Beno, Ke Tang, Yan Xu, Thierry Thomas-Danguin
Summary: This study investigated how key odorants of icewine influence odor mixture perception and mixture-induced perceptual interactions. Results showed that adding odorants affected both the characteristic odor of the individual component and other odor characteristics, revealing specific perceptual interactions. These findings emphasize the complexity of odor mixture perception and provide new insights into the influence of key odorants on the aroma of wine.
Article
Behavioral Sciences
Janine Gellrich, Lisa-Marie Sparing-Paschke, Thomas Hummel, Valentin A. Schriever
Summary: This study found that odor identification test performance is positively correlated with age (r = 0.31) and verbal abilities of children (r = 0.24). Olfactory threshold results are only marginally influenced by age (r = 0.18) and are not associated with cognitive test performance. Olfactory assessment using olfactory threshold and U-Sniff odor identification testing is suitable for children and adolescents when considering age in the interpretation of test results.
Article
Environmental Sciences
Ingrid A. Ekstrom, Debora Rizzuto, Giulia Grande, Tom Bellander, Erika J. Laukka
Summary: The study found that older adults exposed to air pollutants such as PM2.5 and NOx have a faster decline in olfactory ability, suggesting a potential association between air pollution and olfactory decline.
ENVIRONMENTAL HEALTH PERSPECTIVES
(2022)
Article
Oncology
Juncheng Dai, Mingtao Huang, Christopher I. Amos, Rayjean J. Hung, Adonina Tardon, Angeline Andrew, Chu Chen, David C. Christiani, Demetrius Albanes, Gadi Rennert, Jingyi Fan, Gary Goodman, Geoffrey Liu, John K. Field, Kjell Grankvist, Lambertus A. Kiemeney, Loic Le Marchand, Matthew B. Schabath, Mattias Johansson, Melinda C. Aldrich, Mikael Johansson, Neil Caporaso, Philip Lazarus, Stephan Lam, Stig E. Bojesen, Susanne Arnold, Maria Teresa Landi, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Paul Brennan, Sanjay Shete, Olle Melander, Hans Brunnstrom, Shan Zienolddiny, Penella Woll, Victoria Stevens, Zhibin Hu, Hongbing Shen
INTERNATIONAL JOURNAL OF CANCER
(2020)
Article
Multidisciplinary Sciences
Linda Kachuri, Mattias Johansson, Sara R. Rashkin, Rebecca E. Graff, Yohan Bosse, Venkata Manem, Neil E. Caporaso, Maria Teresa Landi, David C. Christiani, Paolo Vineis, Geoffrey Liu, Ghislaine Scelo, David Zaridze, Sanjay S. Shete, Demetrius Albanes, Melinda C. Aldrich, Adonina Tardon, Gad Rennert, Chu Chen, Gary E. Goodman, Jennifer A. Doherty, Heike Bickeboeller, John K. Field, Michael P. Davies, M. Dawn Teare, Lambertus A. Kiemeney, Stig E. Bojesen, Aage Haugen, Shanbeh Zienolddiny, Stephen Lam, Loic Le Marchand, Iona Cheng, Matthew B. Schabath, Eric J. Duell, Angeline S. Andrew, Jonas Manjer, Philip Lazarus, Susanne Arnold, James D. McKay, Nima C. Emami, Matthew T. Warkentin, Yonathan Brhane, Ma'en Obeidat, Richard M. Martin, Caroline Relton, George Davey Smith, Philip C. Haycock, Christopher I. Amos, Paul Brennan, John S. Witte, Rayjean J. Hung
NATURE COMMUNICATIONS
(2020)
Article
Oncology
Yuzhuo Wang, Olga Y. Gorlova, Ivan P. Gorlov, Meng Zhu, Juncheng Dai, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary E. Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, Heunz-Erich Wichmann, Heike Bickeboller, David C. Christiani, Gad Rennert, Susanne M. Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline S. Andrew, Lambertus A. Kiemeney, Shanbeh Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil E. Caporaso, Penella J. Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Hongxia Ma, Guangfu Jin, Zhibin Hu, Christopher I. Amos, Hongbing Shen
CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
(2020)
Article
Multidisciplinary Sciences
Xuemei Ji, Semanti Mukherjee, Maria Teresa Landi, Yohan Bosse, Philippe Joubert, Dakai Zhu, Ivan Gorlov, Xiangjun Xiao, Younghun Han, Olga Gorlova, Rayjean J. Hung, Yonathan Brhane, Robert Carreras-Torres, David C. Christiani, Neil Caporaso, Mattias Johansson, Geoffrey Liu, Stig E. Bojesen, Loic Le Marchand, Demetrios Albanes, Heike Bickeboeller, Melinda C. Aldrich, William S. Bush, Adonina Tardon, Gad Rennert, Chu Chen, Jinyoung Byun, Konstantin H. Dragnev, John K. Field, Lambertus F. A. Kiemeney, Philip Lazarus, Shan Zienolddiny, Stephen Lam, Matthew B. Schabath, Angeline S. Andrew, Pier A. Bertazzi, Angela C. Pesatori, Nancy Diao, Li Su, Lei Song, Ruyang Zhang, Natasha Leighl, Jakob S. Johansen, Anders Mellemgaard, Walid Saliba, Christopher Haiman, Lynne Wilkens, Ana Fernandez-Somoano, Guillermo Fernandez-Tardon, Erik H. F. M. van der Heijden, Jin Hee Kim, Michael P. A. Davies, Michael W. Marcus, Hans Brunnstrom, Jonas Manjer, Olle Melander, David C. Muller, Kim Overvad, Antonia Trichopoulou, Rosario Tumino, Gary E. Goodman, Angela Cox, Fiona Taylor, Penella Woll, Erich Wichmann, Thomas Muley, Angela Risch, Albert Rosenberger, Kjell Grankvist, Mikael Johansson, Frances Shepherd, Ming-Sound Tsao, Susanne M. Arnold, Eric B. Haura, Ciprian Bolca, Ivana Holcatova, Vladimir Janout, Milica Kontic, Jolanta Lissowska, Anush Mukeria, Simona Ognjanovic, Tadeusz M. Orlowski, Ghislaine Scelo, Beata Swiatkowska, David Zaridze, Per Bakke, Vidar Skaug, Lesley M. Butler, Kenneth Offit, Preethi Srinivasan, Chaitanya Bandlamudi, Matthew D. Hellmann, David B. Solit, Mark E. Robson, Charles M. Rudin, Zsofia K. Stadler, Barry S. Taylor, Michael F. Berger, Richard Houlston, John McLaughlin, Victoria Stevens, David C. Nickle, 'en Obeidat, Wim Timens, Maria Soler Artigas, Sanjay Shete, Hermann Brenner, Stephen Chanock, Paul Brennan, James D. McKay, Christopher Amos
NATURE COMMUNICATIONS
(2020)
Article
Genetics & Heredity
Ryan Sun, Miao Xu, Xihao Li, Sheila Gaynor, Hufeng Zhou, Zilin Li, Yohan Bosse, Stephen Lam, Ming-Sound Tsao, Adonina Tardon, Chu Chen, Jennifer Doherty, Gary Goodman, Stig E. Bojesen, Maria T. Landi, Mattias Johansson, John K. Field, Heike Bickeboeller, H-Erich Wichmann, Angela Risch, Gadi Rennert, Suzanne Arnold, Xifeng Wu, Olle Melander, Hans Brunnstrom, Loic Le Marchand, Geoffrey Liu, Angeline Andrew, Eric Duell, Lambertus A. Kiemeney, Hongbing Shen, Aage Haugen, Mikael Johansson, Kjell Grankvist, Neil Caporaso, Penella Woll, M. Dawn Teare, Ghislaine Scelo, Yun-Chul Hong, Jian-Min Yuan, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Demetrios Albanes, Raymond Mak, David Barbie, Paul Brennan, Rayjean J. Hung, Christopher I. Amos, David C. Christiani, Xihong Lin
Summary: This study prioritizes and characterizes single nucleotide polymorphisms (SNPs) that increase the risk of squamous cell lung cancer by utilizing extensive multiomics data sources and genome-wide functional annotations. The reanalysis of data highlights the impact of SNPs from nuclear factor-kappa B signaling pathway genes and major histocompatibility complex-mediated immune responses on lung cancer. The strategies introduced in this study provide informative and systematic approaches for incorporating genome-wide annotation data in genetic association studies.
GENETIC EPIDEMIOLOGY
(2021)
Article
Oncology
Wen Zhou, Geoffrey Liu, Rayjean J. Hung, Philip C. Haycock, Melinda C. Aldrich, Angeline S. Andrew, Susanne M. Arnold, Heike Bickeboeller, Stig E. Bojesen, Paul Brennan, Hans Brunnstrom, Olle Melander, Neil E. Caporaso, Maria Teresa Landi, Chu Chen, Gary E. Goodman, David C. Christiani, Angela Cox, John K. Field, Mikael Johansson, Lambertus A. Kiemeney, Stephen Lam, Philip Lazarus, Loic Le Marchand, Gad Rennert, Angela Risch, Matthew B. Schabath, Sanjay S. Shete, Adonina Tardon, Shanbeh Zienolddiny, Hongbing Shen, Christopher I. Amos
Summary: The study found a positive causal effect of high BMI on small cell lung cancer risk, but a negative effect on lung adenocarcinoma. Smoking behaviors play a mediator role in the association between BMI and lung cancer.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Justus Wilke, Agnes A. Steixner-Kumar
MOLECULAR PSYCHIATRY
(2021)
Review
Immunology
Jukka Partanen, Kati Hyvarinen, Heike Bickeboller, Katarzyna Bogunia-Kubik, Rachel E. Crossland, Milena Ivanova, Francesca Perutelli, Ralf Dressel
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Oncology
Na Qin, Yuancheng Li, Cheng Wang, Meng Zhu, Juncheng Dai, Tongtong Hong, Demetrius Albanes, Stephen Lam, Adonina Tardon, Chu Chen, Gary Goodman, Stig E. Bojesen, Maria Teresa Landi, Mattias Johansson, Angela Risch, H-Erich Wichmann, Heike Bickeboller, Gadi Rennert, Susanne Arnold, Paul Brennan, John K. Field, Sanjay Shete, Loic Le Marchand, Olle Melander, Hans Brunnstrom, Geoffrey Liu, Rayjean J. Hung, Angeline Andrew, Lambertus A. Kiemeney, Shan Zienolddiny, Kjell Grankvist, Mikael Johansson, Neil Caporaso, Penella Woll, Philip Lazarus, Matthew B. Schabath, Melinda C. Aldrich, Victoria L. Stevens, Guangfu Jin, David C. Christiani, Zhibin Hu, Christopher I. Amos, Hongxia Ma, Hongbing Shen
Summary: This study integrated genotype data of lung adenocarcinoma and squamous cell carcinoma cases to analyze susceptibility variants for non-small cell lung cancer, revealing differences between AD and SqCC genes in pathways and functions. The results shed light on the genetic heterogeneity between AD and SqCC in NSCLC.
FRONTIERS OF MEDICINE
(2021)
Article
Oncology
Rayjean J. Hung, Matthew T. Warkentin, Yonathan Brhane, Nilanjan Chatterjee, David C. Christiani, Maria Teresa Landi, Neil E. Caporaso, Geoffrey Liu, Mattias Johansson, Demetrius Albanes, Loic Le Marchand, Adonina Tardon, Gad Rennert, Stig E. Bojesen, Chu Chen, John K. Field, Lambertus A. Kiemeney, Philip Lazarus, Shanbeth Zienolddiny, Stephen Lam, Angeline S. Andrew, Susanne M. Arnold, Melinda C. Aldrich, Heike Bickeboeller, Angela Risch, Matthew B. Schabath, James D. McKay, Paul Brennan, Christopher Amos
Summary: Research suggests that an individual's genetic background may play a role in risk stratification for lung cancer and optimizing LDCT screening.
Article
Biochemistry & Molecular Biology
Agnes A. Steixner-Kumar, Vinicius Daguano Gastaldi, Jan Seidel, Albert Rosenberger, Martin Begemann, Hannelore Ehrenreich
Summary: Accumulation of early-life environmental risks, including cannabis and alcohol, strongly predicts the development of polytoxicomania, while genetic predisposition to this condition remains largely unexplored.
MOLECULAR PSYCHIATRY
(2021)
Review
Biochemistry & Molecular Biology
Martin Begemann, Oliver Gross, Dominik Wincewicz, Ruediger Hardeland, Vinicius Daguano Gastaldi, Eduard Vieta, Karin Weissenborn, Kamilla W. Miskowiak, Onnen Moerer, Hannelore Ehrenreich
Summary: The global spread of SARS-CoV-2 since fall 2019 has caused a major pandemic, with severe COVID-19 patients experiencing multiple organ failure and grave neuropsychiatric manifestations. The development of vaccines has shown promise, but few effective treatment options have emerged to modify the course and outcome of COVID-19. Substituting erythropoietin may help overcome the 'hypoxia paradox' and improve survival and functional status of patients with severe COVID-19.
MOLECULAR MEDICINE
(2021)
Article
Biochemistry & Molecular Biology
Hannelore Ehrenreich, Laura Fernandez Garcia-Agudo, Agnes A. Steixner-Kumar, Justus B. H. Wilke, Umer Javed Butt
Summary: Executive functions, learning, attention, and processing speed are important aspects of cognitive performance, which can be affected in neuropsychiatric disorders. Studies have shown that recombinant human erythropoietin (rhEPO) can improve cognitive abilities and reduce brain matter loss. The administration of rhEPO leads to an increase in pyramidal neurons and oligodendrocytes, while decreasing the number and activity of microglia. This process promotes neurogenesis and increases dendritic spine density, which may contribute to improved cognitive function.
MOLECULAR PSYCHIATRY
(2022)
Article
Biochemical Research Methods
Kolja A. Thormann, Viola Tozzi, Paula Starke, Heike Bickeboeller, Marcus Baum, Albert Rosenberger
Summary: ImputAccur is a software tool that measures genotype-imputation accuracy. It provides accuracy measures from standard output files of imputation software and supports sample and marker filtering.
BMC BIOINFORMATICS
(2022)
Article
Biology
Sahab Arinrad, Constanze Depp, Sophie B. Siems, Andrew Octavian Sasmita, Maria A. Eichel, Anja Ronnenberg, Kurt Hammerschmidt, Katja A. Lueders, Hauke B. Werner, Hannelore Ehrenreich, Klaus-Armin Nave
Summary: The study shows that structural defects of intracortical myelin associated with neuroinflammation are key features of advanced brain aging. A mouse model with similar pathology exhibits behavioral abnormalities, but cognitive assessment is challenging due to motor-sensory functions. However, mice lacking Plp1 gene in ventricular zone stem cells exhibit subtle myelin defects only in certain brain regions and show no basic motor-sensory performance impairments. Interestingly, novel behavioral paradigms reveal catatonia-like symptoms and executive dysfunction.