Role of berberine in anti-bacterial as a high-affinity LPS antagonist binding to TLR4/MD-2 receptor

GROMACS 4.5: a high-throughput and highly parallel open source molecular simulation toolkit

(2013) Sander Pronk et al.   BIOINFORMATICS

GenePainter: a fast tool for aligning gene structures of eukaryotic protein families, visualizing the alignments and mapping gene structures onto protein structures

(2013) Björn Hammesfahr et al.   BMC BIOINFORMATICS

The Origin of 8-Amino-3,8-dideoxy-d-manno-octulosonic Acid (Kdo8N) in the Lipopolysaccharide ofShewanella oneidensis

(2013) Samuel G. Gattis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Behavior of Solvent-Exposed Hydrophobic Groove in the Anti-Apoptotic Bcl-XL Protein: Clues for Its Ability to Bind Diverse BH3 Ligands from MD Simulations

(2013) Dilraj Lama et al.   PLoS One

Tetra- and Penta-Acylated Lipid A Structures of Porphyromonas gingivalis LPS Differentially Activate TLR4-Mediated NF-κB Signal Transduction Cascade and Immuno-Inflammatory Response in Human Gingival Fibroblasts

(2013) Thanuja D. K. Herath et al.   PLoS One

Liposomal Lipopolysaccharide Initiates TRIF-Dependent Signaling Pathway Independent of CD14

(2013) Sachiko Watanabe et al.   PLoS One

Development and application of a particle-particle particle-mesh Ewald method for dispersion interactions

(2012) Rolf E. Isele-Holder et al.   JOURNAL OF CHEMICAL PHYSICS

Structural basis of species-specific endotoxin sensing by innate immune receptor TLR4/MD-2

(2012) U. Ohto et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bacterial Sensing, Cell Signaling, and Modulation of the Immune Response During Sepsis

(2012) Reinaldo Salomao et al.   SHOCK

Systems biology approaches to toll-like receptor signaling

(2012) Alexis Vandenbon et al.   Wiley Interdisciplinary Reviews-Systems Biology and Medicine

Chitohexaose Activates Macrophages by Alternate Pathway through TLR4 and Blocks Endotoxemia

(2012) Santosh K. Panda et al.   PLoS Pathogens

Berberine protects against lipopolysaccharide-induced intestinal injury in mice via alpha 2 adrenoceptor-independent mechanisms

(2011) Hong-mei Li et al.   ACTA PHARMACOLOGICA SINICA

Berberine Ameliorates Intestinal Epithelial Tight-Junction Damage and Down-regulates Myosin Light Chain Kinase Pathways in a Mouse Model of Endotoxinemia

(2011) Lili Gu et al.   JOURNAL OF INFECTIOUS DISEASES

Exploring the LPS/TLR4 signal pathway with small molecules

(2010) Francesco Peri et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Preventive effect of Coptis chinensis and berberine on intestinal injury in rats challenged with lipopolysaccharides

(2010) Qian Zhang et al.   FOOD AND CHEMICAL TOXICOLOGY

Molecular dynamics simulation with weak coupling to heat and material baths

(2010) Hossein Eslami et al.   JOURNAL OF CHEMICAL PHYSICS

A Peptide Antagonist of the TLR4-MD2 Interaction

(2009) Peter F. Slivka et al.   CHEMBIOCHEM

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Non-stereoselective reversal of neuropathic pain by naloxone and naltrexone: involvement of toll-like receptor 4 (TLR4)

(2008) Mark R. Hutchinson et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Discovery and Development of Toll-Like Receptor 4 (TLR4) Antagonists: A New Paradigm for Treating Sepsis and Other Diseases

(2008) Carlos G. Leon et al.   PHARMACEUTICAL RESEARCH