A directional switch of integrin signalling and a new anti-thrombotic strategy

The Role of Rac1 in Glycoprotein Ib-IX–Mediated Signal Transduction and Integrin Activation

(2012) M. Keegan Delaney et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

ADP-Stimulated Activation of Akt During Integrin Outside-In Signaling Promotes Platelet Spreading by Inhibiting Glycogen Synthase Kinase-3β

(2012) Kelly A. O’Brien et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Protein disulfide isomerase capture during thrombus formation in vivo depends on the presence of  3 integrins

(2012) J. Cho et al.   BLOOD

Inside-out, outside-in, and inside–outside-in: G protein signaling in integrin-mediated cell adhesion, spreading, and retraction

(2012) Bo Shen et al.   CURRENT OPINION IN CELL BIOLOGY

An important role for Akt3 in platelet activation and thrombosis

(2011) K. A. O'Brien et al.   BLOOD

Molecular mechanism of inside-out integrin regulation

(2011) F. YE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Talin-dependent integrin activation is required for fibrin clot retraction by platelets

(2010) J. R. Haling et al.   BLOOD

G Protein Subunit G 13 Binds to Integrin  IIb 3 and Mediates Integrin "Outside-In" Signaling

(2010) H. Gong et al.   SCIENCE

Kindlin-2 (Mig-2): a co-activator of β3integrins

(2008) Yan-Qing Ma et al.   JOURNAL OF CELL BIOLOGY

Structural Basis for the Autoinhibition of Talin in Regulating Integrin Activation

(2008) Esen Goksoy et al.   MOLECULAR CELL

Kindlin-3 is essential for integrin activation and platelet aggregation

(2008) Markus Moser et al.   NATURE MEDICINE