Progress toward inducing immunologic tolerance to factor VIII

In Vitro Expansion Improves In Vivo Regulation by CD4+CD25+ Regulatory T Cells

(2014) J.-G. Chai et al.   JOURNAL OF IMMUNOLOGY

Eradication of factor viii inhibitors in patients with mild and moderate hemophilia A

(2012) Christine L. Kempton et al.   AMERICAN JOURNAL OF HEMATOLOGY

Teplizumab for Treatment of Type 1 Diabetes Mellitus

(2012) Jessica W Skelley et al.   ANNALS OF PHARMACOTHERAPY

CD4+ T-cell epitopes associated with antibody responses after intravenously and subcutaneously applied human FVIII in humanized hemophilic E17 HLA-DRB1*1501 mice

(2012) K. N. Steinitz et al.   BLOOD

Modification of an exposed loop in the C1 domain reduces immune responses to factor VIII in hemophilia A mice

(2012) A. Wroblewska et al.   BLOOD

F8 gene mutation type and inhibitor development in patients with severe hemophilia A: systematic review and meta-analysis

(2012) S. C. Gouw et al.   BLOOD

Immune tolerance in haemophilia: the long journey to the fork in the road

(2012) Donna M. DiMichele   BRITISH JOURNAL OF HAEMATOLOGY

Haematopoietic stem cell transplantation for SCID patients: where do we stand?

(2012) Marina Cavazzana-Calvo et al.   BRITISH JOURNAL OF HAEMATOLOGY

Inhibitory antibodies in hemophilia A

(2012) Kathleen P. Pratt   CURRENT OPINION IN HEMATOLOGY

Models for assessing immunogenicity and efficacy of new therapeutics for the treatment of haemophilia

(2012) JEAN-MARIE SAINT-REMY et al.   HAEMOPHILIA

Recent Progress in Gene Therapy for Hemophilia

(2012) Marinee K. Chuah et al.   HUMAN GENE THERAPY

Cytokine-Conditioned Dendritic Cells Induce Humoral Tolerance to Protein Therapy in Mice

(2012) Gautam Sule et al.   HUMAN GENE THERAPY

The Immunologic Functions of the Neonatal Fc Receptor for IgG

(2012) Timo Rath et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Low-titre inhibitors, undetectable by the Nijmegen assay, reduce factor VIII half-life after immune tolerance induction

(2012) M. DARDIKH et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Lentivirus-mediated platelet gene therapy of murine hemophilia A with pre-existing anti-factor VIII immunity

(2012) E. L. KUETHER et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Dangerous liaisons: how the immune system deals with factor VIII

(2012) A. WROBLEWSKA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Biochemical and functional characterization of a recombinant monomeric factor VIII-Fc fusion protein

(2012) R. T. PETERS et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Oral Immunotherapy for Treatment of Egg Allergy in Children

(2012) A. Wesley Burks et al.   NEW ENGLAND JOURNAL OF MEDICINE

Transient B Cell Depletion or Improved Transgene Expression by Codon Optimization Promote Tolerance to Factor VIII in Gene Therapy

(2012) Brandon K. Sack et al.   PLoS One

FEIBA: A Prohemostatic Agent

(2012) Caroline Cromwell et al.   SEMINARS IN THROMBOSIS AND HEMOSTASIS

Recombinant factor IX-Fc fusion protein (rFIXFc) demonstrates safety and prolonged activity in a phase 1/2a study in hemophilia B patients

(2011) A. D. Shapiro et al.   BLOOD

Requirements for immune recognition and processing of factor VIII by antigen-presenting cells

(2011) Simon D. van Haren et al.   BLOOD REVIEWS

Gene therapy for haemophilia: prospects and challenges to prevent or reverse inhibitor formation

(2011) David W. Scott et al.   BRITISH JOURNAL OF HAEMATOLOGY

Effect of HLA DR epitope de-immunization of Factor VIII in vitro and in vivo

(2011) Leonard Moise et al.   CLINICAL IMMUNOLOGY

Phenotypic correction of hemophilia A in sheep by postnatal intraperitoneal transplantation of FVIII-expressing MSC

(2011) Christopher D. Porada et al.   EXPERIMENTAL HEMATOLOGY

Clinical pharmacological study of a plasma-derived factor VIIa and factor X mixture (MC710) in haemophilia patients with inhibitors - Phase I trial

(2011) A. SHIRAHATA et al.   HAEMOPHILIA

Early prophylaxis/FVIII tolerization regimen that avoids immunological danger signals is still effective in minimizing FVIII inhibitor developments in previously untreated patients - long-term follow-up and continuing experience

(2011) G. AUERSWALD et al.   HAEMOPHILIA

Clinical outcomes and patient satisfaction following total joint replacement in haemophilia - 23-year experience in knees, hips and elbows

(2011) K. WANG et al.   HAEMOPHILIA

Surgical Experience with rFVIIa (NovoSeven) in congenital haemophilia A and B patients with inhibitors to factors VIII or IX

(2011) L. A. VALENTINO et al.   HAEMOPHILIA

Oral tolerance

(2011) Howard L. Weiner et al.   IMMUNOLOGICAL REVIEWS

Uptake of blood coagulation factor VIII by dendritic cells is mediated via its C1 domain

(2011) Eszter Herczenik et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tolerance Induced by Apoptotic Antigen-Coupled Leukocytes Is Induced by PD-L1+ and IL-10-Producing Splenic Macrophages and Maintained by T Regulatory Cells

(2011) D. R. Getts et al.   JOURNAL OF IMMUNOLOGY

Successful immune tolerance induction by FVIII in hemophilia A patients with inhibitor may occur without deletion of FVIII-specific T cells

(2011) B. PAUTARD et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Tilt balance towards regulation: evolving new strategy for treatment of hemophilia inhibitors

(2011) C. H. MIAO   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Induction of tolerance to factor VIII by transient co-administration with rapamycin

(2011) B. MOGHIMI et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

T-cell responses in two unrelated hemophilia A inhibitor subjects include an epitope at the factor VIII R593C missense site

(2011) E. A. JAMES et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Suppression of the Immune Response to FVIII in Hemophilia A Mice by Transgene Modified Tolerogenic Dendritic Cells

(2011) Rui-Jun Su et al.   MOLECULAR THERAPY

In Vivo Expansion of Regulatory T cells With IL-2/IL-2 mAb Complexes Prevents Anti-factor VIII Immune Responses in Hemophilia A Mice Treated With Factor VIII Plasmid-mediated Gene Therapy

(2011) Chao-Lien Liu et al.   MOLECULAR THERAPY

A MicroRNA-regulated and GP64-pseudotyped Lentiviral Vector Mediates Stable Expression of FVIII in a Murine Model of Hemophilia A

(2011) Hideto Matsui et al.   MOLECULAR THERAPY

In vivo genome editing restores haemostasis in a mouse model of haemophilia

(2011) Hojun Li et al.   NATURE

Adenovirus-Associated Virus Vector–Mediated Gene Transfer in Hemophilia B

(2011) Amit C. Nathwani et al.   NEW ENGLAND JOURNAL OF MEDICINE

Neonatal Fc receptor for IgG (FcRn) regulates cross-presentation of IgG immune complexes by CD8-CD11b+ dendritic cells

(2011) K. Baker et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prevention and Reversal of Antibody Responses Against Factor IX in Gene Therapy for Hemophilia B

(2011) Sushrusha Nayak et al.   Frontiers in Microbiology

Effect of B-cell depletion using anti-CD20 therapy on inhibitory antibody formation to human FVIII in hemophilia A mice

(2010) A.-H. Zhang et al.   BLOOD

HLA-DR-restricted T-cell responses to factor VIII epitopes in a mild haemophilia A family with missense substitution A2201P

(2010) R. A. ETTINGER et al.   HAEMOPHILIA

B-cell delivered gene therapy for tolerance induction: Role of autoantigen-specific B cells

(2010) Ai-Hong Zhang et al.   JOURNAL OF AUTOIMMUNITY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The long-term course of factor VIII inhibitors in patients with congenital haemophilia A without immune tolerance induction

(2010) C. Caram et al.   THROMBOSIS AND HAEMOSTASIS

CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

(2009) C. H. Miao et al.   BLOOD

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells

(2009) H. Matsui et al.   BLOOD

Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy

(2009) B. Peng et al.   BLOOD

In vivo delivery of a microRNA-regulated transgene induces antigen-specific regulatory T cells and promotes immunologic tolerance

(2009) A. Annoni et al.   BLOOD

B-Cell and T-Cell Epitopes in Anti-factor VIII Immune Responses

(2009) Kathleen P. Pratt et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Hepatic Gene Transfer as a Means of Tolerance Induction to Transgene Products

(2009) Paul LoDuca et al.   CURRENT GENE THERAPY

Dynamics of peripheral tolerance and immune regulation mediated by Treg

(2009) Shimon Sakaguchi et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Indoleamine 2,3-dioxygenase attenuates inhibitor development in gene-therapy-treated hemophilia A mice

(2009) L Liu et al.   GENE THERAPY

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

(2009) S. NAYAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Splenic marginal zone antigen-presenting cells are critical for the primary allo-immune response to therapeutic factor VIII in hemophilia A

(2009) A. NAVARRETE et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Opportunities and limitations of mouse models humanized for HLA class II antigens

(2009) B. M. REIPERT et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Exploiting and antagonizing microRNA regulation for therapeutic and experimental applications

(2009) Brian D. Brown et al.   NATURE REVIEWS GENETICS

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response

(2008) B. Waters et al.   BLOOD

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice

(2008) B. Peng et al.   BLOOD

Activation of natural regulatory T cells by IgG Fc-derived peptide "Tregitopes"

(2008) A. S. De Groot et al.   BLOOD

Reduction of the immune response to factor VIII mediated through tolerogenic factor VIII presentation by immature dendritic cells

(2008) M. QADURA et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Platelet-delivered factor VIII provides limited resistance to anti-factor VIII inhibitors

(2008) J. GEWIRTZ et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS