Induction of tolerance to factor VIII by transient co-administration with rapamycin

Mild haemophilia: a disease with many faces and many unexpected pitfalls

(2010) K. PEERLINCK et al.   HAEMOPHILIA

Understanding inhibitor development in haemophilia A: towards clinical prediction and prevention strategies

(2010) A. COPPOLA et al.   HAEMOPHILIA

B-Cell-Delivered Gene Therapy Induces Functional T Regulatory Cells and Leads to a Loss of Antigen-Specific Effector Cells

(2010) Jonathan Skupsky et al.   MOLECULAR THERAPY

Oral delivery of bioencapsulated coagulation factor IX prevents inhibitor formation and fatal anaphylaxis in hemophilia B mice

(2010) D. Verma et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Induction of heme oxygenase-1 in factor VIII-deficient mice reduces the immune response to therapeutic factor VIII

(2009) J. D. Dimitrov et al.   BLOOD

CD4+FOXP3+ regulatory T cells confer long-term regulation of factor VIII-specific immune responses in plasmid-mediated gene therapy-treated hemophilia mice

(2009) C. H. Miao et al.   BLOOD

Lineages of human T-cell clones, including T helper 17/T helper 1 cells, isolated at different stages of anti-factor VIII immune responses

(2009) R. A. Ettinger et al.   BLOOD

A murine model for induction of long-term immunologic tolerance to factor VIII does not require persistent detectable levels of plasma factor VIII and involves contributions from Foxp3+ T regulatory cells

(2009) H. Matsui et al.   BLOOD

Anti-CD3 antibodies modulate anti-factor VIII immune responses in hemophilia A mice after factor VIII plasmid-mediated gene therapy

(2009) B. Peng et al.   BLOOD

Treatment with sirolimus results in complete responses in patients with autoimmune lymphoproliferative syndrome

(2009) David T. Teachey et al.   BRITISH JOURNAL OF HAEMATOLOGY

Immune Response to FVIII in Hemophilia A: An Overview of Risk Factors

(2009) Kanjaksha Ghosh et al.   CLINICAL REVIEWS IN ALLERGY & IMMUNOLOGY

Prophylactic immune tolerance induced by changing the ratio of antigen-specific effector to regulatory T cells

(2009) S. NAYAK et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Role of regulatory T cells in tolerance to coagulation factors

(2009) O. CAO et al.   JOURNAL OF THROMBOSIS AND HAEMOSTASIS

Impact of the Underlying Mutation and the Route of Vector Administration on Immune Responses to Factor IX in Gene Therapy for Hemophilia B

(2009) Ou Cao et al.   MOLECULAR THERAPY

Anti-CD3 prevents factor VIII inhibitor development in hemophilia A mice by a regulatory CD4+CD25+-dependent mechanism and by shifting cytokine production to favor a Th1 response

(2008) B. Waters et al.   BLOOD

Transient blockade of the inducible costimulator pathway generates long-term tolerance to factor VIII after nonviral gene transfer into hemophilia A mice

(2008) B. Peng et al.   BLOOD