Treatment of erythropoietin deficiency in mice with systemically administered siRNA

The HIF Pathway and Erythrocytosis

(2011) Frank S. Lee et al.   Annual Review of Pathology-Mechanisms of Disease

Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression

(2011) V. R. Gordeuk et al.   BLOOD

Diagnosis and management of anaemia of chronic disease: current status

(2011) Jonathan O. Cullis   BRITISH JOURNAL OF HAEMATOLOGY

Hepatic hypoxia-inducible factor-2 down-regulates hepcidin expression in mice through an erythropoietin-mediated increase in erythropoiesis

(2011) M. Mastrogiannaki et al.   HAEMATOLOGICA

Hypoxia-inducible transcription factor 2α promotes steatohepatitis through augmenting lipid accumulation, inflammation, and fibrosis

(2011) Aijuan Qu et al.   HEPATOLOGY

Pattern of resistance to erythropoietin-stimulating agents in chronic kidney disease

(2011) Oluwatoyin F. Bamgbola   KIDNEY INTERNATIONAL

Oxygen Sensing, Homeostasis, and Disease

(2011) Gregg L. Semenza   NEW ENGLAND JOURNAL OF MEDICINE

Uncoupling hypoxia signaling from oxygen sensing in the liver results in hypoketotic hypoglycemic death

(2011) B Kucejova et al.   ONCOGENE

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Hepatic HIF-2 regulates erythropoietic responses to hypoxia in renal anemia

(2010) P. P. Kapitsinou et al.   BLOOD

Loss of Hypoxia-Inducible Factor Prolyl Hydroxylase Activity in Cardiomyocytes Phenocopies Ischemic Cardiomyopathy

(2010) Javid Moslehi et al.   CIRCULATION

Critical appraisal of randomized controlled trials of anemia correction in patients with renal failure

(2010) Patrick S Parfrey   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Regulation of Type II Transmembrane Serine Proteinase TMPRSS6 by Hypoxia-inducible Factors

(2010) Samira Lakhal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Inhibition of Prolyl Hydroxylases Increases Erythropoietin Production in ESRD

(2010) W. M. Bernhardt et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Targeted Delivery of RNAi Therapeutics With Endogenous and Exogenous Ligand-Based Mechanisms

(2010) Akin Akinc et al.   MOLECULAR THERAPY

Rational design of cationic lipids for siRNA delivery

(2010) Sean C Semple et al.   NATURE BIOTECHNOLOGY

Erythropoiesis-Stimulating Agents — Time for a Reevaluation

(2010) Ellis F. Unger et al.   NEW ENGLAND JOURNAL OF MEDICINE

Lipid-like materials for low-dose, in vivo gene silencing

(2010) K. T. Love et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reactivation of Hepatic EPO Synthesis in Mice After PHD Loss

(2010) Y. A. Minamishima et al.   SCIENCE

Erythropoiesis Stimulatory Agent- Resistant Anemia in Dialysis Patients: Review of Causes and Management

(2009) Mehmet Kanbay et al.   BLOOD PURIFICATION

Phlebotomies or erythropoietin injections allow mobilization of iron stores in a mouse model mimicking intensive care anemia

(2009) Sigismond Lasocki et al.   CRITICAL CARE MEDICINE

Erythropoietin administration in humans causes a marked and prolonged reduction in circulating hepcidin

(2009) D. R. Ashby et al.   HAEMATOLOGICA

A Feedback Loop Involving the Phd3 Prolyl Hydroxylase Tunes the Mammalian Hypoxic Response In Vivo

(2009) Y. A. Minamishima et al.   MOLECULAR AND CELLULAR BIOLOGY

Hypoxia-Inducible Factor 2 Regulates Hepatic Lipid Metabolism

(2009) E. B. Rankin et al.   MOLECULAR AND CELLULAR BIOLOGY

Evidence for a Lack of a Direct Transcriptional Suppression of the Iron Regulatory Peptide Hepcidin by Hypoxia-Inducible Factors

(2009) Melanie Volke et al.   PLoS One

2-Oxoglutarate-dependent oxygenases control hepcidin gene expression

(2008) Georgia G. Braliou et al.   JOURNAL OF HEPATOLOGY

Secondary analysis of the CHOIR trial epoetin-α dose and achieved hemoglobin outcomes

(2008) Lynda A. Szczech et al.   KIDNEY INTERNATIONAL

Oxygen Sensing by Metazoans: The Central Role of the HIF Hydroxylase Pathway

(2008) William G. Kaelin et al.   MOLECULAR CELL

A combinatorial library of lipid-like materials for delivery of RNAi therapeutics

(2008) Akin Akinc et al.   NATURE BIOTECHNOLOGY

Therapeutic RNAi targeting PCSK9 acutely lowers plasma cholesterol in rodents and LDL cholesterol in nonhuman primates

(2008) M. Frank-Kamenetsky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Somatic inactivation of the PHD2 prolyl hydroxylase causes polycythemia and congestive heart failure

(2007) Y. A. Minamishima et al.   BLOOD

Furin-mediated release of soluble hemojuvelin: a new link between hypoxia and iron homeostasis

(2007) L. Silvestri et al.   BLOOD