Review
Gastroenterology & Hepatology
Fei Gao, Hengwei Wu, Limengmeng Wang, Yanmin Zhao, He Huang
Summary: Despite advancements in HSCT, GVHD, especially intestinal GVHD, still poses a significant challenge to the procedure. Traditionally, GVHD has been seen as an immune response, with the intestine as a target. However, factors such as altered intestinal microbiome and epithelial damage contribute to intestinal damage after transplantation. This review summarizes these factors and explores the potential of remodeling intestinal homeostasis in GVHD management.
Article
Immunology
Jiashen Zhang, Yaxuan Zhao, Hengchao Zhang, Kaiyue Han, Junjie Ma, Yanlian Xiong, Guoyan Wang, Xiying Luan
Summary: This study suggests that hPMSCs alleviate intestinal damage in GVHD mice by regulating the levels of IFN-γ and IL-10 in CD4(+)T cells through CD73 and promoting the phosphorylation of AMPK.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Article
Pharmacology & Pharmacy
Hui Li, Qi Liu, Xiaofeng Gao, Di Zhang, Shengjun Mao, Yongqian Jia
Summary: The study explored the potential of human umbilical mesenchymal stem cells transfected with IFN-γ gene and found that this treatment significantly reduced the incidence and severity of GVHD in vivo, providing a significant survival benefit.
INTERNATIONAL JOURNAL OF PHARMACEUTICS
(2021)
Letter
Medicine, General & Internal
Anna R. Schreiber, Dara L. Aisner, Jonathan A. Gutman
Summary: This article reports a case of fetal-induced graft-versus-host disease, in which the mother developed fever, pancytopenia, and rash 3 weeks after the delivery of twin sons that included transfusion.
NEW ENGLAND JOURNAL OF MEDICINE
(2023)
Review
Immunology
Hua Jiang, Denggang Fu, Alan Bidgoli, Sophie Paczesny
Summary: Allogeneic hematopoietic cell transplantation (allo-HCT) is crucial for treating hematological malignancies, but acute and chronic graft-versus-host disease (aGVHD and cGVHD) are major complications. Understanding the roles of T cell subsets in GVHD pathogenesis is essential for identifying new therapeutic targets and improving outcomes.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Linde Dekker, Evy Sanders, Caroline A. Lindemans, Coco de Koning, Stefan Nierkens
Summary: The recovery of naive T cells plays an important role in allo-HCT by functioning as both drivers and regulators in allogeneic reactions. Adequate reconstitution of naive T cells can improve GvHD prevention while maintaining GvL effects to lower relapse risk.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Tarani Kanta Barman, Victor C. Huber, Jesse L. Bonin, Danielle Califano, Sharon L. Salmon, Andrew N. J. McKenzie, Dennis W. Metzger
Summary: This study reveals the interplay between host interferon (IFN)-gamma and viral PB1-F2 virulence protein in regulating the functions of innate lymphoid cells (ILCs) and T cells during influenza virus infection. In the absence of IFN-gamma, lung ILC2s initiate a robust IL-5 response, leading to improved tissue integrity and increased survival. However, the presence of functional PB1-F2 suppresses ILC2 responses and induces a dominant IL-13 CD8 T cell response. This study also demonstrates the importance of IFN-gamma in host resistance against lethal doses of the influenza virus.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Cell Biology
Qin Hao, Sreerama Shetty, Torry A. Tucker, Steven Idell, Hua Tang
Summary: In this study, the researchers found that interferon-gamma (IFN gamma) can enhance the susceptibility of lung epithelial cells to necroptosis, leading to an accelerated release of damage-associated molecular patterns. They also discovered that the necroptosis effector mixed lineage kinase domain-like protein (MLKL) is predominantly induced by IFN gamma in lung epithelial cells.
Article
Biology
Abhisek Dwivedy, Anam Ashraf, Bhavya Jha, Deepak Kumar, Nisheeth Agarwal, Bichitra K. Biswal
Summary: Intracellular pathogens such as Mycobacterium tuberculosis have developed strategies to evade host immune responses and meet their nutritional requirements, even in the presence of immune pressure. Host cells can up-regulate histidine catabolizing enzymes to starve the pathogen of essential amino acids, but the pathogen can overcome this by de novo synthesis. This study sheds light on the importance of histidine biosynthesis for the pathogenesis of Mtb and reveals a potential link between histidine metabolism and Mtb infection.
COMMUNICATIONS BIOLOGY
(2021)
Review
Cell Biology
Konradin F. Muskens, Caroline A. Lindemans, Mirjam E. Belderbos
Summary: GvHD is a major complication of HCT, causing severe hematopoietic dysfunction. Immune activation during GvHD damages hematopoietic stem cells and their niche in the bone marrow, leading to reduced functionality. Complications and treatments associated with HCT exacerbate hematopoietic dysfunction.
Article
Biochemistry & Molecular Biology
Michael J. Workman, Elissa Troisi, Stephan R. Targan, Clive N. Svendsen, Robert J. Barrett
Summary: This study confirmed the fidelity of using iPSC-derived HIO modeling system to evaluate intestinal epithelium alterations in response to IFN-gamma, showing upregulation of several genes previously associated with IFN-gamma response in other cell types. The results also indicated that similar gene expression changes and pathways were observed in datasets comparing IBD patients with healthy controls, suggesting the potential of this model in studying gastrointestinal conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Cell & Tissue Engineering
Fiona Carty, Hazel Dunbar, Ian J. Hawthorne, Anthony E. Ting, Samantha R. Stubblefield, Wouter Van't Hof, Karen English
Summary: Cell-based therapy for the treatment of inflammatory disorders has shown efficacy in some but not all patients, highlighting the need for strategies to enhance therapeutic efficacy. Activation of IFN-gamma has been shown to enhance human MAPC efficacy and retention in a model of acute GvHD. Additionally, the involvement of PPAR delta in influencing MAPC efficacy in vivo has been highlighted, suggesting the importance of understanding the disease microenvironment for successful cell-based therapies.
STEM CELLS TRANSLATIONAL MEDICINE
(2021)
Review
Immunology
Fathima A. Mohamed, Govindarajan Thangavelu, Stephanie Y. Rhee, Peter T. Sage, Roddy S. O'Connor, Jeffrey C. Rathmell, Bruce R. Blazar
Summary: The therapeutic efficacy of allo-HSCT is limited by the development of GVHD, with immune dysregulation leading to expansion of alloreactive cells and reduction in regulatory cells. New therapies are needed to restore the balance between effector and regulatory immune cells while preserving the beneficial graft-versus-tumor effect.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Saurabh Kumar Gupta, Dievya Gohil, Deepshikha Dutta, Girish Ch Panigrahi, Puja Gupta, Kajal Dalvi, Twinkle Khanka, Subhash Yadav, Rajiv Kumar Kaushal, Akanksha Chichra, Sachin Punatar, Anant Gokarn, Sumeet Mirgh, Nishant Jindal, Lingaraj Nayak, Prasanth R. Tembhare, Syed Khizer Hasan, Santosh Kumar Sandur, Lal Hingorani, Navin Khattry, Vikram Gota
Summary: Researchers have found that Withaferin-A (WA), a phytomolecule obtained from Withania somnifera, has significant efficacy in preventing and treating acute graft versus host disease (aGvHD), which accounts for a significant proportion of non-relapse mortality and morbidity in patients undergoing allogeneic hematopoietic stem cell transplantation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2023)
Review
Immunology
Xianjing Cheng, Ruihao Huang, Shiqin Huang, Wei Fan, Rongdi Yuan, Xiaoqi Wang, Xi Zhang
Summary: Ocular graft-versus-host disease (GVHD) is a serious complication after allogeneic hematopoietic stem cell transplantation. It greatly impacts the quality of life of affected individuals due to impaired visual function, pain, and other symptoms. However, the diagnosis and treatment of ocular GVHD pose challenges for hematologists and ophthalmologists, as there are no unified international criteria. This review explores the complex pathogenesis of ocular GVHD, providing a comprehensive summary of the disease's pathogenic mechanisms, related tear biomarkers, and clinical characteristics. Novel therapies based on these mechanisms are also discussed, offering new insights into ocular GVHD treatment.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Immunology
Rui Fu, Minghui Fang, Kai Xu, Jilong Ren, Jun Zou, Long Su, Xinxin Chen, PeiPei An, Dawei Yu, Meina Ka, Tang Hai, Ziyi Li, Wei Li, Yongguang Yang, Qi Zhou, Zheng Hu
Article
Immunology
Mohsen Khosravi-Maharlooei, HaoWei Li, Markus Hoelzl, Guiling Zhao, Amanda Ruiz, Aditya Misra, Yang Li, Nato Teteloshvili, Grace Nauman, Nichole Danzl, Xiaolan Ding, Elisha Y. Pinker, Aleksandar Obradovic, Yong-Guang Yang, Alina Iuga, Remi J. Creusot, Robert Winchester, Megan Sykes
Summary: This study evaluated the role of the thymus in development of multi-organ autoimmunity in HIS mice and found that T cells were crucial for disease development. Mice with a native mouse thymus developed disease earlier than those with a thymocyte-depleted human thymus graft. Failure to tolerize human T cells recognizing mouse antigens may explain eventual disease development.
JOURNAL OF AUTOIMMUNITY
(2021)
Review
Cell Biology
Long Su, Zheng Hu, Yong-Guang Yang
Summary: CXCR4 is expressed on leukemia cells and hematopoietic stem cells, and its regulation plays a crucial role in the retention and migration of these cells in the bone marrow microenvironment. While CXCR4 antagonists can mobilize leukemia cells for effective eradication, drug-resistant leukemia cells may not be affected by these antagonists, indicating alternative pathways in leukemia cell migration.
CELL PROLIFERATION
(2021)
Article
Biochemistry & Molecular Biology
Ye Wang, Wei Shen, Shuhan Liu, Ge Zhu, Xiandi Meng, Kuirong Mao, Jialiang Wang, Yong-Guang Yang, Chunsheng Xiao, Tianmeng Sun
Summary: The synthetic cationic anticancer polypeptide (ACPP) can induce immunogenic cancer cell death (ICD), enhance dendritic cell activation, increase natural killer cell levels, and effectively reprogram the tumor immunosuppressive microenvironment, with the anticancer immunity induced by ACPP being dose-dependent and capable of completely eliminating established tumors in 40% of cases.
MACROMOLECULAR BIOSCIENCE
(2021)
Article
Immunology
Long Su, Ming-Hui Fang, Jun Zou, Su-Jun Gao, Xiao-Yi Gu, Xian-Di Meng, Xue Wang, Zheng Hu, Yong-Guang Yang
Summary: The study showed that posttransplant treatment with the CXCR4 antagonist AMD3100 significantly improved the eradication of leukemia cells in the BM, enhanced GVL effects, and promoted donor hematopoietic engraftment. Additionally, posttransplant treatment with AMD3100 had no detectable deleterious effect related to GVHD.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Immunology
Yixin Wang, Lei Wang, Cong Fu, Xue Wang, Siyao Zuo, Chang Shu, Yanhong Shan, Jin He, Qi Zhou, Wei Li, Yong-Guang Yang, Zheng Hu, Shucheng Hua
Summary: This study utilized a humanized mouse model with human lung tissue xenografts to investigate the immunopathogenesis and therapeutic interventions of viral respiratory diseases. The findings highlight the importance of tissue-resident memory T cells and viral Ag-specific T cells in the immune response against respiratory viruses.
JOURNAL OF IMMUNOLOGY
(2022)
Review
Materials Science, Biomaterials
Ge Zhu, Yong-Guang Yang, Tianmeng Sun
Summary: Vaccination plays a crucial role in preventing diseases, but there are challenges in clinical trials. The development of drug delivery systems may help improve the efficacy of vaccines.
BIOMATERIALS SCIENCE
(2022)
Article
Surgery
Yue Hou, Yanbao Xin, Shuhan Liu, Yong Li, Xiandi Meng, Jialiang Wang, Zhonggao Xu, Tianmeng Sun, Yong-Guang Yang
Summary: In this study, a nanotechnology-based therapy targeting TSP-1 was developed to prevent renal ischemia-reperfusion injury (IRI). The biocompatible nanoparticles effectively adsorbed and neutralized TSP-1, providing strong protection against renal IRI.
AMERICAN JOURNAL OF TRANSPLANTATION
(2022)
Review
Cell & Tissue Engineering
Ying Li, Jie Hao, Zheng Hu, Yong-Guang Yang, Qi Zhou, Liguang Sun, Jun Wu
Summary: This study summarized 79 clinical trials involving the use of MSCs to prevent or treat GVHD, analyzing their characteristics and results. The researchers aimed to gain a comprehensive understanding of the progress, challenges, limitations, and future trends in the field, and provide new perspectives for the design of future trials.
STEM CELL RESEARCH & THERAPY
(2022)
Article
Biochemistry & Molecular Biology
Jilong Ren, Dawei Yu, Jing Wang, Kai Xu, Yanan Xu, Renren Sun, Peipei An, Chongyang Li, Guihai Feng, Ying Zhang, Xiangpeng Dai, Hongye Zhao, Zhengzhu Wang, Zhiqiang Han, Haibo Zhu, Yuchun Ding, Xiaoyan You, Xueqin Liu, Meng Wu, Lin Luo, Ziyi Li, Yong-Guang Yang, Zheng Hu, Hong-Jiang Wei, Liangpeng Ge, Tang Hai, Wei Li
Summary: We successfully generated pig models with severe immunodeficiency that could construct human liver tissues.
CELL AND BIOSCIENCE
(2022)
Article
Medicine, Research & Experimental
Minghui Fang, Jun Zou, Fei Xu, Xue Wang, Shucheng Hua, Qi Zhou, Yong-guang Yang, Zheng Hu
Summary: The development of an animal model to study immune responses to pig vessels is crucial for improving immunosuppressive strategies in clinical pig organ transplantation.
XENOTRANSPLANTATION
(2023)
Article
Cell Biology
Xiaoling Zhang, Xianling Cong, Xiangting Jin, Yu'e Liu, Tong Zhang, Xinyuan Fan, Xiyao Shi, Xiaoying Zhang, Xue Wang, Yong-Guang Yang, Xiangpeng Dai
Summary: The transcription factor MYCN is frequently amplified and overexpressed in various cancers, and is considered undruggable. In this study, BRCA1-associated protein-1 (BAP1) is identified as an upstream regulator that stabilizes MYCN through direct binding. Depletion of BAP1 inhibits neuroblastoma tumor cell growth and migration, and confers cellular resistance to BET protein inhibitor JQ1 and Aurora A kinase inhibitor Alisertib. Our findings suggest that BAP1 could be a potential therapeutic target for MYCN-amplified neuroblastoma.
CELL DEATH & DISEASE
(2023)
Article
Cell Biology
Rui Han, Wenjie Zhao, Xu Gu, Xue Gao, Yong-Guang Yang, Xiaoling Zhang
Summary: In this study, orthotopic and subcutaneous CDX neuroblastoma models were compared. The orthotopic model showed faster tumor growth, increased expression of PHOX2B and GAB2, and exhibited multiple organ metastasis resembling patients, while subcutaneous model mainly had lung metastasis. Both models responded similarly to cyclophosphamide treatment.
Article
Immunology
Dan Li, Wei Xiong, Yuande Wang, Jin Feng, Yuexi He, Juan Du, Jing Wang, Meixiang Yang, Hui Zeng, Yong-Guang Yang, Ning Wu, Shasha Chen, Zhongjun Dong
Summary: The interaction of SIRP alpha with CD47 is an important mechanism for preventing macrophage phagocytosis, but there are poorly defined CD47-independent mechanisms. In this study, the researchers discovered that SLAM family receptors (SFRs) play a critical role in constraining macrophage phagocytosis. These receptors are able to inhibit eat me signals and work in combination with CD47. This tolerance mechanism is compromised in patients with blood diseases, and the loss of SFRs enhances macrophage rejection of tumors.
SCIENCE IMMUNOLOGY
(2022)
Article
Medicine, Research & Experimental
Ting Li, Yanan Lv, Renren Sun, Yong-Guang Yang, Zheng Hu, Guoyue Lv
Summary: The lack of recipient CD47-donor SIRP alpha interaction does not significantly exacerbate platelet and RBC depletion following liver xenotransplantation. Studies using syngeneic mouse liver transplantation model and rat liver xenotransplantation model suggest that CD47-SIRP alpha signaling is not a significant risk factor for LXT-induced thrombocytopenia and anemia.
XENOTRANSPLANTATION
(2021)
