Controlling trisulfide modification in recombinant monoclonal antibody produced in fed-batch cell culture

Characterization and Comparison of Disulfide Linkages and Scrambling Patterns in Therapeutic Monoclonal Antibodies: Using LC-MS with Electron Transfer Dissociation

(2011) Yi Wang et al.   ANALYTICAL CHEMISTRY

Performance of high intensity fed-batch mammalian cell cultures in disposable bioreactor systems

(2011) John Paul Smelko et al.   BIOTECHNOLOGY PROGRESS

Manufacturing recombinant proteins in kg-ton quantities using animal cells in bioreactors

(2011) Maria De Jesus et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Antibody-based therapeutics to watch in 2011

(2011) Janice M. Reichert   mAbs

Characterization of trisulfide modification in antibodies

(2010) Sheng Gu et al.   ANALYTICAL BIOCHEMISTRY

Ranking the Susceptibility of Disulfide Bonds in Human IgG1 Antibodies by Reduction, Differential Alkylation, and LC−MS Analysis

(2010) Hongcheng Liu et al.   ANALYTICAL CHEMISTRY

Trisulfides in Proteins

(2010) Rasmus Wedel Nielsen et al.   ANTIOXIDANTS & REDOX SIGNALING

Control of misincorporation of serine for asparagine during antibody production using CHO cells

(2010) Anurag Khetan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Understanding the intracellular effect of enhanced nutrient feeding toward high titer antibody production process

(2010) Marcella Yu et al.   BIOTECHNOLOGY AND BIOENGINEERING

Current perspectives on therapeutic antibodies

(2010) Soomin Yoon et al.   BIOTECHNOLOGY AND BIOPROCESS ENGINEERING

Maximizing productivity of CHO cell-based fed-batch culture using chemically defined media conditions and typical manufacturing equipment

(2010) Yao-Ming Huang et al.   BIOTECHNOLOGY PROGRESS

Efficient on-column conversion of IgG1 trisulfide linkages to native disulfides in tandem with Protein A affinity chromatography

(2010) Hiromasa Aono et al.   JOURNAL OF CHROMATOGRAPHY A

Metrics for antibody therapeutics development

(2010) Janice M. Reichert   mAbs

Cell culture processes for monoclonal antibody production

(2010) Feng Li et al.   mAbs

Biopharmaceutical benchmarks 2010

(2010) Gary Walsh   NATURE BIOTECHNOLOGY

Recent advances in large-scale production of monoclonal antibodies and related proteins

(2010) Abhinav A. Shukla et al.   TRENDS IN BIOTECHNOLOGY

Evidence for Trisulfide Bonds in a Recombinant Variant of a Human IgG2 Monoclonal Antibody

(2009) Pavlo Pristatsky et al.   ANALYTICAL CHEMISTRY

Whole tissue hydrogen sulfide concentrations are orders of magnitude lower than presently accepted values

(2008) Julie Furne et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Monoclonal Antibodies as Innovative Therapeutics

(2008) Janice Reichert   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Heterogeneity of Monoclonal Antibodies Revealed by Charge-Sensitive Methods

(2008) J. Vlasak et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Applications of CE SDS gel in development of biopharmaceutical antibody-based products

(2008) Richard R. Rustandi et al.   ELECTROPHORESIS

Mass spectrometry for structural characterization of therapeutic antibodies

(2008) Zhongqi Zhang et al.   MASS SPECTROMETRY REVIEWS

Removal of Cysteinylation from an Unpaired Sulfhydryl in the Variable Region of a Recombinant Monoclonal IgG1 Antibody Improves Homogeneity, Stability, and Biological Activity

(2007) Douglas D. Banks et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Heterogeneity of Monoclonal Antibodies

(2007) Hongcheng Liu et al.   JOURNAL OF PHARMACEUTICAL SCIENCES