Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells
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Title
Identifying and engineering promoters for high level and sustainable therapeutic recombinant protein production in cultured mammalian cells
Authors
Keywords
Mammalian cells, Promoter engineering, Promoter identification, Recombinant protein production
Journal
BIOTECHNOLOGY LETTERS
Volume 36, Issue 8, Pages 1569-1579
Publisher
Springer Nature
Online
2014-04-15
DOI
10.1007/s10529-014-1523-4
References
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Note: Only part of the references are listed.- Identification of a novel endogenous regulatory element in Chinese hamster ovary cells by promoter trap
- (2013) Janice Chen et al. JOURNAL OF BIOTECHNOLOGY
- Development of a highly-efficient CHO cell line generation system with engineered SV40E promoter
- (2013) Lianchun Fan et al. JOURNAL OF BIOTECHNOLOGY
- Dynamic gene expression for metabolic engineering of mammalian cells in culture
- (2013) Huong Le et al. METABOLIC ENGINEERING
- Promoter engineering: Recent advances in controlling transcription at the most fundamental level
- (2012) John Blazeck et al. Biotechnology Journal
- A minimal cytomegalovirus intron A variant can improve transgene expression in different mammalian cell lines
- (2012) L. S. Quilici et al. BIOTECHNOLOGY LETTERS
- A comparison study on feature selection of DNA structural properties for promoter prediction
- (2012) Yanglan Gan et al. BMC BIOINFORMATICS
- Identification of a novel enhancer that binds Sp1 and contributes to induction of cold-inducible RNA-binding protein (cirp) expression in mammalian cells
- (2012) Yasuhiko Sumitomo et al. BMC BIOTECHNOLOGY
- What's fueling the biotech engine—2011 to 2012
- (2012) Saurabh Aggarwal NATURE BIOTECHNOLOGY
- Fresh from the biotech pipeline 2011
- (2012) Jim Kling NATURE BIOTECHNOLOGY
- Systematic dissection and optimization of inducible enhancers in human cells using a massively parallel reporter assay
- (2012) Alexandre Melnikov et al. NATURE BIOTECHNOLOGY
- Massively parallel functional dissection of mammalian enhancers in vivo
- (2012) Rupali P Patwardhan et al. NATURE BIOTECHNOLOGY
- ChIP–seq and beyond: new and improved methodologies to detect and characterize protein–DNA interactions
- (2012) Terrence S. Furey NATURE REVIEWS GENETICS
- A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies
- (2011) Minsoo Kim et al. BIOTECHNOLOGY AND BIOENGINEERING
- Promoter methylation and transgene copy numbers predict unstable protein production in recombinant chinese hamster ovary cell lines
- (2011) Andrea Osterlehner et al. BIOTECHNOLOGY AND BIOENGINEERING
- Identification of a novel temperature sensitive promoter in cho cells
- (2011) Haruthai Thaisuchat et al. BMC BIOTECHNOLOGY
- Discriminative prediction of mammalian enhancers from DNA sequence
- (2011) D. Lee et al. GENOME RESEARCH
- Open chromatin defined by DNaseI and FAIRE identifies regulatory elements that shape cell-type identity
- (2011) L. Song et al. GENOME RESEARCH
- Sustained, high transgene expression in liver with plasmid vectors using optimized promoter-enhancer combinations
- (2011) Terese Magnusson et al. JOURNAL OF GENE MEDICINE
- The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line
- (2011) Xun Xu et al. NATURE BIOTECHNOLOGY
- Enhancer function: new insights into the regulation of tissue-specific gene expression
- (2011) Chin-Tong Ong et al. NATURE REVIEWS GENETICS
- Exploiting Nucleotide Composition to Engineer Promoters
- (2011) Manfred G. Grabherr et al. PLoS One
- A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line
- (2010) Michael Kuczewski et al. Biotechnology Journal
- DNA methylation contributes to loss in productivity of monoclonal antibody-producing CHO cell lines
- (2010) Yuansheng Yang et al. JOURNAL OF BIOTECHNOLOGY
- Evaluating regulatory elements of human cytomegalovirus major immediate early gene for enhancing transgene expression levels in CHO K1 and HEK293 cells
- (2010) Mariati et al. JOURNAL OF BIOTECHNOLOGY
- Identification of CHO Endogenous Gene Regulatory Elements
- (2010) Jens Pontiller et al. MOLECULAR BIOTECHNOLOGY
- ChIP-Seq identification of weakly conserved heart enhancers
- (2010) Matthew J Blow et al. NATURE GENETICS
- The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation
- (2010) Sohail Malik et al. NATURE REVIEWS GENETICS
- Synthesis of high-quality libraries of long (150mer) oligonucleotides by a novel depurination controlled process
- (2010) Emily M. LeProust et al. NUCLEIC ACIDS RESEARCH
- Synthetic design of strong promoters
- (2010) M. R. Schlabach et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Eukaryotic and prokaryotic promoter prediction using hybrid approach
- (2010) Hao Lin et al. THEORY IN BIOSCIENCES
- The Biology of Chromatin Remodeling Complexes
- (2009) Cedric R. Clapier et al. Annual Review of Biochemistry
- Regulation of gene expression via the core promoter and the basal transcriptional machinery
- (2009) Tamar Juven-Gershon et al. DEVELOPMENTAL BIOLOGY
- Enhancers: The abundance and function of regulatory sequences beyond promoters
- (2009) Michael Bulger et al. DEVELOPMENTAL BIOLOGY
- Guidelines to cell engineering for monoclonal antibody production
- (2009) A. Rita Costa et al. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
- A study of monoclonal antibody-producing CHO cell lines: What makes a stable high producer?
- (2008) Janet Chusainow et al. BIOTECHNOLOGY AND BIOENGINEERING
- Identification of CHO Endogenous Promoter Elements Based on a Genomic Library Approach
- (2008) Jens Pontiller et al. MOLECULAR BIOTECHNOLOGY
- Generic eukaryotic core promoter prediction using structural features of DNA
- (2007) T. Abeel et al. GENOME RESEARCH
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