A functional high-content miRNA screen identifies miR-30 family to boost recombinant protein production in CHO cells

Downregulation of the miR-30 family microRNAs contributes to endoplasmic reticulum stress in cardiac muscle and vascular smooth muscle cells

(2014) Ming Chen et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

CHO microRNA engineering is growing up: Recent successes and future challenges

(2013) Vaibhav Jadhav et al.   BIOTECHNOLOGY ADVANCES

Anti-cell death engineering of CHO cells: Co-overexpression of Bcl-2 for apoptosis inhibition, Beclin-1 for autophagy induction

(2013) Jae Seong Lee et al.   BIOTECHNOLOGY AND BIOENGINEERING

CHO cell culture longevity and recombinant protein yield are enhanced by depletion of miR-7 activity via sponge decoy vectors

(2013) Noelia Sanchez et al.   Biotechnology Journal

Breaking limitations of complex culture media: Functional non-viral miRNA delivery into pharmaceutical production cell lines

(2013) Simon Fischer et al.   JOURNAL OF BIOTECHNOLOGY

The Role of miRNAs in Regulating Gene Expression Networks

(2013) Allan M. Gurtan et al.   JOURNAL OF MOLECULAR BIOLOGY

Stable inhibition of mmu-miR-466h-5p improves apoptosis resistance and protein production in CHO cells

(2013) Aliaksandr Druz et al.   METABOLIC ENGINEERING

Stable microRNA expression enhances therapeutic antibody productivity of Chinese hamster ovary cells

(2013) Michaela Strotbek et al.   METABOLIC ENGINEERING

Chinese hamster genome sequenced from sorted chromosomes

(2013) Karina Brinkrolf et al.   NATURE BIOTECHNOLOGY

A screening method to assess biological effects of microRNA overexpression in Chinese hamster ovary cells

(2012) Vaibhav Jadhav et al.   BIOTECHNOLOGY AND BIOENGINEERING

MicroRNA-30c targets cytoskeleton genes involved in breast cancer cell invasion

(2012) Jessica Bockhorn et al.   BREAST CANCER RESEARCH AND TREATMENT

miR-30 Family Members Negatively Regulate Osteoblast Differentiation

(2012) Tingting Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Computational identification of microRNA gene loci and precursor microRNA sequences in CHO cell lines

(2012) Matthias Hackl et al.   JOURNAL OF BIOTECHNOLOGY

Glucose depletion activates mmu-miR-466h-5p expression through oxidative stress and inhibition of histone deacetylation

(2012) A. Druz et al.   NUCLEIC ACIDS RESEARCH

Effect of miR-21 and miR-30b/c on TRAIL-induced apoptosis in glioma cells

(2012) C Quintavalle et al.   ONCOGENE

miRNAs – pathway engineering of CHO cell factories that avoids translational burdening

(2012) Matthias Hackl et al.   TRENDS IN BIOTECHNOLOGY

Profiling conserved microRNA expression in recombinant CHO cell lines using illumina sequencing

(2011) Stephanie Hammond et al.   BIOTECHNOLOGY AND BIOENGINEERING

A simplified universal genomic DNA extraction protocol suitable for PCR

(2011) T.Y. Wang et al.   GENETICS AND MOLECULAR RESEARCH

Next-generation sequencing of the Chinese hamster ovary microRNA transcriptome: Identification, annotation and profiling of microRNAs as targets for cellular engineering

(2011) Matthias Hackl et al.   JOURNAL OF BIOTECHNOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Evolution of microRNA diversity and regulation in animals

(2011) Eugene Berezikov   NATURE REVIEWS GENETICS

Methods in mammalian cell line engineering: from random mutagenesis to sequence-specific approaches

(2010) Oliver Krämer et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Generation of stable, high-producing cho cell lines by lentiviral vector-mediated gene transfer in serum-free suspension culture

(2010) Agata Oberbek et al.   BIOTECHNOLOGY AND BIOENGINEERING

MicroRNAs: tiny targets for engineering CHO cell phenotypes?

(2010) Niall Barron et al.   BIOTECHNOLOGY LETTERS

Profiling highly conserved microrna expression in recombinant IgG-producing and parental Chinese hamster ovary cells

(2010) Nan Lin et al.   BIOTECHNOLOGY PROGRESS

Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7

(2010) N. Barron et al.   JOURNAL OF BIOTECHNOLOGY

Mir-30 reduction maintains self-renewal and inhibits apoptosis in breast tumor-initiating cells

(2010) F Yu et al.   ONCOGENE

miR-30 Regulates Mitochondrial Fission through Targeting p53 and the Dynamin-Related Protein-1 Pathway

(2010) Jincheng Li et al.   PLoS Genetics

Mcl-1 overexpression leads to higher viabilities and increased production of humanized monoclonal antibody in Chinese hamster ovary cells

(2009) Brian S. Majors et al.   BIOTECHNOLOGY PROGRESS

Patterns of microRNA expression characterize stages of human B-cell differentiation

(2009) Jenny Zhang et al.   BLOOD

MicroRNAs: Target Recognition and Regulatory Functions

(2009) David P. Bartel   CELL

Recognizing and avoiding siRNA off-target effects for target identification and therapeutic application

(2009) Aimee L. Jackson et al.   NATURE REVIEWS DRUG DISCOVERY

Analyzing real-time PCR data by the comparative CT method

(2008) Thomas D Schmittgen et al.   Nature Protocols

Mechanisms of post-transcriptional regulation by microRNAs: are the answers in sight?

(2008) Witold Filipowicz et al.   NATURE REVIEWS GENETICS

Pre-miRNA Loop Nucleotides Control the Distinct Activities of mir-181a-1 and mir-181c in Early T Cell Development

(2008) Gwen Liu et al.   PLoS One

Gene Regulation by Transcription Factors and MicroRNAs

(2008) O. Hobert   SCIENCE

MicroRNAs as targets for engineering of CHO cell factories

(2008) Dethardt Müller et al.   TRENDS IN BIOTECHNOLOGY