Production of Plant Made Pharmaceuticals: From Plant Host to Functional Protein

The green vaccine: A global strategy to combat infectious and autoimmune diseases

(2014) Abdoreza Davoodi-Semiromi et al.   Human vaccines & immunotherapeutics

N-Glycosylation engineering of plants for the biosynthesis of glycoproteins with bisected and branched complex N-glycans

(2011) Alexandra Castilho et al.   GLYCOBIOLOGY

β-N-Acetylhexosaminidases HEXO1 and HEXO3 Are Responsible for the Formation of PaucimannosidicN-Glycans inArabidopsis thaliana

(2011) Eva Liebminger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein body-inducing fusions for high-level production and purification of recombinant proteins in plants

(2011) Andrew J. Conley et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of Complex Multiantennary N-Glycans in Nicotiana benthamiana Plants

(2011) B. Nagels et al.   PLANT PHYSIOLOGY

Expression of Antibody Fragments with a Controlled N-Glycosylation Pattern and Induction of Endoplasmic Reticulum-Derived Vesicles in Seeds of Arabidopsis

(2011) A. Loos et al.   PLANT PHYSIOLOGY

Engineering of glycosylation in yeast and other fungi: current state and perspectives

(2010) Karen De Pourcq et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Advances in plant molecular farming

(2010) Olawole O. Obembe et al.   BIOTECHNOLOGY ADVANCES

Engineering of N. benthamiana L. plants for production of N-acetylgalactosamine-glycosylated proteins - towards development of a plant-based platform for production of protein therapeutics with mucin type O-glycosylation

(2010) Sasha M Daskalova et al.   BMC BIOTECHNOLOGY

PharmaPlant: the new frontier in vaccines

(2010) Franco M Buonaguro et al.   Expert Review of Vaccines

N-Glycosylation engineering of lepidopteran insect cells by the introduction of the  1,4-N-acetylglucosaminyltransferase III gene

(2010) T. Okada et al.   GLYCOBIOLOGY

In PlantaProtein Sialylation through Overexpression of the Respective Mammalian Pathway

(2010) Alexandra Castilho et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The N-glycan processing enzymes α-mannosidase and β-D-N-acetylhexosaminidase are involved in ripening-associated softening in the non-climacteric fruits of capsicum

(2010) Sumit Ghosh et al.   JOURNAL OF EXPERIMENTAL BOTANY

Pfizer stakes a claim in plant cell–made biopharmaceuticals

(2010) Mark Ratner   NATURE BIOTECHNOLOGY

Plant-made vaccines for humans and animals

(2010) Edward P. Rybicki   PLANT BIOTECHNOLOGY JOURNAL

Plant-specific glycosylation patterns in the context of therapeutic protein production

(2010) Véronique Gomord et al.   PLANT BIOTECHNOLOGY JOURNAL

Seed-based expression systems for plant molecular farming

(2010) Joseph Boothe et al.   PLANT BIOTECHNOLOGY JOURNAL

Success stories in molecular farming-a brief overview

(2010) Loïc Faye et al.   PLANT BIOTECHNOLOGY JOURNAL

Expression and recovery of biologically active recombinant Apolipoprotein AIMilano from transgenic safflower (Carthamus tinctorius) seeds

(2010) Cory L. Nykiforuk et al.   PLANT BIOTECHNOLOGY JOURNAL

Production of monoclonal antibodies with a controlled N-glycosylation pattern in seeds of Arabidopsis thaliana

(2010) Andreas Loos et al.   PLANT BIOTECHNOLOGY JOURNAL

Tomato is a suitable material for producing recombinant miraculin protein in genetically stable manner

(2010) Megumu Yano et al.   PLANT SCIENCE

Enhancement of fruit shelf life by suppressing N-glycan processing enzymes

(2010) V. S. Meli et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytosolic N-terminal arginine-based signals together with a luminal signal target a type II membrane protein to the plant ER

(2009) Aurélia Boulaflous et al.   BMC PLANT BIOLOGY

Synthesis of Lewis X epitopes on plant N-glycans

(2009) Gerard J.A. Rouwendal et al.   CARBOHYDRATE RESEARCH

Cotranslational and Posttranslational N-Glycosylation of Polypeptides by Distinct Mammalian OST Isoforms

(2009) Catalina Ruiz-Canada et al.   CELL

Discovery and development of biopharmaceuticals: current issues

(2009) William R Strohl et al.   CURRENT OPINION IN BIOTECHNOLOGY

Improved Virus Neutralization by Plant-produced Anti-HIV Antibodies with a Homogeneous β1,4-GalactosylatedN-Glycan Profile

(2009) Richard Strasser et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

High-frequency modification of plant genes using engineered zinc-finger nucleases

(2009) Jeffrey A. Townsend et al.   NATURE

Precise genome modification in the crop species Zea mays using zinc-finger nucleases

(2009) Vipula K. Shukla et al.   NATURE

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Transient co-expression for fast and high-yield production of antibodies with human-likeN-glycans in plants

(2009) Louis-P. Vézina et al.   PLANT BIOTECHNOLOGY JOURNAL

Influence of elastin-like peptide fusions on the quantity and quality of a tobacco-derived human immunodeficiency virus-neutralizing antibody

(2009) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

Class I  -Mannosidases Are Required for N-Glycan Processing and Root Development in Arabidopsis thaliana

(2009) E. Liebminger et al.   PLANT CELL

LEW3, encoding a putative α-1,2-mannosyltransferase (ALG11) in N-linked glycoprotein, plays vital roles in cell-wall biosynthesis and the abiotic stress response in Arabidopsis thaliana

(2009) Min Zhang et al.   PLANT JOURNAL

Targeted transgene integration in plant cells using designed zinc finger nucleases

(2009) Charles Q. Cai et al.   PLANT MOLECULAR BIOLOGY

Hydrophobin Fusions for High-Level Transient Protein Expression and Purification in Nicotiana benthamiana

(2009) J. J. Joensuu et al.   PLANT PHYSIOLOGY

Evaluation by double-blind placebo-controlled oral challenge of the clinical relevance of IgE antibodies against plant glycans

(2008) A. Mari et al.   ALLERGY

Cold stress changes the concanavalin A-positive glycosylation pattern of proteins expressed in the basal parts of rice leaf sheaths

(2008) S. Komatsu et al.   AMINO ACIDS

A CMP-sialic acid transporter cloned from Arabidopsis thaliana

(2008) Hans Bakker et al.   CARBOHYDRATE RESEARCH

Suppression of  -N-acetylglucosaminidase in the N-glycosylation pathway for complex glycoprotein formation in Drosophila S2 cells

(2008) Y. K. Kim et al.   GLYCOBIOLOGY

N-glycan trimming by glucosidase II is essential for Arabidopsis development

(2008) Pravina Soussillane et al.   GLYCOCONJUGATE JOURNAL

Bioactive recombinant human lactoferrin, derived from rice, stimulates mammalian cell growth

(2008) N. Huang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL

Does Rft1 flip an N-glycan lipid precursor?

(2008) Christian G. Frank et al.   NATURE

A protocol for expression of foreign genes in chloroplasts

(2008) Dheeraj Verma et al.   Nature Protocols

Down-regulated expression of plant-specific glycoepitopes in alfalfa

(2008) Christophe Sourrouille et al.   PLANT BIOTECHNOLOGY JOURNAL

Biochemical and functional characterization of anti-HIV antibody-ELP fusion proteins from transgenic plants

(2008) Doreen M. Floss et al.   PLANT BIOTECHNOLOGY JOURNAL

Generation of glyco-engineered Nicotiana benthamiana for the production of monoclonal antibodies with a homogeneous human-like N-glycan structure

(2008) Richard Strasser et al.   PLANT BIOTECHNOLOGY JOURNAL

Identification of the Gene Encoding the  1,3-Mannosyltransferase (ALG3) in Arabidopsis and Characterization of Downstream N-Glycan Processing

(2008) M. Henquet et al.   PLANT CELL

Construction of a Functional CMP-Sialic Acid Biosynthesis Pathway in Arabidopsis

(2008) A. Castilho et al.   PLANT PHYSIOLOGY

Maize plants: An ideal production platform for effective and safe molecular pharming

(2008) Koreen Ramessar et al.   PLANT SCIENCE

Salt tolerance of Arabidopsis thaliana requires maturation of N-glycosylated proteins in the Golgi apparatus

(2008) J. S. Kang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA