期刊
BIOTECHNOLOGY JOURNAL
卷 7, 期 9, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/biot.201200032
关键词
Glycobiotechnology; Glyco-engineering; N-Glycosylation; Plant biotechnology; Recombinant proteins
资金
- Laura Bassi Centres of Expertise [822757]
- Fonds zur Forderung der wis-senschaftlichen Forschung FWF [L575-B13]
It is now possible to produce complex human proteins, largely correctly folded and N-glycosylated, in plants. Much effort has been invested in engineering expression technologies to develop products with superior characteristics. The results have begun to show success in controlling important posttranslational modifications such as N-glycosylation. With the emerging data increasingly indicating the significance of proper N-glycosylation for the efficacy of a drug, glyco-engineering has become an important issue not only for academia but also for the biopharmaceutical industry. Plants have demonstrated a high degree of tolerance to changes in the N-glycosylation pathway, allowing recombinant proteins to be modified into human-like structures in a specific and controlled manner. Frequently the results are a largely homogeneously glycosylated product, currently unrivalled by that of any other expression platforms. This review provides a comprehensive analysis of recent advances in plant N-glyco-engineering in the context of the expression of therapeutically relevant proteins, highlighting both the challenges and successes in the application of such powerful technologies.
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