Functional heterogeneity and heritability in CHO cell populations

A mechanistic understanding of production instability in CHO cell lines expressing recombinant monoclonal antibodies

(2011) Minsoo Kim et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell line specific control of polyethylenimine-mediated transient transfection optimized with “Design of experiments” methodology

(2011) Ben C. Thompson et al.   BIOTECHNOLOGY PROGRESS

Genetic Variation and the Fate of Beneficial Mutations in Asexual Populations

(2011) Gregory I. Lang et al.   GENETICS

Large scale microarray profiling and coexpression network analysis of CHO cells identifies transcriptional modules associated with growth and productivity

(2011) Colin Clarke et al.   JOURNAL OF BIOTECHNOLOGY

The genomic sequence of the Chinese hamster ovary (CHO)-K1 cell line

(2011) Xun Xu et al.   NATURE BIOTECHNOLOGY

Variation in the mutation rate across mammalian genomes

(2011) Alan Hodgkinson et al.   NATURE REVIEWS GENETICS

Origins of regulated cell-to-cell variability

(2011) Berend Snijder et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Selection of CHO host cell subclones with increased specific antibody production rates by repeated cycles of transient transfection and cell sorting

(2010) Johannes Pichler et al.   BIOTECHNOLOGY AND BIOENGINEERING

Ectopic expression of human mTOR increases viability, robustness, cell size, proliferation, and antibody production of chinese hamster ovary cells

(2010) Imke A.J. Dreesen et al.   BIOTECHNOLOGY AND BIOENGINEERING

Overexpression of taurine transporter in Chinese hamster ovary cells can enhance cell viability and product yield, while promoting glutamine consumption

(2010) Hisahiro Tabuchi et al.   BIOTECHNOLOGY AND BIOENGINEERING

Cell line-specific control of recombinant monoclonal antibody production by CHO cells

(2010) Peter M. O'Callaghan et al.   BIOTECHNOLOGY AND BIOENGINEERING

Strategies for selecting Recombinant CHO cell lines for cGMP manufacturing: Realizing the potential in bioreactors

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Strategies for selecting recombinant CHO cell lines for cGMP manufacturing: Improving the efficiency of cell line generation

(2010) Alison J. Porter et al.   BIOTECHNOLOGY PROGRESS

Engineering CHO cell growth and recombinant protein productivity by overexpression of miR-7

(2010) N. Barron et al.   JOURNAL OF BIOTECHNOLOGY

Variable Mutation Rates as an Adaptive Strategy in Replicator Populations

(2010) Michael Stich et al.   PLoS One

Population genetics of cancer cell clones: possible implications of cancer stem cells

(2010) Christopher T Naugler   Theoretical Biology and Medical Modelling

Engineering of a genome-reduced host: practical application of synthetic biology in the overproduction of desired secondary metabolites

(2010) Hong Gao et al.   Protein & Cell

The generation of stable, high MAb expressing CHO cell lines based on the artificial chromosome expression (ACE) technology

(2009) Malcolm L. Kennard et al.   BIOTECHNOLOGY AND BIOENGINEERING

N-linked glycosylation is an important parameter for optimal selection of cell lines producing biopharmaceutical human IgG

(2009) Patrick H. C. van Berkel et al.   BIOTECHNOLOGY PROGRESS

THE EFFECTS OF POPULATION BOTTLENECKS ON CLONAL INTERFERENCE, AND THE ADAPTATION EFFECTIVE POPULATION SIZE

(2009) Paulo R. A. Campos et al.   EVOLUTION

Protein and Genome Evolution in Mammalian Cells for Biotechnology Applications

(2009) Brian S. Majors et al.   MOLECULAR BIOTECHNOLOGY

Mechanisms of change in gene copy number

(2009) P. J. Hastings et al.   NATURE REVIEWS GENETICS

Intraclonal Protein Expression Heterogeneity in Recombinant CHO Cells

(2009) Warren Pilbrough et al.   PLoS One

Cell Growth and Size Homeostasis in Proliferating Animal Cells

(2009) A. Tzur et al.   SCIENCE

Impact of Genome Reduction on Bacterial Metabolism and Its Regulation

(2009) E. Yus et al.   SCIENCE

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Nature, Nurture, or Chance: Stochastic Gene Expression and Its Consequences

(2008) Arjun Raj et al.   CELL

Enhanced Recombinant Protein Productivity by Genome Reduction in Bacillus subtilis

(2008) T. Morimoto et al.   DNA RESEARCH

Clonal Interference, Multiple Mutations and Adaptation in Large Asexual Populations

(2008) C. A. Fogle et al.   GENETICS

The Repertoire and Dynamics of Evolutionary Adaptations to Controlled Nutrient-Limited Environments in Yeast

(2008) David Gresham et al.   PLoS Genetics