Review
Cardiac & Cardiovascular Systems
Yifei Zou, Henghe Shi, Ning Liu, He Wang, Xianjing Song, Bin Liu
Summary: Heat shock protein 27 (HSP27) is a small chaperone protein that is overexpressed in various cellular stress states and plays a crucial role in regulating proteostasis and cellular response to stress. It has been extensively studied in cardiovascular diseases, where it is involved in oxidative stress, inflammatory responses, apoptosis, and potentially serves as a diagnostic and therapeutic target. Targeting HSP27 shows promise for the treatment of cardiovascular diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2023)
Review
Physiology
Guangxin Peng, Xiaoling Tang, Yang Gui, Jing Yang, Lifang Ye, Liuyang Wu, Ya Hui Ding, Lihong Wang
Summary: TRPV1 plays a significant role in fibrotic diseases, regulating the fibrotic processes and potentially serving as a therapeutic target.
FRONTIERS IN PHYSIOLOGY
(2022)
Review
Cardiac & Cardiovascular Systems
Qianru Leng, Jie Ding, Meiyan Dai, Lei Liu, Qing Fang, Dao Wen Wang, Lujin Wu, Yan Wang
Summary: This paper elaborates on the roles of platelet-derived miRNAs in cardiovascular disease and cancer, emphasizing the importance of these molecules for human health and their critical roles in the occurrence and development of diseases.
FRONTIERS IN CARDIOVASCULAR MEDICINE
(2022)
Review
Immunology
Shihan Xu, Tingwei Zhang, Zhengguo Cao, Wenjie Zhong, Chuangwei Zhang, Han Li, Jinlin Song
Summary: Integrin-alpha 9 beta 1 is a crucial cell membrane receptor with complex signaling pathways. It plays important roles in regulating cell physiological states and is involved in various diseases such as cancer, autoimmune diseases, nerve injury, and thrombosis.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Mukul Jain, Nil Patil, Gholamreza Abdi, Maryam Abbasi Tarighat, Arifullah Mohammed, Muhammad Rajaei Ahmad Mohd Zain, Khang Wen Goh
Summary: Polyglutamine diseases are congenital neurodegenerative diseases caused by genomic abnormalities in specific disease-related genes. Protein aggregates play a toxic role in these diseases and lead to neuronal death. Autophagy, the catabolic process responsible for removing damaged organelles and toxic protein aggregates, is affected in these diseases due to changes in gene expression. Increasing autophagy vesicles may be a result of either increased autophagy or decreased autophagy flux. Modulating autophagy has been shown to enhance the dissolution of toxic aggregates and delay disease progression. This review analyzes the interaction between autophagy and polyglutamine diseases and establishes a therapeutic approach using autophagy-inducing drugs.
Review
Biochemistry & Molecular Biology
Nicoletta Braidotti, Suet Nee Chen, Carlin S. Long, Dan Cojoc, Orfeo Sbaizero
Summary: This review presents recent discoveries regarding the role of the mechanosensitive ion channel Piezo1 in various diseases, particularly in tumor progression and cardiac mechanobiology. Based on recent findings, Piezo1 could be upregulated in cardiac fibroblasts due to mechanical stress and pro-inflammatory stimuli after myocardial injury, leading to fibrosis progression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Immunology
Pan Shen, Xuan Deng, Zhe Chen, Xin Ba, Kai Qin, Ying Huang, Yao Huang, Tingting Li, Jiahui Yan, Shenghao Tu
Summary: SIRT1, as a member of the class III family of nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylases, plays a crucial role in the progression of various diseases, including autoimmune diseases. Modulating the functions of SIRT1 may serve as a potential therapeutic strategy for these diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Nan Li, Shan Shan, Xiu-Qin Li, Ting-Ting Chen, Meng Qi, Sheng-Nan Zhang, Zi-Ying Wang, Ling-Ling Zhang, Wei Wei, Wu-Yi Sun
Summary: G protein-coupled receptor kinase 2 (GRK2) plays important roles in regulating signaling pathways associated with fibrotic diseases. Recent research suggests that GRK2 could be a potential therapeutic target for fibrotic diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Pharmacology & Pharmacy
Wufei Ye, Xiongwen Lv, Songsen Gao, Yueran Li, Jiajie Luan, Sheng Wang
Summary: Fibrosis, characterized by the increase in fibrous connective tissue and the decrease in parenchymal cells in organs, can occur in various organs such as the heart, lung, liver, and kidney. N6-methyladenosine (m6A) modification, a common type of RNA modification, plays an important role in fibrosis by regulating RNA metabolism. This review summarizes the latest research on m6A modification in fibrosis and focuses on the mechanisms and roles of m6A modification in different organs.
BIOCHEMICAL PHARMACOLOGY
(2023)
Review
Medicine, Research & Experimental
Feng Hu, Meiyong Li, Fengyu Han, Qing Zhang, Yuhao Zeng, Weifang Zhang, Xiaoshu Cheng
Summary: Cardiac fibrosis is a common feature of heart disease, and TRPM7 protein plays a crucial role in its pathogenesis and development, making it a potential therapeutic target for stopping fibrotic cardiac diseases.
EXPERIMENTAL AND THERAPEUTIC MEDICINE
(2021)
Review
Immunology
Jiaqi Kang, Jie Wu, Qinjie Liu, Xiuwen Wu, Yun Zhao, Jianan Ren
Summary: This review discusses the importance of STING in immune responses and its role in disease pathogenesis when over-activated. The focus is on post-translational modifications that regulate the activation and inhibition of STING, and their potential as targeted therapies.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Yan Liu, Kai Xu, Yin Yao, Zheng Liu
Summary: This article reviews the role of A20 in allergic airway diseases, finding that A20 can regulate the inflammatory response in these diseases by inhibiting the NF-κB signaling pathway, thus exerting anti-inflammatory effects. The gene polymorphisms of A20 are also associated with allergic airway diseases.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Jianshu Zhu, Jiawei Fan, Yuanliang Xia, Hengyi Wang, Yuehong Li, Zijia Feng, Changfeng Fu
Summary: Macrophages are a versatile cell type that plays a crucial role in the progression and resolution of diseases and maintaining tissue homeostasis. The activation states and functions of macrophages are influenced by the local microenvironment. Dysfunctional macrophage subpopulations or imbalance in the M1/M2 ratio can contribute to disease pathogenesis. In skeletal muscle disorders, macrophages are involved in immune and inflammatory damage as well as fibrosis. Targeting macrophages is important for maintaining tissue homeostasis and treating skeletal muscle disorders. This review discusses the regulation of macrophages through receptor-ligand interactions and identifies potential targets for inhibiting collateral damage and fibrosis. Strategies for modulating macrophages to maintain tissue homeostasis are also explored.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Zhen Gui, Yan Zhang, Aihua Zhang, Weiwei Xia, Zhanjun Jia
Summary: CARMA3 is a scaffold protein widely expressed in non-hematopoietic cells that can activate NF-κB by forming a complex. It mediates different receptor-dependent signaling pathways and its dysregulation is associated with various diseases. Recent studies have demonstrated its involvement in cancer and non-cancerous diseases.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Pharmacology & Pharmacy
Xie Saiyang, Deng Wei, Tang Qizhu
Summary: SIRT6, a member of the Sirtuin family, plays a crucial role in regulating biological homeostasis, longevity, and disease prevention, particularly in the occurrence and development of various cardiovascular diseases. Recent research has identified SIRT6 as a key intervention target for heart failure, cardiovascular remodeling, and atherosclerosis, bringing it to the forefront of clinical interest.
PHARMACOLOGICAL RESEARCH
(2021)
