Article
Pharmacology & Pharmacy
Pengcheng Luo, Yina Wang, Chongqiang Zhao, Junyi Guo, Wei Shi, Haiyan Ma, Tianshu Liu, Dan Yan, Shengqi Huo, Moran Wang, Chenglong Li, Jiayuh Lin, Sheng Li, Jiagao Lv, Cuntai Zhang, Li Lin
Summary: Bazedoxifene effectively attenuated atherosclerotic plaque area and down-regulated IL-6 levels in ApoE-deficient mice, suggesting its potential as a novel therapeutic reagent for atherosclerosis by regulating the IL-6/IL-6R/STAT3 signaling pathway.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2021)
Article
Endocrinology & Metabolism
Lauren K. Vasilakos, Baiba Steinbrekera, Donna A. Santillan, Mark K. Santillan, Debra S. Brandt, Daniel Dagle, Robert D. Roghair
Summary: Diabetes during pregnancy and chorioamnionitis are associated with increased levels of maternal insulin, leptin, and IL-6. While both leptin and IL-6 play roles in inflammation, they have contrasting effects on neurodevelopment. In a study of cord blood samples from 104 term infants, it was found that maternal diabetes increased levels of leptin and insulin, while chorioamnionitis was associated with elevated IL-6 levels.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Haoyi Han, Ali Mohammed Mohammed Alsayed, Yi Wang, Qi Yan, Ancheng Shen, Jianxia Zhang, Yanfei Ye, Zhiguo Liu, Kun Wang, Xiaohui Zheng
Summary: In this study, a series of beta-cyclocitral-derived mono-carbonyl curcumin analogs were synthesized and A19 exhibited the strongest cytotoxic activity against HCC cells, while showing almost no toxicity to normal liver cells. Mechanistically, A19 induced intense DNA damage through suppression of the ERK/JNK/p38 MAPK signaling pathway. Furthermore, a combination of A19 with sorafenib showed synergistic cytotoxicity in HCC cells. Overall, these findings suggest the potential of A19 as a novel chemotherapeutic agent for HCC treatment, either alone or in combination therapy.
BIOORGANIC CHEMISTRY
(2023)
Article
Pharmacology & Pharmacy
Ziqing Wang, Wenwen Mu, Pengxiao Li, Guoyun Liu, Jie Yang
Summary: Two newly discovered ortho-trifluoromethoxy-substituted 4-piperidione-containing derivatives 22 and 24 exhibited potent anti-inflammatory activity, inhibiting the production of inflammatory factors and alleviating symptoms and pathological damage of ulcerative colitis. These findings provide important insights for the development of more effective anti-inflammatory drug candidates.
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2021)
Article
Medicine, Research & Experimental
Samar Imbaby, Yuichi Hattori
Summary: This study investigates the cardioprotective effects of Stattic, a STAT3 inhibitor, on cardiac inflammation and dysfunction in a mouse model of sepsis. The results show that Stattic reverses the cardiac abnormalities induced by sepsis and restores cardiac function, possibly through its anti-inflammatory activities.
Review
Chemistry, Applied
Wei Luo, Liangyu Bai, Jing Zhang, Zhangwang Li, Yinuo Liu, Xiaoyi Tang, Panpan Xia, Minxuan Xu, Ao Shi, Xiao Liu, Deju Zhang, Peng Yu
Summary: Curcumin (CUR), with its many biological activities, has shown potential as a treatment for various diseases. However, its limitations have led researchers to explore the use of drug carriers, particularly polysaccharides-based nanocarriers, to overcome these drawbacks. Encapsulation offers protective effects and synergistic effects, enhancing CUR's anti-inflammatory capacity. This review highlights the advancements in the encapsulation of CUR using polysaccharides-based nanocarriers and the potential mechanisms of their anti-inflammatory effects.
CARBOHYDRATE POLYMERS
(2023)
Article
Biochemistry & Molecular Biology
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Abid Ullah, Shafiq Ur Rahman, Manzoor Ahmad, Mazen Almehmadi, Osama Abdulaziz, Mamdouh Allahyani, Ahad Amer Alsaiari, Mustafa Halawi, Edrous Alamer
Summary: The study found that mono-carbonyl curcumin analogues h2 and h3 with methoxy and chloro-substituents, respectively, showed promising antioxidant activities in vitro and significantly decreased oxidative stress and memory impairment in in vivo mouse models.
Article
Biochemistry & Molecular Biology
Haya Hussain, Shujaat Ahmad, Syed Wadood Ali Shah, Mehreen Ghias, Abid Ullah, Shafiq Ur Rahman, Zul Kamal, Farman Ali Khan, Nasir Mehmood Khan, Juma Muhammad, Mazen Almehmadi, Osama Abdulaziz, Saad Alghamdi
Summary: This study synthesized five mono-carbonyl curcumin analogs and found that two of them significantly inhibited cholinesterases in vivo and improved memory in mice. Molecular docking study confirmed the mechanism of cholinesterase inhibition for these compounds.
Article
Dermatology
Zhenguo Cai, Yibin Zeng, Zhuohang Liu, Ruizheng Zhu, Wuqing Wang
Summary: Curcumin can improve psoriasis-like dermatitis in mice by inhibiting the expression of inflammatory proteins and genes. It also inhibits the phosphorylation of STAT3 and the expression of downstream associated proteins in the skin. Immunohistochemistry results show that curcumin suppresses the expression of inflammatory factors in psoriasis-like lesions of mice.
CLINICAL COSMETIC AND INVESTIGATIONAL DERMATOLOGY
(2023)
Article
Medicine, Research & Experimental
Lin Ye, Xueting Hu, Xiang Hu, Sihui Yin, Jianqiang Chen, Hanghui He, Shanshan Hong, Bin Yang, Krishna K. Singh, Jianpeng Feng, Yi Wang, Wu Luo, Guang Liang
Summary: Obesity is a major risk factor for chronic kidney disease, but the curcumin derivative C66 has been found to attenuate obesity-induced renal injury by inhibiting chronic inflammation and apoptosis through targeting NF-κB and JNK pathways, suggesting its potential in preventing obesity-associated renal diseases.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Multidisciplinary Sciences
Mai Al-Mohanna, Noura N. Alraouji, Samiah A. Alhabardi, Falah Al-Mohanna, Basem Al-Otaibi, Ibrahim Al-Jammaz, Abdelilah Aboussekhra
Summary: This study evaluated the therapeutic efficacy of a piperidone analogue of curcumin (PAC) for anaplastic thyroid carcinoma (ATC). PAC induced apoptosis in ATC cells through the mitochondrial pathway. It also inhibited the epithelial-to-mesenchymal transition (EMT) process and suppressed the AKT/mTOR pathway in ATC cells. In addition, PAC showed promising anti-tumor effects in vivo. Overall, PAC could be a potential therapeutic agent for ATC.
SCIENTIFIC REPORTS
(2023)
Article
Nutrition & Dietetics
Kyeong-Min Kim, So-Yeon Kim, Tamanna Jahan Mony, Ho Jung Bae, Sang-Deok Han, Eun-Seok Lee, Seung-Hyuk Choi, Sun Hee Hong, Sang-Deok Lee, Se Jin Park
Summary: The study demonstrates that Dracocephalum moldavica ethanol extract (DMEE) exerts anti-inflammatory effects on LPS-stimulated RAW 264.7 macrophages and anti-septic effects in septic mouse models through inhibition of the ERK/JNK/NF-kappa B signaling cascades and IL-6 production.
Article
Medicine, Research & Experimental
Lin Ye, Xiaojun Chen, Minxiu Wang, Leiming Jin, Zaishou Zhuang, Daona Yang, Xinfu Guan, Aleksandr Samorodov, Valentin N. Pavlov, Nipon Chattipakorn, Jianpeng Feng, Yi Wang, Wu Luo, Guang Liang
Summary: C66 provides significant protection against obesity-induced cardiac dysfunction mainly by inhibiting JNK activation and JNK-mediated inflammation.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Immunology
Dhanashree Jagtap, Vikrant M. Bhor, Shilpa Bhowmick, Nandini Kasarpalkar, Pooja Sagvekar, Bhalchandra Kulkarni, Manish Pathak, Nirjhar Chatterjee, Pranam Dolas, Harsha Palav, Snehal Kaginkar, Sharad Bhagat, Itti Munshi, Swapneil Parikh, Sachee Agrawal, Chandrakant Pawar, Mala Kaneria, Smita D. Mahale, Jayanthi Shastri, Vainav Patel
Summary: This study explores the unexplored role of sMAdCAM in COVID-19 pathogenesis. It reveals an inverse correlation between sMAdCAM and IL-6 levels, associations with disease states, and relationships with antiviral antibody levels.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Sarah O. A. M. Costa, Ianny B. Rodrigues, Alysson Braga, Barbara C. M. Barbosa, Roger R. L. Silva, Felipe F. Rodrigues, Ivo S. F. Melo, Marcela Morais, Brenda F. M. Castro, Armando S. Cunha Junior, Vinicius G. Maltarollo, Renata B. Oliveira, Marcio M. Coelho, Renes R. Machado
Summary: The synthetic curcumin analogue RI75 exhibits anti-allodynic and anti-edematogenic activities in mouse models of inflammation and pain. These activities may be mediated through the activation of opioidergic and serotonergic mechanisms, as well as the reduction of inflammatory mediators production and neutrophil recruitment.
INFLAMMOPHARMACOLOGY
(2022)
