Bazedoxifene exhibits anti-inflammation and anti-atherosclerotic effects via inhibition of IL-6/IL-6R/STAT3 signaling

Immunity and Inflammation in Atherosclerosis

(2019) Dennis Wolf et al.   CIRCULATION RESEARCH

The novel coronary artery disease risk gene JCAD/KIAA1462 promotes endothelial dysfunction and atherosclerosis

(2019) Suowen Xu et al.   EUROPEAN HEART JOURNAL

From Focal Lipid Storage to Systemic Inflammation

(2019) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Epigenetic Modification in Coronary Atherosclerosis

(2019) Barbara Rizzacasa et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Adipocyte Hypoxia-Inducible Factor 2α Suppresses Atherosclerosis by Promoting Adipose Ceramide Catabolism

(2019) Xingzhong Zhang et al.   Cell Metabolism

High-fat diet exacerbates SIV pathogenesis and accelerates disease progression

(2019) Tianyu He et al.   JOURNAL OF CLINICAL INVESTIGATION

A defect in endothelial autophagy occurs in patients with nonalcoholic steatohepatitis and promotes inflammation and fibrosis

(2019) Adel Hammoutene et al.   JOURNAL OF HEPATOLOGY

Chronic Kidney Disease and Coronary Artery Disease

(2019) Mark J. Sarnak et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Efficacy and Safety of Low-Dose Colchicine after Myocardial Infarction

(2019) Jean-Claude Tardif et al.   NEW ENGLAND JOURNAL OF MEDICINE

Detection of Atherosclerotic Inflammation by 68 Ga-DOTATATE PET Compared to [ 18 F]FDG PET Imaging

(2017) Jason M. Tarkin et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of interleukin-1β inhibition with canakinumab on incident lung cancer in patients with atherosclerosis: exploratory results from a randomised, double-blind, placebo-controlled trial

(2017) Paul M Ridker et al.   LANCET

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Growth-suppressive activity of raloxifene on liver cancer cells by targeting IL-6/GP130 signaling

(2017) Yina Wang et al.   Oncotarget

Endothelial Cell Dysfunction and the Pathobiology of Atherosclerosis

(2016) Michael A. Gimbrone et al.   CIRCULATION RESEARCH

Bazedoxifene as a Novel GP130 Inhibitor for Pancreatic Cancer Therapy

(2016) X. Wu et al.   MOLECULAR CANCER THERAPEUTICS

A score including ADAM17 substrates correlates to recurring cardiovascular event in subjects with atherosclerosis

(2015) Stefano Rizza et al.   ATHEROSCLEROSIS

Circulating levels of interleukin 6 soluble receptor and its natural antagonist, sgp130, and the risk of myocardial infarction

(2015) Ilais Moreno Velásquez et al.   ATHEROSCLEROSIS

Inflammation and Atherosclerosis

(2014) Joshua Hartman et al.   Cardiology in Review

Drug Design Targeting Protein–Protein Interactions (PPIs) Using Multiple Ligand Simultaneous Docking (MLSD) and Drug Repositioning: Discovery of Raloxifene and Bazedoxifene as Novel Inhibitors of IL-6/GP130 Interface

(2014) Huameng Li et al.   JOURNAL OF MEDICINAL CHEMISTRY

Interleukin-1β inhibition and the prevention of recurrent cardiovascular events: Rationale and Design of the Canakinumab Anti-inflammatory Thrombosis Outcomes Study (CANTOS)

(2011) Paul M Ridker et al.   AMERICAN HEART JOURNAL

Transsignaling of Interleukin-6 Crucially Contributes to Atherosclerosis in Mice

(2011) Harald Schuett et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

IL-6 in human cytomegalovirus secretome promotes angiogenesis and survival of endothelial cells through the stimulation of survivin

(2010) S. Botto et al.   BLOOD

Chronic Apoptosis of Vascular Smooth Muscle Cells Accelerates Atherosclerosis and Promotes Calcification and Medial Degeneration

(2008) Murray C.H. Clarke et al.   CIRCULATION RESEARCH