Cathepsin D and its newly identified transport receptor SEZ6L2 can modulate neurite outgrowth

Lrp1/LDL Receptor Play Critical Roles in Mannose 6-Phosphate-Independent Lysosomal Enzyme Targeting

(2015) Sandra Markmann et al.   TRAFFIC

Systematic Proteomic Analysis Identifies β-Site Amyloid Precursor Protein Cleaving Enzyme 2 and 1 (BACE2 and BACE1) Substrates in Pancreatic β-Cells

(2013) Ina Stützer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of anti-Sez6l2 antibody in a patient with cerebellar ataxia and retinopathy

(2013) Hiroaki Yaguchi et al.   JOURNAL OF NEUROLOGY

Lysosomal dysfunction causes neurodegeneration in mucolipidosis II ‘knock-in’ mice

(2012) K. Kollmann et al.   BRAIN

Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons

(2012) Peer-Hendrik Kuhn et al.   EMBO JOURNAL

Polymorphisms in seizure 6-like gene are associated with bipolar disorder I: Evidence of gene×gender interaction

(2012) Chun Xu et al.   JOURNAL OF AFFECTIVE DISORDERS

Cathepsin D deficiency induces cytoskeletal changes and affects cell migration pathways in the brain

(2012) Sabine Koch et al.   NEUROBIOLOGY OF DISEASE

Morphologic and Functional Correlates of Synaptic Pathology in the Cathepsin D Knockout Mouse Model of Congenital Neuronal Ceroid Lipofuscinosis

(2011) Sabine Koch et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Vacuolization of mucolipidosis type II mouse exocrine gland cells represents accumulation of autolysosomes

(2011) Marielle Boonen et al.   MOLECULAR BIOLOGY OF THE CELL

Cathepsin D is partly endocytosed by the LRP1 receptor and inhibits LRP1-regulated intramembrane proteolysis

(2011) D Derocq et al.   ONCOGENE

Variations of the Candidate SEZ6L2 Gene on Chromosome 16p11.2 in Patients with Autism Spectrum Disorders and in Human Populations

(2011) Marina Konyukh et al.   PLoS One

Disruption of the Man-6-P Targeting Pathway in Mice Impairs Osteoclast Secretory Lysosome Biogenesis

(2011) Eline van Meel et al.   TRAFFIC

Proteolytic Processing of the γ-Subunit Is Associated with the Failure to Form GlcNAc-1-phosphotransferase Complexes and Mannose 6-Phosphate Residues on Lysosomal Enzymes in Human Macrophages

(2010) Sandra Pohl et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Golgi-to-phagosome transport of acid sphingomyelinase and prosaposin is mediated by sortilin

(2010) A. Wahe et al.   JOURNAL OF CELL SCIENCE

Pro-cathepsin D interacts with the extracellular domain of the   chain of LRP1 and promotes LRP1-dependent fibroblast outgrowth

(2010) M. Beaujouin et al.   JOURNAL OF CELL SCIENCE

Mice Lacking Mannose 6-Phosphate Uncovering Enzyme Activity Have a Milder Phenotype than Mice Deficient for N-Acetylglucosamine-1-Phosphotransferase Activity

(2009) Marielle Boonen et al.   MOLECULAR BIOLOGY OF THE CELL

Association and Mutation Analyses of 16p11.2 Autism Candidate Genes

(2009) Ravinesh A. Kumar et al.   PLoS One

A Gene Network Regulating Lysosomal Biogenesis and Function

(2009) Marco Sardiello et al.   SCIENCE

Cathepsin D expression level affects alpha-synuclein processing, aggregation, and toxicity in vivo

(2009) Valerie Cullen et al.   Molecular Brain

Sortilin mediates the lysosomal targeting of cathepsins D and H

(2008) Maryssa Canuel et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

A dileucine signal situated in the C-terminal tail of the lysosomal membrane protein p40 is responsible for its targeting to lysosomes

(2008) Marielle Boonen et al.   BIOCHEMICAL JOURNAL

Cathepsin D Is the Main Lysosomal Enzyme Involved in the Degradation of α-Synuclein and Generation of Its Carboxy-Terminally Truncated Species†

(2008) Daniel Sevlever et al.   BIOCHEMISTRY

Sorting of lysosomal proteins

(2008) Thomas Braulke et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH