Inhibition of motor neuron deathin vitroandin vivoby a p75 neurotrophin receptor intracellular domain fragment

Neuron-type-specific signaling by the p75NTR death receptor is regulated by differential proteolytic cleavage

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Dynamic Nature of the p75 Neurotrophin Receptor in Response to Injury and Disease

(2014) Rick Meeker et al.   Journal of Neuroimmune Pharmacology

The Extracellular Domain of Neurotrophin Receptor p75 as a Candidate Biomarker for Amyotrophic Lateral Sclerosis

(2014) Stephanie R. Shepheard et al.   PLoS One

An Intracellular Domain Fragment of the p75 Neurotrophin Receptor (p75NTR) Enhances Tropomyosin Receptor Kinase A (TrkA) Receptor Function

(2013) Dusan Matusica et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

CD4+ T cell-mediated neuroprotection is independent of T cell-derived BDNF in a mouse facial nerve axotomy model

(2012) Junping Xin et al.   BRAIN BEHAVIOR AND IMMUNITY

Deletion of the BDNF Truncated Receptor TrkB.T1 Delays Disease Onset in a Mouse Model of Amyotrophic Lateral Sclerosis

(2012) Sudhirkumar U. Yanpallewar et al.   PLoS One

p75 neurotrophin receptor signaling in nervous system injury and degeneration: paradox and opportunity

(2012) Carlos F. Ibáñez et al.   TRENDS IN NEUROSCIENCES

Proteolytic processing of the p75 neurotrophin receptor: A prerequisite for signalling?

(2011) Sune Skeldal et al.   BIOESSAYS

Trk-dependent ADAM17 activation facilitates neurotrophin survival signaling

(2011) Reddy P. Kommaddi et al.   FASEB JOURNAL

The in vivo contribution of motor neuron TrkB receptors to mutant SOD1 motor neuron disease

(2011) J. Zhai et al.   HUMAN MOLECULAR GENETICS

Structural Model for p75NTR–TrkA Intracellular Domain Interaction: A Combined FRET and Bioinformatics Study

(2011) María Florencia Iacaruso et al.   JOURNAL OF MOLECULAR BIOLOGY

The p75NTR intracellular domain generated by neurotrophin-induced receptor cleavage potentiates Trk signaling

(2010) C. Ceni et al.   JOURNAL OF CELL SCIENCE

ProNGF Induces PTEN via p75NTR to Suppress Trk-Mediated Survival Signaling in Brain Neurons

(2010) W. Song et al.   JOURNAL OF NEUROSCIENCE

Review: Neuromuscular synaptic vulnerability in motor neurone disease: amyotrophic lateral sclerosis and spinal muscular atrophy

(2010) L. M. Murray et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Neurotrophic growth factors for the treatment of amyotrophic lateral sclerosis: where do we stand ?

(2010) Henriques   Frontiers in Neuroscience

Preconditioning selective ventral root injury promotes plasticity of ascending sensory neurons in the injured spinal cord of adult rats - possible roles of brain-derived 
neurotrophic factor, TrkB and p75 neurotrophin receptor

(2009) Fang Li et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A Switch in Retrograde Signaling from Survival to Stress in Rapid-Onset Neurodegeneration

(2009) E. Perlson et al.   JOURNAL OF NEUROSCIENCE

Isolation and enrichment of embryonic mouse motoneurons from the lumbar spinal cord of individual mouse embryos

(2009) Stefan Wiese et al.   Nature Protocols

The p75 neurotrophin receptor

(2007) Clare K. Underwood et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Palmitoylation of the C-terminal fragment of p75NTR regulates death signaling and is required for subsequent cleavage by γ-secretase

(2007) Clare K. Underwood et al.   MOLECULAR AND CELLULAR NEUROSCIENCE