Article
Environmental Sciences
Xiuhui Tian, Huanjun Li, Xiuzhen Zhang, Yingjiang Xu, Huawei Zhang, Dianfeng Han, Huan Liu, Bin Wang, Yanmei Cui, Huihui Liu, Quanli Zhou, Xianghong Gong
Summary: The study revealed that exposure of sea cucumber to semicarbazide induced morphological alterations, oxidative stress, and changes in neurotransmitter activity, with recovery observed in later stages of exposure. Higher exposure concentrations led to more severe damage, with increased activity of markers in the initial phase of exposure followed by a decrease.
FRONTIERS IN ENVIRONMENTAL SCIENCE
(2021)
Review
Biochemistry & Molecular Biology
Fatima Zahra Kamal, Radu Lefter, Hassna Jaber, Ioana-Miruna Balmus, Alin Ciobica, Alin-Constantin Iordache
Summary: Ischemic strokes occur due to arterial blockage, leading to interrupted blood supply to the brain and potential damage or death of brain cells. Oxidative stress is an essential mechanism in ischemic stroke, and the assessment of oxidative stress biomarkers can aid in diagnosing the severity and guiding neuroprotective therapies.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Pei Zhang, Jiazhen Xu, Qianfei Cui, Guoqiang Lin, Feiyun Wang, Xinyue Ding, Suxin You, Nina Sang, Junchao Tan, Wenwen Xu, Changsen Zhan, Yuying Zhu, Jiange Zhang
Summary: SHPL-49, a novel glycoside derivative derived from salidroside, exhibited neuroprotective effects against cerebral ischemic injury in a rat model. It could alleviate cerebral infarct volume, reduce neurological deficit score, increase the number of neurons, and reduce apoptosis through multiple pathways including reducing calcium overload, oxidative stress damage, and inhibiting apoptosis.
EUROPEAN JOURNAL OF PHARMACOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Anamaria Jurcau, Adriana Ioana Ardelean
Summary: This article discusses the application of recanalization therapy in the treatment of acute ischemic stroke and the potential ischemia/reperfusion injuries it may cause. Oxidative stress and mitochondrial dysfunction have been identified as significant factors in the pathogenesis of these injuries, but clinical studies targeting oxidative pathways have mostly been unsuccessful.
Article
Biochemistry & Molecular Biology
Elena Anca Pinosanu, Roxana Surugiu, Emilia Burada, Denisa Pirscoveanu, Camelia Elena Stanciulescu, Raluca Elena Sandu, Catalina Pisoschi, Carmen Valeria Albu
Summary: This study investigates whether patients with acute ischemic stroke and COVID-19 exhibit higher oxidative stress and altered antioxidant defense mechanisms. The results showed increased oxidative stress and inflammation markers in these patients, highlighting the complex relationship between oxidative stress, inflammation, and concurrent health conditions.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Sofia Orellana-Urzua, Camilo Briones-Valdivieso, Silvia Chichiarelli, Luciano Saso, Ramon Rodrigo
Summary: Stroke and acute myocardial infarction are major causes of death worldwide, with ischemic stroke also contributing to adult physical disability. Oxidative stress is a primary cause of tissue injury, and natural antioxidants can counteract this process. However, the effects of different antioxidants vary, and combination therapy may have synergistic effects.
Review
Medicine, General & Internal
Yumeng Song, Xiaohong Zhang, Chaoxiu Li, Shuang Xu, Baosen Zhou, Xiaomei Wu
Summary: There is no consensus on the role of bilirubin in acute ischemic stroke. Higher levels of serum bilirubin may indicate greater oxidative stress and severity of stroke. A study found that both total bilirubin and direct bilirubin levels are positively associated with the severity of ischemic stroke, with a linear correlation observed for direct bilirubin.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Neurosciences
George Fadoul, Milos Ikonomovic, Feng Zhang, Tuo Yang
Summary: Ischemic stroke is a significant cause of mortality and disability, and Nrf2 has been investigated as a therapeutic target for reducing oxidative damage. This review comprehensively summarizes the protective effects of Nrf2 in different cell types during acute and chronic phases of stroke and highlights the importance of targeting Nrf2 in clinical settings while considering various factors.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Environmental Sciences
Jones A. Kapeleka, Elingarami Sauli, Patrick A. Ndakidemi
Summary: Continuous exposure to pesticides can cause oxidative stress, mutations, and cell death, affecting DNA and gene activities, leading to various forms of cancer. Although pesticides are evident in human biological matrices, detection methods are complex and inconsistent.
INTERNATIONAL JOURNAL OF ENVIRONMENTAL HEALTH RESEARCH
(2021)
Article
Clinical Neurology
Yanyan Wang, Wenzhe Sun, Jinfeng Miao, Zhou Zhu, Wenwen Liang, Xiuli Qiu, Chensheng Pan, Guo Li, Yan Lan, Xin Zhao, Yi Xu
Summary: The prevalence of post-stroke depression (PSD) remains high even in patients with mild acute ischemic stroke (MAIS). Factors such as indirect bilirubin, physical activity, smoking, hospitalization days, neuroticism, and MMSE are independently associated with PSD. A practical and convenient nomogram has been developed to predict PSD in MAIS patients.
FRONTIERS IN NEUROLOGY
(2023)
Review
Chemistry, Medicinal
Yash Pal Singh, Himanshu Rai, Gourav Singh, Gireesh Kumar Singh, Sunil Mishra, Saroj Kumar, S. Srikrishna, Gyan Modi
Summary: Alzheimer's disease is an age-related neurodegenerative disorder characterized by central cholinergic neuronal loss leading to cognitive dysfunction and impaired motor activity. Current therapies only offer symptomatic relief without addressing the underlying factors, and there is no drug to slow down disease progression. Researchers are investigating new hybrid compounds, such as ferulic acid-based derivatives, as potential treatments for Alzheimer's disease.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Environmental Sciences
Sukesh Narayan Sinha, Kumpati Rajesh Kumar, Ramakrishna Ungarala, Dileshwar Kumar, Abhijeet Deshpande, K. Vasudev, Naveen Kumar Boiroju, Amrisha Singh, R. Pandu Naik, Sunil Pokharakar
Summary: This study investigated pesticide concentration and AChE activity in OP-associated suicide cases in South India, finding that chlorpyrifos ingestion resulted in the highest concentration and dimethoate exhibited the lowest concentration, with monocrotophos and dimethoate showing faster elimination rates.
Article
Medicine, Research & Experimental
Pedro Rojas-Morales, Juan Carlos Leon-Contreras, Monica Sanchez-Tapia, Alejandro Silva-Palacios, Agustina Cano-Martinez, Susana Gonzalez-Reyes, Angelica Sarai Jimenez-Osorio, Rogelio Hernandez-Pando, Horacio Osorio-Alonso, Laura Gabriela Sanchez-Lozada, Armando R. Tovar, Jose Pedraza-Chaverri, Edilia Tapia
Summary: This study found that short-term ketogenic diet can increase tolerance to experimental kidney ischemia, reduce kidney injury and inflammation, and enhance antioxidant defenses. This finding opens up possibilities for future therapeutic strategies.
Article
Clinical Neurology
Fang Yu, Lin Zhang, Di Liao, Yunfang Luo, Xianjing Feng, Zeyu Liu, Jian Xia
Summary: The study suggests that lower serum bilirubin levels may be associated with severe and multiple intracranial atherosclerotic stenoses.
FRONTIERS IN NEUROLOGY
(2021)
Article
Neurosciences
Xiaotang Ma, Jia Zhao, Suqing Li, Yan Wang, Jinhua Liu, Yumeng Shi, Jiehong Liu, Yanyu Chen, Yanfang Chen, Qunwen Pan
Summary: The study demonstrates that Rab27a regulates brain EXs secretion and functions, contributing to cerebral vascular protection from ischemic insult by preventing oxidative stress and apoptosis via down-regulating NOX2 and cleaved caspase-3 expression.
CNS NEUROSCIENCE & THERAPEUTICS
(2022)
Article
Biochemistry & Molecular Biology
Margarete Dulce Bagatini, Kalyne Bertolin, Alessandra Bridi, Luana Paula Pelinson, Beatriz da Silva Rosa Bonadiman, Michele Mainardi Pillat, Paulo Bayard Dias Goncalves, Henning Ulrich, Maria Rosa Chitolina Schetinger, Vera Maria Morsch
JOURNAL OF CELLULAR BIOCHEMISTRY
(2019)
Article
Cell Biology
Vanessa Valeria Miron, Jucimara Baldissarelli, Gabriel Pranke, Aline Manica, Beatriz da Silva Rosa Bonadiman, Leandro Henrique Manfredi, Vera Maria Morsch, Maria Rosa Chitolina Schetinger, Andreia Machado Cardoso
Article
Neurosciences
Juliana Sorraila de Oliveira, Fatima Husein Abdalla, Guilherme Lopes Dornelles, Tais Vidal Palma, Cristiane Signor, Jamile da Silva Bernardi, Jucimara Baldissarelli, Luana Sueling Lenz, Vitor Antunes de Oliveira, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch, Maribel Antonello Rubin, Cinthia Melazzo de Andrade
PSYCHOPHARMACOLOGY
(2019)
Article
Biochemistry & Molecular Biology
Nathieli B. Bottari, Micheli M. Pillat, Maria R. C. Schetinger, Karine P. Reichert, Vanessa Machado, Charles E. Assmann, Henning Ulrich, Anielen Dutra, Vera M. Morsch, Tais Vidal, Ivana B. M. Da Cruz, Cinthia Melazzo, Aleksandro Schafer Da Silva
PURINERGIC SIGNALLING
(2019)
Article
Pharmacology & Pharmacy
Maria Rosa Chitolina Schetinger, Tanara V. Peres, Leticia P. Arantes, Fabian Carvalho, Valderi Dressler, Graciela Heidrich, Aaron B. Bowman, Michael Aschner
Article
Immunology
Marcela C. S. Sousa, Gabriela M. Galli, Nathieli B. Bottari, Davi F. Alba, Karoline W. Leal, Thalison F. Lopes, Leticia Druzian, Maria Rosa C. Schetinger, Eduardo M. Gloria, Ricardo E. Mendes, Lenita M. Stefani, Aleksandro S. Da Silva
MICROBIAL PATHOGENESIS
(2020)
Review
Medicine, Research & Experimental
Karine Paula Reichert, Milagros Fanny Vera Castro, Charles Elias Assmann, Nathieli Bianchin Bottari, Vanessa Valeria Miron, Andreia Cardoso, Naiara Stefanello, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: This review focuses on the role of the purinergic system in diabetes and hypertension, highlighting changes in the expression of P1 and P2 receptors, as well as the activities of CD39, CD73, and ADA. It suggests that manipulating the purinergic axis at various levels could potentially prevent or exacerbate the development of diabetes and hypertension as a compensatory mechanism.
BIOMEDICINE & PHARMACOTHERAPY
(2021)
Article
Cell Biology
Maria Luiza Mukai Franciosi, Millena Daher Medeiros Lima, Maria Rosa Chitolina Schetinger, Andreia Machado Cardoso
Summary: This review explores the potential role of purinergic signaling in COVID-19, focusing on purinergic receptors and components such as ATP, CD39, and CD73. It suggests therapeutic combination or association possibilities targeting purinergic system components as a useful tool for future research, aiming to unveil a novel option to treat COVID-19 patients.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Charles Elias Assmann, Grazielle Castagna Cezimbra Weis, Jessica Righi da Rosa, Beatriz da Silva Rosa Bonadiman, Audrei de Oliveira Alves, Maria Rosa Chitolina Schetinger, Euler Esteves Ribeiro, Vera Maria Melchiors Morsch, Ivana Beatrice Manica da Cruz
Summary: Nutraceuticals have been the subject of extensive research in recent years, with some showing promise in promoting certain health benefits. Certain Amazonian fruits and seeds may have potential beneficial impacts on the human nervous system, possibly due to the presence of various bioactive molecules.
NEUROCHEMISTRY INTERNATIONAL
(2021)
Article
Chemistry, Analytical
Graciela M. Heidrich, Vinicius M. Neves, Naiara Stefanello, Vanessa V. Miron, Thauan F. Lopes, Sindy R. Krzyzaniak, Paola de A. Mello, Maria Rosa C. Schetinger, Dirce Pozebon, Valderi L. Dressler
Summary: Adult Wistar rats were exposed to lanthanum oxide nanoparticles (La(2)O(3)NPs) at different doses. Histological analysis revealed that higher doses of La2O3-NPs caused hepatic lesions in rats. However, the La2O3-NPs did not affect body weight, organ weight, and blood serum parameters. Increased reactive oxygen species (ROS) were found in the kidneys of rats treated with high dose of La2O3-NPs. Lanthanum was detected in organs but not in the blood.
BRAZILIAN JOURNAL OF ANALYTICAL CHEMISTRY
(2023)
Article
Biochemistry & Molecular Biology
Milagros Fanny Vera Castro, Charles Elias Assmann, Naiara Stefanello, Karine Paula Reichert, Tais Vidal Palma, Anielen Dutra da Silva, Vanessa Valeria Miron, Vitor Bastianello Mostardeiro, Vera Maria Melchiors Morsch, Maria Rosa Chitolina Schetinger
Summary: The study investigated the effects of caffeic acid (CA) on learning and memory tasks in diabetic rats. The researchers also assessed the impact of CA on the activities of specific enzymes and the density of certain receptors and inflammatory parameters in the cortex and hippocampus of diabetic rats. The results showed that CA improved learning and memory deficits, normalized enzyme activities, and modulated receptor density in the diabetic animals, suggesting its potential for treating cognitive deficits associated with the cholinergic and purinergic signaling pathways in diabetes. (c) 2023 Elsevier Inc. All rights reserved.
JOURNAL OF NUTRITIONAL BIOCHEMISTRY
(2023)
Article
Cell Biology
Pedro Henrique Doleski, Fernanda Licker Cabral, Matheus Henrique Jantsch, Renan Silva Ebone, Stephen Adeniyi Adefegha, Daniela Bitencourt Rosa Leal, Maria Rosa Chitolina Schetinger
Summary: Plasma membrane anchored nucleotidases (E-ATPDases) play an important role in the hydrolysis and regulation of nucleotides in lymphocytes. The activities of E-ATPDases vary in different immune organs and resident subpopulations of lymphocytes. This study characterizes the E-ATPDases activities in bone marrow, thymus, and mesenteric lymph node lymphocytes of Wistar rats. The results suggest that the kinetic values of E-NTPDase activity in immune tissue lymphocytes could be an important therapeutic target for immune-related diseases.
MOLECULAR AND CELLULAR BIOCHEMISTRY
(2023)
Article
Agriculture, Dairy & Animal Science
Vanessa Dazuk, Lara Tarasconi, Vitor Luiz Molosse, Bruno Giorgio Oliveira Cecere, Guilherme Luiz Deolindo, Joao Vitor Strapazzon, Nathieli Bianchi Bottari, Bianca Fagan Bissacotti, Maria Rosa Chitolina Schetinger, Laercio Sareta, Ricardo Evandro Mendes, Marcelo Vedovatto, Eduardo Micotti Gloria, Diovani Paiano, Gabriela Miotto Galli, Aleksandro Schafer Da Silva
Summary: This study aimed to determine the effects of adding vegetable biocholine (VB) to pigs' diets to minimize the negative effects caused by daily aflatoxin intake. Consuming aflatoxin-contaminated feed reduced feed consumption and weight gain in piglets and caused oxidative stress in their intestines and livers. However, VB supplementation did not improve performance but showed hepatoprotective potential when facing aflatoxin challenge.
Article
Biology
Vinicius Leobet Lunkes, Tais Vidal Palma, Charles Elias Assmann, Vitor Bastianello Mostardeiro, Maria Rosa Chitolina Schetinger, Vera Maria Melchiors Morsch, Cinthia Melazzo de Andrade
Summary: Cancer, especially melanoma skin cancer, is a major cause of death. Curcumin, extracted from the Curcuma longa plant, shows potential as an adjuvant therapy for melanoma by modulating the immune response, oxidative stress, and purinergic signaling cascade. This study found that vinblastine, a chemotherapeutic agent, may increase adenosine concentration in melanoma cells, while curcumin increases reactive oxygen species production and disrupts purinergic signaling. Therefore, curcumin may be a promising addition to melanoma treatment.
BRAZILIAN ARCHIVES OF BIOLOGY AND TECHNOLOGY
(2022)
Article
Immunology
Gabriela M. Galli, Luiz Gustavo Griss, Bruno F. Fortuoso, Anielen D. Silva, Mateus Fracasso, Thalisson F. Lopes, Maria Rosa S. Schetinger, Samanta Gundel, Aline F. Ourique, Christofe Carneiro, Ricardo E. Mendes, Marcel M. Boiago, Aleksandro S. Da Silva
MICROBIAL PATHOGENESIS
(2020)
Review
Medicine, Research & Experimental
Weizhuo Lu, Zhiwu Chen, Jiyue Wen
Summary: Ischemic stroke is a common and serious disease, and neuroinflammation plays a crucial role in its progression. Microglia, astrocytes, and infiltrating immune cells are involved in the complicated neuroinflammation cascade, releasing different molecules that affect inflammation. Flavonoids, plant-specific compounds, have shown protective effects against cerebral ischemia injury by modulating the inflammatory responses.
BIOMEDICINE & PHARMACOTHERAPY
(2024)