Journal
NEUROCHEMISTRY INTERNATIONAL
Volume 148, Issue -, Pages -Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.neuint.2021.105085
Keywords
Neurodegenerative diseases; Microglia; Inflammation; Oxidative stress; Amazon Biome; Natural compounds
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Funding
- Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior (CAPES) [001]
- CAPES/PROEX fellowship grant [88882.182154/201801]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
- Fundacao de Amparo a Pesquisa do Estado do Rio Grande do Sul (FAPERGS)
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Nutraceuticals have been the subject of extensive research in recent years, with some showing promise in promoting certain health benefits. Certain Amazonian fruits and seeds may have potential beneficial impacts on the human nervous system, possibly due to the presence of various bioactive molecules.
Nutraceuticals have been the focus of numerous research in recent years and accumulating data support their use for promoting some health benefits. Several nutraceuticals have been widely studied as supplements due to their functional properties ameliorating symptoms associated with neurological disorders, such as oxidative stress and chronic inflammatory states. This seems to be the case of some fruits and seeds from the Amazon Biome consumed since the pre-Columbian period that could have potential beneficial impact on the human nervous system. The beneficial activities of these food sources are possibly related to a large number of bioactive molecules including polyphenols, carotenoids, unsaturated fatty acids, vitamins, and trace elements. In this context, this review compiled the research on six Amazonian fruits and seeds species and some of the major nutraceuticals found in their composition, presenting brief mechanisms related to their protagonist action in improving inflammatory responses and neuroinflammation.
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