VAMP8-dependent fusion of recycling endosomes with the plasma membrane facilitates T lymphocyte cytotoxicity

Transcriptional regulation of Munc13-4 expression in cytotoxic lymphocytes is disrupted by an intronic mutation associated with a primary immunodeficiency

(2014) Frank Cichocki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Comparison of primary human cytotoxic T-cell and natural killer cell responses reveal similar molecular requirements for lytic granule exocytosis but differences in cytokine production

(2013) S. C. C. Chiang et al.   BLOOD

Syntaxin11 serves as a t-SNARE for the fusion of lytic granules in human cytotoxic T lymphocytes

(2013) Mahantappa Halimani et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Regulated vesicle fusion generates signaling nanoterritories that control T cell activation at the immunological synapse

(2013) Helena Soares et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Rapid and Unidirectional Perforin Pore Delivery at the Cytotoxic Immune Synapse

(2013) J. A. Lopez et al.   JOURNAL OF IMMUNOLOGY

VAMP7 controls T cell activation by regulating the recruitment and phosphorylation of vesicular Lat at TCR-activation sites

(2013) Paola Larghi et al.   NATURE IMMUNOLOGY

Synaptobrevin2 is the v-SNARE required for cytotoxic T-lymphocyte lytic granule fusion

(2013) Ulf Matti et al.   Nature Communications

VAMP4- and VAMP7-expressing vesicles are both required for cytotoxic granule exocytosis in NK cells

(2011) Konrad Krzewski et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

SNARE protein expression and localization in human cytotoxic T lymphocytes

(2011) Varsha Pattu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Docking of Lytic Granules at the Immunological Synapse in Human CTL Requires Vti1b-Dependent Pairing with CD3 Endosomes

(2011) B. Qu et al.   JOURNAL OF IMMUNOLOGY

ORAI1-mediated calcium influx is required for human cytotoxic lymphocyte degranulation and target cell lysis

(2011) A. Maul-Pavicic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Syntaxin7 Is Required for Lytic Granule Release from Cytotoxic T Lymphocytes

(2011) Varsha Pattu et al.   TRAFFIC

Natural Killer Cell Lytic Granule Secretion Occurs through a Pervasive Actin Network at the Immune Synapse

(2011) Gregory D. Rak et al.   PLOS BIOLOGY

Cytotoxic immunological synapses

(2010) Michael L. Dustin et al.   IMMUNOLOGICAL REVIEWS

The Exocytosis of Lytic Granules Is Impaired in Vti1b- or Vamp8-Deficient CTL Leading to a Reduced Cytotoxic Activity following Antigen-Specific Activation

(2010) R. Dressel et al.   JOURNAL OF IMMUNOLOGY

Familial Hemophagocytic Lymphohistiocytosis Type 5 (FHL-5) Is Caused by Mutations in Munc18-2 and Impaired Binding to Syntaxin 11

(2009) Udo zur Stadt et al.   AMERICAN JOURNAL OF HUMAN GENETICS

A role for endobrevin/VAMP8 in CTL lytic granule exocytosis

(2009) Li Shen Loo et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Integrin-Dependent Organization and Bidirectional Vesicular Traffic at Cytotoxic Immune Synapses

(2009) Dongfang Liu et al.   IMMUNITY

The Strength of T Cell Receptor Signal Controls the Polarization of Cytotoxic Machinery to the Immunological Synapse

(2009) Misty R. Jenkins et al.   IMMUNITY

Munc18-2 deficiency causes familial hemophagocytic lymphohistiocytosis type 5 and impairs cytotoxic granule exocytosis in patient NK cells

(2009) Marjorie Côte et al.   JOURNAL OF CLINICAL INVESTIGATION

Sorting in early endosomes reveals connections to docking- and fusion-associated factors

(2009) S. V. Barysch et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Membrane Fusion: Grappling with SNARE and SM Proteins

(2009) T. C. Sudhof et al.   SCIENCE

Three-Dimensional Resolution Doubling in Wide-Field Fluorescence Microscopy by Structured Illumination

(2008) Mats G.L. Gustafsson et al.   BIOPHYSICAL JOURNAL

Thymic alterations in mice deficient for the SNARE protein VAMP8/endobrevin

(2008) Namita Kanwar et al.   CELL AND TISSUE RESEARCH

Vesicle associated membrane protein (VAMP)-7 and VAMP-8, but not VAMP-2 or VAMP-3, are required for activation-induced degranulation of mature human mast cells

(2008) Leif E. Sander et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Lifeact: a versatile marker to visualize F-actin

(2008) Julia Riedl et al.   NATURE METHODS

Mast cells possess distinct secretory granule subsets whose exocytosis is regulated by different SNARE isoforms

(2008) N. Puri et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA