Article
Immunology
Jana Blazkova, Erin D. Huiting, Arun Kumar Boddapati, Victoria Shi, Emily J. Whitehead, Jesse S. Justement, Jeffrey L. Nordstrom, Susan Moir, Justin Lack, Tae-Wook Chun
Summary: The study found that levels of TIGIT were positively correlated with CD8(+) T-lymphocyte activity in HIV-infected and healthy individuals, but not in HIV-viremic individuals. Furthermore, TIGIT(+)CD8(+) T cells maintained intrinsic cytotoxicity in HIV-infected individuals, suggesting they may not represent a state of immune exhaustion.
JOURNAL OF INFECTIOUS DISEASES
(2021)
Review
Immunology
Xueyang Bao, Yingyu Qin, Linrong Lu, Mingzhu Zheng
Summary: This review summarizes the transcriptional regulators involved in the early stages of T cell development and explores the cascade networks during the entire developmental process. Using advanced techniques, this study provides possible directions for future research.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Jens Schuster, Joakim Klar, Ayda Khalfallah, Loora Laan, Jan Hoeber, Ambrin Fatima, Velin Marita Sequeira, Zhe Jin, Sergiy V. Korol, Mikael Huss, Ann Nordgren, Britt Marie Anderlid, Caroline Gallant, Bryndis Birnir, Niklas Dahl
Summary: This study investigates the dysregulated gene network and altered electrophysiological properties in ZEB2 haploinsufficient GABAergic development, providing insights into the neuropathogenesis and seizures in MWS.
FRONTIERS IN MOLECULAR NEUROSCIENCE
(2022)
Article
Biochemistry & Molecular Biology
Naoya Nakagawa, Yutaka Fujisawa, Huihui Xiang, Hidemitsu Kitamura, Keigo Nishida
Summary: Zinc is an essential trace element with various functions in the body. Zinc deficiency can cause immune abnormalities. This study focused on tumor immunity to investigate the effect of zinc on colorectal cancer. The results showed that zinc intake significantly reduced the number of tumors in the colon, and this inhibitory effect was dependent on T cells. Zinc also increased the transcription of granzyme B, an important molecule in tumor immunity.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Multidisciplinary Sciences
Bin Zhang, Shaowei Dong, Jian Wang, Tuxiong Huang, Pan Zhao, Jing Xu, Dongcheng Liu, Li Fu, Lingwei Wang, Guangsuo Wang, Chang Zou
Summary: By using 3D printed patient derived xenograft models, this study identifies a NOTCH mutation as a predictor of response to EGFR-TKI therapy in LUAD. The NOTCH4(Delta L12_16) mutation increases the occurrence in EGFR-TKI-sensitive patients and sensitizes EGFR-TKI-resistant LUAD cells to the drug. This is mediated by reduced localization of NOTCH4 and down-regulation of HES1 expression. Inhibition of the NOTCH4-HES1 pathway can reverse EGFR-TKI resistance.
NATURE COMMUNICATIONS
(2023)
Article
Biochemistry & Molecular Biology
Sergey Ivanov, Dmitry Filimonov, Olga Tarasova
Summary: Different CD8(+) cell transcription profiles in elite controllers (ECs) were analyzed, leading to the identification of distinct groups with unique associations to untreated progressors and healthy controls. The CD8(+) lymphocytes from these EC groups may contribute to HIV control and slower disease progression. Targeting key receptors identified in the analysis could potentially help decelerate disease progression.
COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL
(2021)
Article
Pharmacology & Pharmacy
Sana-Kay Whyte-Allman, Rupert Kaul, Reina Bendayan
Summary: In this study, we found that exposure to an HIV pseudotype virus led to a significant increase in the expression of ABC drug efflux transporters in CD4(+) T-cells, which was attenuated by mTOR inhibitors. Furthermore, inhibition of P-gp or MRP1 activity resulted in lower concentrations of proinflammatory cytokines in supernatants of PBMC exposed to the virus.
FRONTIERS IN PHARMACOLOGY
(2021)
Review
Immunology
Meyer J. Friedman, Haram Lee, June-Yong Lee, Soohwan Oh
Summary: This paragraph discusses the close relationship between Th cell lineage determination and functional specialization with the activation of lineage-determining transcription factors. It also mentions the recent advances in understanding the epigenetic programs that govern T cell subset specification and immunological memory. The review provides an overview of recent genome-wide insights into the transcriptional and epigenetic regulation of CD4+ T cell-mediated adaptive immunity and discusses the implications for disease and immunotherapies.
Article
Pediatrics
Yu Zhu, Lili Ye, Hua Huang, Xuemei Xu, Yu Liu, Jian Wang, Yanliang Jin
Summary: CARMIL2 is an important regulator in cell activity and immune system, and its deficiency can lead to dysfunctional immune responses and various symptoms. With appropriate medication, the patient's symptoms and immune cell counts improved.
FRONTIERS IN PEDIATRICS
(2023)
Article
Oncology
Aamir Ali Khan, Hua Huang, Yue Zhao, Huan Li, Ruining Pan, Sijia Wang, Xinhui Liu
Summary: The study revealed that WBSCR22 plays a tumor suppressive role in pancreatic cancer by inhibiting cellular proliferation, migration, invasion, and tumor formation. WBSCR22 negatively regulates the transcription of ISG15, leading to its antitumor function, while ISG15 upregulation promotes the malignant characteristics of pancreatic cancer. Additionally, WBSCR22 and TRMT112 synergistically function in pancreatic cancer, and the concurrent overexpression of WBSCR22 and TRMT112 enhances the tumor suppressive potential of WBSCR22.
INTERNATIONAL JOURNAL OF ONCOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Brandon Cieniewicz, Ankit Bhatta, Damoun Torabi, Priya Baichoo, Mike Saxton, Alexander Arballo, Linh Nguyen, Sunil Thomas, Harini Kethar, Phanidhar Kukutla, Omolola Shoaga, Bi Yu, Zhuo Yang, Maria Fate, Edson Oliveira, Hongxiu Ning, Lawrence Corey, Daniel Corey
Summary: In order to improve cancer cell removal, a novel cell engineering and therapeutic strategy was developed, combining phagocytic clearance and antigen presentation activity into T cells. This was achieved by engineering a chimeric receptor that enhances phagocytosis and T cell cytotoxic function. The engineered T cells demonstrated target-dependent phagocytic function and induced transcriptional signatures of key regulators responsible for phagocytic recognition and uptake. In pre-clinical models, these T cells were able to elicit immune responses and showed potential for achieving tumor control.
Article
Genetics & Heredity
Yike Zhou, Shuangjie Shen, Chengcheng Du, Ying Wang, Yi Liu, Qun He
Summary: The spindle assembly checkpoint factors Bub3 and BuGZ have been found to play critical roles in mitotic process and they also have a novel function in transcriptional regulation of catalase genes in filamentous fungus Neurospora crassa. The amount of BuGZ, rather than the interaction between Bub3 and BuGZ, determines the transcription level of cat-3. BuGZ can directly bind to the cat-3 gene and respond to oxidative stress. The conserved zinc finger domains of BuGZ are important for transcriptional repression beyond its classical DNA binding function.
Article
Plant Sciences
Risaku Hirai, Shumin Wang, Taku Demura, Misato Ohtani
Summary: This study identifies histone deacetylase (HDAC) inhibitors as regulators of xylem vessel cell differentiation, affecting gene expression and the formation of the negative regulator complex OFP1/4-MYB75-KNAT7-BLH6. The findings suggest that active regulation of histone deacetylation by HDACs plays a role in xylem vessel cell differentiation.
FRONTIERS IN PLANT SCIENCE
(2022)
Article
Agriculture, Multidisciplinary
Yunika Mayangsari, Natsumi Sugimachi, Wenxi Xu, Chinatsu Mano, Yuki Tanaka, Osamu Ueda, Tomohiro Sakuta, Yoshiharu Suzuki, Yoshinari Yamamoto, Takuya Suzuki
Summary: This study demonstrated that 3,5,7,3',4'- pentamethoxyflavone (PMF) can enhance the intestinal tight junction (TJ) barrier integrity by regulating the transcription of TJ proteins, such as occludin, claudin-3, and claudin-4.
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
(2021)
Article
Immunology
George Georgoulias, Apostolos Zaravinos
Summary: Skin melanoma cells are interconnected with their tumor microenvironment, which affects their response to immune checkpoint inhibition therapy. Analysis of gene expression and immune-related features in tumors highlights the significance of T-cell immunity in therapeutic outcomes.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Jeffrey S. Miller, Zachary B. Davis, Erika Helgeson, Cavan Reilly, Ann Thorkelson, Jodi Anderson, Noemia S. Lima, Siri Jorstad, Geoffrey T. Hart, John H. Lee, Jeffrey T. Safrit, Hing Wong, Sarah Cooley, Lavina Gharu, Hyunsoo Chung, Patrick Soon-Shiong, Curtis Dobrowolski, Courtney Fletcher, Jonathan Karn, Daniel C. Douek, Timothy W. Schacker
Summary: N-803 is a safe and potential treatment for reducing virus reservoirs in people living with HIV by activating latent virus and enhancing immune cell function.
Letter
Oncology
Audrone Muleviciene, Takuya Sekine, Timo Zondag, Yenan T. Bryceson, Bianca Tesi, Jelena Rascon
PEDIATRIC BLOOD & CANCER
(2022)
Review
Immunology
Hannes Lindahl, Yenan T. Bryceson
Summary: The development of high-throughput sequencing has advanced the understanding of genotype-phenotype correlations in congenital diseases. Neuroinflammatory diseases, although rare, are increasingly recognized among inborn errors of immunity and can have a significant impact on patient care. This review focuses on the signs and symptoms of neuroinflammation associated with pathogenic variants in immune genes and proposes a subdivision based on underlying mechanisms.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Oncology
Heather H. Nelson, Emma Contestabile, De Von Hunter-Schlichting, Devin Koestler, Michael Pawlita, Tim Waterboer, Brock C. Christensen, Curtis L. Petersen, Jeffrey S. Miller, Karl T. Kelsey
Summary: Cytomegalovirus (CMV) infection alters T cell proportions, but does not increase the risk of HPV16 infection or head and neck cancer. Our findings, based on serology and tumor biomarkers, suggest that CMV is associated with worse patient survival.
Letter
Biochemistry & Molecular Biology
Petter Brodin, Giorgio Casari, Liam Townsend, Cliona O'Farrelly, Ivan Tancevski, Judith Loeffler-Ragg, Trine H. Mogensen, Jean Laurent Casanova
Review
Immunology
Carl Inge Edvard Smith, Rula Zain, Anders osterborg, Marzia Palma, Marcus Buggert, Peter Bergman, Yenan Bryceson
Summary: The scarcity of plasmacytoid dendritic cells (pDCs) in patients with chronic lymphocytic leukaemia (CLL) may contribute to the severe clinical course of COVID-19 in these patients. Treatment of CLL with Bruton's tyrosine kinase (BTK) inhibitors can increase the number of pDCs.
SCANDINAVIAN JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Tessa Mollie Campbell, Zhiyong Liu, Qian Zhang, Marcela Moncada-Velez, Laura E. Covill, Peng Zhang, Ilad Alavi Darazam, Paul Bastard, Lucy Bizien, Giorgia Bucciol, Sara Lind Enoksson, Emmanuelle Jouanguy, Semsi Nur Karabela, Taushif Khan, Yasemin Kendir-Demirkol, Andres Augusto Arias, Davood Mansouri, Per Marits, Nico Marr, Isabelle Migeotte, Leen Moens, Tayfun Ozcelik, Isabelle Pellier, Anton Sendel, Sevtap Senoglu, Mohammad Shahrooei, C. I. Edvard Smith, Isabelle Vandernoot, Karen Willekens, Kadriye Kart Yasar, Peter Bergman, Laurent Abel, Aurelie Cobat, Jean-Laurent Casanova, Isabelle Meyts, Yenan T. Bryceson
Summary: IRF7-deficient individuals are prone to viral infections of the respiratory tract but are otherwise healthy, potentially due to residual IFN-beta and compensatory adaptive immunity.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Immunology
Qian Zhang, Daniela Matuozzo, Jeremie Le Pen, Danyel Lee, Leen Moens, Takaki Asano, Jonathan Bohlen, Zhiyong Liu, Marcela Moncada-Velez, Yasemin Kendir-Demirkol, Huie Jing, Lucy Bizien, Astrid Marchal, Hassan Abolhassani, Selket Delafontaine, Giorgia Bucciol, Gulsum Ical Bayhan, Sevgi Keles, Ayca Kiykim, Selda Hancerli, Filomeen Haerynck, Benoit Florkin, Nevin Hatipoglu, Tayfun Ozcelik, Guillaume Morelle, Mayana Zatz, Lisa F. P. Ng, David Chien Lye, Barnaby Edward Young, Yee-Sin Leo, Clifton L. Dalgard, Richard P. Lifton, Laurent Renia, Isabelle Meyts, Emmanuelle Jouanguy, Lennart Hammarstrom, Qiang Pan-Hammarstrom, Bertrand Boisson, Paul Bastard, Helen C. Su, Stephanie Boisson-Dupuis, Laurent Abel, Charles M. Rice, Shen-Ying Zhang, Aurelie Cobat, Jean-Laurent Casanova
Summary: In an international cohort of 112 hospitalized children with COVID-19 pneumonia, 12 children with recessive inborn errors of type I interferon immunity were identified. These deficiencies may contribute to the development of COVID-19 pneumonia in children. Additionally, these deficiencies were not found in individuals without pneumonia from SARS-CoV-2 infection.
JOURNAL OF EXPERIMENTAL MEDICINE
(2022)
Article
Multidisciplinary Sciences
Victoria Walker-Sperling, Jean C. Digitale, Mathias Viard, Maureen P. Martin, Arman Bashirova, Yuko Yuki, Veron Ramsuran, Smita Kulkarni, Vivek Naranbhai, Hongchuan Li, Stephen K. Anderson, Lauren Yum, Robert Clifford, Hannah Kibuuka, Julie Ake, Rasmi Thomas, Sarah Rowland-Jones, John Rek, Emmanuel Arinaitwe, Moses Kamya, Isabel Rodriguez-Barraquer, Margaret E. Feeney, Mary Carrington
Summary: Two single-nucleotide polymorphisms regulating TAPBP mRNA expression were identified in Africans, associated with lower Plasmodium falciparum parasite prevalence and lower incidence of clinical malaria among individuals carrying tapasin-dependent HLA-I allotypes.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Medicine, Research & Experimental
Jacob A. Myers, Dawn Schirm, Laura Bendzick, Rachel Hopps, Carly Selleck, Peter Hinderlie, Martin Felices, Jeffrey S. Miller
Summary: This paper investigates the mechanisms and reversal strategies of NK cell exhaustion, and proposes an in vitro model as a valuable tool for studying exhaustion regulation processes.
Article
Oncology
Martin Felices, Erin Wesley, Laura E. Bendzick, Behiye Kodal, Rachel Hopps, Bartosz Grzywacz, Peter Hinderlie, Jeffrey S. Miller, Melissa A. Geller
Summary: We investigated the effects of combined treatment with an IL15 superagonist (N-803) and immune checkpoint blockade (ICB) on immune activation in ovarian cancer patients. Our results showed that N-803 stimulated initial expansion of natural killer (NK) cells in patients, and combining ICB enhanced NK cell function. In preclinical studies, the combination of N-803 and ICB also showed improved anti-tumor control and enhanced NK cell persistence and expansion in vivo.
CANCER IMMUNOLOGY RESEARCH
(2023)
Review
Oncology
Jawad Fares, Zachary B. Davis, Julian S. Rechberger, Stephanie A. Toll, Jonathan D. Schwartz, David J. Daniels, Jeffrey S. Miller, Soumen Khatua
Summary: Despite current treatment advancements for brain tumors, including surgery, chemotherapy, and radiation, the prognosis remains poor, especially for recurrent cases. The close proximity to delicate neural structures often prevents complete surgical removal, and the toxicities of systemic therapy are a concern. However, the field of NK cell-based cancer therapy shows promise as a new avenue for treating brain tumors.
NPJ PRECISION ONCOLOGY
(2023)
Article
Hematology
Shernan G. Holtan, Andrea Hoeschen, Qing Cao, Celalettin Ustun, Brian C. Betts, Najla El Jurdi, Joseph Maakaron, Armin Rashidi, Jeffrey S. Miller, John E. Wagner, Bruce R. Blazar, Pamala A. Jacobson, Angela Panoskaltsis-Mortari, Daniel J. Weisdorf, Margaret L. Macmillan
Summary: Studies have shown that treatments that aid inflammation resolution, immune tolerance, and epithelial repair may improve outcomes for life-threatening acute graft-versus-host disease (aGVHD) beyond traditional immunosuppressants. Addition of urinary-derived human chorionic gonadotropin/epidermal growth factor (uhCG/EGF) to standard aGVHD therapy has been found to be a feasible supportive care measure with potential to reduce morbidity and mortality. Further research is needed to explore the efficacy of uhCG/EGF as a complementary treatment for aGVHD.
TRANSPLANTATION AND CELLULAR THERAPY
(2023)
Article
Hematology
Armin Rashidi, Corinna La Rosa, Julie Curtsinger, Qing Cao, Qiao Zhou, Chetan Raj Lingaraju, Daniel J. Weisdorf, Frank Cichocki, Jeffrey S. Miller, Don J. Diamond
Summary: This study evaluated whether vaccination with a recombinant modified vaccinia Ankara expressing CMV antigens could improve the reconstitution of adaptive NK cells and CMV-specific T cells after auto-HCT in lymphoma and myeloma patients. The results showed that the vaccine increased the abundance of adaptive NK cells and CMV-specific T cells, suggesting a potential role in preventing relapse.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)
Article
Hematology
Nuttavut Sumransub, Qing Cao, Rose Wangen, Claudio Brunstein, Jeffrey S. Miller, Veronika Bachanova
Summary: This study analyzed the patterns of regulatory T cell reconstitution after autologous hematopoietic cell transplantation in non-Hodgkin lymphoma patients and found that the level of proliferating Tregs at day +28 post-transplantation was associated with patient survival.
TRANSPLANTATION AND CELLULAR THERAPY
(2022)