Is High-Intensity Interval Training Suitable to Promote Neuroplasticity and Cognitive Functions after Stroke?

Locomotor training intensity after stroke: Effects of interval type and mode

(2020) Pierce Boyne et al.   Topics in Stroke Rehabilitation

Acute Sprint Interval Exercise Increases Both Cognitive Functions and Peripheral Neurotrophic Factors in Humans: The Possible Involvement of Lactate

(2020) Sylwester Kujach et al.   Frontiers in Neuroscience

Increased serum brain-derived neurotrophic factor with high-intensity interval training in stroke patients: A randomized controlled trial

(2020) Chih-Chin Hsu et al.   Annals of Physical and Rehabilitation Medicine

Systematic review and meta-analysis investigating moderators of long-term effects of exercise on cognition in healthy individuals

(2020) Sebastian Ludyga et al.   Nature Human Behaviour

One-Week High-Intensity Interval Training Increases Hippocampal Plasticity and Mitochondrial Content without Changes in Redox State

(2020) Jonathas Rodrigo dos Santos et al.   Antioxidants

Exercise ameliorates post-stroke depression by inhibiting PTEN elevation-mediated upregulation of TLR4/NF-κB/NLRP3 signaling in mice

(2020) Congqin Li et al.   BRAIN RESEARCH

Effects of exercise timing and intensity on neuroplasticity in a rat model of cerebral infarction

(2020) Min-Keun Song et al.   BRAIN RESEARCH BULLETIN

HIITing the brain with exercise: mechanisms, consequences and practical recommendations

(2020) Thomas A. Calverley et al.   JOURNAL OF PHYSIOLOGY-LONDON

High-intensity interval training is superior to moderate intensity training on aerobic capacity in rats: Impact on hippocampal plasticity markers

(2020) Annabelle Constans et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of Aerobic Exercise on Tau and Related Proteins in Rats with the Middle Cerebral Artery Occlusion

(2020) Sakulrat Mankhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Cortical priming strategies for gait training after stroke: a controlled, stratified trial

(2020) Sangeetha Madhavan et al.   Journal of NeuroEngineering and Rehabilitation

High-intensity interval training reduces neutrophil-to-lymphocyte ratio in persons with multiple sclerosis during inpatient rehabilitation

(2020) Niklas Joisten et al.   Multiple Sclerosis Journal

Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?

(2020) Davide Pozzi et al.   Translational Psychiatry

High intensity interval training protects from Post Traumatic Stress Disorder induced cognitive impairment

(2020) Türkan Koyuncuoğlu et al.   BEHAVIOURAL BRAIN RESEARCH

Bumetanide Prevents Brain Trauma-Induced Depressive-Like Behavior

(2019) Emmanuelle Goubert et al.   Frontiers in Molecular Neuroscience

Standardization of exercise intensity and consideration of a dose-response is essential. Commentary on “Exercise-linked FNDC5/irisin rescues synaptic plasticity and memory defects in Alzheimer's models”, by Lourenco et al., published 2019 in Nature Medicine

(2019) Thomas Gronwald et al.   Journal of Sport and Health Science

Effects of different protocols of high intensity interval training for VO2max improvements in adults: A meta-analysis of randomised controlled trials

(2019) Daizong Wen et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Lactate mediates the effects of exercise on learning and memory through SIRT1-dependent activation of hippocampal brain-derived neurotrophic factor (BDNF)

(2019) Lauretta El Hayek et al.   JOURNAL OF NEUROSCIENCE

Born this way: Hippocampal neurogenesis across the lifespan

(2019) Danka A. Kozareva et al.   AGING CELL

Role of the BDNF-TrkB pathway in KCC2 regulation and rehabilitation following neuronal injury: A mini review

(2019) Sachiko Lee-Hotta et al.   NEUROCHEMISTRY INTERNATIONAL

Interval Training Improves Depressive Symptoms But Not Anxious Symptoms in Healthy Women

(2019) Ricardo Borges Viana et al.   Frontiers in Psychiatry

A single session of high-intensity interval exercise increases antioxidants defenses in the hippocampus of Wistar rats

(2019) Camila S. Melo et al.   PHYSIOLOGY & BEHAVIOR

High Intensity Interval Training (HIIT) for people with Severe Mental Illness: A systematic review & meta-analysis of intervention studies– considering diverse approaches for mental and physical recovery

(2019) Nicole Korman et al.   PSYCHIATRY RESEARCH

Effects of High Intensity Interval Training on Executive Function in Children Aged 8–12 Years

(2019) Nobuaki Tottori et al.   International Journal of Environmental Research and Public Health

Aerobic Training and Mobilization Early Post-stroke: Cautions and Considerations

(2019) Susan Marzolini et al.   Frontiers in Neurology

High-intensity interval training improves cerebellar antioxidant capacity without affecting cognitive functions in rats

(2019) Daniel Almeida Freitas et al.   BEHAVIOURAL BRAIN RESEARCH

Interval and continuous exercise overcome memory deficits related to β-Amyloid accumulation through modulating mitochondrial dynamics

(2019) Baixia Li et al.   BEHAVIOURAL BRAIN RESEARCH

The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia

(2019) Sadegh Abbasian et al.   BRAIN RESEARCH

The effects of different protocols of physical exercise and rest on long-term memory

(2019) Wesley Pyke et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Short-Term Acute Exercise Preconditioning Reduces Neurovascular Injury After Stroke Through Induced eNOS Activation

(2019) Sherif Hafez et al.   Translational Stroke Research

High intensity exercise preconditioning provides differential protection against brain injury following experimental stroke

(2018) Rasoul Rezaei et al.   LIFE SCIENCES

Memory formation depends on both synapse-specific modifications of synaptic strength and cell-specific increases in excitability

(2018) John Lisman et al.   NATURE NEUROSCIENCE

High intensity interval training modulates hippocampal oxidative stress, BDNF and inflammatory mediators in rats

(2018) Daniel A. Freitas et al.   PHYSIOLOGY & BEHAVIOR

Impact of a single bout of high-intensity interval exercise and short-term interval training on interleukin-6, FNDC5, and METRNL mRNA expression in human skeletal muscle

(2018) Malcolm Eaton et al.   Journal of Sport and Health Science

Exercise-Mediated Neurogenesis in the Hippocampus via BDNF

(2018) Patrick Z. Liu et al.   Frontiers in Neuroscience

Cerebral Ischemia Changed the Effect of Metabosensitive Muscle Afferents on Somatic Reflex Without Affecting Thalamic Activity

(2018) Caroline Pin-Barre et al.   Frontiers in Physiology

Effects of combined intervention of physical exercise and cognitive training on cognitive function in stroke survivors with vascular cognitive impairment: a randomized controlled trial

(2018) Wang Bo et al.   CLINICAL REHABILITATION

Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer’s mouse model

(2018) Se Hoon Choi et al.   SCIENCE

BDNF, endurance activity, and mechanisms underlying the evolution of hominin brains

(2018) Tyler Hill et al.   AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY

High-intensity interval training in people with Parkinson’s disease: a randomized, controlled feasibility trial

(2018) Marguerite Harvey et al.   CLINICAL REHABILITATION

Exercise intensity affects acute neurotrophic and neurophysiologic responses post-stroke

(2018) Pierce Boyne et al.   JOURNAL OF APPLIED PHYSIOLOGY

Efficacy and feasibility of HIIT training for university students: The Uni-HIIT RCT

(2018) Narelle Eather et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

High-Intensity Interval Training on Neuroplasticity, Balance between Brain-Derived Neurotrophic Factor and Precursor Brain-Derived Neurotrophic Factor in Poststroke Depression Rats

(2018) Lu Luo et al.   Journal of Stroke & Cerebrovascular Diseases

Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Hmwe Hmwe Kyu et al.   LANCET

Effect of regular swimming exercise to duration-intensity on neurocognitive function in cerebral infarction rat model

(2018) Min-Keun Song et al.   NEUROLOGICAL RESEARCH

The Effects of Physical Exercise and Cognitive Training on Memory and Neurotrophic Factors

(2017) Jennifer J. Heisz et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

High-intensity Interval Exercise Promotes Motor Cortex Disinhibition and Early Motor Skill Consolidation

(2017) Ellen L. Stavrinos et al.   JOURNAL OF COGNITIVE NEUROSCIENCE

Effects of High- Versus Moderate-Intensity Training on Neuroplasticity and Functional Recovery After Focal Ischemia

(2017) Caroline Pin-Barre et al.   STROKE

Intense Exercise Promotes Adult Hippocampal Neurogenesis But Not Spatial Discrimination

(2017) Ji H. So et al.   Frontiers in Cellular Neuroscience

Exercise induces cerebral VEGF and angiogenesis via the lactate receptor HCAR1

(2017) Cecilie Morland et al.   Nature Communications

Brain BDNF levels are dependent on cerebrovascular endothelium-derived nitric oxide

(2016) Hayat Banoujaafar et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Environmental enrichment and physical exercise revert behavioral and electrophysiological impairments caused by reduced adult neurogenesis

(2016) Marna Eliana Sakalem et al.   HIPPOCAMPUS

Physiological adaptations to interval training and the role of exercise intensity

(2016) Martin J. MacInnis et al.   JOURNAL OF PHYSIOLOGY-LONDON

Physical exercise increases adult hippocampal neurogenesis in male rats provided it is aerobic and sustained

(2016) Miriam S. Nokia et al.   JOURNAL OF PHYSIOLOGY-LONDON

High- and low-intensity exercise do not improve cognitive function after stroke: A randomized controlled trial

(2016) A Tang et al.   JOURNAL OF REHABILITATION MEDICINE

Aerobic Exercises for Cognition Rehabilitation following Stroke: A Systematic Review

(2016) Guohua Zheng et al.   Journal of Stroke & Cerebrovascular Diseases

Exercise in the Early Stage after Stroke Enhances Hippocampal Brain-Derived Neurotrophic Factor Expression and Memory Function Recovery

(2016) Naoyuki Himi et al.   Journal of Stroke & Cerebrovascular Diseases

High-Intensity Interval Training and Moderate-Intensity Continuous Training in Ambulatory Chronic Stroke: Feasibility Study

(2016) P. Boyne et al.   PHYSICAL THERAPY

Acute Exercise and Motor Memory Consolidation: The Role of Exercise Intensity

(2016) Richard Thomas et al.   PLoS One

Guidelines for Adult Stroke Rehabilitation and Recovery

(2016) Carolee J. Winstein et al.   STROKE

Influence of Aerobic Training and Combinations of Interventions on Cognition and Neuroplasticity after Stroke

(2016) Annabelle Constans et al.   Frontiers in Aging Neuroscience

Aerobic Exercises for Cognition Rehabilitation following Stroke: A Systematic Review

(2016) Guohua Zheng et al.   Journal of Stroke & Cerebrovascular Diseases

Exercise in the Early Stage after Stroke Enhances Hippocampal Brain-Derived Neurotrophic Factor Expression and Memory Function Recovery

(2016) Naoyuki Himi et al.   Journal of Stroke & Cerebrovascular Diseases

Effects of a Single Session of High Intensity Interval Treadmill Training on Corticomotor Excitability following Stroke: Implications for Therapy

(2016) Sangeetha Madhavan et al.   NEURAL PLASTICITY

Ultra-sensitive detection of brain-derived neurotrophic factor (BDNF) in the brain of freely moving mice using an interdigitated microelectrode (IME) biosensor

(2016) Yong Kyoung Yoo et al.   Scientific Reports

Endurance Exercise as an “Endogenous” Neuro-enhancement Strategy to Facilitate Motor Learning

(2015) Marco Taubert et al.   Frontiers in Human Neuroscience

High-intensity interval training evokes larger serum BDNF levels compared with intense continuous exercise

(2015) Cinthia Maria Saucedo Marquez et al.   JOURNAL OF APPLIED PHYSIOLOGY

Efficacy and safety of very early mobilisation within 24 h of stroke onset (AVERT): a randomised controlled trial

(2015)   LANCET

Motor System Reorganization After Stroke: Stimulating and Training Toward Perfection

(2015) Theresa A. Jones et al.   PHYSIOLOGY

Comparing interval and continuous exercise training regimens on neurotrophic factors in rat brain

(2015) Mohammad Esmaiel Afzalpour et al.   PHYSIOLOGY & BEHAVIOR

Physical exercise and vascular endothelial growth factor (VEGF) in elderly: A systematic review

(2014) Thays Martins Vital et al.   ARCHIVES OF GERONTOLOGY AND GERIATRICS

Rehabilitation for post-stroke cognitive impairment: an overview of recommendations arising from systematic reviews of current evidence

(2014) David C Gillespie et al.   CLINICAL REHABILITATION

Does Aerobic Exercise and the FITT Principle Fit into Stroke Recovery?

(2014) Sandra A. Billinger et al.   Current Neurology and Neuroscience Reports

Thinking outside the brain: Structural plasticity in the spinal cord promotes recovery from cortical stroke

(2014) Kelly A. Tennant   EXPERIMENTAL NEUROLOGY

A single bout of high-intensity aerobic exercise facilitates response to paired associative stimulation and promotes sequence-specific implicit motor learning

(2014) Cameron S. Mang et al.   JOURNAL OF APPLIED PHYSIOLOGY

Effect of high-intensity exercise on aged mouse brain mitochondria, neurogenesis, and inflammation

(2014) Lezi E et al.   NEUROBIOLOGY OF AGING

Acute exercise improves motor memory: Exploring potential biomarkers

(2014) Kasper Skriver et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Acute Neuromuscular Adaptation at the Spinal Level Following Middle Cerebral Artery Occlusion-Reperfusion in the Rat

(2014) Caroline Pin-Barre et al.   PLoS One

Physical Activity and Exercise Recommendations for Stroke Survivors

(2014) Sandra A. Billinger et al.   STROKE

The Effects of Poststroke Aerobic Exercise on Neuroplasticity: A Systematic Review of Animal and Clinical Studies

(2014) Michelle Ploughman et al.   Translational Stroke Research

Exercise Induces Hippocampal BDNF through a PGC-1α/FNDC5 Pathway

(2013) Christiane D. Wrann et al.   Cell Metabolism

Effects of Exercise Intensity on Spatial Memory Performance and Hippocampal Synaptic Plasticity in Transient Brain Ischemic Rats

(2013) Pei-Cheng Shih et al.   PLoS One

High-Intensity Interval Training, Solutions to the Programming Puzzle

(2013) Martin Buchheit et al.   SPORTS MEDICINE

High-Intensity Interval Training, Solutions to the Programming Puzzle

(2013) Martin Buchheit et al.   SPORTS MEDICINE

Meta-analysis of the Efficacy of Different Training Strategies in Animal Models of Ischemic Stroke

(2013) Antje Schmidt et al.   STROKE

Bridging animal and human models of exercise-induced brain plasticity

(2013) Michelle W. Voss et al.   TRENDS IN COGNITIVE SCIENCES

Low-speed treadmill running exercise improves memory function after transient middle cerebral artery occlusion in rats

(2012) Haruka Shimada et al.   BEHAVIOURAL BRAIN RESEARCH

The effects of acute exercise on cognitive performance: A meta-analysis

(2012) Y.K. Chang et al.   BRAIN RESEARCH

The severity of cognitive deficits predicts return to work after a first-ever ischaemic stroke

(2012) T. Kauranen et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Neuronal circuitry mechanism regulating adult quiescent neural stem-cell fate decision

(2012) Juan Song et al.   NATURE

A PGC1-α-dependent myokine that drives brown-fat-like development of white fat and thermogenesis

(2012) Pontus Boström et al.   NATURE

Training your brain: Do mental and physical (MAP) training enhance cognition through the process of neurogenesis in the hippocampus?

(2012) D.M. Curlik et al.   NEUROPHARMACOLOGY

A Single Bout of Exercise Improves Motor Memory

(2012) Marc Roig et al.   PLoS One

The Feasibility of Cardiopulmonary Exercise Testing for Prescribing Exercise to People After Stroke

(2012) Susan Marzolini et al.   STROKE

Astrocyte-Neuron Lactate Transport Is Required for Long-Term Memory Formation

(2011) Akinobu Suzuki et al.   CELL

The effect of physical activity on cognitive function after stroke: a systematic review

(2011) Toby B. Cumming et al.   INTERNATIONAL PSYCHOGERIATRICS

Speed-dependent treadmill training is effective to improve gait and balance performance in patients with sub-acute stroke

(2011) MKY Mak et al.   JOURNAL OF REHABILITATION MEDICINE

Running is the neurogenic and neurotrophic stimulus in environmental enrichment

(2011) T. Kobilo et al.   LEARNING & MEMORY

Exercise preconditioning and brain ischemic tolerance

(2011) F. Zhang et al.   NEUROSCIENCE

Circulating and Brain BDNF Levels in Stroke Rats. Relevance to Clinical Studies

(2011) Yannick Béjot et al.   PLoS One

Exercise training increases size of hippocampus and improves memory

(2011) K. I. Erickson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Physical Activity and Functional Outcomes From Cerebral Vascular Events in Men

(2011) Pamela M. Rist et al.   STROKE

Exercise preconditioning reduces neuronal apoptosis in stroke by up-regulating heat shock protein-70 (heat shock protein-72) and extracellular-signal-regulated-kinase 1/2

(2010) B. Liebelt et al.   NEUROSCIENCE

Lactate infusion at rest increases BDNF blood concentration in humans

(2010) Thorsten Schiffer et al.   NEUROSCIENCE LETTERS

Elevated blood lactate is associated with increased motor cortex excitability

(2010) Marinella Coco et al.   SOMATOSENSORY AND MOTOR RESEARCH

Downregulation of Potassium Chloride Cotransporter KCC2 After Transient Focal Cerebral Ischemia

(2010) Nadine Jaenisch et al.   STROKE

Evidence for a release of brain-derived neurotrophic factor from the brain during exercise

(2009) Peter Rasmussen et al.   EXPERIMENTAL PHYSIOLOGY

Differential effects of treadmill running and wheel running on spatial or aversive learning and memory: roles of amygdalar brain-derived neurotrophic factor and synaptotagmin I

(2009) Yu-Fan Liu et al.   JOURNAL OF PHYSIOLOGY-LONDON

Cation-Chloride Cotransporters and Neuronal Function

(2009) Peter Blaesse et al.   NEURON

Lactate Threshold Concepts

(2009) Oliver Faude et al.   SPORTS MEDICINE

Priming the motor system enhances the effects of upper limb therapy in chronic stroke

(2008) Cathy M. Stinear et al.   BRAIN

Cortisol Inhibits Neuroplasticity Induction in Human Motor Cortex

(2008) M. V. Sale et al.   JOURNAL OF NEUROSCIENCE

Be smart, exercise your heart: exercise effects on brain and cognition

(2007) Charles H. Hillman et al.   NATURE REVIEWS NEUROSCIENCE