Article
Biophysics
Ozge Karabiyik Acar, G. Delal Nozhatzadeh, A. Alperen Tuncer, Gamze Torun Kose, Erhan Aysan
Summary: This study compared the cell transplantation potentials of two commercial alginate brands and found that PRONATAL KF200, with a lower M/G ratio, was more rigid and robust, making it a promising choice for microcapsule preparation.
JOURNAL OF MECHANICS IN MEDICINE AND BIOLOGY
(2023)
Article
Nanoscience & Nanotechnology
Jin-Ok Chu, Yoon Choi, Do-Wan Kim, Hye-Seon Jeong, Jong Pil Park, David A. Weitz, Sei-Jung Lee, Hyomin Lee, Chang-Hyung Choi
Summary: This study reports the development of cell-inspired hydrogel microcapsules that effectively encapsulate and retain antioxidants. The microcapsules have an interstitial oil layer and an ionic gelation hydrogel shell, providing enhanced retention and protection of the antioxidants. Addition of a lipophilic reducing agent in the oil layer enhances the antioxidant activity, and lowering the storage temperature further improves the antioxidant activity.
ACS APPLIED MATERIALS & INTERFACES
(2022)
Article
Chemistry, Multidisciplinary
Shuaikai Ren, Chunxin Wang, Liang Guo, Congcong Xu, Yan Wang, Changjiao Sun, Haixin Cui, Xiang Zhao
Summary: Microcapsules with uniform size and tailored dimensions were prepared using emulsification and solvent evaporation methods in this study for the construction of controlled-release drug carriers. Morphology and structure of the microcapsules could be tailored by regulating the preparation conditions, and the release rate of protein could be controlled by adjusting the pore size. This controlled-release novel microcapsule carrier system shows great potential for biomedical applications.
Article
Chemistry, Physical
Seong-Geun Jeong, Yoon Choi, Jin-Oh Nam, Chang-Soo Lee, Chang-Hyung Choi
Summary: In this study, double emulsion drops were produced by utilizing phase separation in micromolds and surface-tension-induced drop formation, without the need for surfactants or complex formulations. The size of the compartments in the emulsion drops can be controlled by adjusting the composition of the solution and separation agent, enabling encapsulation of different cargoes in desired compartments. Additionally, hydrogel microcapsules were produced by solidifying the middle phase in the double emulsion drops, allowing for encapsulation of large cargo in the core and release of small cargo via temperature tuning.
JOURNAL OF COLLOID AND INTERFACE SCIENCE
(2021)
Article
Polymer Science
Sujin Ryu, Jaeyun Shim
Summary: The study introduces a method to enhance the functionality of textiles by encapsulating ginseng oil as the core material in microcapsules. The treated fabric shows excellent antibacterial and deodorizing properties, indicating potential for producing highly hygienic textiles.
Article
Biophysics
Hao Cheng, Xuan Chang, Hui Luo, Honggang Tang, Lihong Chen, Li Liang
Summary: This study demonstrates the possibility of encapsulating resveratrol in emulsified oil droplets at high wall/core ratios. The optimal microcapsule with 1.75% surface oil was fabricated using 15% transglutaminase-crosslinked WPI (TGase-WPI) and 5% gum Arabic (GA). Resveratrol was mainly located in the protein matrix of the initial emulsion and reconstituted microcapsule. The effects of TGase-WPI/GA microcapsule and resveratrol co-encapsulation on DHA/EPA and lipid hydroperoxides/TBARS were different. The results highlight the potential use of spray-dried microcapsules as co-encapsulation carriers.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2023)
Article
Pharmacology & Pharmacy
E. C. Morais, H. T. Schroeder, C. H. Muller, S. R. Rodrigues, C. S. Souza, I. Homen de Bittencourt, J. H. Z. dos Santos
Summary: In this study, the effects of different encapsulating systems on cell viability and physiology were investigated using MIN-6 cells. The alginate/gelatin/PEG system and the alginate/chitosan matrix were found to be the most effective encapsulation systems in terms of cell viability and insulin secretion capacity.
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
(2021)
Article
Biophysics
Md Danish Eqbal, Farha Naaz, Kajal Sharma, Venkat Gundabala
Summary: The development of a 3D glass-PDMS hybrid device allows for complete on-chip generation of cell-laden alginate beads in the presence of electric fields, with active control of droplet size. This approach successfully encapsulated E. coli cells into alginate microbeads and demonstrated promising technology for cell encapsulation with applications in various fields.
COLLOIDS AND SURFACES B-BIOINTERFACES
(2021)
Article
Food Science & Technology
Yanhong Liu, Wanqi Cao, Jiahao Wang, Lingling Zhang, Yajiao Yang, Mengyao Liu, Hui Wang, Shuo Wang
Summary: A novel double-layer Perilla essential oil composite membrane microcapsule was successfully prepared with good pressure resistance and thermal stability, showing significant fresh-keeping effects on nectarines.
JOURNAL OF FOOD SCIENCE
(2022)
Article
Food Science & Technology
Sebastiao anderson Dantas da Silva, Leonam da Silva Pereira Batista, Dara Souza Diniz, Sara Sayonara da Cruz Nascimento, Neyna Santos Morais, Cristiane Fernandes de Assis, Thais Souza Passos, Francisco Caninde de Sousa Junior
Summary: This study aimed to produce and characterize alginate or gelatin-based microparticles containing probiotics and evaluate their stability under storage conditions. The results showed that probiotics encapsulated in gelatin-based microparticles had smaller diameters and higher encapsulation efficiency compared to those encapsulated in alginate-based microparticles. Furthermore, gelatin-based microparticles exhibited good stability during storage, indicating that gelatin encapsulation is a promising strategy for protecting and stabilizing probiotics.
Article
Chemistry, Multidisciplinary
Hye-Seon Jeong, Eunseo Kim, Jong Pil Park, Sei-Jung Lee, Hyomin Lee, Chang Hyung Choi
Summary: We developed PNIPAm-co-PEGDA hydrogel shelled microcapsules with a thin oil layer for tunable thermo-responsive release of small hydrophilic actives. By using a microfluidic device integrated with a temperature-controlled chamber, we were able to consistently produce the microcapsules using triple emulsion drops as capsule templates. The presence of an interstitial oil layer between the aqueous core and the hydrogel shell allowed for controlled release of the encapsulated substances upon reaching a critical temperature. Additionally, the incorporation of gold nanorods in the hydrogel shell enables spatiotemporal regulation of the active release using near infrared light.
JOURNAL OF CONTROLLED RELEASE
(2023)
Article
Food Science & Technology
Nikita Tyutkov, Anastasia Zhernyakova, Artyom Birchenko, Elmira Eminova, Liudmila Nadtochii, Denis Baranenko
Summary: Introducing probiotics into frozen foods is a promising method to extend their shelf life, although freezing can damage bacterial cells, therefore, technological solutions are required to protect probiotics. Techniques such as encapsulation, addition of cryoprotectants and prebiotics, as well as adaptation of microorganisms, are commonly used for probiotic protection.
Article
Nanoscience & Nanotechnology
Kai Yang, Qian Wang, Yu Wang, Sha Li, Yian Gu, Nan Gao, Fuhai Zhang, Peng Lei, Rui Wang, Hong Xu
Summary: A novel strategy of forming a nanocoating on bacterial surfaces to enhance viability is proposed in this study. The coating composed of NHS-modified gamma-PGA and calcium ions significantly increased the resistance and survival rate of bacteria, leading to better growth-promoting properties in plant growth.
ACS APPLIED MATERIALS & INTERFACES
(2021)
Article
Materials Science, Textiles
Su-Jin Ryu, Hyun-Sook Bae
Summary: In this study, eco-friendly microcapsules were manufactured using chitosan and basil oil to minimize the use of chemicals. Optimum manufacturing conditions were established through shape and size analysis, and the thermal stability of the prepared microcapsules was evaluated. The microcapsules containing basil oil showed sustained-release characteristics and could be applied to textile finishing.
FASHION AND TEXTILES
(2021)
Article
Food Science & Technology
Xin Ying, Jiaxing Gao, Jing Lu, Changlu Ma, Jiaping Lv, Benu Adhikari, Bo Wang
Summary: In this study, soy peptide solution was successfully encapsulated in a W-1/O/W-2 double emulsion using PGPR as an effective inner emulsifier. The droplet size and encapsulation efficiency of the peptide solution depended on various factors including the ratio and concentration of phases. The freeze-dried microcapsule powder showed higher encapsulation efficiency compared to spray-dried one, indicating the potential of this double emulsion as a delivery matrix for hydrophilic ingredients.
FOOD RESEARCH INTERNATIONAL
(2021)
Article
Biochemistry & Molecular Biology
Elisabet Ferrer, Benjamin J. Dunmore, Dhiya Hassan, Mark L. Ormiston, Stephen Moore, John Deighton, Lu Long, Xu Dong Yang, Duncan J. Stewart, Nicholas W. Morrell
AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY
(2018)
Article
Cardiac & Cardiovascular Systems
Kuang-Hueih Chen, Asish Dasgupta, Jianhui Lin, Francois Potus, Sebastien Bonnet, James Iremonger, Jennifer Fu, Jeffrey Mewburn, Danchen Wu, Kimberly Dunham-Snary, Anne L. Theilmann, Zhi-Cheng Jing, Charles Hindmarch, Mark L. Ormiston, Allan Lawrie, Stephen L. Archer
Review
Medicine, General & Internal
Thenappan Thenappan, Mark L. Ormiston, John J. Ryan, Stephen L. Archer
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Review
Medicine, General & Internal
Thenappan Thenappan, Mark L. Ormiston, John J. Ryan, Stephen L. Archer
BMJ-BRITISH MEDICAL JOURNAL
(2018)
Article
Physiology
Matthew T. Ratsep, Stephen D. Moore, Salema Jafri, Melissa Mitchell, Hugh J. M. Brady, Ofer Mandelboim, Mark Southwood, Nicholas W. Morrell, Francesco Colucci, Mark L. Ormiston
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
(2018)
Article
Multidisciplinary Sciences
Salema Jafri, Stephen D. Moore, Nicholas W. Morrell, Mark L. Ormiston
SCIENTIFIC REPORTS
(2017)
Article
Respiratory System
Benjamin E. Garfield, Alexi Crosby, Dongmin Shao, Peiran Yang, Cai Read, Steven Sawiak, Stephen Moore, Lisa Parfitt, Carl Harries, Martin Rice, Richard Paul, Mark L. Ormiston, Nicholas W. Morrell, Michael I. Polkey, Stephen John Wort, Paul R. Kemp
Editorial Material
Cardiac & Cardiovascular Systems
Mark L. Ormiston, Rafael Soares Godoy, Ketul R. Chaudhary, Duncan J. Stewart
CIRCULATION RESEARCH
(2019)
Editorial Material
Hematology
L. Rhiannon Hilton, Mark L. Ormiston
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
(2019)
Review
Peripheral Vascular Disease
Nicholas D. Cober, M. Martin VandenBroek, Mark L. Ormiston, Duncan J. Stewart
Summary: Pulmonary arterial hypertension (PAH) is a deadly disease characterized by imbalances in pulmonary endothelial cells. Endothelial cell apoptosis and the imbalance between injury and repair may play a crucial role in the development of PAH, making endothelial cells a major target for therapeutic interventions. Arterial pruning and endothelial injury contribute to occlusive arterial remodeling in PAH. Endothelial cell senescence and the effects of female sex hormones on arterial changes in PAH are complex.
Review
Oncology
Kassandra M. Coyle, Lindsey G. Hawke, Mark L. Ormiston
Summary: Natural killer (NK) cells are cytotoxic innate lymphoid cells known for killing stressed, cancerous, and virally infected cells. They also influence broader immune responses through cytokine production and play roles in non-immune processes. NK cell-based cancer therapies have shown promise, but the tumor microenvironment can suppress NK cell function and induce a phenotypic shift. This review summarizes current approaches and challenges of NK cell-based cancer therapies, and discusses efforts to overcome these challenges and potential applications outside cancer.
Article
Cardiac & Cardiovascular Systems
Paola Caruso, Benjamin J. Dunmore, Kenny Schlosser, Sandra Schoors, Claudia Dos Santos, Carol Perez-Iratxeta, Jessie R. Lavoie, Hui Zhang, Lu Long, Amanda R. Flockton, Maria G. Frid, Paul D. Upton, Angelo D'Alessandro, Charaka Hadinnapola, Fedir N. Kiskin, Mohamad Taha, Liam A. Hurst, Mark L. Ormiston, Akiko Hata, Kurt R. Stenmark, Peter Carmeliet, Duncan J. Stewart, Nicholas W. Morrell
Review
Physiology
Salema Jafri, Mark L. Ormiston
AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY
(2017)
Article
Hematology
Soundarya N. Selvam, Lara J. Casey, Mackenzie L. Bowman, Lindsey G. Hawke, Avery J. Longmore, Jeffrey Mewburn, Mark L. Ormiston, Stephen L. Archer, Donald H. Maurice, Paula James
BLOOD COAGULATION & FIBRINOLYSIS
(2017)
Article
Critical Care Medicine
Zhigang Hong, Kuang-Hueih Chen, Asish DasGupta, Francois Potus, Kimberly Dunham-Snary, Sebastien Bonnet, Lian Tian, Jennifer Fu, Sandra Breuils-Bonnet, Steeve Provencher, Danchen Wu, Jeffrey Mewburn, Mark L. Ormiston, Stephen L. Archers
AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE
(2017)
Article
Engineering, Biomedical
Lin-Lin Luo, Jie Xu, Bing-Qiao Wang, Chen Chen, Xi Chen, Qiu-Mei Hu, Yu-Qiu Wang, Wan-Yun Zhang, Wan-Xiang Jiang, Xin-Ting Li, Hu Zhou, Xiao Xiao, Kai Zhao, Sen Lin
Summary: A novel AAV serotype, AAVYC5, introduced in this study, showed more efficient transduction into multiple retinal layers compared to AAV2, and enabled successful delivery of anti-angiogenic molecules in mice and non-human primates.