Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway
Published 2015 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Loss of fatty acid synthase suppresses the malignant phenotype of colorectal cancer cells by down-regulating energy metabolism and mTOR signaling pathway
Authors
Keywords
FASN, mTOR, Colorectal cancer, Energy metabolism
Journal
JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY
Volume 142, Issue 1, Pages 59-72
Publisher
Springer Nature
Online
2015-06-24
DOI
10.1007/s00432-015-2000-8
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- mTOR pathway in colorectal cancer: an update
- (2015) Maria Giovanna Francipane et al. Oncotarget
- PIK3CA Mutation in Colorectal Cancer: Relationship with Genetic and Epigenetic Alterations
- (2015) Katsuhiko Nosho et al. NEOPLASIA
- Rapamycin: One Drug, Many Effects
- (2014) Jing Li et al. Cell Metabolism
- Repositioning Proton Pump Inhibitors as Anticancer Drugs by Targeting the Thioesterase Domain of Human Fatty Acid Synthase
- (2014) Valerie E. Fako et al. JOURNAL OF MEDICINAL CHEMISTRY
- Overexpression of fatty acid synthase in human gliomas correlates with the WHO tumor grade and inhibition with Orlistat reduces cell viability and triggers apoptosis
- (2014) Susanne Grube et al. JOURNAL OF NEURO-ONCOLOGY
- Alpha-2-Glycoprotein 1(AZGP1) Regulates Biological Behaviors of LoVo Cells by Down-Regulating mTOR Signaling Pathway and Endogenous Fatty Acid Synthesis
- (2014) Ligong Chang et al. PLoS One
- The mTOR Inhibitor Rapamycin Synergizes with a Fatty Acid Synthase Inhibitor to Induce Cytotoxicity in ER/HER2-Positive Breast Cancer Cells
- (2014) Chen Yan et al. PLoS One
- Fatty acid synthase (FASN) levels in serum of colorectal cancer patients: correlation with clinical outcomes
- (2014) Qi-qiang Long et al. TUMOR BIOLOGY
- Role of abnormal lipid metabolism in development, progression, diagnosis and therapy of pancreatic cancer
- (2014) Julian Swierczynski WORLD JOURNAL OF GASTROENTEROLOGY
- Effects of metformin on breast cancer cell proliferation, the AMPK pathway and the cell cycle
- (2013) S. M. Hadad et al. Clinical & Translational Oncology
- Molecular Pathways: Fumarate Hydratase-Deficient Kidney Cancer--Targeting the Warburg Effect in Cancer
- (2013) W. M. Linehan et al. CLINICAL CANCER RESEARCH
- Epigenetic Reprogramming in Cancer
- (2013) M. L. Suva et al. SCIENCE
- Targeting the PI3-Kinase/Akt/mTOR Signaling Pathway
- (2013) Burhan Hassan et al. Surgical Oncology Clinics of North America
- Fatty acid synthase inhibitor cerulenin inhibits topoisomerase I catalytic activity and augments SN-38-induced apoptosis
- (2012) Na Young Jeong et al. APOPTOSIS
- New strategies for targeting the hypoxic tumour microenvironment in breast cancer
- (2012) Carol Ward et al. CANCER TREATMENT REVIEWS
- G Protein-coupled Estrogen Receptor Mediates the Up-regulation of Fatty Acid Synthase Induced by 17β-Estradiol in Cancer Cells and Cancer-associated Fibroblasts
- (2012) Maria Francesca Santolla et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- How cancer metabolism is tuned for proliferation and vulnerable to disruption
- (2012) Almut Schulze et al. NATURE
- The translational landscape of mTOR signalling steers cancer initiation and metastasis
- (2012) Andrew C. Hsieh et al. NATURE
- De Novo Lipogenesis in Adipose Tissue Is Associated with Course of Morbid Obesity after Bariatric Surgery
- (2012) Lourdes Garrido-Sánchez et al. PLoS One
- Therapeutic and Toxicologic Evaluation of Anti-Lipogenic Agents in Cancer Cells Compared with Non-Neoplastic Cells
- (2011) Perinkulam Ravi Deepa et al. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
- Antitumor effect of orlistat, a fatty acid synthase inhibitor, is via activation of caspase-3 on human colorectal carcinoma-bearing animal
- (2011) Hui-Yen Chuang et al. BIOMEDICINE & PHARMACOTHERAPY
- From cancer metabolism to new biomarkers and drug targets
- (2011) F. Chiaradonna et al. BIOTECHNOLOGY ADVANCES
- Novel Theranostic Opportunities Offered by Characterization of Altered Membrane Lipid Metabolism in Breast Cancer Progression
- (2011) M. Hilvo et al. CANCER RESEARCH
- PIK3CA Mutations in Patients with Advanced Cancers Treated with PI3K/AKT/mTOR Axis Inhibitors
- (2011) F. Janku et al. MOLECULAR CANCER THERAPEUTICS
- Fatty acid synthase as a potential therapeutic target in cancer
- (2010) Richard Flavin et al. Future Oncology
- Activation of a Metabolic Gene Regulatory Network Downstream of mTOR Complex 1
- (2010) Katrin Düvel et al. MOLECULAR CELL
- De novo fatty-acid synthesis and related pathways as molecular targets for cancer therapy
- (2009) T Mashima et al. BRITISH JOURNAL OF CANCER
- Fatty Acid Synthase: A Metabolic Enzyme and Candidate Oncogene in Prostate Cancer
- (2009) Toshiro Migita et al. JNCI-Journal of the National Cancer Institute
- Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation
- (2009) M. G. Vander Heiden et al. SCIENCE
- Tumor Cell Metabolism: Cancer's Achilles' Heel
- (2008) Guido Kroemer et al. CANCER CELL
- The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation
- (2008) Ralph J. DeBerardinis et al. Cell Metabolism
- Control of Cell Growth and Survival by Enzymes of the Fatty Acid Synthesis Pathway in HCT-116 Colon Cancer Cells
- (2008) Y. Zhan et al. CLINICAL CANCER RESEARCH
- Targeting the PI3K–AKT–mTOR pathway: progress, pitfalls, and promises
- (2008) Timothy A Yap et al. CURRENT OPINION IN PHARMACOLOGY
- Targeting the PI3K/Akt/mTOR pathway: Effective combinations and clinical considerations
- (2008) J LOPICCOLO et al. DRUG RESISTANCE UPDATES
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search