The mTOR Inhibitor Rapamycin Synergizes with a Fatty Acid Synthase Inhibitor to Induce Cytotoxicity in ER/HER2-Positive Breast Cancer Cells

Growth factor receptor/steroid receptor cross talk in trastuzumab-treated breast cancer

(2014) D C Collins et al.   ONCOGENE

Alterations of the genes involved in the PI3K and estrogen-receptor pathways influence outcome in human epidermal growth factor receptor 2-positive and hormone receptor-positive breast cancer patients treated with trastuzumab-containing neoadjuvant chemotherapy

(2013) Mamoru Takada et al.   BMC CANCER

Breast cancer statistics, 2013

(2013) Carol DeSantis et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Phase I study evaluating the combination of lapatinib (a Her2/Neu and EGFR inhibitor) and everolimus (an mTOR inhibitor) in patients with advanced cancers: South West Oncology Group (SWOG) Study S0528

(2013) Shirish M. Gadgeel et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Novel Approaches for Molecular Targeted Therapy of Breast Cancer: Interfering with PI3K/AKT/mTOR Signaling

(2013) Thomas W. Grunt et al.   CURRENT CANCER DRUG TARGETS

Effect of visceral metastases on the efficacy and safety of everolimus in postmenopausal women with advanced breast cancer: Subgroup analysis from the BOLERO-2 study

(2013) Mario Campone et al.   EUROPEAN JOURNAL OF CANCER

Cytostatic versus cytocidal profiling of quinoline drug combinations via modified fixed-ratio isobologram analysis

(2013) Alexander P Gorka et al.   MALARIA JOURNAL

Fatty Acid Synthase Is a Potential Therapeutic Target in Estrogen Receptor-/Progesterone Receptor-Positive Endometrioid Endometrial Cancer

(2013) Mohammed Tanjimur Rahman et al.   ONCOLOGY

Adding hormonal therapy to chemotherapy and trastuzumab improves prognosis in patients with hormone receptor-positive and human epidermal growth factor receptor 2-positive primary breast cancer

(2012) Naoki Hayashi et al.   BREAST CANCER RESEARCH AND TREATMENT

Dual mTORC1/2 and HER2 Blockade Results in Antitumor Activity in Preclinical Models of Breast Cancer Resistant to Anti-HER2 Therapy

(2012) C. Garcia-Garcia et al.   CLINICAL CANCER RESEARCH

G Protein-coupled Estrogen Receptor Mediates the Up-regulation of Fatty Acid Synthase Induced by 17β-Estradiol in Cancer Cells and Cancer-associated Fibroblasts

(2012) Maria Francesca Santolla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Comprehensive molecular portraits of human breast tumours

(2012) Daniel C. Koboldt et al.   NATURE

Histological grade as an alternative to the Ki67 labeling index is only available for luminal-type breast cancers

(2012) Satoshi Hayashi et al.   Breast Cancer

A shift in the treatment of hormone receptor and human epidermal growth factor receptor 2-positive metastatic breast cancer

(2011) Zoe Kemp et al.   ADVANCES IN THERAPY

Strategies for subtypes—dealing with the diversity of breast cancer: highlights of the St Gallen International Expert Consensus on the Primary Therapy of Early Breast Cancer 2011

(2011) A. Goldhirsch et al.   ANNALS OF ONCOLOGY

mTORC1-Mediated Cell Proliferation, But Not Cell Growth, Controlled by the 4E-BPs

(2010) R. J. O. Dowling et al.   SCIENCE

mTOR inhibitors and the anti-diabetic biguanide metformin: new insights into the molecular management of breast cancer resistance to the HER2 tyrosine kinase inhibitor lapatinib (Tykerb®)

(2009) Alejandro Vázquez-Martín et al.   Clinical & Translational Oncology

Inhibition of Mammalian Target of Rapamycin Is Required for Optimal Antitumor Effect of HER2 Inhibitors against HER2-Overexpressing Cancer Cells

(2009) T. W. Miller et al.   CLINICAL CANCER RESEARCH

Ki67 Index, HER2 Status, and Prognosis of Patients With Luminal B Breast Cancer

(2009) Maggie C. U. Cheang et al.   JNCI-Journal of the National Cancer Institute

Deciphering downstream gene targets of PI3K/mTOR/p70S6K pathway in breast cancer

(2008) Henna Heinonen et al.   BMC GENOMICS

ERBB2 influences the subcellular localization of the estrogen receptor in tamoxifen-resistant MCF-7 cells leading to the activation of AKT and RPS6KA2

(2008) S. Pancholi et al.   ENDOCRINE-RELATED CANCER

Her2 cross talk and therapeutic resistance in breast cancer

(2008) Laura et al.   Frontiers in Bioscience-Landmark

Inhibition of Fatty-acid Synthase Induces Caspase-8-mediated Tumor Cell Apoptosis by Up-regulating DDIT4

(2008) Lynn M. Knowles et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The tyrosine kinase receptor HER2 (erbB-2): From oncogenesis to adipogenesis

(2008) Alejandro Vazquez-Martin et al.   JOURNAL OF CELLULAR BIOCHEMISTRY