Article
Biochemistry & Molecular Biology
Vittoria Borgonetti, Nicoletta Galeotti
Summary: The study showed that rosmarinic acid can improve cell viability, reduce inflammatory factors, and decrease microglial senescence markers, suggesting its potential as a pharmacological target for controlling symptoms of peripheral neuropathy.
Article
Immunology
Kazue Hisaoka-Nakashima, Kodai Moriwaki, Natsuki Yoshimoto, Toshiki Yoshii, Yoki Nakamura, Yukio Ago, Norimitsu Morioka
Summary: Neuropathic pain causes severe pain and comorbidities such as cognitive impairment, which are not effectively treated with current analgesics. This study demonstrates the role of interleukin-6 (IL-6) in neuropathic pain and cognitive impairment. Blocking the IL-6 receptor improves cognitive impairment, while inhibiting IL-6 activity reduces allodynia.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Immunology
George Sideris-Lampretsas, Marzia Malcangio
Summary: This review summarizes the existing preclinical evidence on how the CNS compartment and sex impact microglia functions in health, emphasizing recent advances in transcriptomics analyses for characterizing disease-associated microglial states. The specific scenario of peripheral nerve or tissue injury inducing expression of a specific subset of genes in microglia in the dorsal horn of the spinal cord is discussed, along with the possibility of a unique microglia transcriptional profile associated with chronic pain conditions. The evidence also suggests microglial activation in pain-related areas of the brain can be observed in models of neuropathic pain, highlighting the potential for future studies to further explore neuroimmune interactions in chronic pain using novel approaches like scRNA-seq and CYTOF.
BRAIN BEHAVIOR AND IMMUNITY
(2021)
Article
Immunology
Ao Guo, Jingfan Li, Lan Luo, Chunyi Chen, Qing Lu, Jianjuan Ke, Xiaobo Feng
Summary: This study shows that VPA alleviates neuropathic pain by suppressing proinflammatory cytokines, promoting M2 microglial polarization, reducing spinal cell apoptosis, and regulating the STAT1/NF-kappa B and JAK2/STAT3 signaling pathways to modulate microglial function and suppress spinal neuroinflammation.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2021)
Review
Immunology
Erliang Kong, Yongchang Li, Mengqiu Deng, Tong Hua, Mei Yang, Jian Li, Xudong Feng, Hongbin Yuan
Summary: Neuropathic pain is characterized by hyperalgesia and allodynia. Inflammation plays a role in the development of neuropathic pain, affecting synaptic transmission and regulated by glial cells. Glycometabolism reprogramming in inflammatory cells, specifically impaired oxidative phosphorylation and enhanced glycolysis, promotes neural inflammation in peripheral and central nervous system. Further research is needed to explore the role of glycometabolism in glial cells in neuropathic pain.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Neurosciences
Wenyao Wu, Xianwei Zhang, Shuo Wang, Tian Li, Quanshui Hao, Shiyong Li, Wenlong Yao, Rao Sun
Summary: The cGAS-STING pathway may be a potential therapeutic target for treating neuropathic pain by suppressing microglial M1 polarization. Activation of the cGAS-STING pathway occurs mainly in neurons and microglia, and inhibition of the pathway can suppress microglial M1 polarization and improve mechanical allodynia.
Review
Biochemistry & Molecular Biology
Aijun Ji, Jinbin Xu
Summary: NP is a common accompanying symptom of many diseases, seriously affecting the quality of life of patients. Neuron-microglia interaction has been found by experts to play a vital role in the occurrence and development of NP. Advanced studies and interventions using pharmaceuticals and traditional herbal medicines extracts have been attempted to address NP due to its unsatisfactory clinical treatments.
Article
Pharmacology & Pharmacy
Qianqian Liu, Rui Li, Wei Yang, Ranji Cui, Bingjin Li
Summary: This study summarized the role of neuroglia in neuropathic pain and depression, revealing a bridging role of neuroglia in both conditions.
PHARMACOLOGICAL RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Chih-Cheng Wu, Cheng-Yi Chang, Chung-Yuh Tzeng, Jen-Hsuan Huang, Chih-Jen Hung, Wen-Ying Chen, Su-Lan Liao, Yu-Hsiang Kuan, Chun-Jung Chen
Summary: In this study, the preventive effects of intrathecal bupivacaine administration against neuropathic pain were investigated. Bupivacaine attenuated pain behaviors and inflammatory alternations by suppressing microglia M1 polarization and pro-inflammatory cytokine expression. The Interferon Regulatory Factor 5 (IRF5)/P2X Purinoceptor 4 (P2X4R) and High Mobility Group Box 1 (HMGB1)/Toll-Like Receptor 4 (TLR4)/NF-kappa B inflammatory axes were identified as key players in microglia polarization and cytokine expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Hiroshi Ueda
Summary: Membrane lipid-derived mediators play important roles in acute and chronic pain, with some mediators such as LPAR(1) and LPAR(3) involved in the molecular mechanisms of NeuP and FM. Acute pain, caused by mediators like prostaglandins, can be reversed by opioid analgesics and anti-inflammatory drugs, while chronic pain is refractory and difficult to treat.
PROGRESS IN LIPID RESEARCH
(2021)
Article
Neurosciences
Fabiolla Rocha Santos Passos, Erik W. M. Pereira, Luana Heimfarth, Brenda S. Monteiro, Yasmim Maria Barbosa Gomes de Carvalho, Pollyana S. Siqueira-Lima, Henrique Douglas Melo Coutinho, Adriano Antunes de Souza Araujo, Jackson Roberto Guedes da Silva Almeida, Rosana S. S. Barreto, Laurent Picot, Lucindo J. Quintans-Junior, Jullyana S. S. Quintans
Summary: Neuropathic pain arises from damage to the somatosensory system, impacting quality of life. Hecogenin acetate (HA), a steroidal sapogenin with anti-inflammatory and antinociceptive properties, has low water solubility affecting bioavailability. Both pure and complexed HA/I3CD demonstrated anti-hyperalgesic activity in animal models.
Article
Biotechnology & Applied Microbiology
Yuanxing Cai, Jing Xu, Qinghao Cheng
Summary: Chronic neuroinflammation contributes to neuropathic pain development, and inhibiting Src can protect against neuroinflammation induced by microglia, reducing mechanical allodynia in mouse models of neuropathic pain.
Article
Oncology
Yuyin Zheng, Chengqian Jia, Xia Jiang, Jie Chen, Xiao-Long Chen, Xinwang Ying, Jiayu Wu, Mingchen Jiang, Guanhu Yang, Wenzhan Tu, Kecheng Zhou, Songhe Jiang
Summary: The study found that electroacupuncture could alleviate neuropathic pain in rats with spinal nerve ligation, possibly by regulating P2X4R in the spinal cord to achieve pain relief.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Nanoscience & Nanotechnology
Hao Zhang, Ping Zhou, Yi Jiang, Liu Li, Fei Ju, Quan Cheng, You Lang Zhou, Yuan Zhou
Summary: A nanosized drug delivery system based on PLGA nanoparticles and HA hydrogel was developed for sustained-release of esketamine, which effectively attenuated neuropathic pain without obvious adverse reactions. The mechanism might be related to modulating the activation of spinal cord astrocytes and inhibiting the excitability of dorsal root ganglion neurons.
INTERNATIONAL JOURNAL OF NANOMEDICINE
(2023)
Article
Neurosciences
Siyuan Wang, Chao Jiang, Kelei Cao, Run Li, Zhihua Gao, Yue Wang
Summary: Neuropathic pain is a complex pain condition accompanied by neuroinflammation, and HK2 plays an important role in regulating immune cell responses in neuropathic pain.
