Article
Multidisciplinary Sciences
Eunah Kim, Andrea Annibal, Yujin Lee, Hae-Eun H. Park, Seokjin Ham, Dae-Eun Jeong, Younghun Kim, Sangsoon Park, Sujeong Kwon, Yoonji Jung, JiSoo Park, Sieun S. Kim, Adam Antebi, Seung-Jae V. Lee
Summary: Mitochondrial Krebs cycle plays a crucial role in immunity, and the genetic inhibition of mitochondrial aconitase can enhance immunity against pathogenic bacteria.
NATURE COMMUNICATIONS
(2023)
Article
Cell Biology
Tanima SenGupta, Konstantinos Palikaras, Ying Q. Esbensen, Georgios Konstantinidis, Francisco Jose Naranjo Galindo, Kavya Achanta, Henok Kassahun, Ioanna Stavgiannoudaki, Vilhelm A. Bohr, Mansour Akbari, Johannes Gaare, Charalampos Tzoulis, Nektarios Tavernarakis, Hilde Nilsen
Summary: Aging, genomic stress, and mitochondrial dysfunction contribute to neurodegenerative diseases like Parkinson's disease. Base excision repair can generate genomic stress and promote neurodegeneration, while deficiency of NTH-1 may protect against neurotoxicity and rely on mitochondrial transcription for neuroprotection. This highlights the importance of integrating DNA repair mechanisms and transcription regulation in the aging process and susceptibility to neurodegenerative diseases.
Article
Biochemistry & Molecular Biology
Srijit Das, Sehee Min, Veena Prahlad
Summary: Maternal stress can trigger long-lasting epigenetic effects on offspring through the activation of the heat shock transcription factor HSF-1 in the germline of Caenorhabditis elegans. This leads to a heritable epigenetic memory of stress exposure in the next generation, shifting their stress response strategy towards decreased insulin/IGF-1-like signaling.
Article
Multidisciplinary Sciences
Wang Yuan, Yi M. Weaver, Svetlana Earnest, Clinton A. Taylor, Melanie H. Cobb, Benjamin P. Weaver
Summary: The authors found that the pool of non-phosphorylated p38 MAPK can modulate signaling to control growth, lysosome formation, and neuronal integrity. By altering the stoichiometry of non-phospho-p38, they enhanced PMK-1 signaling to promote tissue integrity and longevity. Their findings suggest that reducing the reservoir of non-phospho-p38 can enhance signaling without hyper-activation of stress response during aging.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Ivan Gusarov, Ilya Shamovsky, Bibhusita Pani, Laurent Gautier, Svetlana Eremina, Olga Katkova-Zhukotskaya, Alexander Mironov, Alexander A. Makarov, Evgeny Nudler
Summary: Restricting dietary thiols, including GSH and NAC, can extend lifespan and increase proteotoxic stress resistance in organisms. Excessive intake of dietary antioxidants like GSH may accelerate aging, and healthy individuals are better off relying on intrinsic GSH biosynthesis to promote cellular redox balance.
NATURE COMMUNICATIONS
(2021)
Article
Cell Biology
Andy B. Lam, Kirsten Kervin, Jessica E. Tanis
Summary: The study found that dietary vitamin B-12 can alleviate mitochondrial fragmentation, bioenergetic defects, and oxidative stress caused by Ab proteotoxicity, delaying the onset of the disease. Vitamin B-12 acts as a cofactor for methionine synthase, impacting the methionine/S-adenosylmethionine (SAMe) cycle, showing potential as a therapy to target pathogenic features of AD.
Article
Geriatrics & Gerontology
Bhaswati Ghosh, Hayden J. Guidry, Maxwell Johnston, K. Adam Bohnert
Summary: A botanical extract from Artemisia scoparia (SCO) has been found to extend the lifespan of Caenorhabditis elegans by up to 40%. This lifespan extension is dependent on SCO's effects on fat regulation, and treated worms show increased levels of unsaturated fat. The extract also improves stress resistance in late adulthood, indicating its potential to promote healthy aging.
JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES
(2022)
Article
Biophysics
Mohammad Rahimi, Salman Sohrabi, Coleen T. Murphy
Summary: Changes in biomechanical properties have significant effects on human health. C. elegans can be used as a model for studying the molecular genetics of mammalian tissue decline. This study found that the cuticle, not the muscle, is responsible for changes in the stretchiness of C. elegans, and collagen mutations alter the integrity and elasticity of the cuticle. Aging also stiffens the cuticle under mechanical loads beyond its healthy stretched state. Long-lived daf-2 mutants are better at preventing progressive mechanical changes with age.
BIOPHYSICAL JOURNAL
(2022)
Article
Cell Biology
Aseem Shrivastava, Carl Alexander Sandhof, Kevin Reinle, Areeb Jawed, Carmen Ruger-Herreros, Dominic Schwarz, Declan Creamer, Carmen Nussbaum-Krammer, Axel Mogk, Bernd Bukau
Summary: Sequestration of misfolded proteins is an evolutionarily conserved activity of the sHsp family and is executed by specific family members. Certain sHsps in Caenorhabditis elegans have specific sequence features and can buffer limitations in sequestrase capacity, contributing to lifespan extension.
JOURNAL OF CELL BIOLOGY
(2022)
Article
Environmental Sciences
Haibo Chen, Xin Hua, Hui Li, Chen Wang, Yao Dang, Ping Ding, Yunjiang Yu
Summary: This study found that maternal exposure to PS-MPs can result in the transgenerational neurotoxicity in C. elegans, with oxidative stress playing a key role in this process. Furthermore, the upregulation of oxidative stress-related genes across generations may be involved in regulating neurotoxicity in C. elegans.
Article
Environmental Sciences
Rong Zhou, Yue Yu, Huan Miao, Na Zhao, Yuanqing Bu, Houhu Zhang
Summary: In this study, the toxicity of the herbicide atrazine and its main metabolites, deethylatrazine (DEA) and deisopropylatrazine (DIA), was compared using the in vivo model Caenorhabditis elegans. The results showed that DEA and DIA had lower toxicity on locomotion and reproduction compared to atrazine. Additionally, DEA and DIA induced less transgenerational toxicity on locomotion than atrazine and caused less oxidative stress and alteration in gene expression.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2023)
Article
Multidisciplinary Sciences
Shruthi Hamsanathan, Tamil Anthonymuthu, Suhao Han, Himaly Shinglot, Ella Siefken, Austin Sims, Payel Sen, Hannah L. Pepper, Nathaniel W. Snyder, Hulya Bayir, Valerian Kagan, Aditi U. Gurkar
Summary: Using a DNA repair-deficient model in Caenorhabditis elegans, researchers discovered that DNA damage promotes metabolic shift to beta-oxidation, resulting in loss of fat depots. This metabolic alteration leads to histone hyperacetylation, changes in immune and cytochrome gene expression, and a subsequent immune-like response. The histone acetyltransferase MYS-1 was identified as a critical regulator of this metabolic-epigenetic axis. These findings shed light on the link between DNA damage, metabolism, and aging.
Article
Multidisciplinary Sciences
Jun Sung Kim, Sang-Kyu Park, Haeshin Lee
Summary: Additive manufacturing, or 3D printing, has revolutionized object creation, but it may lead to increased local defects compared to traditional casting methods. Factors like light intensity and temperature fluctuations contribute to defect formations. Detecting and locating toxic sources in 3D printed materials is a challenge, and current toxicological assessments rely on passive detection. Introducing the nematode model organism, C. elegans, offers an active system for identification and localization due to its unique sensing and locomotion capabilities.
Article
Chemistry, Medicinal
Haiyan Wu, Balakrishnan Prithiviraj, Zhijun Tan
Summary: This study evaluated the neurotoxicity and chronic toxicology of Saxitoxin (STX) on Caenorhabditis elegans. It found that STX does not cause lethal effects on the worms but does induce substantial oxidative stress, with a dose-responsive relationship. The lifespan, productivity, and body size of the worms were all influenced by STX exposure.
Article
Cell Biology
Maria Lucia da Silva Cordeiro, Ana Raquel Carneiro Ribeiro, Luciana Fentanes Moura de Melo, Lucas Felipe da Silva, Gabriel Pereira Fidelis, Larissa Marina Pereira Silva, Ricardo Basilio de Oliveira Caland, Cesar Orlando Munoz Cadavid, Cicero Flavio Soares Aragao, Silvana Maria Zucolotto, Riva de Paula Oliveira, Deborah Yara Alves Cursino dos Santos, Hugo Alexandre Oliveira Rocha, Katia Castanho Scortecci
Summary: The study evaluated the chemical profile and antioxidant activity of Commiphora leptophloeos leaf extracts, finding that ethanol and methanol extracts displayed high antioxidant capacity and had no effect on non-tumour cells, but showed toxicity to tumour cells. In vivo assays using C. elegans N2 demonstrated that the ethanol extract was non-toxic, increased worm survival under oxidative stress, and reduced intracellular ROS levels. These findings suggest that the polyphenols in EE extract may have potential for various biotechnological applications.
OXIDATIVE MEDICINE AND CELLULAR LONGEVITY
(2021)
Article
Biochemistry & Molecular Biology
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Takashi Tanikawa, Saori Oka, Yusuke Tanaka, Seisuke Arai, Ikuo Wada, Takayuki Sugiura, Atsushi Yamashita
JOURNAL OF BIOLOGICAL CHEMISTRY
(2017)
Article
Biochemistry & Molecular Biology
Yoko Nemoto-Sasaki, Ko Hayama, Hiroyuki Ohya, Yoichiro Arata, Mika Kato Kaneko, Naruya Saitou, Jun Hirabayashi, Ken-ichi Kasai
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS
(2008)
Article
Pharmacology & Pharmacy
Tomoharu Takeuchi, Yoko Nemoto-Sasaki, Yoichiro Arata, Ken-ichi Kasai
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2011)
Article
Pharmacology & Pharmacy
Yoko Nemoto-Sasaki, Shunsuke Takai, Tomoharu Takeuchi, Yoichiro Arata, Kazusa Nishiyama, Atsushi Yamada, Hideyo Takahashi, Hideaki Natsugari, Ken-ichi Kasai
BIOLOGICAL & PHARMACEUTICAL BULLETIN
(2011)
Article
Biochemistry & Molecular Biology
Kentaro Kato, Hideyuki Takeuchi, Akira Kanoh, Naoki Miyahara, Yoko Nemoto-Sasaki, Megumi Morimoto-Tomita, Azusa Matsubara, Yoshimi Ohashi, Michihiko Waki, Katsuaki Usami, Ulla Mandel, Henrik Clausen, Nobuaki Higashi, Tatsuro Irimura
GLYCOCONJUGATE JOURNAL
(2010)
Article
Biochemistry & Molecular Biology
Tomoharu Takeuchi, Yoko Nemoto-Sasaki, Ken-ichi Sugiura, Yoichiro Arata, Ken-ichi Kasai
JOURNAL OF BIOCHEMISTRY
(2013)
Article
Biochemistry & Molecular Biology
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Takashi Tanikawa, Saori Oka, Kiyoto Tsuchiya, Kouta Zama, Susumu Mitsutake, Takayuki Sugiura, Atsushi Yamashita
JOURNAL OF BIOLOGICAL CHEMISTRY
(2014)
Article
Biochemistry & Molecular Biology
Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Kotaro Hama, Takashi Tanikawa, Saori Oka, Tadaaki Saeki, Tatsuya Kumasaka, Takanori Koizumi, Seisuke Arai, Ikuo Wada, Kazuaki Yokoyama, Takayuki Sugiura, Atsushi Yamashita
JOURNAL OF BIOLOGICAL CHEMISTRY
(2018)
Review
Biochemistry & Molecular Biology
Atsushi Yamashita, Saori Oka, Takashi Tanikawa, Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Takayuki Sugiura
PROSTAGLANDINS & OTHER LIPID MEDIATORS
(2013)
Article
Biochemistry & Molecular Biology
Naoki Matsumoto, Yoko Nemoto-Sasaki, Saori Oka, Seisuke Arai, Ikuo Wada, Atsushi Yamashita
Summary: Phospholipase A1 (PLA1) hydrolyzes glycerophospholipid fatty acids in cellular membranes and genetic mutations in DDHD1 gene result in hereditary spastic paraplegia (HSP). This study identified multiple phosphorylation sites in human DDHD1 and the protein kinases responsible for regulating these sites, suggesting potential implications for HSP pathogenesis.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Virology
Yasuhiro Hayashi, Kiyoto Tsuchiya, Mizuki Yamamoto, Yoko Nemoto-Sasaki, Kazunari Tanigawa, Kotaro Hama, Yusuke Ueda, Takashi Tanikawa, Jin Gohda, Kenji Maeda, Jun-ichiro Inoue, Atsushi Yamashita
Summary: The study reveals that the sphingolipid metabolism inhibitor 4-HPR suppresses SARS-CoV-2 infection by increasing the ratio of saturated sphinganine-based lipids, particularly inhibiting membrane fusion and viral infection through a DES1-independent mechanism.
JOURNAL OF VIROLOGY
(2021)
Article
Biochemistry & Molecular Biology
Keisuke Nakajima, Saori Oka, Takashi Tanikawa, Yoko Nemoto-Sasaki, Naoki Matsumoto, Hiroki Ishiguro, Yoichiro Arata, Takayuki Sugiura, Atsushi Yamashita
Summary: This study found that LPI induced morphological changes and cytoskeleton rearrangement in GPR55-expressing HEK293 cells, which was mediated through the GPR55-RhoA-ROCK signaling pathway.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biology
Atsushi Yamashita, Yasuhiro Hayashi, Naoki Matsumoto, Yoko Nemoto-Sasaki, Takanori Koizumi, Yusuke Inagaki, Saori Oka, Takashi Tanikawa, Takayuki Sugiura
Article
Oncology
Y Tomita, XQ Yang, Y Ishida, Y Nemoto-Sasaki, T Kondo, M Oda, G Watanabe, GN Chaldakov, C Fujii, N Mukaida
INTERNATIONAL JOURNAL OF CANCER
(2004)