Planar Cell Polarity Aligns Osteoblast Division in Response to Substrate Strain

SaOS2 Osteosarcoma Cells as an In Vitro Model for Studying the Transition of Human Osteoblasts to Osteocytes

(2014) Matthew Prideaux et al.   CALCIFIED TISSUE INTERNATIONAL

Syndecan 4 interacts genetically with Vangl2 to regulate neural tube closure and planar cell polarity

(2013) N. Escobedo et al.   DEVELOPMENT

Regulation of cell polarity in the cartilage growth plate and perichondrium of metacarpal elements by HOXD13 and WNT5A

(2013) Pia Kuss et al.   DEVELOPMENTAL BIOLOGY

Estrogen Receptor α Mediates Proliferation of Osteoblastic Cells Stimulated by Estrogen and Mechanical Strain, but Their Acute Down-regulation of the Wnt AntagonistSostIs Mediated by Estrogen Receptor β

(2013) Gabriel L. Galea et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of a Single β-Catenin Allele in Osteocytes Abolishes the Bone Anabolic Response to Loading

(2013) Behzad Javaheri et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Missense polymorphisms of the WNT16 gene are associated with bone mass, hip geometry and fractures

(2013) C. García-Ibarbia et al.   OSTEOPOROSIS INTERNATIONAL

Mechanical regulation of signaling pathways in bone

(2012) William R. Thompson et al.   GENE

The Wnt Coreceptor Ryk Regulates Wnt/Planar Cell Polarity by Modulating the Degradation of the Core Planar Cell Polarity Component Vangl2

(2012) Philipp Andre et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bones' adaptive response to mechanical loading is essentially linear between the low strains associated with disuse and the high strains associated with the lamellar/woven bone transition

(2012) Toshihiro Sugiyama et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen receptor-α is required for the osteogenic response to mechanical loading in a ligand-independent manner involving its activation function 1 but not 2

(2012) Sara H Windahl et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of Wnt Planar cell polarity (PCP) signaling promotes growth plate column formation in vitro

(2012) Rachel M. Randall et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Wnt5a-Ror2 signaling between osteoblast-lineage cells and osteoclast precursors enhances osteoclastogenesis

(2012) Kazuhiro Maeda et al.   NATURE MEDICINE

Comparison of Phenotypes between Different vangl2 Mutants Demonstrates Dominant Effects of the Looptail Mutation during Hair Cell Development

(2012) Haifeng Yin et al.   PLoS One

WNT16 Influences Bone Mineral Density, Cortical Bone Thickness, Bone Strength, and Osteoporotic Fracture Risk

(2012) Hou-Feng Zheng et al.   PLoS Genetics

Wnt5a: its signalling, functions and implication in diseases

(2011) A. Kikuchi et al.   Acta Physiologica

Sclerostin expression is induced by BMPs in human Saos-2 osteosarcoma cells but not via direct effects on the sclerostin gene promoter or ECR5 element

(2011) Longchuan Yu et al.   BONE

A Wolff in sheep's clothing: Trabecular bone adaptation in response to changes in joint loading orientation

(2011) Meir M. Barak et al.   BONE

Sost downregulation and local Wnt signaling are required for the osteogenic response to mechanical loading

(2011) Xiaolin Tu et al.   BONE

Planar Cell Polarity: Coordinating Morphogenetic Cell Behaviors with Embryonic Polarity

(2011) Ryan S. Gray et al.   DEVELOPMENTAL CELL

Sostdown-regulation by mechanical strain in human osteoblastic cells involves PGE2 signaling via EP4

(2011) Gabriel L. Galea et al.   FEBS LETTERS

Rho-associated Kinase Connects a Cell Cycle-controlling Anchorage Signal to the Mammalian Target of Rapamycin Pathway

(2011) Jung-ha Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Type XII collagen regulates osteoblast polarity and communication during bone formation

(2011) Yayoi Izu et al.   JOURNAL OF CELL BIOLOGY

Mechanical loading-related changes in osteocyte sclerostin expression in mice are more closely associated with the subsequent osteogenic response than the peak strains engendered

(2011) A. Moustafa et al.   OSTEOPOROSIS INTERNATIONAL

Remodeling of Actin Cytoskeleton in Mouse Periosteal Cells under Mechanical Loading Induces Periosteal Cell Proliferation during Bone Formation

(2011) Daisuke Sakai et al.   PLoS One

Rack1 is required for Vangl2 membrane localization and planar cell polarity signaling while attenuating canonical Wnt activity

(2011) S. Li et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Bone Morphogenetic Protein-2-Induced Signaling and Osteogenesis Is Regulated by Cell Shape, RhoA/ROCK, and Cytoskeletal Tension

(2011) Yang-Kao Wang et al.   STEM CELLS AND DEVELOPMENT

Cell polarity

(2011) Sarah M. Romereim et al.   Organogenesis

Role of Endocrine and Paracrine Factors in the Adaptation of Bone to Mechanical Loading

(2011) Joanna S. Price et al.   Current Osteoporosis Reports

The cell cycle, including the mitotic cycle and organelle division cycles, as revealed by cytological observations

(2011) Y. Imoto et al.   Microscopy

Quasi-3D Cytoskeletal Dynamics of Osteocytes under Fluid Flow

(2010) Andrew D. Baik et al.   BIOPHYSICAL JOURNAL

Cell Flow Reorients the Axis of Planar Polarity in the Wing Epithelium of Drosophila

(2010) Benoît Aigouy et al.   CELL

Cortical Actin Dynamics Facilitate Early-Stage Centrosome Separation

(2010) Jian Cao et al.   CURRENT BIOLOGY

WNT5A induces osteogenic differentiation of human adipose stem cells via rho-associated kinase Rock

(2010) Ana Santos et al.   CYTOTHERAPY

Oriented cell motility and division underlie early limb bud morphogenesis

(2010) L. A. Wyngaarden et al.   DEVELOPMENT

The Fz-Dsh Planar Cell Polarity Pathway Induces Oriented Cell Division via Mud/NuMA in Drosophila and Zebrafish

(2010) Marion Ségalen et al.   DEVELOPMENTAL CELL

Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells

(2010) Shinji Matsumoto et al.   EMBO JOURNAL

Mechanical Loading-Related Bone Gain Is Enhanced by Tamoxifen but Unaffected by Fulvestrant in Female Mice

(2010) Toshihiro Sugiyama et al.   ENDOCRINOLOGY

The planar cell polarity gene Vangl2 is required for mammalian kidney-branching morphogenesis and glomerular maturation

(2010) Laura L. Yates et al.   HUMAN MOLECULAR GENETICS

Disruption of PCP signaling causes limb morphogenesis and skeletal defects and may underlie Robinow syndrome and brachydactyly type B

(2010) Bing Wang et al.   HUMAN MOLECULAR GENETICS

Early strain-related changes in enzyme activity in osteocytes following bone loading in vivo

(2010) Timothy M. Skerry et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Guidelines for assessment of bone microstructure in rodents using micro-computed tomography

(2010) Mary L Bouxsein et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Planar cell polarity breaks bilateral symmetry by controlling ciliary positioning

(2010) Hai Song et al.   NATURE

Inhibition of tumorigenesis driven by different Wnt proteins requires blockade of distinct ligand-binding regions by LRP6 antibodies

(2010) S. A. Ettenberg et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common themes in centriole and centrosome movements

(2010) Sue Vaughan et al.   TRENDS IN CELL BIOLOGY

Non-canonical Wnt signaling regulates cell polarity in female reproductive tract development via van gogh-like 2

(2009) A. L. vandenBerg et al.   DEVELOPMENT

The planar cell polarity pathway directs parietal endoderm migration

(2009) Kristi LaMonica et al.   DEVELOPMENTAL BIOLOGY

Wnt5a regulates distinct signalling pathways by binding to Frizzled2

(2009) Akira Sato et al.   EMBO JOURNAL

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Strabismus regulates asymmetric cell divisions and cell fate determination in the mouse brain

(2009) Blue B. Lake et al.   JOURNAL OF CELL BIOLOGY

Mechanically induced osteogenic differentiation - the role of RhoA, ROCKII and cytoskeletal dynamics

(2009) E. J. Arnsdorf et al.   JOURNAL OF CELL SCIENCE

Human embryonic stem cells are pre-mitotically committed to self-renewal and acquire a lengthened G1 phase upon lineage programming

(2009) Klaus A. Becker et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Wnt activity guides facial branchiomotor neuron migration, and involves the PCP pathway and JNK and ROCK kinases

(2009) Valerie Vivancos et al.   Neural Development

Structural Plasticity in Actin and Tubulin Polymer Dynamics

(2009) H. Y. Kueh et al.   SCIENCE

Dissection of sets of genes that control the character of wnt5a-deficient mouse calvarial cells

(2008) Juanli Guo et al.   BONE

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice

(2008) Toshihiro Sugiyama et al.   BONE

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

(2008) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functional Characterization of Genetic Variation in the Frizzled 1 (FZD1) Promoter and Association With Bone Phenotypes: More to the LRP5 Story?

(2008) Laura M Yerges et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Genetic interaction between members of the Vangl family causes neural tube defects in mice

(2008) E. Torban et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA