Role of Endocrine and Paracrine Factors in the Adaptation of Bone to Mechanical Loading

Estrogen receptor and Wnt signaling interact to regulate early gene expression in response to mechanical strain in osteoblastic cells

(2010) Astrid Liedert et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Activation of β-catenin signaling in MLO-Y4 osteocytic cells versus 2T3 osteoblastic cells by fluid flow shear stress and PGE2: Implications for the study of mechanosensation in bone

(2010) Mohamed A. Kamel et al.   BONE

Thiazolidinediones induce osteocyte apoptosis and increase sclerostin expression

(2010) G. Mabilleau et al.   DIABETIC MEDICINE

Mechanical Loading-Related Bone Gain Is Enhanced by Tamoxifen but Unaffected by Fulvestrant in Female Mice

(2010) Toshihiro Sugiyama et al.   ENDOCRINOLOGY

Intermittent Parathyroid Hormone Administration Counteracts the Adverse Effects of Glucocorticoids on Osteoblast and Osteocyte Viability, Bone Formation, and Strength in Mice

(2010) Robert S. Weinstein et al.   ENDOCRINOLOGY

Leptin Receptor (Lepr) Is a Negative Modulator of Bone Mechanosensitivity and Genetic Variations inLeprMay Contribute to the Differential Osteogenic Response to Mechanical Stimulation in the C57BL/6J and C3H/HeJ Pair of Mouse Strains

(2010) Sonia Kapur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Timing of ibuprofen use and bone mineral density adaptations to exercise training

(2010) Wendy M Kohrt et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin and the regulation of bone formation: Effects in hip osteoarthritis and femoral neck fracture

(2010) Jon Power et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Mechanical induction of PGE2 in osteocytes blocks glucocorticoid-induced apoptosis through both the β-catenin and PKA pathways

(2010) Yukiko Kitase et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Two doses of sclerostin antibody in cynomolgus monkeys increases bone formation, bone mineral density, and bone strength

(2010) Michael S Ominsky et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Single-dose, placebo-controlled, randomized study of AMG 785, a sclerostin monoclonal antibody

(2010) Desmond Padhi et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Regulation of circulating sclerostin levels by sex steroids in women and in men

(2010) Ulrike IL Mödder et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Increased Sclerostin Serum Levels Associated with Bone Formation and Resorption Markers in Patients with Immobilization-Induced Bone Loss

(2010) Agostino Gaudio et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Osteocyte Wnt/ -Catenin Signaling Is Required for Normal Bone Homeostasis

(2010) I. Kramer et al.   MOLECULAR AND CELLULAR BIOLOGY

Mechanical Stress Activates Smad Pathway through PKCδ to Enhance Interleukin-11 Gene Transcription in Osteoblasts

(2010) Shinsuke Kido et al.   PLoS One

Rescuing Loading Induced Bone Formation at Senescence

(2010) Sundar Srinivasan et al.   PLoS Computational Biology

Mechanical stimulus alters conformation of type 1 parathyroid hormone receptor in bone cells

(2009) Yan-Liang Zhang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Loading-related regulation of gene expression in bone in the contexts of estrogen deficiency, lack of estrogen receptor α and disuse

(2009) Gul Zaman et al.   BONE

Nuclear factor of activated T cells mediates fluid shear stress- and tensile strain-induced Cox2 in human and murine bone cells

(2009) Ayse B. Celil Aydemir et al.   BONE

Functional adaptation to mechanical loading in both cortical and cancellous bone is controlled locally and is confined to the loaded bones

(2009) Toshihiro Sugiyama et al.   BONE

Deletion of β1 Integrins from Cortical Osteocytes Reduces Load-Induced Bone Formation

(2009) Julie B. Litzenberger et al.   Cellular and Molecular Bioengineering

PTH and PTHrP signaling in osteoblasts

(2009) Nabanita S. Datta et al.   CELLULAR SIGNALLING

Mechanical Loading Regulates NFATc1 and β-Catenin Signaling through a GSK3β Control Node

(2009) Buer Sen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Matricellular Protein Periostin Is Required forSostInhibition and the Anabolic Response to Mechanical Loading and Physical Activity

(2009) Nicolas Bonnet et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mechano-transduction in Osteoblastic Cells Involves Strain-regulated Estrogen Receptor α-mediated Control of Insulin-like Growth Factor (IGF) I Receptor Sensitivity to Ambient IGF, Leading to Phosphatidylinositol 3-Kinase/AKT-dependent Wnt/LRP5 Receptor-independent Activation of β-Catenin Signaling

(2009) Andrew Sunters et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Androgen receptor disruption increases the osteogenic response to mechanical loading in male mice

(2009) Filip Callewaert et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Sclerostin Mediates Bone Response to Mechanical Unloading Through Antagonizing Wnt/β-Catenin Signaling

(2009) Chuwen Lin et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Parathyroid hormone (PTH)–induced bone gain is blunted in SOST overexpressing and deficient mice

(2009) Ina Kramer et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Estrogen augments shear stress–induced signaling and gene expression in osteoblast-like cells via estrogen receptor–mediated expression of β1-integrin

(2009) Chiuan-Ren Yeh et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Prostaglandin Promotion of Osteocyte Gap Junction Function through Transcriptional Regulation of Connexin 43 by Glycogen Synthase Kinase 3/ -Catenin Signaling

(2009) X. Xia et al.   MOLECULAR AND CELLULAR BIOLOGY

Non-Canonical Wnt Signaling and N-Cadherin Related β-Catenin Signaling Play a Role in Mechanically Induced Osteogenic Cell Fate

(2009) Emily J. Arnsdorf et al.   PLoS One

The response of bone to mechanical loading and disuse: Fundamental principles and influences on osteoblast/osteocyte homeostasis

(2008) Tim M. Skerry   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Mechanical loading enhances the anabolic effects of intermittent parathyroid hormone (1–34) on trabecular and cortical bone in mice

(2008) Toshihiro Sugiyama et al.   BONE

Parathyroid hormone signaling through low-density lipoprotein-related protein 6

(2008) M. Wan et al.   GENES & DEVELOPMENT

β-Catenin Levels Influence Rapid Mechanical Responses in Osteoblasts

(2008) Natasha Case et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adaptation of Connexin 43-Hemichannel Prostaglandin Release to Mechanical Loading

(2008) Arlene J. Siller-Jackson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Attenuated Response to In Vivo Mechanical Loading in Mice With Conditional Osteoblast Ablation of the Connexin43 Gene (Gja1)

(2008) Susan K Grimston et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Bone Mass Is Preserved and Cancellous Architecture Altered Due to Cyclic Loading of the Mouse Tibia After Orchidectomy

(2008) J Christopher Fritton et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Role for β1 integrins in cortical osteocytes during acute musculoskeletal disuse

(2008) J PHILLIPS et al.   MATRIX BIOLOGY

Regulation of bone metabolism by nuclear receptors

(2008) Yuuki Imai et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Control of Bone Mass and Remodeling by PTH Receptor Signaling in Osteocytes

(2008) Charles A. O'Brien et al.   PLoS One

PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3β in osteoblastic Saos-2 cells

(2007) Akira Suzuki et al.   JOURNAL OF CELLULAR BIOCHEMISTRY