Mitochondrial dysfunction in psychiatric and neurological diseases: Cause(s), consequence(s), and implications of antioxidant therapy

Mitochondrial modulators for bipolar disorder: A pathophysiologically informed paradigm for new drug development

(2012) Andrew A Nierenberg et al.   AUSTRALIAN AND NEW ZEALAND JOURNAL OF PSYCHIATRY

Glucocorticoid receptor mRNA and protein isoform alterations in the orbitofrontal cortex in schizophrenia and bipolar disorder

(2012) Duncan Sinclair et al.   BMC Psychiatry

Mitochondria as sources and targets of damage in cellular aging

(2012) Mari Carmen Gomez-Cabrera et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Novel S-acyl glutathione derivatives prevent amyloid oxidative stress and cholinergic dysfunction in Alzheimer disease models

(2012) Mariagioia Zampagni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Abnormal interaction between the mitochondrial fission protein Drp1 and hyperphosphorylated tau in Alzheimer's disease neurons: implications for mitochondrial dysfunction and neuronal damage

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Genetic and functional abnormalities of the melatonin biosynthesis pathway in patients with bipolar disorder

(2012) Bruno Etain et al.   HUMAN MOLECULAR GENETICS

Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease

(2012) M. Manczak et al.   HUMAN MOLECULAR GENETICS

Mitochondria: Mitochondrial membranes in brain ageing and neurodegeneration

(2012) Janett Eckmann et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

New Evidence for the Involvement of Mitochondrial Inheritance in Schizophrenia

(2012) Begoña Verge et al.   JOURNAL OF CLINICAL PSYCHIATRY

NADPH oxidase-dependent oxidative stress and mitochondrial damage in hippocampus of D-galactose-induced aging rats

(2012) Zhengde Du et al.   Journal of Huazhong University of Science and Technology-Medical Sciences

Parkinson’s disease-associated DJ-1 mutations impair mitochondrial dynamics and cause mitochondrial dysfunction

(2012) Xinglong Wang et al.   JOURNAL OF NEUROCHEMISTRY

Estrogen and the regulation of mitochondrial structure and function in the brain

(2012) Susanne Arnold et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

Melatonin: an overlooked factor in schizophrenia and in the inhibition of anti-psychotic side effects

(2012) George Anderson et al.   METABOLIC BRAIN DISEASE

N-Acetylcysteine Reverses Mitochondrial Dysfunctions and Behavioral Abnormalities in 3-Nitropropionic Acid-Induced Huntington’s Disease

(2012) Rajat Sandhir et al.   Neurodegenerative Diseases

Glucocorticoid Receptor 1B and 1C mRNA Transcript Alterations in Schizophrenia and Bipolar Disorder, and Their Possible Regulation by GR Gene Variants

(2012) Duncan Sinclair et al.   PLoS One

DJ-1 Null Dopaminergic Neuronal Cells Exhibit Defects in Mitochondrial Function and Structure: Involvement of Mitochondrial Complex I Assembly

(2012) Jun Young Heo et al.   PLoS One

Oxidative Stress and Heart Failure in Altered Thyroid States

(2012) Pallavi Mishra et al.   TheScientificWorldJOURNAL

Deceleration of Fusion–Fission Cycles Improves Mitochondrial Quality Control during Aging

(2012) Marc Thilo Figge et al.   PLoS Computational Biology

Genetic inactivation of mitochondria-targeted redox enzyme p66ShcA preserves neuronal viability and mitochondrial integrity in response to oxidative challenges

(2012) Kimmy Su et al.   Frontiers in Physiology

Parkin, PINK1 and mitochondrial integrity: emerging concepts of mitochondrial dysfunction in Parkinson’s disease

(2011) Anna Pilsl et al.   ACTA NEUROPATHOLOGICA

Assessing mitochondrial dysfunction in cells

(2011) Martin D. Brand et al.   BIOCHEMICAL JOURNAL

Elevation of glutathione as a therapeutic strategy in Alzheimer disease

(2011) Chava B. Pocernich et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and synaptic degeneration as early events in Alzheimer's disease: Implications to mitochondria-targeted antioxidant therapeutics

(2011) P. Hemachandra Reddy et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial DNA deletions and differential mitochondrial DNA content in Rhesus monkeys: Implications for aging

(2011) Peizhong Mao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Perturbation in Mitochondrial Network Dynamics and in Complex I Dependent Cellular Respiration in Schizophrenia

(2011) Marina Rosenfeld et al.   BIOLOGICAL PSYCHIATRY

Bcl-2 SNP rs956572 associates with disrupted intracellular calcium homeostasis in bipolar I disorder

(2011) Takuji Uemura et al.   BIPOLAR DISORDERS

Mitochondria as a Therapeutic Target for Aging and Neurodegenerative Diseases

(2011) P. H. Reddy et al.   Current Alzheimer Research

Activation of the mitochondrial permeability transition pore modulates Ca2+ responses to physiological stimuli in adult neurons

(2011) Anna Barsukova et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Mitochondrial transcription factor A overexpression and base excision repair deficiency in the inner ear of rats with d-galactose-induced aging

(2011) Yi Zhong et al.   FEBS Journal

Effect of Vitamin E Administration on the Elevated Oxygen Stress and the Telomeric and Subtelomeric Status in Alzheimer’s Disease

(2011) Jing-Zhi Guan et al.   GERONTOLOGY

Abnormal mitochondrial dynamics, mitochondrial loss and mutant huntingtin oligomers in Huntington's disease: implications for selective neuronal damage

(2011) U. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Mutant huntingtin's interaction with mitochondrial protein Drp1 impairs mitochondrial biogenesis and causes defective axonal transport and synaptic degeneration in Huntington's disease

(2011) U. P. Shirendeb et al.   HUMAN MOLECULAR GENETICS

Impaired mitochondrial biogenesis contributes to mitochondrial dysfunction in Alzheimer’s disease

(2011) Baiyang Sheng et al.   JOURNAL OF NEUROCHEMISTRY

The Mitochondria-Targeted Antioxidant MitoQ Prevents Loss of Spatial Memory Retention and Early Neuropathology in a Transgenic Mouse Model of Alzheimer's Disease

(2011) M. J. McManus et al.   JOURNAL OF NEUROSCIENCE

Melatonin treatment restores mitochondrial function in Alzheimer’s mice: a mitochondrial protective role of melatonin membrane receptor signaling

(2011) Natasa Dragicevic et al.   JOURNAL OF PINEAL RESEARCH

Unstable genes unstable mind: Beyond the central dogma of molecular biology

(2011) Mahabaleshwar V. Hegde et al.   MEDICAL HYPOTHESES

Mitochondrial calcium homeostasis as potential target for mitochondrial medicine

(2011) Carlotta Giorgi et al.   MITOCHONDRION

Evidence for behavioral benefits of early dietary supplementation with CoEnzymeQ10 in a slowly progressing mouse model of Huntington's disease

(2011) Miriam A. Hickey et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Parkinson's syndrome and Parkinson's disease in mitochondrial disorders

(2011) Josef Finsterer   MOVEMENT DISORDERS

Mutant huntingtin binds the mitochondrial fission GTPase dynamin-related protein-1 and increases its enzymatic activity

(2011) Wenjun Song et al.   NATURE MEDICINE

PPARgamma rescue of the mitochondrial dysfunction in Huntington's disease

(2011) Ming-Chang Chiang et al.   NEUROBIOLOGY OF DISEASE

N-acetyl cysteine restores brain glutathione loss in combined 2-cyclohexene-1-one and d-amphetamine-treated rats: Relevance to schizophrenia and bipolar disorder

(2011) Olivia M. Dean et al.   NEUROSCIENCE LETTERS

Inhibition of Pyruvate Kinase M2 by Reactive Oxygen Species Contributes to Cellular Antioxidant Responses

(2011) D. Anastasiou et al.   SCIENCE

Mitochondrial therapeutics in Alzheimer's disease and Parkinson's disease

(2011) Jake G Hoekstra et al.   Alzheimers Research & Therapy

The Mitochondrial Antioxidants MitoE2 and MitoQ10 Increase Mitochondrial Ca2+ Load upon Cell Stimulation by Inhibiting Ca2+ Efflux from the Organelle

(2010) Sara Leo et al.   Annals of the New York Academy of Sciences

Mitochondrial Energetics and Therapeutics

(2010) Douglas C. Wallace et al.   Annual Review of Pathology-Mechanisms of Disease

Mitochondrial Complex I Activity and Oxidative Damage to Mitochondrial Proteins in the Prefrontal Cortex of Patients With Bipolar Disorder

(2010) Ana C. Andreazza et al.   ARCHIVES OF GENERAL PSYCHIATRY

Dynamin-related protein 1 and mitochondrial fragmentation in neurodegenerative diseases

(2010) P. Hemachandra Reddy et al.   BRAIN RESEARCH REVIEWS

Mitochondria-Targeted Antioxidant Peptides

(2010) Milagros Rocha et al.   CURRENT PHARMACEUTICAL DESIGN

Nitrosylation and nitration of mitochondrial complex I in Parkinson's disease

(2010) Shankar J. Chinta et al.   FREE RADICAL RESEARCH

Mitochondrial loss, dysfunction and altered dynamics in Huntington's disease

(2010) J. Kim et al.   HUMAN MOLECULAR GENETICS

Mitochondrial dysfunction and pathology in bipolar disorder and schizophrenia

(2010) Hayley B. Clay et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Mitochondrial dysfunction and intracellular calcium dysregulation in ALS

(2010) Hibiki Kawamata et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Is it time to reassess alpha lipoic acid and niacinamide therapy in schizophrenia?

(2010) Sheila E.J. Seybolt   MEDICAL HYPOTHESES

Mitochondrial Quality Control and Parkinson’s Disease: A Pathway Unfolds

(2010) Inês Pimenta de Castro et al.   MOLECULAR NEUROBIOLOGY

Formulation of a Medical Food Cocktail for Alzheimer's Disease: Beneficial Effects on Cognition and Neuropathology in a Mouse Model of the Disease

(2010) Anna Parachikova et al.   PLoS One

Therapeutic prospects for mitochondrial disease

(2010) Eric A. Schon et al.   TRENDS IN MOLECULAR MEDICINE

Mitochondrial mechanisms of estrogen neuroprotection

(2009) James W. Simpkins et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Cause and consequence: Mitochondrial dysfunction initiates and propagates neuronal dysfunction, neuronal death and behavioral abnormalities in age-associated neurodegenerative diseases

(2009) Gary E. Gibson et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondrial permeability transition pore in Alzheimer's disease: Cyclophilin D and amyloid beta

(2009) Heng Du et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Abnormal mitochondrial dynamics and neurodegenerative diseases

(2009) Bo Su et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria: A therapeutic target in neurodegeneration

(2009) Paula I. Moreira et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Role of mitochondrial dysfunction in the pathogenesis of Huntington's disease

(2009) Rodrigo A. Quintanilla et al.   BRAIN RESEARCH BULLETIN

Expression analyses of the mitochondrial complex I 75-kDa subunit in early onset schizophrenia and autism spectrum disorder: increased levels as a potential biomarker for early onset schizophrenia

(2009) Regina Taurines et al.   EUROPEAN CHILD & ADOLESCENT PSYCHIATRY

Mitochondrial dynamics-fusion, fission, movement, and mitophagy-in neurodegenerative diseases

(2009) H. Chen et al.   HUMAN MOLECULAR GENETICS

Melatonin as a potential therapeutic agent in psychiatric illness

(2009) Maria D. Maldonado et al.   HUMAN PSYCHOPHARMACOLOGY-CLINICAL AND EXPERIMENTAL

Parkinson’s disease and mitochondrial complex I: a perspective on the Ndi1 therapy

(2009) Mathieu Marella et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Disorders from perturbations of nuclear-mitochondrial intergenomic cross-talk

(2009) A. Spinazzola et al.   JOURNAL OF INTERNAL MEDICINE

Coenzyme Q10 Reduces β-Amyloid Plaque in an APP/PS1 Transgenic Mouse Model of Alzheimer’s Disease

(2009) Xifei Yang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Combination therapy with Coenzyme Q10and creatine produces additive neuroprotective effects in models of Parkinson’s and Huntington’s Diseases

(2009) Lichuan Yang et al.   JOURNAL OF NEUROCHEMISTRY

Impaired Balance of Mitochondrial Fission and Fusion in Alzheimer's Disease

(2009) X. Wang et al.   JOURNAL OF NEUROSCIENCE

Randomized, double-blind, pilot evaluation of intravenous glutathione in Parkinson's disease

(2009) Robert A. Hauser et al.   MOVEMENT DISORDERS

Dynamic regulation of mitochondrial function by glucocorticoids

(2009) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mitochondrial bioenergetic deficit precedes Alzheimer's pathology in female mouse model of Alzheimer's disease

(2009) J. Yao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Brain Bioenergetics and Response to Triiodothyronine Augmentation in Major Depressive Disorder

(2008) Dan V. Iosifescu et al.   BIOLOGICAL PSYCHIATRY

Elevated Cerebrospinal Fluid Lactate Concentrations in Patients with Bipolar Disorder and Schizophrenia: Implications for the Mitochondrial Dysfunction Hypothesis

(2008) William T. Regenold et al.   BIOLOGICAL PSYCHIATRY

Role of mitochondrial DNA in calcium signaling abnormality in bipolar disorder

(2008) T KATO   CELL CALCIUM

Progesterone and Estrogen Regulate Oxidative Metabolism in Brain Mitochondria

(2008) Ronald W. Irwin et al.   ENDOCRINOLOGY

Quinone and oxyradical scavenging properties of N-acetylcysteine prevent dopamine mediated inhibition of Na+, K+-ATPase and mitochondrial electron transport chain activity in rat brain: Implications in the neuroprotective therapy of Parkinson's disease

(2008) Maria B. Bagh et al.   FREE RADICAL RESEARCH

Oxidative stress in psychiatric disorders: evidence base and therapeutic implications

(2008) Felicity Ng et al.   INTERNATIONAL JOURNAL OF NEUROPSYCHOPHARMACOLOGY

Combined R-α-lipoic acid and acetyl-L-carnitine exerts efficient preventative effects in a cellular model of Parkinson’s disease

(2008) Hongyu Zhang et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Estrogenic control of mitochondrial function and biogenesis

(2008) Carolyn M. Klinge   JOURNAL OF CELLULAR BIOCHEMISTRY

Mitochondrial dysfunction: An early event in Alzheimer pathology accumulates with age in AD transgenic mice

(2008) S. Hauptmann et al.   NEUROBIOLOGY OF AGING

Mitochondrial Medicine for Aging and Neurodegenerative Diseases

(2008) P. Hemachandra Reddy   NEUROMOLECULAR MEDICINE

Creatine and Its Potential Therapeutic Value for Targeting Cellular Energy Impairment in Neurodegenerative Diseases

(2008) Peter J. Adhihetty et al.   NEUROMOLECULAR MEDICINE

Mitochondria in Neuroplasticity and Neurological Disorders

(2008) Mark P. Mattson et al.   NEURON

Neuroanatomical Pattern of Mitochondrial Complex I Pathology Varies between Schizophrenia, Bipolar Disorder and Major Depression

(2008) Dorit Ben-Shachar et al.   PLoS One

Amyloid beta, mitochondrial dysfunction and synaptic damage: implications for cognitive decline in aging and Alzheimer's disease

(2008) P. Hemachandra Reddy et al.   TRENDS IN MOLECULAR MEDICINE

Glutathione: a novel treatment target in psychiatry

(2008) Michael Berk et al.   TRENDS IN PHARMACOLOGICAL SCIENCES