BMP growth factor signaling in a biomechanical context

Effect of BMP-2 from matrices of different stiffnesses for the modulation of stem cell fate

(2013) Omar F. Zouani et al.   BIOMATERIALS

Fine-tuned shuttles for bone morphogenetic proteins

(2013) Kristi A Wharton et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Caveolae as plasma membrane sensors, protectors and organizers

(2013) Robert G. Parton et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Prediction of heparin binding sites in bone morphogenetic proteins (BMPs)

(2012) Neha S. Gandhi et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

BMP2 and mechanical loading cooperatively regulate immediate early signalling events in the BMP pathway

(2012) Jessica Kopf et al.   BMC BIOLOGY

Mechanical stretch down-regulates expression of the Smad6 gene in cultured rat mesangial cells

(2012) Yoshimitsu Hayashi et al.   Clinical and Experimental Nephrology

A new mechanobiological era: microfluidic pathways to apply and sense forces at the cellular level

(2012) Felix Kurth et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Endothelial mechanosensors of shear stress as regulators of atherogenesis

(2012) Carlos Zaragoza et al.   CURRENT OPINION IN LIPIDOLOGY

The signaling and functions of heterodimeric bone morphogenetic proteins

(2012) Jing Guo et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Stalk Cell Phenotype Depends on Integration of Notch and Smad1/5 Signaling Cascades

(2012) Iván M. Moya et al.   DEVELOPMENTAL CELL

Context-Dependent Proangiogenic Function of Bone Morphogenetic Protein Signaling Is Mediated by Disabled Homolog 2

(2012) Jun-Dae Kim et al.   DEVELOPMENTAL CELL

Spatial Restriction of Bone Morphogenetic Protein Signaling in Mouse Gastrula through the mVam2-Dependent Endocytic Pathway

(2012) Minako Aoyama et al.   DEVELOPMENTAL CELL

BMP signaling in vascular diseases

(2012) Jie Cai et al.   FEBS LETTERS

Spatial regulation of BMP activity

(2012) Marie-Christine Ramel et al.   FEBS LETTERS

Phosphatases in SMAD regulation

(2012) David L. Bruce et al.   FEBS LETTERS

Promiscuity and specificity in BMP receptor activation

(2012) Thomas D. Mueller et al.   FEBS LETTERS

A portrait of Transforming Growth Factor β superfamily signalling: Background matters

(2012) Daniel Horbelt et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

TGF-β and BMP Signaling in Osteoblast Differentiation and Bone Formation

(2012) Guiqian Chen et al.   International Journal of Biological Sciences

Regulation of bone and cartilage development by network between BMP signalling and transcription factors

(2012) R. Nishimura et al.   JOURNAL OF BIOCHEMISTRY

SMADversusNon-SMAD Signaling Is Determined by Lateral Mobility of Bone Morphogenetic Protein (BMP) Receptors

(2012) Asja Guzman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins

(2012) Junjing Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Signalling through mechanical inputs – a coordinated process

(2012) Huimin Zhang et al.   JOURNAL OF CELL SCIENCE

Mechanosensitive mechanisms in transcriptional regulation

(2012) Akiko Mammoto et al.   JOURNAL OF CELL SCIENCE

Deconstructing the third dimension – how 3D culture microenvironments alter cellular cues

(2012) Brendon M. Baker et al.   JOURNAL OF CELL SCIENCE

Low-Intensity Pulsed Ultrasound Enhances BMP-7-Induced Osteogenic Differentiation of Human Fracture Hematoma-Derived Progenitor Cells In Vitro

(2012) Sang Yang Lee et al.   JOURNAL OF ORTHOPAEDIC TRAUMA

Transforming Growth Factor   Inhibits Bone Morphogenetic Protein-Induced Transcription through Novel Phosphorylated Smad1/5-Smad3 Complexes

(2012) E. Gronroos et al.   MOLECULAR AND CELLULAR BIOLOGY

Distinct and separable activities of the endocytic clathrin-coat components Fcho1/2 and AP-2 in developmental patterning

(2012) P. K. Umasankar et al.   NATURE CELL BIOLOGY

TGFβ signalling in context

(2012) Joan Massagué   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The mechanobiology of brain function

(2012) William J. Tyler   NATURE REVIEWS NEUROSCIENCE

Multistep molecular mechanism for Bone morphogenetic protein extracellular transport in the Drosophila embryo

(2012) A. Sawala et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Force-specific activation of Smad1/5 regulates vascular endothelial cell cycle progression in response to disturbed flow

(2012) J. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Large Bioactive BMP Ligand with Distinct Signaling Properties Is Produced by Alternative Proconvertase Processing

(2012) T. Akiyama et al.   Science Signaling

Mechanical Load Modulates the Stimulatory Effect of BMP2 in a Rat Nonunion Model

(2012) Carolin Schwarz et al.   TISSUE ENGINEERING PART A

Surface immobilization of bone morphogenetic protein 2 via a self-assembled monolayer formation induces cell differentiation

(2011) Theresa L.M. Pohl et al.   Acta Biomaterialia

Presentation of BMP-2 from a Soft Biopolymeric Film Unveils its Activity on Cell Adhesion and Migration

(2011) Thomas Crouzier et al.   ADVANCED MATERIALS

Biomechanical Forces Shape the Tumor Microenvironment

(2011) Adrian C. Shieh   ANNALS OF BIOMEDICAL ENGINEERING

The performance of BMP-2 loaded TCP/HAP porous ceramics with a polyelectrolyte multilayer film coating

(2011) Thomas Crouzier et al.   BIOMATERIALS

Cells Respond to Mechanical Stress by Rapid Disassembly of Caveolae

(2011) Bidisha Sinha et al.   CELL

Involvement of BMPs/Smad Signaling Pathway in Mechanical Response in Osteoblasts

(2011) Liang Wang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Homomeric and heteromeric complexes among TGF-β and BMP receptors and their roles in signaling

(2011) Marcelo Ehrlich et al.   CELLULAR SIGNALLING

Biomaterials meet microfluidics: building the next generation of artificial niches

(2011) Stefan Kobel et al.   CURRENT OPINION IN BIOTECHNOLOGY

More than a feeling: discovering, understanding, and influencing mechanosensing pathways

(2011) Andrew W Holle et al.   CURRENT OPINION IN BIOTECHNOLOGY

Mechanotransduction at cadherin-mediated adhesions

(2011) Deborah E Leckband et al.   CURRENT OPINION IN CELL BIOLOGY

Systems control of BMP morphogen flow in vertebrate embryos

(2011) Jean-Louis Plouhinec et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Few Smad proteins and many Smad-interacting proteins yield multiple functions and action modes in TGFβ/BMP signaling in vivo

(2011) Andrea Conidi et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Novel functions of Noggin proteins: inhibition of Activin/Nodal and Wnt signaling

(2011) A. V. Bayramov et al.   DEVELOPMENT

Hippo pathway regulation by cell morphology and stress fibers

(2011) K.-I. Wada et al.   DEVELOPMENT

A Smad action turnover switch operated by WW domain readers of a phosphoserine code

(2011) E. Aragon et al.   GENES & DEVELOPMENT

Mechanical signaling through the cytoskeleton regulates cell proliferation by coordinated focal adhesion and Rho GTPase signaling

(2011) P. P. Provenzano et al.   JOURNAL OF CELL SCIENCE

Initiation of BMP2 signaling in domains on the plasma membrane

(2011) Jeremy Bonor et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Effects of in vivo mechanical loading on large bone defect regeneration

(2011) Joel D. Boerckel et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Latent TGF-β structure and activation

(2011) Minlong Shi et al.   NATURE

Role of YAP/TAZ in mechanotransduction

(2011) Sirio Dupont et al.   NATURE

Dynamic molecular processes mediate cellular mechanotransduction

(2011) Brenton D. Hoffman et al.   NATURE

Actin dynamics counteract membrane tension during clathrin-mediated endocytosis

(2011) Steeve Boulant et al.   NATURE CELL BIOLOGY

Fibroblast polarization is a matrix-rigidity-dependent process controlled by focal adhesion mechanosensing

(2011) Masha Prager-Khoutorsky et al.   NATURE CELL BIOLOGY

Bridging membrane and cytoskeleton dynamics in the secretory and endocytic pathways

(2011) Mihaela Anitei et al.   NATURE CELL BIOLOGY

Artificial niche microarrays for probing single stem cell fate in high throughput

(2011) Samy Gobaa et al.   NATURE METHODS

The nucleoskeleton as a genome-associated dynamic 'network of networks'

(2011) Dan N. Simon et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular control of endothelial cell behaviour during blood vessel morphogenesis

(2011) Shane P. Herbert et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Balancing forces: architectural control of mechanotransduction

(2011) Christopher C. DuFort et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Effects of Disturbed Flow on Vascular Endothelium: Pathophysiological Basis and Clinical Perspectives

(2011) Jeng-Jiann Chiu et al.   PHYSIOLOGICAL REVIEWS

Spatial Segregation of BMP/Smad Signaling Affects Osteoblast Differentiation in C2C12 Cells

(2011) Eva Heining et al.   PLoS One

Integrin activation and internalization on soft ECM as a mechanism of induction of stem cell differentiation by ECM elasticity

(2011) J. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transcription factor genes Smad4 and Gata4 cooperatively regulate cardiac valve development

(2011) I. P. Moskowitz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Synergistic Control of Mesenchymal Stem Cell Differentiation by Nanoscale Surface Geometry and Immobilized Growth Factors on TiO2 Nanotubes

(2011) Jung Park et al.   Small

Mechanotransduction of shear in the endothelium: Basic studies and clinical implications

(2011) Blair D Johnson et al.   VASCULAR MEDICINE

A High Precision Survey of the Molecular Dynamics of Mammalian Clathrin-Mediated Endocytosis

(2011) Marcus J. Taylor et al.   PLOS BIOLOGY

Bone morphogenetic protein and growth differentiation factor cytokine families and their protein antagonists

(2010) Christopher C. Rider et al.   BIOCHEMICAL JOURNAL

Differentiation of pre-osteoblast cells on poly(ethylene terephthalate) grafted with RGD and/or BMPs mimetic peptides

(2010) Omar F. Zouani et al.   BIOMATERIALS

The identification of a heparin binding domain peptide from bone morphogenetic protein-4 and its role on osteogenesis

(2010) Yoon Jung Choi et al.   BIOMATERIALS

Controlled spatial and conformational display of immobilised bone morphogenetic protein-2 and osteopontin signalling motifs regulates osteoblast adhesion and differentiation in vitro

(2010) Elizabeth A Mitchell et al.   BMC BIOLOGY

Mechanical control of tissue and organ development

(2010) T. Mammoto et al.   DEVELOPMENT

Mechanotransduction in bone repair and regeneration

(2010) Chenyu Huang et al.   FASEB JOURNAL

The Hippo-YAP pathway in organ size control and tumorigenesis: an updated version

(2010) B. Zhao et al.   GENES & DEVELOPMENT

Fibrillin-1 and -2 differentially modulate endogenous TGF-β and BMP bioavailability during bone formation

(2010) Harikiran Nistala et al.   JOURNAL OF CELL BIOLOGY

Matrix elasticity, cytoskeletal forces and physics of the nucleus: how deeply do cells 'feel' outside and in?

(2010) A. Buxboim et al.   JOURNAL OF CELL SCIENCE

Mechanisms of mechanical signaling in development and disease

(2010) P. A. Janmey et al.   JOURNAL OF CELL SCIENCE

Harnessing traction-mediated manipulation of the cell/matrix interface to control stem-cell fate

(2010) Nathaniel Huebsch et al.   NATURE MATERIALS

Regulatory mechanisms in vascular calcification

(2010) Andrew P. Sage et al.   Nature Reviews Cardiology

Mechanical signals as anabolic agents in bone

(2010) Engin Ozcivici et al.   Nature Reviews Rheumatology

Mechanical Stress Activates Smad Pathway through PKCδ to Enhance Interleukin-11 Gene Transcription in Osteoblasts

(2010) Shinsuke Kido et al.   PLoS One

Signaling by members of the TGF-β family in vascular morphogenesis and disease

(2010) Evangelia Pardali et al.   TRENDS IN CELL BIOLOGY

Genetic Control of Bone Formation

(2009) Gerard Karsenty et al.   Annual Review of Cell and Developmental Biology

Biochemical and functional characterization of the Ror2/BRIb receptor complex

(2009) Marei Sammar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Receptor oligomerization and beyond: a case study in bone morphogenetic proteins

(2009) Kai Heinecke et al.   BMC BIOLOGY

Mechanics, malignancy, and metastasis: The force journey of a tumor cell

(2009) Sanjay Kumar et al.   CANCER AND METASTASIS REVIEWS

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Matrix Crosslinking Forces Tumor Progression by Enhancing Integrin Signaling

(2009) Kandice R. Levental et al.   CELL

Smooth Muscle Cells Give Rise to Osteochondrogenic Precursors and Chondrocytes in Calcifying Arteries

(2009) Mei Y. Speer et al.   CIRCULATION RESEARCH

Extracellular microfibrils: contextual platforms for TGFβ and BMP signaling

(2009) Francesco Ramirez et al.   CURRENT OPINION IN CELL BIOLOGY

BMP2 signaling in bone development and repair

(2009) Vicki Rosen   CYTOKINE & GROWTH FACTOR REVIEWS

Integration of BMP and Wnt signaling via vertebrate Smad1/5/8 and Drosophila Mad

(2009) Edward Eivers et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Emerging role of bone morphogenetic proteins in angiogenesis

(2009) Laurent David et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Recent advances in BMP receptor signaling

(2009) Christina Sieber et al.   CYTOKINE & GROWTH FACTOR REVIEWS

TGF-β Superfamily Signaling in Embryonic Development and Homeostasis

(2009) Mary Y. Wu et al.   DEVELOPMENTAL CELL

Novel crosstalk to BMP signalling: cGMP-dependent kinase I modulates BMP receptor and Smad activity

(2009) Raphaela Schwappacher et al.   EMBO JOURNAL

The role of endogenous bone morphogenetic proteins in normal skeletal repair

(2009) Richard Marsell et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Synergistic action of static stretching and BMP-2 stimulation in the osteoblast differentiation of C2C12 myoblasts

(2009) In Sook Kim et al.   JOURNAL OF BIOMECHANICS

Boning up on Wolff's Law: Mechanical regulation of the cells that make and maintain bone

(2009) Jan-Hung Chen et al.   JOURNAL OF BIOMECHANICS

A concentration-dependent endocytic trap and sink mechanism converts Bmper from an activator to an inhibitor of Bmp signaling

(2009) Rusty Kelley et al.   JOURNAL OF CELL BIOLOGY

PP2A regulates BMP signalling by interacting with BMP receptor complexes and by dephosphorylating both the C-terminus and the linker region of Smad1

(2009) L. Bengtsson et al.   JOURNAL OF CELL SCIENCE

Cellular and molecular mechanisms of thoracic aortic aneurysms

(2009) Ismail El-Hamamsy et al.   Nature Reviews Cardiology

Growth Factors, Matrices, and Forces Combine and Control Stem Cells

(2009) D. E. Discher et al.   SCIENCE

Mechanotransduction in osteoblast regulation and bone disease

(2009) Katerina K. Papachroni et al.   TRENDS IN MOLECULAR MEDICINE

Daily low-intensity pulsed ultrasound stimulates production of bone morphogenetic protein in ROS 17/2.8 cells

(2009) Akito Suzuki et al.   Journal of Oral Science

Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Focus on Smooth Muscle Cell Contractile Dysfunction

(2008) Dianna M. Milewicz et al.   Annual Review of Genomics and Human Genetics

Role of transforming growth factor-β superfamily signaling pathways in human disease

(2008) Kelly J. Gordon et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Angiopoietin-1 mediates the proangiogenic activity of the bone morphogenic protein antagonist Drm

(2008) S. Mitola et al.   BLOOD

Neural guidance molecules, tip cells, and mechanical factors in vascular development

(2008) F. le Noble et al.   CARDIOVASCULAR RESEARCH

TGF-β signaling in vascular biology and dysfunction

(2008) Marie-José Goumans et al.   CELL RESEARCH

Mechanical Load and BMP Signaling During Tendon Repair: A Role for Follistatin?

(2008) Pernilla Eliasson et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Otefin, a Nuclear Membrane Protein, Determines the Fate of Germline Stem Cells in Drosophila via Interaction with Smad Complexes

(2008) Xiaoyong Jiang et al.   DEVELOPMENTAL CELL

Tissue Deformation Modulates Twist Expression to Determine Anterior Midgut Differentiation in Drosophila Embryos

(2008) Nicolas Desprat et al.   DEVELOPMENTAL CELL

Targeting of Bone Morphogenetic Protein Growth Factor Complexes to Fibrillin

(2008) Gerhard Sengle et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Compressive forces induce osteogenic gene expression in calvarial osteoblasts

(2008) Bjoern Rath et al.   JOURNAL OF BIOMECHANICS

Mechanotransduction and Fracture Repair

(2008) Elise F. Morgan et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

TAZ controls Smad nucleocytoplasmic shuttling and regulates human embryonic stem-cell self-renewal

(2008) Xaralabos Varelas et al.   NATURE CELL BIOLOGY

Mechanotransduction in development: a growing role for contractility

(2008) Michele A. Wozniak et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Environmental sensing through focal adhesions

(2008) Benjamin Geiger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction gone awry

(2008) Diana E. Jaalouk et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction in vascular physiology and atherogenesis

(2008) Cornelia Hahn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanotransduction at a distance: mechanically coupling the extracellular matrix with the nucleus

(2008) Ning Wang et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

How the Smads regulate transcription

(2007) Sarah Ross et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Microenvironments Engineered by Inkjet Bioprinting Spatially Direct Adult Stem Cells Toward Muscle- and Bone-Like Subpopulations

(2007) Julie A. Phillippi et al.   STEM CELLS