The promise of perfect adult tissue repair and regeneration in mammals: Learning from regenerative amphibians and fish

Complete cardiac regeneration in a mouse model of myocardial infarction

(2016) Bernhard Johannes Haubner et al.   Aging-US

Spinal cord regeneration: where fish, frogs and salamanders lead the way, can we follow?

(2013) Juan Felipe Diaz Quiroz et al.   BIOCHEMICAL JOURNAL

Cycling progenitors maintain epithelia while diverse cell types contribute to repair

(2013) David P. Doupé et al.   BIOESSAYS

Lin28 Enhances Tissue Repair by Reprogramming Cellular Metabolism

(2013) Ng Shyh-Chang et al.   CELL

Fundamental Differences in Dedifferentiation and Stem Cell Recruitment during Skeletal Muscle Regeneration in Two Salamander Species

(2013) Tatiana Sandoval-Guzmán et al.   Cell Stem Cell

Technological Overview of iPS Induction from Human Adult Somatic Cells

(2013) Emilie Bayart et al.   CURRENT GENE THERAPY

Epigenetics of cellular reprogramming

(2013) Raga Krishnakumar et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Tumor suppressors: enhancers or suppressors of regeneration?

(2013) J. H. Pomerantz et al.   DEVELOPMENT

Pseudotyped retroviruses for infecting axolotl in vivo and in vitro

(2013) J. L. Whited et al.   DEVELOPMENT

Connective tissue cells, but not muscle cells, are involved in establishing the proximo-distal outcome of limb regeneration in the axolotl

(2013) E. Nacu et al.   DEVELOPMENT

Nerve independent limb induction in axolotls

(2013) Aki Makanae et al.   DEVELOPMENTAL BIOLOGY

A reference transcriptome and inferred proteome for the salamander Notophthalmus viridescens

(2013) Ilgar Abdullayev et al.   EXPERIMENTAL CELL RESEARCH

Cardiac regeneration in non-mammalian vertebrates

(2013) Claudia Garcia-Gonzalez et al.   EXPERIMENTAL CELL RESEARCH

How induced pluripotent stem cells are redefining personalized medicine

(2013) Leonardo M.R. Ferreira et al.   GENE

Underlying potential: cellular and molecular determinants of adult liver repair

(2013) Anna Mae Diehl et al.   JOURNAL OF CLINICAL INVESTIGATION

Adult Zebrafish as a Model System for Cutaneous Wound-Healing Research

(2013) Rebecca Richardson et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Macrophage phenotypes during tissue repair

(2013) Margaret L. Novak et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Epigenetic Regulation of Sensory Axon Regeneration after Spinal Cord Injury

(2013) M. J. Finelli et al.   JOURNAL OF NEUROSCIENCE

D-type Cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells

(2013) Qian Zhang et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

In vivo cardiac reprogramming contributes to zebrafish heart regeneration

(2013) Ruilin Zhang et al.   NATURE

Wnt activation in nail epithelium couples nail growth to digit regeneration

(2013) Makoto Takeo et al.   NATURE

Proliferation zones in the axolotl brain and regeneration of the telencephalon

(2013) Malcolm Maden et al.   Neural Development

Comparative Transcriptional Profiling of the Axolotl Limb Identifies a Tripartite Regeneration-Specific Gene Program

(2013) Dunja Knapp et al.   PLoS One

Transcriptome Analysis of Newt Lens Regeneration Reveals Distinct Gradients in Gene Expression Patterns

(2013) Konstantinos Sousounis et al.   PLoS One

Changes in the Inflammatory Response to Injury and Its Resolution during the Loss of Regenerative Capacity in Developing Xenopus Limbs

(2013) Anthony L. Mescher et al.   PLoS One

Macrophages are required for adult salamander limb regeneration

(2013) James W. Godwin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The zebrafish as a model for complex tissue regeneration

(2013) Matthew Gemberling et al.   TRENDS IN GENETICS

Agr genes, missing in amniotes, are involved in the body appendages regeneration in frog tadpoles

(2013) Anastasiya S. Ivanova et al.   Scientific Reports

Comparative RNA-seq Analysis in the Unsequenced Axolotl: The Oncogene Burst Highlights Early Gene Expression in the Blastema

(2013) Ron Stewart et al.   PLoS Computational Biology

A de novo assembly of the newt transcriptome combined with proteomic validation identifies new protein families expressed during tissue regeneration

(2013) Mario Looso et al.   GENOME BIOLOGY

Germline Transgenic Methods for Tracking Cells and Testing Gene Function during Regeneration in the Axolotl

(2013) Shahryar Khattak et al.   Stem Cell Reports

Cellular Mechanisms of Tissue Fibrosis. 1. Common and organ-specific mechanisms associated with tissue fibrosis

(2012) Michael Zeisberg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Studying Mechanisms of Regeneration in Amphibian and Reptilian Vertebrate Models

(2012) Kenro Kusumi et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

The DevelopingXenopusLimb as a Model for Studies on the Balance between Inflammation and Regeneration

(2012) Michael W. King et al.   Anatomical Record-Advances in Integrative Anatomy and Evolutionary Biology

Lens and retina regeneration: new perspectives from model organisms

(2012) Karla Barbosa-Sabanero et al.   BIOCHEMICAL JOURNAL

Heterochronic parabiosis for the study of the effects of aging on stem cells and their niches

(2012) Irina M. Conboy et al.   CELL CYCLE

Regeneration and reprogramming

(2012) Dunja Knapp et al.   CURRENT OPINION IN GENETICS & DEVELOPMENT

Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2

(2012) S. Li et al.   DEVELOPMENT

Regeneration of Amputated Zebrafish Fin Rays from De Novo Osteoblasts

(2012) Sumeet Pal Singh et al.   DEVELOPMENTAL CELL

Imparting Regenerative Capacity to Limbs by Progenitor Cell Transplantation

(2012) Gufa Lin et al.   DEVELOPMENTAL CELL

Live Imaging Reveals Differing Roles of Macrophages and Neutrophils during Zebrafish Tail Fin Regeneration

(2012) Li Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Anterior Gradient 2 (Agr2) Expression Results in Hyperplasia and Defective Lineage Maturation in the Murine Stomach

(2012) Aparna Gupta et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Negative Regulators of Schwann Cell Differentiation—Novel Targets for Peripheral Nerve Therapies?

(2012) André Heinen et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Spiked-in Pulsed in Vivo Labeling Identifies a New Member of the CCN Family in Regenerating Newt Hearts

(2012) Mario Looso et al.   JOURNAL OF PROTEOME RESEARCH

Histone deacetylases are required for amphibian tail and limb regeneration but not development

(2012) Amy J. Taylor et al.   MECHANISMS OF DEVELOPMENT

Distinct contribution of stem and progenitor cells to epidermal maintenance

(2012) Guilhem Mascré et al.   NATURE

Dll1+ secretory progenitor cells revert to stem cells upon crypt damage

(2012) Johan H. van Es et al.   NATURE CELL BIOLOGY

Epigenetic repression of cardiac progenitor gene expression by Ezh2 is required for postnatal cardiac homeostasis

(2012) Paul Delgado-Olguín et al.   NATURE GENETICS

Macrophage-derived Wnt opposes Notch signaling to specify hepatic progenitor cell fate in chronic liver disease

(2012) Luke Boulter et al.   NATURE MEDICINE

Emerging roles for the pro-oncogenic anterior gradient-2 in cancer development

(2012) E Chevet et al.   ONCOGENE

PhOTO Zebrafish: A Transgenic Resource for In Vivo Lineage Tracing during Development and Regeneration

(2012) William P. Dempsey et al.   PLoS One

Skin Regeneration in Adult Axolotls: A Blueprint for Scar-Free Healing in Vertebrates

(2012) Ashley W. Seifert et al.   PLoS One

Zebrafish Agr2 Is Required for Terminal Differentiation of Intestinal Goblet Cells

(2012) Yi-Chung Chen et al.   PLoS One

Multi-Tissue Microarray Analysis Identifies a Molecular Signature of Regeneration

(2012) Sarah E. Mercer et al.   PLoS One

Inducible genetic system for the axolotl

(2012) J. L. Whited et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nerve dependence in tissue, organ, and appendage regeneration

(2012) Anoop Kumar et al.   TRENDS IN NEUROSCIENCES

Limb regeneration

(2012) András Simon et al.   Wiley Interdisciplinary Reviews-Developmental Biology

Gene expression patterns specific to the regenerating limb of the Mexican axolotl

(2012) James R. Monaghan et al.   Biology Open

Cellular and Molecular Mechanisms of Chronic Inflammation-Associated Organ Fibrosis

(2012) Satoshi Ueha et al.   Frontiers in Immunology

tcf21+ epicardial cells adopt non-myocardial fates during zebrafish heart development and regeneration

(2011) K. Kikuchi et al.   DEVELOPMENT

Dedifferentiation and the role of sall4 in reprogramming and patterning during amphibian limb regeneration

(2011) Anton W. Neff et al.   DEVELOPMENTAL DYNAMICS

Gene expression profile of the regeneration epithelium during axolotl limb regeneration

(2011) Leah J. Campbell et al.   DEVELOPMENTAL DYNAMICS

The role of peripheral nerves in urodele limb regeneration

(2011) David L. Stocum   EUROPEAN JOURNAL OF NEUROSCIENCE

The interplay between macrophages and angiogenesis in development, tissue injury and regeneration

(2011) Silvia Nucera et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL BIOLOGY

A reserve stem cell population in small intestine renders Lgr5-positive cells dispensable

(2011) Hua Tian et al.   NATURE

Different Requirement for Wnt/β-Catenin Signaling in Limb Regeneration of Larval and Adult Xenopus

(2011) Hitoshi Yokoyama et al.   PLoS One

Mouse digit tip regeneration is mediated by fate-restricted progenitor cells

(2011) J. A. Lehoczky et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Transient Regenerative Potential of the Neonatal Mouse Heart

(2011) E. R. Porrello et al.   SCIENCE

Natural Killer Cells Preferentially Target Cancer Stem Cells; Role of Monocytes in Protection Against NK Cell Mediated Lysis of Cancer Stem Cells

(2011) Anahid Jewett et al.   Current Drug Delivery

AmbLOXe—An Epidermal Lipoxygenase of the Mexican Axolotl in the Context of Amphibian Regeneration and Its Impact on Human Wound Closure In Vitro

(2010) Bjoern Menger et al.   ANNALS OF SURGERY

Regeneration and reprogramming compared

(2010) Bea Christen et al.   BMC BIOLOGY

Transient Inactivation of Rb and ARF Yields Regenerative Cells from Postmitotic Mammalian Muscle

(2010) Kostandin V. Pajcini et al.   Cell Stem Cell

Potential and pitfalls of stem cell therapy in old age

(2010) D. Piccin et al.   Disease Models & Mechanisms

Oocyte-type linker histone B4 is required for transdifferentiation of somatic cells in vivo

(2010) Nobuyasu Maki et al.   FASEB JOURNAL

Deer Antlers – A Model of Mammalian Appendage Regeneration: An Extensive Review

(2010) Uwe Kierdorf et al.   GERONTOLOGY

Evolutionary Loss of Animal Regeneration: Pattern and Process

(2010) A. E. Bely   INTEGRATIVE AND COMPARATIVE BIOLOGY

Evidence for the Local Evolution of Mechanisms Underlying Limb Regeneration in Salamanders

(2010) A. Acely Garza-Garcia et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

Functional convergence of signalling by GPI-anchored and anchorless forms of a salamander protein implicated in limb regeneration

(2010) R. A. Blassberg et al.   JOURNAL OF CELL SCIENCE

Skin wound healing in axolotls: a scarless process

(2010) Mathieu Lévesque et al.   JOURNAL OF EXPERIMENTAL ZOOLOGY PART B-MOLECULAR AND DEVELOPMENTAL EVOLUTION

Differential Roles of Macrophages in Diverse Phases of Skin Repair

(2010) T. Lucas et al.   JOURNAL OF IMMUNOLOGY

Regenerative medicine. Opportunities and challenges: a brief overview

(2010) D. J. Polak   Journal of the Royal Society Interface

Primary contribution to zebrafish heart regeneration by gata4 + cardiomyocytes

(2010) Kazu Kikuchi et al.   NATURE

Zebrafish heart regeneration occurs by cardiomyocyte dedifferentiation and proliferation

(2010) Chris Jopling et al.   NATURE

Increased Lysis of Stem Cells but Not Their Differentiated Cells by Natural Killer Cells; De-Differentiation or Reprogramming Activates NK Cells

(2010) Han-Ching Tseng et al.   PLoS One

Macrophage Wnt7b is critical for kidney repair and regeneration

(2010) S.-L. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proteomic analysis of blastema formation in regenerating axolotl limbs

(2009) Nandini Rao et al.   BMC BIOLOGY

Loss of Dnmt1 catalytic activity reveals multiple roles for DNA methylation during pancreas development and regeneration

(2009) Ryan M. Anderson et al.   DEVELOPMENTAL BIOLOGY

Expression of stem cell pluripotency factors during regeneration in newts

(2009) Nobuyasu Maki et al.   DEVELOPMENTAL DYNAMICS

Plasticity and recovery of skeletal muscle satellite cells during limb regeneration

(2009) Jamie I. Morrison et al.   FASEB JOURNAL

The Role of Nerve Signaling in Limb Genesis and Agenesis During Axolotl Limb Regeneration

(2009) Akira Satoh et al.   JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME

Cells keep a memory of their tissue origin during axolotl limb regeneration

(2009) Martin Kragl et al.   NATURE

Lin28-mediated post-transcriptional regulation of Oct4 expression in human embryonic stem cells

(2009) Caihong Qiu et al.   NUCLEIC ACIDS RESEARCH

A CREB-C/EBP  cascade induces M2 macrophage-specific gene expression and promotes muscle injury repair

(2009) D. Ruffell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Evolution of animal regeneration: re-emergence of a field

(2009) Alexandra E. Bely et al.   TRENDS IN ECOLOGY & EVOLUTION

Comparative Aspects of Animal Regeneration

(2008) Jeremy P. Brockes et al.   Annual Review of Cell and Developmental Biology

Mammalian regeneration and regenerative medicine

(2008) Ken Muneoka et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Inhibition of mammalian muscle differentiation by regeneration blastema extract of Sternopygus macrurus

(2008) Hyun-Jung Kim et al.   DEVELOPMENTAL DYNAMICS

Development and regeneration of the neonatal digit tip in mice

(2007) Manjong Han et al.   DEVELOPMENTAL BIOLOGY

Cellular and molecular mechanisms of fibrosis

(2007) TA Wynn   JOURNAL OF PATHOLOGY