Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners

Yeast Nab3 Protein Contains a Self-assembly Domain Found in Human Heterogeneous Nuclear Ribonucleoprotein-C (hnRNP-C) That Is Necessary for Transcription Termination

(2012) Travis J. Loya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Evolution and function of CAG/polyglutamine repeats in protein–protein interaction networks

(2012) Martin H. Schaefer et al.   NUCLEIC ACIDS RESEARCH

Large-Scale Screen for Modifiers of Ataxin-3-Derived Polyglutamine-Induced Toxicity in Drosophila

(2012) Hannes Voßfeldt et al.   PLoS One

Stress and aging induce distinct polyQ protein aggregation states

(2012) L. E. Moronetti Mazzeo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Human Proteins That Modify Misfolding and Proteotoxicity of Pathogenic Ataxin-1

(2012) Spyros Petrakis et al.   PLoS Genetics

Huntingtin affinity for partners is not changed by polyglutamine length: aggregation itself triggers aberrant interactions

(2011) Aurélien Davranche et al.   HUMAN MOLECULAR GENETICS

A Genetic Screening Strategy Identifies Novel Regulators of the Proteostasis Network

(2011) M. Catarina Silva et al.   PLoS Genetics

Essential Role of Coiled Coils for Aggregation and Activity of Q/N-Rich Prions and PolyQ Proteins

(2010) Ferdinando Fiumara et al.   CELL

Polyglutamine Induced Misfolding of Huntingtin Exon1 is Modulated by the Flanking Sequences

(2010) Vinal V. Lakhani et al.   PLoS Computational Biology

Secondary Structure of Huntingtin Amino-Terminal Region

(2009) Mee Whi Kim et al.   STRUCTURE

Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1

(2008) Janghoo Lim et al.   NATURE