Review
Pharmacology & Pharmacy
Atsushi Onodera, Kota Kokubo, Mikiko Okano, Miki Onoue, Masahiro Kiuchi, Chiaki Iwamura, Tomohisa Iinuma, Motoko Y. Kimura, Nobuyuki Ebihara, Toyoyuki Hanazawa, Toshinori Nakayama, Kiyoshi Hirahara
Summary: Allergic diseases are the result of a complex interaction between the immune system and environmental factors. Recent research has led to significant developments in therapeutic agents for these diseases, including IL-5 and IL-5 receptor antagonists, JAK inhibitors, and sub-lingual immunotherapy. This review provides an updated view on the treatment and cause of allergic diseases, with a focus on the role of conventional and pathogenic Th2 cells.
PHARMACOLOGY & THERAPEUTICS
(2023)
Article
Immunology
Yasmeen S. El Ansari, Cynthia Kanagaratham, Oliver T. Burton, Jenna V. Santos, Brianna-Marie A. Hollister, Owen L. Lewis, Harald Renz, Hans C. Oettgen
Summary: Mast cells and basophils play important roles in IgE-mediated hypersensitivity reactions. IgG and IgA antibodies can regulate the activation of these cells by activating or inhibiting receptors. This study found that IgA antibodies can bind to mast cells and basophils, and inhibit their activation to maintain immune homeostasis at mucosal sites.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Alvaro Diaz, Ignacio Gonzalez-Alayon, Valentina Perez-Torrado, Mariana Suarez-Martins
Summary: The interaction between CD40 and CD154 plays a central role in immunology, involving processes such as DC priming of CD4(+) T cells, CD4(+) T cell help to B cells, and classical macrophage activation. While the role of CD40 and CD154 in Th2 immune responses is still not fully understood, they are crucial for inducing most Th2 responses despite not causing significant up-regulation of CD40 in DC in Th2 systems. Exogenous CD40 ligation can shift Th2-biased systems towards Th1 by enhancing IL-12 production, indicating the importance of these interactions in immune polarization.
SEMINARS IN IMMUNOLOGY
(2021)
Article
Immunology
Miaomiao Han, Jingyu Ma, Suidong Ouyang, Yanyan Wang, Tingting Zheng, Peishan Lu, Zihan Zheng, Weiheng Zhao, Hongjin Li, Yun Wu, Baohua Zhang, Ran Hu, Kinya Otsu, Xinguang Liu, Ying Wan, Huabin Li, Gonghua Huang
Summary: Dendritic cells (DCs) play a critical role in controlling T helper 2 (Th2) cell-dependent diseases. Our study identifies p38 alpha signaling as a central pathway in DCs that regulates Th2-cell differentiation and function, integrating allergic and parasitic instructive signals with Th2-instructive cytokines from the microenvironment.
CELLULAR & MOLECULAR IMMUNOLOGY
(2022)
Review
Immunology
Daniel Radtke, David Voehringer
Summary: Granulocytes provide a rapid response to pathogens and allergens through the release of inflammatory mediators and recruitment of different cell types. They play a role in both promoting and limiting tissue damage and are potential targets for therapeutic interventions in allergic disorders.
EUROPEAN JOURNAL OF IMMUNOLOGY
(2023)
Article
Immunology
Remo Poto, Isabella Quinti, Gianni Marone, Maurizio Taglialatela, Amato de Paulis, Vincenzo Casolaro, Gilda Varricchi
Summary: Release of proinflammatory mediators and cytokines from basophils and mast cells mediated by IgE is a key event in allergic disorders. The presence and functional activity of anti-IgE autoantibodies in atopic dermatitis (AD) are largely unknown. This study evaluated the ability of IgG anti-IgE from patients with AD to induce in vitro IgE-dependent activation of basophils and mast cells.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Allergy
Dubravka Smiljkovic, Harald Herrmann, Irina Sadovnik, Susanne Gamperl, Daniela Berger, Gabriele Stefanzl, Gregor Eisenwort, Gregor Hoermann, Sonja Kopanja, Yulia Dorofeeva, Margarete Focke-Tejkl, Peter Jaksch, Konrad Hoetzenecker, Zsolt Szepfalusi, Rudolf Valenta, Michel Arock, Peter Valent
Summary: Siglec-6 is identified as a surface antigen specifically expressed on human MC and basophils. Its expression is dynamically regulated and varies depending on cell types and activation factors. Understanding the expression changes of Siglec-6 provides insights into the function of MC and basophils in allergic reactions.
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2023)
Article
Immunology
Alessandro Toscano, Jessy Elst, Athina L. Van Gasse, Michiel Beyens, Marie-Line van der Poorten, Chris H. Bridts, Christel Mertens, Michel Van Houdt, Margo M. Hagendorens, Samuel Van Remoortel, Jean-Pierre Timmermans, Didier G. Ebo, Vito Sabato
Summary: This study explored the expression and functionality of MRGPRX2 in and on basophils. The results showed that basophils barely express MRGPRX2 in resting conditions, but it can be quickly upregulated after stimulation and make cells responsive to MRGPRX2 occupation. These findings provide a model for studying MRGPRX2 agonism or antagonism and the mechanisms associated with IDHRs.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Multidisciplinary Sciences
Wei-Le Wang, Jun Kasamatsu, Satoru Joshita, Susan Gilfillan, Blanda Di Luccia, Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Jennifer K. Bando, Stanley Ching-Cheng Huang, Kentaro Yomogida, Hitomi Hoshino, Mana Fukushima, Elizabeth A. Jacobsen, Steven J. Van Dyken, Christiane Ruedl, Marina Cella, Marco Colonna
Summary: This study identified a unique subset of eosinophils expressing Clec4a4 in the small intestine, which exhibited an immunomodulatory profile. These Clec4a4+ eosinophils expressed high levels of aryl hydrocarbon receptor (Ahr) and showed a dependence on dietary AHR ligands.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Multidisciplinary Sciences
Wei-Le Wang, Jun Kasamatsu, Satoru Joshita, Susan Gilfillan, Blanda Di Luccia, Santosh K. Panda, Do-Hyun Kim, Pritesh Desai, Jennifer K. Bando, Stanley Ching-Cheng Huang, Kentaro Yomogida, Hitomi Hoshino, Mana Fukushima, Elizabeth A. Jacobsen, Steven J. Van Dyken, Christiane Ruedl, Marina Cella, Marco Colonna
Summary: A unique subset of eosinophils expressing high levels of Ahr and exhibiting immunomodulatory features is found in the small intestine. The abundance of these eosinophils depends on dietary AHR ligands and increases with aging, but decreases in inflammatory conditions.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2022)
Article
Biochemistry & Molecular Biology
Tianheng Hou, Miranda Sin-Man Tsang, Lea Ling-Yu Kan, Peiting Li, Ida Miu-Ting Chu, Christopher Wai-Kei Lam, Chun-Kwok Wong
Summary: IL-37b has been shown to regulate basophil activation mediated by TSLP and reduce the release of IL-4, suggesting its potential as a target for alleviating symptoms of AD.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biology
Daniel Radtke, Natalie Thuma, Christine Schuelein, Philipp Kirchner, Arif B. Ekici, Kilian Schober, David Voehringer, Bernard Malissen
Summary: After infecting mice with Nippostrongylus brasiliensis, researchers found that Th2 cells in the mesenteric lymph nodes and lungs have organ-specific expression profiles, with some populations showing conserved migration or effector/resident memory signatures, and unexpectedly clustering with potentially regulatory cells expressing Il10(pos)Foxp3(neg). The results suggest a role for interferon signaling in Th2 differentiation or diversification, and highlight the importance of proliferation in differentiation decisions.
Review
Immunology
Mohamed Hamed Abdelaziz, Xiaoyun Ji, Jie Wan, Fatma A. Abouelnazar, Sayed F. Abdelwahab, Huaxi Xu
Summary: This article discusses the correlation between allergic asthma and natural infections, exploring effective methods for preventing allergic asthma through natural infections. The authors mentioned the impact of Mycobacterium tuberculosis and helminth infections on the development of allergic asthma, as well as possible pathways for preventing allergic asthma through vaccine design.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Takuma Kitano, Kaho Togawa, Juri Takemori, Yuya Motoki, Keitaroh Kishida, Saotomo Itoh, Masaya Takamoto, Shinsuke Taki, Shigeaki Hida
Summary: Basophils produce IL-4 in response to IL-3 and acquire responsiveness to Fc epsilon RI cross-linking through infection or superantigen administration. This acquisition of responsiveness also occurs for other stimuli, such as CD200R3 cross-linking and papain allergen. The IL-3 signal bifurcates downstream of Jak, leading to IL-4 production and rendering basophils competent for IL-4 production through ITAM-containing adaptors.
Article
Multidisciplinary Sciences
Hannah L. Miller, Prabhakar Sairam Andhey, Melissa K. Swiecki, Bruce A. Rosa, Konstantin Zaitsev, Alexandra-Chloe Villani, Makedonka Mitreva, Maxim N. Artyomov, Susan Gilfillan, Marina Cella, Marco Colonna
Summary: This study revealed that depletion of pDCs in mice through injection of diphtheria toxin can enhance Th2-dependent skin inflammation, independent of reduced IFN-I. Additionally, treatment with DT alters the representation of conventional dendritic cells in the skin-draining lymph nodes, leading to Th2-driven contact hypersensitivity.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
(2021)
Article
Hematology
Christian Schwartz, Ralf Willebrand, Silke Huber, Rudolf A. Rupec, Davina Wu, Richard Locksley, David Voehringer
Article
Medicine, Research & Experimental
Katrina J. Binger, Matthias Gebhardt, Matthias Heinig, Carola Rintisch, Agnes Schroeder, Wolfgang Neuhofer, Karl Hilgers, Arndt Manzel, Christian Schwartz, Markus Kleinewietfeld, Jakob Voelkl, Valentin Schatz, Ralf A. Linker, Florian Lang, David Voehringer, Mark D. Wright, Norbert Hubner, Ralf Dechend, Jonathan Jantsch, Jens Titze, Dominik N. Mueller
JOURNAL OF CLINICAL INVESTIGATION
(2015)
Article
Cell Biology
Nathalie Geurts, Tim Vangansewinkel, Stefanie Lemmens, Sofie Nelissen, Lies Geboes, Christian Schwartz, David Voehringer, Sven Hendrix
JOURNAL OF LEUKOCYTE BIOLOGY
(2016)
Review
Immunology
Christian Schwartz, Katie O'Grady, Ed C. Lavelle, Padraic G. Fallon
EUROPEAN JOURNAL OF IMMUNOLOGY
(2016)
Letter
Allergy
Christian Schwartz, Joerg U. Eberle, Thomas Hoyler, Andreas Diefenbach, Matthias Lechmann, David Voehringer
JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY
(2016)
Article
Immunology
Carlos M. Minutti, Sebastian Drube, Natalie Blair, Christian Schwartz, Jame C. McCrae, Andrew N. McKenzie, Thomas Kamradt, Michal Mokry, Paul J. Coffer, Maria Sibilia, Alice J. Sijts, Padraic G. Fallon, Rick M. Maizels, Dietmar M. Zaiss
Article
Immunology
Christian Schwartz, Adnan R. Khan, Achilleas Floudas, Sean P. Saunders, Emily Hams, Hans-Reimer Rodewald, Andrew N. J. McKenzie, Padraic G. Fallon
JOURNAL OF EXPERIMENTAL MEDICINE
(2017)
Article
Immunology
Achilleas Floudas, Sean P. Saunders, Tara Moran, Christian Schwartz, Emily Hams, Denise C. Fitzgerald, James A. Johnston, Graham S. Ogg, Andrew N. McKenzie, Patrick T. Walsh, Padraic G. Fallon
JOURNAL OF IMMUNOLOGY
(2017)
Review
Parasitology
Christian Schwartz, Emily Hams, Padraic G. Fallon
TRENDS IN PARASITOLOGY
(2018)
Review
Immunology
Christian Schwartz, Padraic G. Fallon
FRONTIERS IN IMMUNOLOGY
(2018)
Article
Allergy
Christian Schwartz, Tara Moran, Sean P. Saunders, Agnieszka Kaszlikowska, Achilleas Floudas, Joana Bom, Gabriel Nunez, Yoichiro Iwakura, Luke O'Neill, Alan D. Irvine, Andrew N. J. McKenzie, Graham Ogg, Patrick T. Walsh, Jocelyne Demengeot, Padraic G. Fallon
Article
Immunology
Achilleas Floudas, Gabriella Aviello, Christian Schwartz, Ian B. Jeffery, Paul W. O'Toole, Padraic G. Fallon
INFECTION AND IMMUNITY
(2019)
Article
Allergy
Sean P. Saunders, Achilleas Floudas, Tara Moran, Ciara M. Byrne, Michael D. Rooney, Caoimhe M. R. Fahy, Joan A. Geoghegan, Yoichiro Iwakura, Padraic G. Fallon, Christian Schwartz
Article
Cell Biology
Christian Schwartz, Viviane Schmidt, Andrea Deinzer, Heike C. Hawerkamp, Emily Hams, Jasmin Bayerlein, Ole Roeger, Moritz Bailer, Christian Krautz, Amr El Gendy, Moustafa Elshafei, Helen M. Heneghan, Andrew E. Hogan, Donal O'Shea, Padraic G. Fallon
Summary: Obesity is a major health problem in the industrialized world. Immune regulation plays an important role in adipose tissue homeostasis. A recent study found that the costimulatory molecule programmed death-ligand 1 (PD-L1) plays a role in limiting diet-induced obesity. PD-L1 expression on dendritic cells (DCs) is essential for obesity control.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Review
Immunology
Viviane Schmidt, Andrew E. Hogan, Padraic G. Fallon, Christian Schwartz
Summary: In recent decades, the relationship between the immune system and metabolism has become a major research focus. The secretion of immunomodulatory molecules by adipose tissue during obesity, along with underlying low-grade inflammation, has brought attention to the impact obesity has on the immune system. Adipokines and nutrient availability play crucial roles in the differentiation and activation of T cells. The influence of obesity on the immune system is particularly evident in Th2-dominated immune responses.
FRONTIERS IN IMMUNOLOGY
(2022)
