IL-17 Receptor A Maintains and Protects the Skin Barrier To Prevent Allergic Skin Inflammation

The Skin Microbiome Differs with Age in Atopic Dermatitis

(2016) Baochen Shi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Multifactorial skin barrier deficiency and atopic dermatitis: Essential topics to prevent the atopic march

(2016) Gyohei Egawa et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human TH2 cell subpopulation with enhanced function

(2016) Alyssa Mitson-Salazar et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Spontaneous atopic dermatitis is mediated by innate immunity, with the secondary lung inflammation of the atopic march requiring adaptive immunity

(2016) Sean P. Saunders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cellular and molecular immunologic mechanisms in patients with atopic dermatitis

(2016) Thomas Werfel et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-23 induced in keratinocytes by endogenous TLR4 ligands polarizes dendritic cells to drive IL-22 responses to skin immunization

(2016) Juhan Yoon et al.   JOURNAL OF EXPERIMENTAL MEDICINE

MCPIP1/Regnase-1 Restricts IL-17A– and IL-17C–Dependent Skin Inflammation

(2016) Leticia Monin et al.   JOURNAL OF IMMUNOLOGY

Genetic, immunological, and clinical features of patients with bacterial and fungal infections due to inherited IL-17RA deficiency

(2016) Romain Lévy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combinatorial targeting of TSLP, IL-25, and IL-33 in type 2 cytokine–driven inflammation and fibrosis

(2016) Kevin M. Vannella et al.   Science Translational Medicine

Whole metagenome profiling reveals skin microbiome-dependent susceptibility to atopic dermatitis flare

(2016) Kern Rei Chng et al.   Nature Microbiology

Interleukin-23-Independent IL-17 Production Regulates Intestinal Epithelial Permeability

(2015) Jacob S. Lee et al.   IMMUNITY

Differential Roles for Interleukin-23 and Interleukin-17 in Intestinal Immunoregulation

(2015) Joseph R. Maxwell et al.   IMMUNITY

Barrier Epithelial Cells and the Control of Type 2 Immunity

(2015) Hamida Hammad et al.   IMMUNITY

Dysbiosis and Staphylococcus aureus Colonization Drives Inflammation in Atopic Dermatitis

(2015) Tetsuro Kobayashi et al.   IMMUNITY

The translational revolution and use of biologics in patients with inflammatory skin diseases

(2015) Shinji Noda et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

PD-L1hi B cells are critical regulators of humoral immunity

(2015) Adnan R. Khan et al.   Nature Communications

DAMP molecules S100A9 and S100A8 activated by IL-17A and house-dust mites are increased in atopic dermatitis

(2014) Shan Jin et al.   EXPERIMENTAL DERMATOLOGY

The importance of TSLP in allergic disease and its role as a potential therapeutic target

(2014) Antonella Cianferoni et al.   Expert Review of Clinical Immunology

An in vitro culture model to study the dynamics of colonic microbiota in Syrian golden hamsters and their susceptibility to infection with Clostridium difficile

(2014) Matthew Miezeiewski et al.   ISME Journal

Exposure to food allergens through inflamed skin promotes intestinal food allergy through the thymic stromal lymphopoietin–basophil axis

(2014) Mario Noti et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

IL-17A as an Inducer for Th2 Immune Responses in Murine Atopic Dermatitis Models

(2014) Saeko Nakajima et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Secukinumab in Plaque Psoriasis — Results of Two Phase 3 Trials

(2014) Richard G. Langley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Severe skin inflammation and filaggrin mutation similarly alter the skin barrier in patients with atopic dermatitis

(2013) G. Mócsai et al.   BRITISH JOURNAL OF DERMATOLOGY

A homozygous nonsense mutation in the gene for Tmem79, a component for the lamellar granule secretory system, produces spontaneous eczema in an experimental model of atopic dermatitis

(2013) Takashi Sasaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Tmem79/Matt is the matted mouse gene and is a predisposing gene for atopic dermatitis in human subjects

(2013) Sean P. Saunders et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

A role for IL-25 and IL-33–driven type-2 innate lymphoid cells in atopic dermatitis

(2013) Maryam Salimi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TSLP Elicits IL-33-Independent Innate Lymphoid Cell Responses to Promote Skin Inflammation

(2013) B. S. Kim et al.   Science Translational Medicine

Pathogenic memory type Th2 cells in allergic inflammation

(2013) Yusuke Endo et al.   TRENDS IN IMMUNOLOGY

Skin thymic stromal lymphopoietin initiates Th2 responses through an orchestrated immune cascade

(2013) Juan Manuel Leyva-Castillo et al.   Nature Communications

IL-33 citrine reporter mice reveal the temporal and spatial expression of IL-33 during allergic lung inflammation

(2012) Clare S. Hardman et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Temporal shifts in the skin microbiome associated with disease flares and treatment in children with atopic dermatitis

(2012) H. H. Kong et al.   GENOME RESEARCH

Multiple-checkpoint inhibition of thymic stromal lymphopoietin–induced TH2 response by TH17-related cytokines

(2012) Sofia I. Bogiatzi et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Filaggrin loss-of-function mutations are associated with enhanced expression of IL-1 cytokines in the stratum corneum of patients with atopic dermatitis and in a murine model of filaggrin deficiency

(2012) Sanja Kezic et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Altered stratum corneum barrier and enhanced percutaneous immune responses in filaggrin-null mice

(2012) Hiroshi Kawasaki et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Langerhans cells are critical in epicutaneous sensitization with protein antigen via thymic stromal lymphopoietin receptor signaling

(2012) Saeko Nakajima et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Progressive activation of TH2/TH22 cytokines and selective epidermal proteins characterizes acute and chronic atopic dermatitis

(2012) Julia K. Gittler et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

An Alternative Pathway of Imiquimod-Induced Psoriasis-Like Skin Inflammation in the Absence of Interleukin-17 Receptor A Signaling

(2012) Khalifa El Malki et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The psoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90

(2012) Chenhui Wang et al.   NATURE IMMUNOLOGY

Brodalumab, an Anti–Interleukin-17–Receptor Antibody for Psoriasis

(2012) Kim A. Papp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Filaggrin Genotype in Ichthyosis Vulgaris Predicts Abnormalities in Epidermal Structure and Function

(2011) Robert Gruber et al.   AMERICAN JOURNAL OF PATHOLOGY

IL-17 downregulates filaggrin and affects keratinocyte expression of genes associated with cellular adhesion

(2011) Danuta Gutowska-Owsiak et al.   EXPERIMENTAL DERMATOLOGY

Mouse CCL8, a CCR8 agonist, promotes atopic dermatitis by recruiting IL-5+ TH2 cells

(2011) Sabina A Islam et al.   NATURE IMMUNOLOGY

Filaggrin Mutations Associated with Skin and Allergic Diseases

(2011) Alan D. Irvine et al.   NEW ENGLAND JOURNAL OF MEDICINE

Sensing the outside world: TSLP regulates barrier immunity

(2010) Steven F Ziegler et al.   NATURE IMMUNOLOGY

Metagenomic analyses reveal antibiotic-induced temporal and spatial changes in intestinal microbiota with associated alterations in immune cell homeostasis

(2009) D A Hill et al.   Mucosal Immunology

A homozygous frameshift mutation in the mouse Flg gene facilitates enhanced percutaneous allergen priming

(2009) Padraic G Fallon et al.   NATURE GENETICS

Understanding Asthma Using Animal Models

(2009) Yoo Seob Shin et al.   Allergy Asthma & Immunology Research

Atopic Dermatitis

(2008) Thomas Bieber   NEW ENGLAND JOURNAL OF MEDICINE